AATK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.86248489
2central nervous system myelination (GO:0022010)5.86248489
3synaptic vesicle maturation (GO:0016188)5.45488684
4neuronal action potential propagation (GO:0019227)4.98830928
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.97843360
6locomotory exploration behavior (GO:0035641)4.97648242
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78633639
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.77610909
9synaptic vesicle exocytosis (GO:0016079)4.35783792
10regulation of synaptic vesicle exocytosis (GO:2000300)4.30762494
11vocalization behavior (GO:0071625)4.18052488
12ensheathment of neurons (GO:0007272)4.13612000
13axon ensheathment (GO:0008366)4.13612000
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.11459994
15glutamate secretion (GO:0014047)4.11126085
16L-amino acid import (GO:0043092)4.10274366
17neuron cell-cell adhesion (GO:0007158)4.10121273
18myelination (GO:0042552)4.04841537
19regulation of ARF protein signal transduction (GO:0032012)4.03493517
20glycine transport (GO:0015816)4.01715933
21negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.01676671
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.98880697
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.96508736
24transmission of nerve impulse (GO:0019226)3.93007260
25dendritic spine morphogenesis (GO:0060997)3.90847224
26gamma-aminobutyric acid transport (GO:0015812)3.86931775
27regulation of neuronal synaptic plasticity (GO:0048168)3.84144086
28protein localization to synapse (GO:0035418)3.80486271
29neuronal ion channel clustering (GO:0045161)3.75073503
30regulation of synaptic vesicle transport (GO:1902803)3.71548395
31regulation of glutamate receptor signaling pathway (GO:1900449)3.68583448
32layer formation in cerebral cortex (GO:0021819)3.66139593
33positive regulation of synapse maturation (GO:0090129)3.63486700
34neurotransmitter secretion (GO:0007269)3.63121373
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.60453265
36exploration behavior (GO:0035640)3.59795649
37adult walking behavior (GO:0007628)3.58154615
38synaptic transmission, glutamatergic (GO:0035249)3.55248360
39cellular potassium ion homeostasis (GO:0030007)3.52706767
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50413607
41glutamate receptor signaling pathway (GO:0007215)3.50409708
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.46617254
43regulation of synapse structural plasticity (GO:0051823)3.46041488
44positive regulation of membrane potential (GO:0045838)3.42415490
45neuron-neuron synaptic transmission (GO:0007270)3.42113578
46neuromuscular process controlling posture (GO:0050884)3.41824509
47synaptic vesicle docking involved in exocytosis (GO:0016081)3.37611698
48positive regulation of Rap GTPase activity (GO:0032854)3.37013790
49long-term memory (GO:0007616)3.36333275
50presynaptic membrane organization (GO:0097090)3.32942719
51neuromuscular process controlling balance (GO:0050885)3.28508654
52negative regulation of neurotransmitter transport (GO:0051589)3.28348275
53sodium ion export (GO:0071436)3.23715658
54neuron recognition (GO:0008038)3.23406183
55long-chain fatty acid biosynthetic process (GO:0042759)3.22259682
56dendrite morphogenesis (GO:0048813)3.21938487
57regulation of dendritic spine morphogenesis (GO:0061001)3.21120532
58presynaptic membrane assembly (GO:0097105)3.20275360
59negative regulation of neurotransmitter secretion (GO:0046929)3.19217778
60regulation of excitatory postsynaptic membrane potential (GO:0060079)3.19014306
61neurotransmitter transport (GO:0006836)3.17030982
62neurotransmitter-gated ion channel clustering (GO:0072578)3.15411481
63amino acid import (GO:0043090)3.14253092
64negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.13203204
65negative regulation of cell killing (GO:0031342)3.13203204
66cerebellar granule cell differentiation (GO:0021707)3.11835490
67G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.09760782
68mating behavior (GO:0007617)3.06018617
69membrane hyperpolarization (GO:0060081)3.06007131
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03705780
71auditory behavior (GO:0031223)3.01880430
72regulation of postsynaptic membrane potential (GO:0060078)3.01397592
73gamma-aminobutyric acid signaling pathway (GO:0007214)3.00942552
74regulation of synaptic plasticity (GO:0048167)3.00236676
75regulation of Rap GTPase activity (GO:0032317)2.99343342
76potassium ion import (GO:0010107)2.99314630
77fatty acid elongation (GO:0030497)2.98876243
78signal complex assembly (GO:0007172)2.98604390
79regulation of voltage-gated calcium channel activity (GO:1901385)2.96955152
80cerebellar Purkinje cell differentiation (GO:0021702)2.96816618
81positive regulation of synaptic transmission, GABAergic (GO:0032230)2.96647297
82axonal fasciculation (GO:0007413)2.96644988
83establishment of mitochondrion localization (GO:0051654)2.94598076
84negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.92278454
85positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.92150789
86regulation of neurotransmitter secretion (GO:0046928)2.92074493
87positive regulation of neurotransmitter secretion (GO:0001956)2.91938560
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90808340
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.89986495
90regulation of neurotransmitter levels (GO:0001505)2.89753818
91positive regulation of neurotransmitter transport (GO:0051590)2.89533476
92synaptic vesicle endocytosis (GO:0048488)2.87576936
93potassium ion homeostasis (GO:0055075)2.85492309
94regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85297587
95regulation of synapse maturation (GO:0090128)2.84911613
96acidic amino acid transport (GO:0015800)2.84705855
97positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.84586567
98prepulse inhibition (GO:0060134)2.84499349
99cell communication by electrical coupling (GO:0010644)2.84061290
100long-term synaptic potentiation (GO:0060291)2.84026416
101response to auditory stimulus (GO:0010996)2.83953643
102nerve growth factor signaling pathway (GO:0038180)2.83619674
103regulation of synaptic transmission, glutamatergic (GO:0051966)2.82454696
104dendritic spine organization (GO:0097061)2.78928139
105regulation of neurotransmitter transport (GO:0051588)2.78841537
106regulation of vesicle fusion (GO:0031338)2.78065707
107regulation of dendritic spine development (GO:0060998)2.77777862
108regulation of ARF GTPase activity (GO:0032312)2.77363984
109regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.77298343
110proline transport (GO:0015824)2.75203940
111activation of protein kinase A activity (GO:0034199)2.75046668
112regulation of exocytosis (GO:0017157)2.74490556
113neurotransmitter uptake (GO:0001504)2.74465550
114vesicle transport along microtubule (GO:0047496)2.74167202
115membrane depolarization (GO:0051899)2.73772841
116postsynaptic membrane organization (GO:0001941)2.73345411
117cellular sodium ion homeostasis (GO:0006883)2.72767160
118G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71731549
119myelin maintenance (GO:0043217)2.71548172
120membrane depolarization during action potential (GO:0086010)2.70930638
121myelination in peripheral nervous system (GO:0022011)2.70920485
122peripheral nervous system axon ensheathment (GO:0032292)2.70920485
123positive regulation of dendritic spine development (GO:0060999)2.70742590
124regulation of regulated secretory pathway (GO:1903305)2.67910534
125macrophage activation involved in immune response (GO:0002281)2.67179664
126cytoskeletal anchoring at plasma membrane (GO:0007016)2.64323843
127regulation of beta-amyloid formation (GO:1902003)2.63153677
128adenosine receptor signaling pathway (GO:0001973)2.58475728
129negative regulation of dendrite morphogenesis (GO:0050774)2.57645352
130L-glutamate transport (GO:0015813)2.56086051
131regulation of amyloid precursor protein catabolic process (GO:1902991)2.54851100
132regulation of synaptic transmission (GO:0050804)2.54205999
133antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.51456790
134regulation of T-helper 2 cell differentiation (GO:0045628)2.49350086
135positive regulation of synaptic transmission (GO:0050806)2.42032248
136cell differentiation in hindbrain (GO:0021533)2.41503210
137actin filament polymerization (GO:0030041)2.38206508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.64313426
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.36243091
3GBX2_23144817_ChIP-Seq_PC3_Human3.12341041
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03447290
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97530757
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90110536
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70959611
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70959611
9DROSHA_22980978_ChIP-Seq_HELA_Human2.68691443
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56703962
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53516746
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51958847
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.50229708
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43801057
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.42858264
16REST_21632747_ChIP-Seq_MESCs_Mouse2.41012074
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39286151
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38898515
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.31362790
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29845513
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28155913
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.18538032
23LXR_22292898_ChIP-Seq_THP-1_Human2.16464405
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.13731119
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.02235091
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91643793
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.90493312
28AR_21572438_ChIP-Seq_LNCaP_Human1.89649893
29* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82271489
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76896009
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76150917
32KDM2B_26808549_Chip-Seq_DND41_Human1.72846514
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62209693
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59645096
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53279526
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.51491605
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.48688184
38TCF7_22412390_ChIP-Seq_EML_Mouse1.48069542
39TAF15_26573619_Chip-Seq_HEK293_Human1.43874197
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.41861835
41* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40571023
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40119287
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39778110
44* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36054078
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36004665
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34550214
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33906781
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33864561
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33668701
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31899059
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31364470
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31219527
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31009865
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.30929589
55SMAD4_21799915_ChIP-Seq_A2780_Human1.30668709
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30245841
57VDR_21846776_ChIP-Seq_THP-1_Human1.30070593
58SPI1_23127762_ChIP-Seq_K562_Human1.29481358
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.28999373
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28101076
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27854497
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26766077
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25362026
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.24198406
65OCT4_19829295_ChIP-Seq_ESCs_Human1.23263962
66SMC4_20622854_ChIP-Seq_HELA_Human1.22034347
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.21795435
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21231481
69STAT3_23295773_ChIP-Seq_U87_Human1.18355550
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18159622
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17888345
72VDR_24763502_ChIP-Seq_THP-1_Human1.17831289
73P68_20966046_ChIP-Seq_HELA_Human1.17633735
74KDM2B_26808549_Chip-Seq_K562_Human1.17505162
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.16132893
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14568353
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14494147
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14087182
79SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13883066
80* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13303852
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.13062622
82P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11505560
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10430259
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10398323
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10008515
86CBX2_27304074_Chip-Seq_ESCs_Mouse1.08805887
87AR_19668381_ChIP-Seq_PC3_Human1.07687705
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05547805
89P300_19829295_ChIP-Seq_ESCs_Human1.05473378
90RACK7_27058665_Chip-Seq_MCF-7_Human1.05026941
91CREB1_26743006_Chip-Seq_LNCaP_Human1.03376391
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02842617
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01920997
94ZNF274_21170338_ChIP-Seq_K562_Hela1.01595128
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01295091
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00924422
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00833814
98STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00450973
99SCL_19346495_ChIP-Seq_HPC-7_Human1.00202047
100TCF4_23295773_ChIP-Seq_U87_Human1.00184599
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00032332
102KLF4_19829295_ChIP-Seq_ESCs_Human0.99934526
103IRF8_27001747_Chip-Seq_BMDM_Mouse0.99652781
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99541525
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99413849
106PIAS1_25552417_ChIP-Seq_VCAP_Human0.98739509
107MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97823330
108TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97818579
109EGR1_19032775_ChIP-ChIP_M12_Human0.97284481
110AHR_22903824_ChIP-Seq_MCF-7_Human0.97232955
111* SA1_27219007_Chip-Seq_ERYTHROID_Human0.97193626
112BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96494072
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96311058
114EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95518131
115ARNT_22903824_ChIP-Seq_MCF-7_Human0.94908578
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94597584
117IRF8_21731497_ChIP-ChIP_J774_Mouse0.93887813
118TET1_21490601_ChIP-Seq_MESCs_Mouse0.93056606
119SA1_27219007_Chip-Seq_Bcells_Human0.92983186
120DPY_21335234_ChIP-Seq_ESCs_Mouse0.92847577
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92829954
122GATA1_19941826_ChIP-Seq_K562_Human0.92757424
123BCOR_27268052_Chip-Seq_Bcells_Human0.92286644
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91895933
125ER_23166858_ChIP-Seq_MCF-7_Human0.91795173
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.91617044
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91588307
128CTCF_27219007_Chip-Seq_Bcells_Human0.91477530
129SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91013364
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90447637
131AR_25329375_ChIP-Seq_VCAP_Human0.89219978
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88774064
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.88667844
134* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88360606
135ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87770026
136TP53_16413492_ChIP-PET_HCT116_Human0.87484516
137GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87348403
138RUNX1_22412390_ChIP-Seq_EML_Mouse0.87203877
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86741759
140EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86542405
141YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86457243
142RUNX_20019798_ChIP-Seq_JUKART_Human0.84932390
143* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84846599
144SMAD_19615063_ChIP-ChIP_OVARY_Human0.84682580
145BCL6_27268052_Chip-Seq_Bcells_Human0.84653956
146SMAD4_21741376_ChIP-Seq_ESCs_Human0.84208632
147RNF2_27304074_Chip-Seq_NSC_Mouse0.84152839
148STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84062033
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83469587
150ELK3_25401928_ChIP-Seq_HUVEC_Human0.82898013
151LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82683040
152RUNX2_22187159_ChIP-Seq_PCA_Human0.81978053
153SMAD4_21741376_ChIP-Seq_EPCs_Human0.81822401
154SMAD3_21741376_ChIP-Seq_HESCs_Human0.81465103
155LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81401721
156GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79271982
157TET1_21451524_ChIP-Seq_MESCs_Mouse0.79224596

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.64118013
2MP0003880_abnormal_central_pattern4.64160606
3MP0004270_analgesia3.89550501
4MP0003635_abnormal_synaptic_transmissio3.66991857
5MP0002064_seizures3.17147844
6MP0000920_abnormal_myelination3.16095961
7MP0009046_muscle_twitch3.13000236
8MP0009745_abnormal_behavioral_response3.09000491
9MP0002272_abnormal_nervous_system3.02184988
10MP0005423_abnormal_somatic_nervous2.89249919
11MP0001486_abnormal_startle_reflex2.82122012
12MP0002063_abnormal_learning/memory/cond2.78902542
13MP0002734_abnormal_mechanical_nocicepti2.70391644
14MP0001968_abnormal_touch/_nociception2.58064349
15MP0002822_catalepsy2.57691024
16MP0002572_abnormal_emotion/affect_behav2.42389974
17MP0003329_amyloid_beta_deposits2.39227269
18MP0004885_abnormal_endolymph2.29173458
19MP0008569_lethality_at_weaning2.17824035
20MP0003303_peritoneal_inflammation2.14443821
21MP0003690_abnormal_glial_cell2.06793552
22MP0002733_abnormal_thermal_nociception2.00720095
23MP0001970_abnormal_pain_threshold1.98662678
24MP0001440_abnormal_grooming_behavior1.94592915
25MP0002067_abnormal_sensory_capabilities1.94474563
26MP0000778_abnormal_nervous_system1.93685135
27MP0001501_abnormal_sleep_pattern1.89518621
28MP0003724_increased_susceptibility_to1.87194728
29MP0004142_abnormal_muscle_tone1.84846122
30MP0003634_abnormal_glial_cell1.80867930
31MP0000955_abnormal_spinal_cord1.76778960
32MP0002735_abnormal_chemical_nociception1.76598694
33MP0002736_abnormal_nociception_after1.74713184
34MP0001529_abnormal_vocalization1.72543283
35MP0003436_decreased_susceptibility_to1.69415088
36MP0004742_abnormal_vestibular_system1.62866107
37MP0004924_abnormal_behavior1.62682738
38MP0005386_behavior/neurological_phenoty1.62682738
39MP0003633_abnormal_nervous_system1.60063197
40MP0004811_abnormal_neuron_physiology1.58179359
41MP0002882_abnormal_neuron_morphology1.56823859
42MP0003183_abnormal_peptide_metabolism1.55552265
43MP0002184_abnormal_innervation1.54204803
44MP0002066_abnormal_motor_capabilities/c1.53998948
45MP0002229_neurodegeneration1.52049051
46MP0001905_abnormal_dopamine_level1.50708929
47MP0003631_nervous_system_phenotype1.50100006
48MP0004858_abnormal_nervous_system1.47226893
49MP0004510_myositis1.46971277
50MP0006082_CNS_inflammation1.46860878
51MP0002557_abnormal_social/conspecific_i1.46009087
52MP0009780_abnormal_chondrocyte_physiolo1.45459105
53MP0003632_abnormal_nervous_system1.44180555
54MP0004145_abnormal_muscle_electrophysio1.30876267
55MP0005646_abnormal_pituitary_gland1.28334064
56MP0001485_abnormal_pinna_reflex1.26845670
57MP0005166_decreased_susceptibility_to1.24979574
58MP0005645_abnormal_hypothalamus_physiol1.24382100
59MP0005171_absent_coat_pigmentation1.23951776
60MP0005409_darkened_coat_color1.21850738
61MP0002909_abnormal_adrenal_gland1.21045952
62MP0001984_abnormal_olfaction1.20853289
63MP0005551_abnormal_eye_electrophysiolog1.18299292
64MP0001502_abnormal_circadian_rhythm1.18198761
65MP0003191_abnormal_cellular_cholesterol1.16962477
66MP0000604_amyloidosis1.16234283
67MP0002419_abnormal_innate_immunity1.14838001
68MP0003123_paternal_imprinting1.13546851
69MP0000747_muscle_weakness1.07297284
70MP0002152_abnormal_brain_morphology1.07038712
71MP0006276_abnormal_autonomic_nervous1.06385004
72MP0005058_abnormal_lysosome_morphology1.06238909
73MP0000751_myopathy1.04137878
74MP0005623_abnormal_meninges_morphology1.02603437
75MP0003879_abnormal_hair_cell1.00124507
76MP0005025_abnormal_response_to0.99298317
77MP0001177_atelectasis0.99294437
78MP0005000_abnormal_immune_tolerance0.98515721
79MP0001963_abnormal_hearing_physiology0.97229079
80MP0002752_abnormal_somatic_nervous0.96641223
81MP0001986_abnormal_taste_sensitivity0.96148206
82MP0000013_abnormal_adipose_tissue0.92894395
83MP0001299_abnormal_eye_distance/0.90570386
84MP0003136_yellow_coat_color0.89420552
85MP0003075_altered_response_to0.86417947
86MP0003283_abnormal_digestive_organ0.84954187
87MP0003866_abnormal_defecation0.84908989
88MP0004043_abnormal_pH_regulation0.84898257
89MP0001533_abnormal_skeleton_physiology0.83195567
90MP0008874_decreased_physiological_sensi0.82197451
91MP0009278_abnormal_bone_marrow0.81338294
92MP0004130_abnormal_muscle_cell0.81268573
93MP0002069_abnormal_eating/drinking_beha0.80756049
94MP0002090_abnormal_vision0.76222240
95MP0003172_abnormal_lysosome_physiology0.75862033
96MP0003137_abnormal_impulse_conducting0.75006531
97MP0001790_abnormal_immune_system0.72831136
98MP0005387_immune_system_phenotype0.72831136
99MP0003122_maternal_imprinting0.72490443
100MP0003787_abnormal_imprinting0.71958029
101MP0005410_abnormal_fertilization0.71829788
102MP0002723_abnormal_immune_serum0.70745389
103MP0008872_abnormal_physiological_respon0.69154549
104MP0004085_abnormal_heartbeat0.68614128
105MP0008260_abnormal_autophagy0.68194656
106MP0005388_respiratory_system_phenotype0.67964362
107MP0002133_abnormal_respiratory_system0.67964362
108MP0002420_abnormal_adaptive_immunity0.66888064
109MP0005671_abnormal_response_to0.66594264
110MP0001819_abnormal_immune_cell0.65641961
111MP0002998_abnormal_bone_remodeling0.65351216
112MP0009840_abnormal_foam_cell0.64454040
113MP0000631_abnormal_neuroendocrine_gland0.63724718
114MP0003300_gastrointestinal_ulcer0.63354903
115MP0003950_abnormal_plasma_membrane0.63061481
116MP0004947_skin_inflammation0.63012963
117MP0000462_abnormal_digestive_system0.62178732
118MP0005535_abnormal_body_temperature0.61009665
119MP0001765_abnormal_ion_homeostasis0.60898075
120MP0005167_abnormal_blood-brain_barrier0.59763053
121MP0001943_abnormal_respiration0.59286966
122MP0002148_abnormal_hypersensitivity_rea0.59227392
123MP0006072_abnormal_retinal_apoptosis0.58849535
124MP0005310_abnormal_salivary_gland0.58266584
125MP0001188_hyperpigmentation0.58188736
126MP0001800_abnormal_humoral_immune0.57605071
127MP0001851_eye_inflammation0.56976877
128MP0003045_fibrosis0.56047097
129MP0005253_abnormal_eye_physiology0.54351675
130MP0005464_abnormal_platelet_physiology0.53997524
131MP0009785_altered_susceptibility_to0.53355957
132MP0001348_abnormal_lacrimal_gland0.52698032
133MP0000003_abnormal_adipose_tissue0.52583956
134MP0001835_abnormal_antigen_presentation0.52581982
135MP0010769_abnormal_survival0.51838655
136MP0003861_abnormal_nervous_system0.50347999
137MP0002082_postnatal_lethality0.49021196
138MP0010770_preweaning_lethality0.49021196

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.42039714
2Action tremor (HP:0002345)5.58862395
3Focal motor seizures (HP:0011153)5.47633624
4Termporal pattern (HP:0011008)4.64765532
5Insidious onset (HP:0003587)4.64765532
6Peripheral hypomyelination (HP:0007182)4.62954534
7Neurofibrillary tangles (HP:0002185)4.47815428
8Supranuclear gaze palsy (HP:0000605)4.43997896
9Focal seizures (HP:0007359)4.37542964
10Ankle clonus (HP:0011448)4.27466186
11Onion bulb formation (HP:0003383)4.02044087
12Ulnar claw (HP:0001178)3.83057239
13Obstructive sleep apnea (HP:0002870)3.77186182
14Visual hallucinations (HP:0002367)3.75347792
15Dysmetria (HP:0001310)3.72244892
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.71324287
17Degeneration of the lateral corticospinal tracts (HP:0002314)3.71324287
18Abnormality of the corticospinal tract (HP:0002492)3.65375535
19Intention tremor (HP:0002080)3.60949003
20Spastic gait (HP:0002064)3.60654887
21Atonic seizures (HP:0010819)3.60054374
22Segmental peripheral demyelination/remyelination (HP:0003481)3.56313065
23Cerebral inclusion bodies (HP:0100314)3.53543751
24Progressive cerebellar ataxia (HP:0002073)3.45510698
25Epileptic encephalopathy (HP:0200134)3.42500355
26Annular pancreas (HP:0001734)3.26134121
27Eczematoid dermatitis (HP:0000976)3.20549647
28Scanning speech (HP:0002168)3.11827553
29Absence seizures (HP:0002121)2.90604912
30Dysdiadochokinesis (HP:0002075)2.89642818
31Tetraplegia (HP:0002445)2.85325285
32Dialeptic seizures (HP:0011146)2.84523330
33Generalized tonic-clonic seizures (HP:0002069)2.80519937
34Gaze-evoked nystagmus (HP:0000640)2.79466213
35Hammertoe (HP:0001765)2.79442925
36Febrile seizures (HP:0002373)2.77886467
37Postural instability (HP:0002172)2.77330579
38Urinary bladder sphincter dysfunction (HP:0002839)2.73040854
39Broad-based gait (HP:0002136)2.71118869
40Urinary urgency (HP:0000012)2.70165642
41Pheochromocytoma (HP:0002666)2.67163513
42Depression (HP:0000716)2.65954413
43Anxiety (HP:0000739)2.65730654
44Megalencephaly (HP:0001355)2.65253272
45Cerebral hypomyelination (HP:0006808)2.64420596
46Apathy (HP:0000741)2.63842246
47Mutism (HP:0002300)2.60298943
48Orchitis (HP:0100796)2.59981357
49Lower limb muscle weakness (HP:0007340)2.57930982
50Myositis (HP:0100614)2.56215714
51Abnormal eating behavior (HP:0100738)2.54419409
52Postural tremor (HP:0002174)2.53836932
53Clonus (HP:0002169)2.52165341
54Impaired vibration sensation in the lower limbs (HP:0002166)2.52067661
55Abnormality of macrophages (HP:0004311)2.51698743
56Recurrent abscess formation (HP:0002722)2.51454212
57Torticollis (HP:0000473)2.50119260
58Recurrent bacterial skin infections (HP:0005406)2.47612766
59Truncal ataxia (HP:0002078)2.45724673
60Decreased motor nerve conduction velocity (HP:0003431)2.45638162
61Diminished motivation (HP:0000745)2.44884332
62Delusions (HP:0000746)2.44033830
63Foot dorsiflexor weakness (HP:0009027)2.43775539
64Akinesia (HP:0002304)2.43073266
65Sensory axonal neuropathy (HP:0003390)2.42518102
66Abnormal auditory evoked potentials (HP:0006958)2.41267057
67Steppage gait (HP:0003376)2.38908959
68Poor eye contact (HP:0000817)2.37630662
69Memory impairment (HP:0002354)2.37272979
70Amyloidosis (HP:0011034)2.35954188
71Retrobulbar optic neuritis (HP:0100654)2.34229869
72Optic neuritis (HP:0100653)2.34229869
73Hemiparesis (HP:0001269)2.30126484
74Alacrima (HP:0000522)2.29723676
75Slow saccadic eye movements (HP:0000514)2.27587806
76Progressive inability to walk (HP:0002505)2.24892960
77Episodic fever (HP:0001954)2.23878745
78Abnormality of the foot musculature (HP:0001436)2.23719682
79Abnormal social behavior (HP:0012433)2.22526646
80Impaired social interactions (HP:0000735)2.22526646
81Abnormality of the periventricular white matter (HP:0002518)2.22375385
82Neuroendocrine neoplasm (HP:0100634)2.21492541
83Recurrent gram-negative bacterial infections (HP:0005420)2.21275808
84Retinal dysplasia (HP:0007973)2.19297119
85Focal dystonia (HP:0004373)2.18150775
86Papilledema (HP:0001085)2.17949797
87Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.17405992
88Limb dystonia (HP:0002451)2.16542767
89Stereotypic behavior (HP:0000733)2.16188258
90Dementia (HP:0000726)2.13992477
91Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.13033045
92Distal sensory impairment (HP:0002936)2.12672130
93Abnormality of binocular vision (HP:0011514)2.11286743
94Diplopia (HP:0000651)2.11286743
95Aplasia involving bones of the upper limbs (HP:0009823)2.11232967
96Aplasia of the phalanges of the hand (HP:0009802)2.11232967
97Aplasia involving bones of the extremities (HP:0009825)2.11232967
98Increased circulating renin level (HP:0000848)2.10696676
99Abnormality of saccadic eye movements (HP:0000570)2.09181490
100Increased cerebral lipofuscin (HP:0011813)2.08893626
101Neuronal loss in central nervous system (HP:0002529)2.08862859
102Sleep apnea (HP:0010535)2.08412514
103Spastic tetraparesis (HP:0001285)2.08118663
104Cellulitis (HP:0100658)2.06795347
105Hemiplegia (HP:0002301)2.06466695
106Axonal loss (HP:0003447)2.06147362
107Craniofacial dystonia (HP:0012179)2.04369787
108Insomnia (HP:0100785)2.01373875
109Status epilepticus (HP:0002133)2.00754286
110Stomatitis (HP:0010280)1.98614823
111Generalized myoclonic seizures (HP:0002123)1.98220744
112Spinal canal stenosis (HP:0003416)1.96490306
113Gait ataxia (HP:0002066)1.93357718
114Choreoathetosis (HP:0001266)1.92438690
115Urinary incontinence (HP:0000020)1.92089088
116Slow progression (HP:0003677)1.91385342
117Ventricular fibrillation (HP:0001663)1.91320000
118Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91004300
119Genetic anticipation (HP:0003743)1.90513756
120Obstructive lung disease (HP:0006536)1.90027404
121Chronic obstructive pulmonary disease (HP:0006510)1.90027404
122Drooling (HP:0002307)1.88980802
123Excessive salivation (HP:0003781)1.88980802
124Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88153755
125Rigidity (HP:0002063)1.87967050
126Bradykinesia (HP:0002067)1.86220000
127Gingivitis (HP:0000230)1.83537274
128Lower limb asymmetry (HP:0100559)1.83427251
129Amblyopia (HP:0000646)1.83003459
130CNS hypomyelination (HP:0003429)1.81474970
131Ocular albinism (HP:0001107)1.81338120
132Hyperventilation (HP:0002883)1.81261214
133Disinhibition (HP:0000734)1.80964505
134Peripheral demyelination (HP:0011096)1.80308102
135Thickened helices (HP:0000391)1.80165038
136Blue irides (HP:0000635)1.79623931
137Decreased lacrimation (HP:0000633)1.79429510
138Rapidly progressive (HP:0003678)1.78133705
139Impaired smooth pursuit (HP:0007772)1.76778107
140Lower limb amyotrophy (HP:0007210)1.76548211
141Mediastinal lymphadenopathy (HP:0100721)1.73014106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.51177615
2STK393.21655796
3NTRK33.15929970
4MAP3K93.09416155
5PAK62.51103527
6OXSR12.50963960
7MARK12.46465041
8NTRK12.35580032
9TNIK2.15245996
10UHMK12.09338681
11RIPK12.03840500
12MINK12.03083927
13PRKD32.01611114
14MAP3K41.97472178
15KSR21.93054299
16CDK191.86995137
17NTRK21.84369220
18PRPF4B1.80743151
19MAP3K111.80099559
20DAPK21.71028118
21TYRO31.68593826
22WNK11.62269416
23PKN11.53800378
24* CDK51.46172405
25EPHB11.45787825
26ERN11.41438905
27WNK41.41023127
28CAMKK11.39225197
29PNCK1.36249062
30SGK2231.33138194
31SGK4941.33138194
32MAP2K71.32324779
33ICK1.30072907
34PHKG21.25813957
35PHKG11.25813957
36FES1.24131058
37NEK61.22730828
38LIMK11.20676014
39CAMK2B1.19840974
40ARAF1.19083578
41IRAK41.18912430
42MAPKAPK51.17921074
43CASK1.12619729
44MARK21.12361088
45MAP3K131.09889945
46FGFR21.08499541
47MAP3K21.07821750
48BCR1.06848882
49MAPK131.05722981
50CDK141.04673459
51MAP4K11.04451163
52CDK151.04171229
53MAP2K41.03498707
54RIPK41.02264719
55CDK181.00294811
56CSNK1G21.00100688
57PRKCH0.99819876
58SGK30.99783689
59MAPK120.99733869
60PRKG20.97661443
61ROCK20.97623685
62CAMK2A0.95657566
63CAMK2D0.95453362
64PAK30.95291192
65SGK20.93602693
66SIK10.93174893
67GRK50.92476314
68BLK0.92260067
69PINK10.92018693
70CDK11A0.91919524
71CSK0.91883001
72MAP2K30.91822049
73STK110.90515937
74PRKCG0.87336062
75FGR0.86391771
76STK380.86383968
77PDPK10.84550225
78JAK20.84243752
79CAMK2G0.82498112
80RET0.80932324
81DAPK10.80208695
82CAMKK20.79823173
83CSNK1G30.79783188
84KSR10.79325041
85TRIB30.77429910
86CSNK1A1L0.76104550
87CAMK10.74364261
88GRK60.72943078
89ALK0.72938918
90IRAK20.70474207
91PLK20.70069715
92TAOK20.69899785
93BMPR20.68809446
94PDK10.68278859
95TYK20.66803619
96LMTK20.62383401
97CAMK40.62260965
98CAMK1G0.61642807
99HCK0.60091116
100JAK10.60073386
101SIK20.59149973
102* FYN0.58683843
103SYK0.58481014
104MET0.58353327
105PRKD20.58316355
106PRKCE0.58177253
107PRKD10.57737745
108SGK10.56974821
109ZAP700.56091453
110MAP2K60.54625429
111MAP3K10.54431545
112TNK20.53615256
113DYRK1A0.53513922
114TAOK10.53323536
115PTK2B0.53089961
116DDR20.51808642
117MAP3K30.51498461
118MAPK100.49979315
119IRAK30.49899180
120CSNK1G10.49593142
121RPS6KA30.48071559
122LATS20.47692730
123CDC42BPA0.47419393
124PRKCZ0.46791260
125MAP3K120.46220342
126TESK20.44256998
127PRKCQ0.42322582
128MUSK0.42217010
129BMX0.42120678
130DAPK30.39749428

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.96641285
2Synaptic vesicle cycle_Homo sapiens_hsa047212.87624163
3GABAergic synapse_Homo sapiens_hsa047272.71023199
4Glutamatergic synapse_Homo sapiens_hsa047242.57319104
5Circadian entrainment_Homo sapiens_hsa047132.42714965
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39924888
7Morphine addiction_Homo sapiens_hsa050322.39165433
8Olfactory transduction_Homo sapiens_hsa047402.38806367
9Long-term potentiation_Homo sapiens_hsa047202.12502731
10Salivary secretion_Homo sapiens_hsa049702.00869519
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97747370
12Amphetamine addiction_Homo sapiens_hsa050311.95148261
13Dopaminergic synapse_Homo sapiens_hsa047281.93378922
14Nitrogen metabolism_Homo sapiens_hsa009101.85524146
15Gastric acid secretion_Homo sapiens_hsa049711.82581938
16Cholinergic synapse_Homo sapiens_hsa047251.82134905
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76399629
18Insulin secretion_Homo sapiens_hsa049111.72506701
19Long-term depression_Homo sapiens_hsa047301.72445407
20Serotonergic synapse_Homo sapiens_hsa047261.66669923
21Cocaine addiction_Homo sapiens_hsa050301.65124061
22Axon guidance_Homo sapiens_hsa043601.64242058
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55984431
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52362279
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52067937
26Taste transduction_Homo sapiens_hsa047421.48000133
27Renin secretion_Homo sapiens_hsa049241.44143738
28Oxytocin signaling pathway_Homo sapiens_hsa049211.37326008
29Osteoclast differentiation_Homo sapiens_hsa043801.32497881
30Calcium signaling pathway_Homo sapiens_hsa040201.29741233
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29333591
32Gap junction_Homo sapiens_hsa045401.28812378
33GnRH signaling pathway_Homo sapiens_hsa049121.24638467
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19559525
35cAMP signaling pathway_Homo sapiens_hsa040241.18832738
36Collecting duct acid secretion_Homo sapiens_hsa049661.15654199
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.08768898
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08076427
39ErbB signaling pathway_Homo sapiens_hsa040121.07351996
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06760787
41Type II diabetes mellitus_Homo sapiens_hsa049301.06559090
42Dorso-ventral axis formation_Homo sapiens_hsa043201.06203539
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06019682
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04439810
45Ether lipid metabolism_Homo sapiens_hsa005651.03199050
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99518319
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99484937
48Steroid biosynthesis_Homo sapiens_hsa001000.98648278
49Tuberculosis_Homo sapiens_hsa051520.98435184
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.98282913
51Estrogen signaling pathway_Homo sapiens_hsa049150.97689045
52Pancreatic secretion_Homo sapiens_hsa049720.97357330
53Leishmaniasis_Homo sapiens_hsa051400.96884020
54Fatty acid elongation_Homo sapiens_hsa000620.94991067
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93787786
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91629172
57Histidine metabolism_Homo sapiens_hsa003400.91526262
58Vibrio cholerae infection_Homo sapiens_hsa051100.90856641
59Cardiac muscle contraction_Homo sapiens_hsa042600.89693496
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87282774
61B cell receptor signaling pathway_Homo sapiens_hsa046620.87034624
62Glioma_Homo sapiens_hsa052140.86920830
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86047151
64Melanogenesis_Homo sapiens_hsa049160.83899655
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82800784
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.82678161
67Endocytosis_Homo sapiens_hsa041440.82439839
68Phototransduction_Homo sapiens_hsa047440.79602246
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78798577
70Staphylococcus aureus infection_Homo sapiens_hsa051500.77793609
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77159029
72Renal cell carcinoma_Homo sapiens_hsa052110.76011195
73Choline metabolism in cancer_Homo sapiens_hsa052310.75657841
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74066375
75Ras signaling pathway_Homo sapiens_hsa040140.73066196
76Dilated cardiomyopathy_Homo sapiens_hsa054140.71278348
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71085042
78Thyroid hormone synthesis_Homo sapiens_hsa049180.70815353
79African trypanosomiasis_Homo sapiens_hsa051430.69271182
80MAPK signaling pathway_Homo sapiens_hsa040100.67415665
81Vitamin B6 metabolism_Homo sapiens_hsa007500.64596062
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64417758
83Salmonella infection_Homo sapiens_hsa051320.61144152
84Phagosome_Homo sapiens_hsa041450.60509218
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60194084
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.59826168
87Tight junction_Homo sapiens_hsa045300.58765867
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56842299
89Butanoate metabolism_Homo sapiens_hsa006500.56555036
90Bile secretion_Homo sapiens_hsa049760.56437936
91Ovarian steroidogenesis_Homo sapiens_hsa049130.56019838
92Oocyte meiosis_Homo sapiens_hsa041140.55670551
93Alcoholism_Homo sapiens_hsa050340.55067063
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54966185
95Non-small cell lung cancer_Homo sapiens_hsa052230.54846308
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.54729104
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54704392
98Platelet activation_Homo sapiens_hsa046110.54698135
99Prion diseases_Homo sapiens_hsa050200.53465201
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53351537
101Rap1 signaling pathway_Homo sapiens_hsa040150.53237210
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52068844
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50855532
104VEGF signaling pathway_Homo sapiens_hsa043700.50624886
105Endometrial cancer_Homo sapiens_hsa052130.50495381
106mTOR signaling pathway_Homo sapiens_hsa041500.50094514
107Notch signaling pathway_Homo sapiens_hsa043300.49589518
108Inositol phosphate metabolism_Homo sapiens_hsa005620.49576830
109Insulin signaling pathway_Homo sapiens_hsa049100.49416541
110Sphingolipid metabolism_Homo sapiens_hsa006000.48957404
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47761812
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47440850
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.47285700
114Acute myeloid leukemia_Homo sapiens_hsa052210.47194610
115Fatty acid biosynthesis_Homo sapiens_hsa000610.47010600
116Other glycan degradation_Homo sapiens_hsa005110.46801074
117T cell receptor signaling pathway_Homo sapiens_hsa046600.46175919
118Pertussis_Homo sapiens_hsa051330.45725446
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44553287
120Chemokine signaling pathway_Homo sapiens_hsa040620.44007588
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.41833051
122Alzheimers disease_Homo sapiens_hsa050100.36562087
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34923551
124Mineral absorption_Homo sapiens_hsa049780.33998206
125Hedgehog signaling pathway_Homo sapiens_hsa043400.33303880
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32889465
127Wnt signaling pathway_Homo sapiens_hsa043100.31543177
128Lysosome_Homo sapiens_hsa041420.30124851

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