AAMP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-arginine omega-N-methylation (GO:0035247)5.14034132
2COPI coating of Golgi vesicle (GO:0048205)5.08014294
3Golgi transport vesicle coating (GO:0048200)5.08014294
4protein maturation by protein folding (GO:0022417)4.46932984
5regulation of translational fidelity (GO:0006450)4.46791379
6histone arginine methylation (GO:0034969)4.36430864
7DNA unwinding involved in DNA replication (GO:0006268)4.23695597
8peptidyl-arginine methylation (GO:0018216)4.15654406
9peptidyl-arginine N-methylation (GO:0035246)4.15654406
10negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.15232268
11pentose-phosphate shunt (GO:0006098)4.14799079
12DNA deamination (GO:0045006)4.09337944
13oxaloacetate metabolic process (GO:0006107)4.04861127
14establishment of integrated proviral latency (GO:0075713)3.99373212
15NADPH regeneration (GO:0006740)3.95210207
16nucleobase biosynthetic process (GO:0046112)3.90020183
17purine nucleobase biosynthetic process (GO:0009113)3.83476800
18tricarboxylic acid cycle (GO:0006099)3.82708699
19nuclear envelope reassembly (GO:0031468)3.80189481
20mitotic nuclear envelope reassembly (GO:0007084)3.80189481
21NADH metabolic process (GO:0006734)3.79619921
22spliceosomal tri-snRNP complex assembly (GO:0000244)3.69882052
23establishment of viral latency (GO:0019043)3.69563786
24ribosomal small subunit biogenesis (GO:0042274)3.69412515
25glycine metabolic process (GO:0006544)3.66925224
26glucose catabolic process (GO:0006007)3.63130732
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.60282974
28L-phenylalanine metabolic process (GO:0006558)3.60282974
29binding of sperm to zona pellucida (GO:0007339)3.56609393
30lysine catabolic process (GO:0006554)3.52170062
31lysine metabolic process (GO:0006553)3.52170062
32cullin deneddylation (GO:0010388)3.50333978
33folic acid-containing compound biosynthetic process (GO:0009396)3.46468977
34sperm-egg recognition (GO:0035036)3.44866491
35serine family amino acid biosynthetic process (GO:0009070)3.43823214
36regulation of mammary gland epithelial cell proliferation (GO:0033599)3.43148342
37deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.38458635
38proline biosynthetic process (GO:0006561)3.33385572
39formation of translation preinitiation complex (GO:0001731)3.28460787
40folic acid metabolic process (GO:0046655)3.27197922
41DNA strand elongation involved in DNA replication (GO:0006271)3.26987305
42valine metabolic process (GO:0006573)3.26945442
43protein deneddylation (GO:0000338)3.26186240
44galactose catabolic process (GO:0019388)3.24656928
45sulfur amino acid catabolic process (GO:0000098)3.23805296
46DNA strand elongation (GO:0022616)3.23597070
47pentose metabolic process (GO:0019321)3.21737477
48L-serine metabolic process (GO:0006563)3.20467519
49maturation of SSU-rRNA (GO:0030490)3.19895965
50regulation of translational termination (GO:0006449)3.18666011
51fusion of sperm to egg plasma membrane (GO:0007342)3.18360062
52mitochondrial fusion (GO:0008053)3.18187810
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.16951065
54L-phenylalanine catabolic process (GO:0006559)3.16951065
55fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.16288549
56regulation of mitochondrial translation (GO:0070129)3.15981724
57aspartate family amino acid catabolic process (GO:0009068)3.11367466
58negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.08146931
59glyoxylate metabolic process (GO:0046487)3.07936748
60cell-cell recognition (GO:0009988)3.06662801
61serine family amino acid metabolic process (GO:0009069)3.06614360
62nucleobase-containing small molecule interconversion (GO:0015949)3.06428200
63alpha-linolenic acid metabolic process (GO:0036109)3.04993787
642-oxoglutarate metabolic process (GO:0006103)3.04314994
65protein complex localization (GO:0031503)3.04176286
66amino-acid betaine metabolic process (GO:0006577)3.04015372
67ribosomal small subunit assembly (GO:0000028)2.98891487
68tricarboxylic acid metabolic process (GO:0072350)2.98515580
69serine family amino acid catabolic process (GO:0009071)2.97357232
70rRNA transcription (GO:0009303)2.97039323
71glycolytic process (GO:0006096)2.96716089
72chaperone-mediated protein complex assembly (GO:0051131)2.95180990
73glucose 6-phosphate metabolic process (GO:0051156)2.94105289
74maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.92162509
75amino acid salvage (GO:0043102)2.91491492
76L-methionine salvage (GO:0071267)2.91491492
77L-methionine biosynthetic process (GO:0071265)2.91491492
78fructose metabolic process (GO:0006000)2.87909873
79pteridine-containing compound biosynthetic process (GO:0042559)2.86121298
80synaptonemal complex assembly (GO:0007130)2.85931688
81ribonucleoprotein complex biogenesis (GO:0022613)2.85550983
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85036302
83protein retention in ER lumen (GO:0006621)2.84861694
84hexose biosynthetic process (GO:0019319)2.83188441
85IMP biosynthetic process (GO:0006188)2.82974473
86aspartate family amino acid biosynthetic process (GO:0009067)2.82125433
87misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.80638793
88sulfur amino acid biosynthetic process (GO:0000097)2.79703823
89sperm motility (GO:0030317)2.79351300
90succinate metabolic process (GO:0006105)2.78365625
91regulation of cellular amino acid metabolic process (GO:0006521)2.77081337
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.76910242
93tRNA aminoacylation for protein translation (GO:0006418)2.76547202
94gluconeogenesis (GO:0006094)2.76509008
95synaptonemal complex organization (GO:0070193)2.75411094
96regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.75350896
97nucleoside salvage (GO:0043174)2.75258252
98monosaccharide biosynthetic process (GO:0046364)2.73241888
99L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72749231
100retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.72034912
101telomere maintenance via semi-conservative replication (GO:0032201)2.71547378
102glutamine family amino acid biosynthetic process (GO:0009084)2.71319308
103aspartate family amino acid metabolic process (GO:0009066)2.70817136
104ribosome assembly (GO:0042255)2.70623906
1054-hydroxyproline metabolic process (GO:0019471)2.70217791
106guanosine-containing compound biosynthetic process (GO:1901070)2.68311296
107regulation of cholesterol biosynthetic process (GO:0045540)2.68197838
108ribosome biogenesis (GO:0042254)2.67998378
109carnitine metabolic process (GO:0009437)2.67938132
110maternal placenta development (GO:0001893)2.67515523
111anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67038386
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.66074876
113negative regulation of ligase activity (GO:0051352)2.66074876
114GDP-mannose metabolic process (GO:0019673)2.65198247
115proline metabolic process (GO:0006560)2.64989054
116cellular protein complex localization (GO:0034629)2.64802158
117aromatic amino acid family catabolic process (GO:0009074)2.64247715
118negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.64034161
119DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.63823563
120endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.63207477
121pinocytosis (GO:0006907)2.62095417
122amino acid activation (GO:0043038)2.61968321
123tRNA aminoacylation (GO:0043039)2.61968321
124antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.61388329
125piRNA metabolic process (GO:0034587)2.60879145
126negative regulation of cell size (GO:0045792)2.59814065
127branched-chain amino acid catabolic process (GO:0009083)2.59683857
128oxidative phosphorylation (GO:0006119)2.59420593
129protein insertion into membrane (GO:0051205)2.59233318
130spliceosomal snRNP assembly (GO:0000387)2.58893363
131signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.58172645
132intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.58172645
133cysteine metabolic process (GO:0006534)2.57188884
134nucleotide salvage (GO:0043173)2.56871871
135organic cation transport (GO:0015695)2.56579349
136proteasome assembly (GO:0043248)2.55798024
137NADP metabolic process (GO:0006739)2.55340999
138viral mRNA export from host cell nucleus (GO:0046784)2.55111478
139signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.54872824
140signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.54872824
141signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.54872824
142pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.54450976
143UMP metabolic process (GO:0046049)2.54450976
144pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.54450976
145UMP biosynthetic process (GO:0006222)2.54450976
146positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.54444174
147tetrahydrofolate metabolic process (GO:0046653)2.54135792
148positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.54035491
149negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.52708676
150de novo protein folding (GO:0006458)2.52505209
151de novo posttranslational protein folding (GO:0051084)2.52492973
152pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.52294855
153viral transcription (GO:0019083)2.52162039
154branched-chain amino acid metabolic process (GO:0009081)2.51971516
155signal transduction involved in DNA integrity checkpoint (GO:0072401)2.51906215
156signal transduction involved in DNA damage checkpoint (GO:0072422)2.51906215
157positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.51735795
158apoptotic process involved in morphogenesis (GO:0060561)2.51304242
159peptidyl-arginine modification (GO:0018195)2.47700888
160UV protection (GO:0009650)2.47141261
161DNA replication initiation (GO:0006270)2.47001246
162nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.46406937
163regulation of translational elongation (GO:0006448)2.45369566
164adenine nucleotide transport (GO:0051503)2.45329530
165pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.43548938
166purine ribonucleotide transport (GO:0015868)2.42273232
167heterochromatin organization (GO:0070828)2.41801321
168translational elongation (GO:0006414)2.41716632
169lipopolysaccharide biosynthetic process (GO:0009103)2.41478681
170regulation of superoxide anion generation (GO:0032928)2.40530863
171ribosomal large subunit biogenesis (GO:0042273)2.40284327
172barbed-end actin filament capping (GO:0051016)2.40052679
173pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.38651846
174activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38108178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64351561
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.39787072
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.29782062
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.85275525
5* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75668909
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.71234142
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68661260
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.64820599
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34631336
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.33112259
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32875414
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.21802575
13E2F7_22180533_ChIP-Seq_HELA_Human2.17656279
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.17359497
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.16851839
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.05064038
17* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01065434
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.00851589
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.99433136
20MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96733625
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94095024
22XRN2_22483619_ChIP-Seq_HELA_Human1.88194236
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85698984
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84400226
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79996325
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77760686
27GABP_19822575_ChIP-Seq_HepG2_Human1.77687035
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75942215
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75241879
30VDR_21846776_ChIP-Seq_THP-1_Human1.69078023
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68923831
32* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66112801
33* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64990670
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64616754
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60909316
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.60729338
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60085019
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58283503
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.57538401
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55476736
41RACK7_27058665_Chip-Seq_MCF-7_Human1.54968921
42* DCP1A_22483619_ChIP-Seq_HELA_Human1.54023833
43* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51432175
44* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50268941
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.48408586
46MYC_22102868_ChIP-Seq_BL_Human1.46323228
47VDR_23849224_ChIP-Seq_CD4+_Human1.45510279
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44802855
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.40981249
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38611874
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37824998
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36302123
53FOXP3_21729870_ChIP-Seq_TREG_Human1.35288197
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35266894
55FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34234894
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32867682
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32014036
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31658258
59* TTF2_22483619_ChIP-Seq_HELA_Human1.31088192
60MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30881050
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29868098
62* TET1_21451524_ChIP-Seq_MESCs_Mouse1.29408070
63FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28018813
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27726380
65HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27566777
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25651962
67SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.24243396
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23933176
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23228133
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22335705
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21365190
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20684658
73* KDM5A_27292631_Chip-Seq_BREAST_Human1.19574002
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.19521391
75CIITA_25753668_ChIP-Seq_RAJI_Human1.17820468
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.17641702
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17018037
78* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16957525
79EGR1_19374776_ChIP-ChIP_THP-1_Human1.15695361
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15252256
81CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15124882
82BCL6_27268052_Chip-Seq_Bcells_Human1.15106681
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.14419080
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13594217
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13125555
86TFEB_21752829_ChIP-Seq_HELA_Human1.13051523
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12930527
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10466912
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10428459
90ZNF263_19887448_ChIP-Seq_K562_Human1.09549370
91FOXP1_21924763_ChIP-Seq_HESCs_Human1.08358416
92CLOCK_20551151_ChIP-Seq_293T_Human1.07900667
93* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06737789
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06606415
95* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06275506
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06232443
97AR_21909140_ChIP-Seq_LNCAP_Human1.05063025
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03394988
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02894062
100RARA_24833708_ChIP-Seq_LIVER_Mouse1.02756667
101P68_20966046_ChIP-Seq_HELA_Human1.02656060
102* BCOR_27268052_Chip-Seq_Bcells_Human1.02043113
103* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01063587
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00754128
105HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00592657
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99966718
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99051007
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98865825
109* PHF8_20622854_ChIP-Seq_HELA_Human0.98416170
110ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98253210
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97987728
112LXR_22292898_ChIP-Seq_THP-1_Human0.97650700
113CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96826846
114* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96801939
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96723984
116SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96455891
117CTCF_26484167_Chip-Seq_Bcells_Mouse0.95954623
118OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94640676
119FOXM1_23109430_ChIP-Seq_U2OS_Human0.94461882
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94068421
121ATF3_27146783_Chip-Seq_COLON_Human0.93828137
122NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93731006
123TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93522007
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93386684
125RXRA_24833708_ChIP-Seq_LIVER_Mouse0.93038222

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.36123936
2MP0005451_abnormal_body_composition4.27845205
3MP0002139_abnormal_hepatobiliary_system4.09748402
4MP0005365_abnormal_bile_salt3.55275581
5MP0005360_urolithiasis3.30902281
6MP0005410_abnormal_fertilization2.91114645
7MP0009840_abnormal_foam_cell2.90147305
8MP0005085_abnormal_gallbladder_physiolo2.81717108
9MP0003693_abnormal_embryo_hatching2.46272132
10MP0008875_abnormal_xenobiotic_pharmacok2.36228522
11MP0005332_abnormal_amino_acid2.27426175
12MP0001849_ear_inflammation2.19182391
13MP0004957_abnormal_blastocyst_morpholog2.17479814
14MP0005501_abnormal_skin_physiology2.13868220
15MP0003705_abnormal_hypodermis_morpholog2.13519220
16MP0003186_abnormal_redox_activity2.07059049
17MP0002653_abnormal_ependyma_morphology2.04818734
18MP0002877_abnormal_melanocyte_morpholog2.04692466
19MP0002796_impaired_skin_barrier2.04470206
20MP0003191_abnormal_cellular_cholesterol2.01877721
21MP0003123_paternal_imprinting2.00829288
22MP0010329_abnormal_lipoprotein_level2.00288067
23MP0005083_abnormal_biliary_tract1.96250639
24MP0000537_abnormal_urethra_morphology1.92655952
25MP0004858_abnormal_nervous_system1.92469762
26MP0005319_abnormal_enzyme/_coenzyme1.87805615
27MP0005257_abnormal_intraocular_pressure1.87757669
28MP0003329_amyloid_beta_deposits1.87008488
29MP0000678_abnormal_parathyroid_gland1.82398197
30MP0010030_abnormal_orbit_morphology1.73536972
31MP0005670_abnormal_white_adipose1.73218477
32MP0006036_abnormal_mitochondrial_physio1.72878992
33MP0003315_abnormal_perineum_morphology1.71312370
34MP0004185_abnormal_adipocyte_glucose1.65830021
35MP0001764_abnormal_homeostasis1.59271175
36MP0008007_abnormal_cellular_replicative1.58627387
37MP0001727_abnormal_embryo_implantation1.54459033
38MP0003077_abnormal_cell_cycle1.54158221
39MP0006054_spinal_hemorrhage1.54075363
40MP0009643_abnormal_urine_homeostasis1.53192877
41MP0003195_calcinosis1.51748870
42MP0003252_abnormal_bile_duct1.51068895
43MP0000751_myopathy1.50952157
44MP0002249_abnormal_larynx_morphology1.50868949
45MP0003111_abnormal_nucleus_morphology1.49325075
46MP0000609_abnormal_liver_physiology1.48037295
47MP0000358_abnormal_cell_content/1.45348821
48MP0001730_embryonic_growth_arrest1.45146016
49MP0001661_extended_life_span1.45128775
50MP0008438_abnormal_cutaneous_collagen1.40731638
51MP0008877_abnormal_DNA_methylation1.40223652
52MP0005058_abnormal_lysosome_morphology1.39230304
53MP0001666_abnormal_nutrient_absorption1.38247900
54MP0001756_abnormal_urination1.36468168
55MP0004019_abnormal_vitamin_homeostasis1.36049194
56MP0000566_synostosis1.35975989
57MP0000598_abnormal_liver_morphology1.34313969
58MP0001929_abnormal_gametogenesis1.32851991
59MP0003453_abnormal_keratinocyte_physiol1.30748060
60MP0000013_abnormal_adipose_tissue1.28459090
61MP0005076_abnormal_cell_differentiation1.27311018
62MP0000750_abnormal_muscle_regeneration1.26775595
63MP0003221_abnormal_cardiomyocyte_apopto1.25469690
64MP0002089_abnormal_postnatal_growth/wei1.21765606
65MP0000747_muscle_weakness1.20477153
66MP0003566_abnormal_cell_adhesion1.20091416
67MP0002269_muscular_atrophy1.19231765
68MP0003698_abnormal_male_reproductive1.18703583
69MP0005023_abnormal_wound_healing1.18251583
70MP0008058_abnormal_DNA_repair1.17554866
71MP0000467_abnormal_esophagus_morphology1.17337438
72MP0004264_abnormal_extraembryonic_tissu1.16468741
73MP0002132_abnormal_respiratory_system1.14089889
74MP0002098_abnormal_vibrissa_morphology1.13796577
75MP0000490_abnormal_crypts_of1.13304233
76MP0002822_catalepsy1.12576300
77MP0005330_cardiomyopathy1.12542059
78MP0010094_abnormal_chromosome_stability1.12262375
79MP0010352_gastrointestinal_tract_polyps1.11158185
80MP0002118_abnormal_lipid_homeostasis1.10884160
81MP0003646_muscle_fatigue1.09085660
82MP0005397_hematopoietic_system_phenotyp1.07895705
83MP0001545_abnormal_hematopoietic_system1.07895705
84MP0008260_abnormal_autophagy1.07355555
85MP0001346_abnormal_lacrimal_gland1.07304517
86MP0004233_abnormal_muscle_weight1.06611848
87MP0000003_abnormal_adipose_tissue1.06263352
88MP0005666_abnormal_adipose_tissue1.05722325
89MP0005584_abnormal_enzyme/coenzyme_acti1.04406728
90MP0009379_abnormal_foot_pigmentation1.02667231
91MP0004272_abnormal_basement_membrane1.01135270
92MP0002210_abnormal_sex_determination1.01074597
93MP0001145_abnormal_male_reproductive0.99840939
94MP0005636_abnormal_mineral_homeostasis0.99625913
95MP0002080_prenatal_lethality0.99438011
96MP0001216_abnormal_epidermal_layer0.98912429
97MP0010307_abnormal_tumor_latency0.97099020
98MP0006035_abnormal_mitochondrial_morpho0.94088676
99MP0005084_abnormal_gallbladder_morpholo0.93678722
100MP0002060_abnormal_skin_morphology0.92591520
101MP0005266_abnormal_metabolism0.91465507
102MP0004043_abnormal_pH_regulation0.91313835
103MP0003786_premature_aging0.90894476
104MP0003941_abnormal_skin_development0.90794312
105MP0001881_abnormal_mammary_gland0.90696090
106MP0004084_abnormal_cardiac_muscle0.90016052
107MP0009672_abnormal_birth_weight0.88261879
108MP0003984_embryonic_growth_retardation0.87801103
109MP0000681_abnormal_thyroid_gland0.87287346
110MP0002088_abnormal_embryonic_growth/wei0.86870038
111MP0008932_abnormal_embryonic_tissue0.86669969
112MP0001348_abnormal_lacrimal_gland0.86619959
113MP0001697_abnormal_embryo_size0.86127836
114MP0001672_abnormal_embryogenesis/_devel0.86045949
115MP0005380_embryogenesis_phenotype0.86045949
116MP0005375_adipose_tissue_phenotype0.85167208
117MP0002970_abnormal_white_adipose0.84760223
118MP0000604_amyloidosis0.84665918
119MP0005384_cellular_phenotype0.84062625
120MP0000762_abnormal_tongue_morphology0.83344159
121MP0002085_abnormal_embryonic_tissue0.83287532
122MP0005621_abnormal_cell_physiology0.82805209
123MP0003718_maternal_effect0.82300387
124MP0000477_abnormal_intestine_morphology0.81325828
125MP0002161_abnormal_fertility/fecundity0.80981013
126MP0002160_abnormal_reproductive_system0.80130799
127MP0000579_abnormal_nail_morphology0.79407451
128MP0004782_abnormal_surfactant_physiolog0.79262030
129MP0001915_intracranial_hemorrhage0.79014013
130MP0008469_abnormal_protein_level0.78479642
131MP0000858_altered_metastatic_potential0.78264132
132MP0009278_abnormal_bone_marrow0.77590364
133MP0000350_abnormal_cell_proliferation0.77149515
134MP0000653_abnormal_sex_gland0.77015906
135MP0002138_abnormal_hepatobiliary_system0.74598121
136MP0002136_abnormal_kidney_physiology0.74528356
137MP0010234_abnormal_vibrissa_follicle0.74276201
138MP0002019_abnormal_tumor_incidence0.73850436
139MP0000313_abnormal_cell_death0.72786358
140MP0000377_abnormal_hair_follicle0.71954375
141MP0000627_abnormal_mammary_gland0.70736805
142MP0002086_abnormal_extraembryonic_tissu0.70591613
143MP0005275_abnormal_skin_tensile0.70387464
144MP0009642_abnormal_blood_homeostasis0.70206699
145MP0005376_homeostasis/metabolism_phenot0.68086956
146MP0003656_abnormal_erythrocyte_physiolo0.67088736
147MP0005220_abnormal_exocrine_pancreas0.66418194
148MP0002135_abnormal_kidney_morphology0.65938277
149MP0002078_abnormal_glucose_homeostasis0.65407127
150MP0000749_muscle_degeneration0.63234598
151MP0009333_abnormal_splenocyte_physiolog0.63168640
152MP0004197_abnormal_fetal_growth/weight/0.63135807
153MP0002909_abnormal_adrenal_gland0.60068904
154MP0004808_abnormal_hematopoietic_stem0.59031563

Predicted human phenotypes

RankGene SetZ-score
1Microvesicular hepatic steatosis (HP:0001414)4.24680685
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.09430880
3Abnormality of fatty-acid metabolism (HP:0004359)3.72338682
4Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.68890321
5Gout (HP:0001997)3.57587087
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.49039118
7Abnormality of the anterior horn cell (HP:0006802)3.44417676
8Degeneration of anterior horn cells (HP:0002398)3.44417676
9Hyperglycinuria (HP:0003108)3.40044602
10Hyperammonemia (HP:0001987)3.25002199
11Hypoglycemic coma (HP:0001325)3.14388722
12Hypobetalipoproteinemia (HP:0003563)3.09039162
13Abnormality of the lower motor neuron (HP:0002366)3.07851665
14Hyperglycinemia (HP:0002154)3.05190311
15Ketosis (HP:0001946)2.97908785
16Trismus (HP:0000211)2.94839958
17Rhabdomyolysis (HP:0003201)2.93775472
18Hyperacusis (HP:0010780)2.92649138
19Abnormality of glycine metabolism (HP:0010895)2.87578638
20Abnormality of serine family amino acid metabolism (HP:0010894)2.87578638
21Hand muscle atrophy (HP:0009130)2.84172961
22Achilles tendon contracture (HP:0001771)2.83522562
23Myoglobinuria (HP:0002913)2.79247909
24Multiple enchondromatosis (HP:0005701)2.78618517
25Deep venous thrombosis (HP:0002625)2.74679510
26Intrahepatic cholestasis (HP:0001406)2.69792641
27Xanthomatosis (HP:0000991)2.68066422
28Abnormality of the Achilles tendon (HP:0005109)2.60765511
29Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59204909
30Dicarboxylic aciduria (HP:0003215)2.59204909
31Spastic diplegia (HP:0001264)2.55315732
32Ketoacidosis (HP:0001993)2.54811975
33Generalized aminoaciduria (HP:0002909)2.54555392
34Insomnia (HP:0100785)2.52432746
35Abnormality of glycolysis (HP:0004366)2.49335694
36Increased serum pyruvate (HP:0003542)2.49335694
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.48159175
38Late onset (HP:0003584)2.47416793
39Cholecystitis (HP:0001082)2.46676796
40Abnormal gallbladder physiology (HP:0012438)2.46676796
41Testicular atrophy (HP:0000029)2.45167923
42Brushfield spots (HP:0001088)2.42968962
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41227925
44Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41227925
45Nasal polyposis (HP:0100582)2.40630338
46Abnormality of the intrinsic pathway (HP:0010989)2.40108954
47Ragged-red muscle fibers (HP:0003200)2.38670570
48Rough bone trabeculation (HP:0100670)2.38404543
49Abnormality of the nasal mucosa (HP:0000433)2.38397856
50Reticulocytosis (HP:0001923)2.37846142
51Abnormality of serum amino acid levels (HP:0003112)2.37571379
52Hepatic necrosis (HP:0002605)2.36933461
53Cerebral hypomyelination (HP:0006808)2.36375497
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.36323888
55Lethargy (HP:0001254)2.31597532
56Abnormality of pyrimidine metabolism (HP:0004353)2.31345203
57Upper limb amyotrophy (HP:0009129)2.28250034
58Distal upper limb amyotrophy (HP:0007149)2.28250034
59Broad distal phalanx of finger (HP:0009836)2.24455958
60Abnormality of sulfur amino acid metabolism (HP:0004339)2.23545585
61Distal lower limb amyotrophy (HP:0008944)2.22086144
62Abnormality of nucleobase metabolism (HP:0010932)2.20904377
63Complement deficiency (HP:0004431)2.19955283
64Spastic paraparesis (HP:0002313)2.18403349
65Thrombocytosis (HP:0001894)2.16729936
66Myopathic facies (HP:0002058)2.16672087
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16092050
68Abnormality of purine metabolism (HP:0004352)2.15683964
69Chronic bronchitis (HP:0004469)2.14701605
70Abnormality of the umbilical cord (HP:0010881)2.14289112
71Palpitations (HP:0001962)2.14054212
72Abnormality of reticulocytes (HP:0004312)2.12788912
73Hypolipoproteinemia (HP:0010981)2.11894191
74Oligomenorrhea (HP:0000876)2.10255022
75Protrusio acetabuli (HP:0003179)2.09624082
76Aplastic anemia (HP:0001915)2.09336850
77Abnormal neuron morphology (HP:0012757)2.08784944
78Abnormality of the motor neurons (HP:0002450)2.08784944
79Epiphyseal stippling (HP:0010655)2.08510032
80Opisthotonus (HP:0002179)2.05462173
81Neuroendocrine neoplasm (HP:0100634)2.05419557
82Proximal tubulopathy (HP:0000114)2.05401682
83Short nail (HP:0001799)2.04307931
84CNS demyelination (HP:0007305)2.04189795
85Abnormal cartilage morphology (HP:0002763)2.04040684
86Fasciculations (HP:0002380)2.03922436
87Hyperbilirubinemia (HP:0002904)2.03314865
88Esophageal neoplasm (HP:0100751)2.03206979
89Neoplasm of head and neck (HP:0012288)2.03206979
90Premature rupture of membranes (HP:0001788)1.98772053
91Abnormality of the distal phalanges of the toes (HP:0010182)1.97134177
92Pili torti (HP:0003777)1.96816618
93Vertebral compression fractures (HP:0002953)1.96618636
94Abnormal number of erythroid precursors (HP:0012131)1.95996889
95Upper motor neuron abnormality (HP:0002127)1.95395722
96Abnormality of cells of the erythroid lineage (HP:0012130)1.94250631
97Muscle fibrillation (HP:0010546)1.93897312
98Hypokinesia (HP:0002375)1.93395050
99Neoplasm of the adrenal gland (HP:0100631)1.93390922
100Hyperuricemia (HP:0002149)1.93286108
101Increased purine levels (HP:0004368)1.93286108
102Flat acetabular roof (HP:0003180)1.93071076
103Atrophy/Degeneration involving motor neurons (HP:0007373)1.92852183
104Distal lower limb muscle weakness (HP:0009053)1.92653264
105Back pain (HP:0003418)1.92452698
106Tongue fasciculations (HP:0001308)1.92193900
107Long palpebral fissure (HP:0000637)1.90370637
108Selective tooth agenesis (HP:0001592)1.89364679
109Nonimmune hydrops fetalis (HP:0001790)1.89325597
110Insulin resistance (HP:0000855)1.89318705
111Axonal loss (HP:0003447)1.89240284
112Hypoglycemic seizures (HP:0002173)1.89203330
113Increased connective tissue (HP:0009025)1.88526309
114Pheochromocytoma (HP:0002666)1.88371528
115Cholelithiasis (HP:0001081)1.87462047
116Seborrheic dermatitis (HP:0001051)1.87446158
117Type I transferrin isoform profile (HP:0003642)1.87209895
118Hepatocellular necrosis (HP:0001404)1.86440257
119Personality changes (HP:0000751)1.86230138
120Progressive muscle weakness (HP:0003323)1.86161055
121Nausea (HP:0002018)1.85443516
122Hypertensive crisis (HP:0100735)1.85412088
123Generalized amyotrophy (HP:0003700)1.85240061
124Irritability (HP:0000737)1.84904017
125Growth hormone excess (HP:0000845)1.84860419
126Delayed CNS myelination (HP:0002188)1.84297842
127Athetosis (HP:0002305)1.83703870
128Hemorrhage of the eye (HP:0011885)1.83551615
129Oral leukoplakia (HP:0002745)1.83519593
130Abnormality of carpal bone ossification (HP:0006257)1.82707738
131Increased muscle lipid content (HP:0009058)1.81366375
132Infertility (HP:0000789)1.81222839
133Gonadotropin excess (HP:0000837)1.80998119
134Secondary amenorrhea (HP:0000869)1.80723510
135Death in childhood (HP:0003819)1.80172274
136Ulnar bowing (HP:0003031)1.79372353
137Hyperparathyroidism (HP:0000843)1.79122044
138Metabolic acidosis (HP:0001942)1.79121784
139Abnormal trabecular bone morphology (HP:0100671)1.79017782
140Abnormality of the pancreatic islet cells (HP:0006476)1.78401333
141Abnormality of endocrine pancreas physiology (HP:0012093)1.78401333
142Progressive external ophthalmoplegia (HP:0000590)1.77954969
143Abnormal gallbladder morphology (HP:0012437)1.77878430
144Megaloblastic anemia (HP:0001889)1.77607817
145Overriding aorta (HP:0002623)1.77098534
146Death in infancy (HP:0001522)1.76018262
147Abnormal hair laboratory examination (HP:0003328)1.75847495
148Stridor (HP:0010307)1.74247585
149Abnormalities of placenta or umbilical cord (HP:0001194)1.71865223
150Abnormality of the gallbladder (HP:0005264)1.71739555
151Reduced antithrombin III activity (HP:0001976)1.70484413
152Increased intramyocellular lipid droplets (HP:0012240)1.70043450
153Entropion (HP:0000621)1.69057918
154Premature ovarian failure (HP:0008209)1.68713741
155Microretrognathia (HP:0000308)1.67724411
156J-shaped sella turcica (HP:0002680)1.65878682
157Microglossia (HP:0000171)1.61452265
158Difficulty climbing stairs (HP:0003551)1.61225619
159Hypercalcemia (HP:0003072)1.61067987
160Abnormality of pain sensation (HP:0010832)1.61004001
161Impaired pain sensation (HP:0007328)1.61004001
162Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60100247
163Reticulocytopenia (HP:0001896)1.59890314
164Sparse eyelashes (HP:0000653)1.59832974
165Biconcave vertebral bodies (HP:0004586)1.59720142
166Prolonged neonatal jaundice (HP:0006579)1.59241881
167Truncus arteriosus (HP:0001660)1.58764427
168Hepatosplenomegaly (HP:0001433)1.58014626
169Exercise intolerance (HP:0003546)1.56804613

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.31359116
2PDK44.31359116
3TESK14.10230790
4BCKDK3.64701900
5SMG13.46912713
6TRIB33.11504533
7BUB13.08580667
8PDK23.01194432
9VRK22.94583157
10TSSK62.91774353
11ERN12.52398615
12NEK12.50766791
13IRAK32.49413090
14TESK22.36373104
15SRPK12.13389788
16PKN22.12650196
17PRPF4B1.84120473
18WEE11.83860682
19EPHA21.80225488
20FLT31.78984208
21PASK1.76548175
22PAK41.75584242
23EIF2AK11.68519507
24PBK1.60313906
25PRKD31.52760798
26MST1R1.45876810
27ACVR1B1.42826966
28EEF2K1.42188495
29STK161.40810652
30PIM21.40387805
31ZAP701.38200687
32NEK21.37244021
33MAP3K111.35743102
34SCYL21.28395317
35BRAF1.28297647
36NME21.28287691
37ARAF1.27976820
38KDR1.26798211
39MYLK1.26212343
40CCNB11.20813248
41NME11.19139363
42TGFBR11.17071475
43FGFR41.16813069
44MAP2K31.15408894
45LIMK11.12023740
46CDK121.10443540
47MAP3K101.06240407
48MAPKAPK31.05210568
49LRRK21.02663700
50DAPK11.01567974
51AKT30.97918899
52EIF2AK30.95690992
53DAPK30.93871705
54RIPK10.92257997
55STK38L0.92079758
56BRSK20.89712465
57BRSK10.86895481
58RPS6KB20.82411905
59PTK60.80692979
60PINK10.79091725
61SIK10.78660435
62MAP2K60.78471198
63ILK0.77844604
64TBK10.76996791
65MAP3K30.75229622
66TYK20.70691118
67MAP4K10.69736784
68PLK10.69144257
69PAK10.67582281
70WNK30.65839664
71MAP3K80.65601117
72AKT20.64517318
73NTRK10.63048733
74CDK11A0.60968430
75TTK0.60037087
76TAOK20.59466318
77WNK40.59178091
78RPS6KA40.58677446
79CDK150.57296644
80CDK140.54993899
81CDK80.54980588
82CDK180.54750065
83PDGFRA0.54651985
84CSNK1G30.53836177
85MAP2K20.52666495
86AURKA0.51625190
87ICK0.51515252
88PRKCI0.50769504
89PTK20.48919438
90MAP3K120.48904237
91MAP2K10.47928382
92TTN0.47813438
93CHEK20.47623265
94ATR0.47485789
95CDK90.47238636
96PDPK10.46676451
97CHEK10.45941504
98BMX0.44542218
99CDK40.43887305
100DYRK1B0.43629973
101ALK0.43183610
102MAPK110.41433853
103MAP2K70.40688277
104DDR20.40567461
105SIK30.40246468
106MUSK0.38847803
107CDK60.38812497
108RAF10.37816675
109PTK2B0.37779103
110MTOR0.37427548
111MET0.37036843
112CSNK1A1L0.36097523
113LATS20.34423836
114AURKB0.34312288
115STK40.33748100
116VRK10.33727994
117TAOK10.32900089
118KSR20.31764595
119KIT0.31594196
120CSF1R0.30960343
121JAK30.30625082
122MAP3K10.29916285
123PLK30.29902047
124ABL20.29076747
125CDK70.28820012
126STK100.27301938
127NEK90.26381799
128LMTK20.25324420
129PIM10.24570532
130CSNK2A20.24328882
131FER0.24167083
132CDC70.23772631

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.41148099
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.15721484
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.02203416
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.83024631
5Proteasome_Homo sapiens_hsa030502.66813499
6Pyruvate metabolism_Homo sapiens_hsa006202.46636622
7Biosynthesis of amino acids_Homo sapiens_hsa012302.43561403
8Carbon metabolism_Homo sapiens_hsa012002.39701621
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.18544938
10Propanoate metabolism_Homo sapiens_hsa006402.16268026
11Cysteine and methionine metabolism_Homo sapiens_hsa002702.11556648
12Selenocompound metabolism_Homo sapiens_hsa004502.07716344
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.07400989
14Fatty acid degradation_Homo sapiens_hsa000712.06595485
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.04895242
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92909725
17Pentose phosphate pathway_Homo sapiens_hsa000301.91764799
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85611281
19Fructose and mannose metabolism_Homo sapiens_hsa000511.76495773
20Vitamin B6 metabolism_Homo sapiens_hsa007501.72038315
21Folate biosynthesis_Homo sapiens_hsa007901.70442234
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.69609141
23One carbon pool by folate_Homo sapiens_hsa006701.68468552
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67704286
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.60050654
26Arginine biosynthesis_Homo sapiens_hsa002201.58796644
27DNA replication_Homo sapiens_hsa030301.55748970
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.51519621
29Tryptophan metabolism_Homo sapiens_hsa003801.45030822
30Sulfur relay system_Homo sapiens_hsa041221.44807980
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41211974
32Fatty acid metabolism_Homo sapiens_hsa012121.40941294
33Peroxisome_Homo sapiens_hsa041461.36566684
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34383960
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26994228
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26677812
37Galactose metabolism_Homo sapiens_hsa000521.25339221
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23837271
39RNA transport_Homo sapiens_hsa030131.23774231
40Mismatch repair_Homo sapiens_hsa034301.17956450
41Pyrimidine metabolism_Homo sapiens_hsa002401.14919047
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13593294
43Base excision repair_Homo sapiens_hsa034101.13189911
44PPAR signaling pathway_Homo sapiens_hsa033201.07804490
45beta-Alanine metabolism_Homo sapiens_hsa004101.07719956
46Glutathione metabolism_Homo sapiens_hsa004801.07158318
47Butanoate metabolism_Homo sapiens_hsa006501.01596333
48Phenylalanine metabolism_Homo sapiens_hsa003601.01242195
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97634116
50Steroid biosynthesis_Homo sapiens_hsa001000.95380114
51RNA polymerase_Homo sapiens_hsa030200.94726475
52Spliceosome_Homo sapiens_hsa030400.93690034
53Chemical carcinogenesis_Homo sapiens_hsa052040.91415023
54Fat digestion and absorption_Homo sapiens_hsa049750.87910034
55Arginine and proline metabolism_Homo sapiens_hsa003300.86475702
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85339312
57mRNA surveillance pathway_Homo sapiens_hsa030150.82076972
58Complement and coagulation cascades_Homo sapiens_hsa046100.80766365
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80165256
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79035582
61Parkinsons disease_Homo sapiens_hsa050120.78208243
62Legionellosis_Homo sapiens_hsa051340.78118999
63Nucleotide excision repair_Homo sapiens_hsa034200.76942220
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76873465
65Antigen processing and presentation_Homo sapiens_hsa046120.76870579
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.74513575
67Starch and sucrose metabolism_Homo sapiens_hsa005000.71536811
68Huntingtons disease_Homo sapiens_hsa050160.70993294
69Sulfur metabolism_Homo sapiens_hsa009200.70934284
70Non-homologous end-joining_Homo sapiens_hsa034500.70117684
71Tyrosine metabolism_Homo sapiens_hsa003500.69110413
72Oxidative phosphorylation_Homo sapiens_hsa001900.68504157
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67797126
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66270136
75Nitrogen metabolism_Homo sapiens_hsa009100.65682519
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65327801
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64522501
78Shigellosis_Homo sapiens_hsa051310.60983563
79Caffeine metabolism_Homo sapiens_hsa002320.60503672
80Histidine metabolism_Homo sapiens_hsa003400.58949994
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.57640840
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.57584955
83Collecting duct acid secretion_Homo sapiens_hsa049660.57172902
84Metabolic pathways_Homo sapiens_hsa011000.55929230
85Vibrio cholerae infection_Homo sapiens_hsa051100.55454982
86Chronic myeloid leukemia_Homo sapiens_hsa052200.54835653
87Glycerolipid metabolism_Homo sapiens_hsa005610.53625790
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52541494
89Purine metabolism_Homo sapiens_hsa002300.52152453
90Ribosome_Homo sapiens_hsa030100.51610569
91N-Glycan biosynthesis_Homo sapiens_hsa005100.50675604
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49237654
93Other glycan degradation_Homo sapiens_hsa005110.48381496
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45414561
95Cell cycle_Homo sapiens_hsa041100.45318159
96Apoptosis_Homo sapiens_hsa042100.44218150
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42651293
98Epstein-Barr virus infection_Homo sapiens_hsa051690.41059158
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40973330
100Retinol metabolism_Homo sapiens_hsa008300.40347812
101Protein export_Homo sapiens_hsa030600.40300469
102Viral carcinogenesis_Homo sapiens_hsa052030.39802983
103AMPK signaling pathway_Homo sapiens_hsa041520.39513711
104Glucagon signaling pathway_Homo sapiens_hsa049220.38669499
105Salmonella infection_Homo sapiens_hsa051320.38563578
106Lysosome_Homo sapiens_hsa041420.38548786
107Acute myeloid leukemia_Homo sapiens_hsa052210.37958690
108Vitamin digestion and absorption_Homo sapiens_hsa049770.37724944
109Prion diseases_Homo sapiens_hsa050200.37548836
110Basal transcription factors_Homo sapiens_hsa030220.37524103
111Regulation of autophagy_Homo sapiens_hsa041400.36440201
112Alzheimers disease_Homo sapiens_hsa050100.35010027
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.34816074
114Bile secretion_Homo sapiens_hsa049760.34697103
115Fatty acid elongation_Homo sapiens_hsa000620.34426326
116Insulin signaling pathway_Homo sapiens_hsa049100.31236167
117Notch signaling pathway_Homo sapiens_hsa043300.31168376
118Thyroid cancer_Homo sapiens_hsa052160.30367774
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.29586366
120Pancreatic cancer_Homo sapiens_hsa052120.29422855
121p53 signaling pathway_Homo sapiens_hsa041150.26980811
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26484621
123Bladder cancer_Homo sapiens_hsa052190.26087125
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25507423
125Non-small cell lung cancer_Homo sapiens_hsa052230.25418904
126Homologous recombination_Homo sapiens_hsa034400.23816874
127Endocytosis_Homo sapiens_hsa041440.22194867
128Systemic lupus erythematosus_Homo sapiens_hsa053220.21094447
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20832693
130Lysine degradation_Homo sapiens_hsa003100.20568174
131HTLV-I infection_Homo sapiens_hsa051660.17951739
132Alcoholism_Homo sapiens_hsa050340.16569063
133Renin-angiotensin system_Homo sapiens_hsa046140.15198509

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