Name

PTPN13 Gene

protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

PHACTR4 Gene

phosphatase and actin regulator 4

This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PHACTR1 Gene

phosphatase and actin regulator 1

PHACTR3 Gene

phosphatase and actin regulator 3

This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PHACTR2 Gene

phosphatase and actin regulator 2

PTPN18 Gene

protein tyrosine phosphatase, non-receptor type 18 (brain-derived)

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

PTPN12 Gene

protein tyrosine phosphatase, non-receptor type 12

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

PTPN11 Gene

protein tyrosine phosphatase, non-receptor type 11

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

PTPN14 Gene

protein tyrosine phosphatase, non-receptor type 14

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]

PPP1R1AP2 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 1A pseudogene 2

ALPP Gene

alkaline phosphatase, placental

The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]

ALPI Gene

alkaline phosphatase, intestinal

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014]

ALPL Gene

alkaline phosphatase, liver/bone/kidney

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

PTPMT1 Gene

protein tyrosine phosphatase, mitochondrial 1

PPP3CA Gene

protein phosphatase 3, catalytic subunit, alpha isozyme

PPP3CB Gene

protein phosphatase 3, catalytic subunit, beta isozyme

PPP3CC Gene

protein phosphatase 3, catalytic subunit, gamma isozyme

Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

INPP4A Gene

inositol polyphosphate-4-phosphatase, type I, 107kDa

This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008]

PPP1R26 Gene

protein phosphatase 1, regulatory subunit 26

PPP1R27 Gene

protein phosphatase 1, regulatory subunit 27

PPP1R21 Gene

protein phosphatase 1, regulatory subunit 21

LOC105369264 Gene

tyrosine-protein phosphatase non-receptor type 20

PPP1R13B Gene

protein phosphatase 1, regulatory subunit 13B

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]

PPP1R13L Gene

protein phosphatase 1, regulatory subunit 13 like

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

LOC100631380 Gene

protein phosphatase 6, regulatory subunit 2 pseudogene 1

LHPP Gene

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

LOC100271656 Gene

N-acetylneuraminic acid phosphatase pseudogene

ALPPP Gene

alkaline phosphatase, pseudogene

PPFIA4 Gene

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4

PPFIA4, or liprin-alpha-4, belongs to the liprin-alpha gene family. See liprin-alpha-1 (LIP1, or PPFIA1; MIM 611054) for background on liprins.[supplied by OMIM, Mar 2008]

LOC101929101 Gene

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 pseudogene

PDXP Gene

pyridoxal (pyridoxine, vitamin B6) phosphatase

Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003 [PubMed 14522954]).[supplied by OMIM, Mar 2008]

RNGTT Gene

RNA guanylyltransferase and 5'-phosphatase

LOC100420466 Gene

dual specificity phosphatase 3 pseudogene

LOC105379539 Gene

tyrosine-protein phosphatase non-receptor type 23-like

PXYLP1 Gene

2-phosphoxylose phosphatase 1

PPP6C Gene

protein phosphatase 6, catalytic subunit

This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]

LOC100421419 Gene

protein phosphatase 4, regulatory subunit 2 pseudogene

EEPD1 Gene

endonuclease/exonuclease/phosphatase family domain containing 1

PDPR Gene

pyruvate dehydrogenase phosphatase regulatory subunit

PDP1 Gene

pyruvate dehyrogenase phosphatase catalytic subunit 1

Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

PDP2 Gene

pyruvate dehyrogenase phosphatase catalytic subunit 2

TPTE2 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2

TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002]

INPP1 Gene

inositol polyphosphate-1-phosphatase

This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008]

PPP1R10P1 Gene

protein phosphatase 1, regulatory subunit 10 pseudogene 1

LOC102725016 Gene

serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

LOC100128407 Gene

N-acetylneuraminic acid phosphatase pseudogene

PPP6CP Gene

protein phosphatase 6, catalytic subunit pseudogene

PTPN22 Gene

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]

PTPN23 Gene

protein tyrosine phosphatase, non-receptor type 23

PTPN20 Gene

protein tyrosine phosphatase, non-receptor type 20

The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

PTPN21 Gene

protein tyrosine phosphatase, non-receptor type 21

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]

LOC390705 Gene

protein phosphatase 2, regulatory subunit B'', beta pseudogene

PHLPP1 Gene

PH domain and leucine rich repeat protein phosphatase 1

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]

PPP1R14D Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14D

Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010]

PPP1R14B Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14B

PPP1R14C Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14C

The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]

PPP1R14A Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14A

The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]

ALPPL2 Gene

alkaline phosphatase, placental-like 2

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]

LOC100133326 Gene

serine/threonine-protein phosphatase 4 regulatory subunit 2-like

LOC100130747 Gene

N-acetylneuraminic acid phosphatase pseudogene

LOC100420515 Gene

CTD nuclear envelope phosphatase 1 pseudogene

DUSP12P1 Gene

dual specificity phosphatase 12 pseudogene 1

INPP4B Gene

inositol polyphosphate-4-phosphatase, type II, 105kDa

INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]

PPP1R12BP1 Gene

protein phosphatase 1, regulatory subunit 12B pseudogene, Y-linked 1

PPP1R12BP2 Gene

protein phosphatase 1, regulatory subunit 12B Y-linked pseudogene 2

LOC102724525 Gene

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 pseudogene

LOC100422713 Gene

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 pseudogene

LOC100422710 Gene

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 pseudogene

LOC100419991 Gene

phosphoserine phosphatase pseudogene

LOC442113 Gene

protein tyrosine phosphatase, non-receptor type 11 pseudogene

PTPRCAP Gene

protein tyrosine phosphatase, receptor type, C-associated protein

The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008]

LOC100421808 Gene

protein phosphatase 2, regulatory subunit B, gamma pseudogene

LOC100421802 Gene

protein phosphatase 2, regulatory subunit B, alpha pseudogene

LOC647208 Gene

protein phosphatase 2, regulatory subunit B'', beta pseudogene

PPP2R2DP1 Gene

protein phosphatase 2, regulatory subunit B, delta pseudogene 1

LOC101929749 Gene

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 pseudogene

PPP1R26P5 Gene

protein phosphatase 1, regulatory subunit 26 pseudogene 5

PPP1R26P2 Gene

protein phosphatase 1, regulatory subunit 26 pseudogene 2

PTENP1 Gene

phosphatase and tensin homolog pseudogene 1 (functional)

The phosphatase and tensin homolog (PTEN) gene encodes a tumor suppressor that functions by negatively regulating the AKT/PKB signaling pathway. A highly homologous processed pseudogene of PTEN is found on chromosome 9 and regulates PTEN by both sense and antisense RNAs (Gene ID: 101243555). This long-noncoding RNA (lncRNA) acts as a decoy for PTEN targeting microRNAs and also exerts a tumor suppressive activity. [provided by RefSeq, Apr 2013]

ALPQTL3 Gene

Alkaline phosphatase, plasma level of, QTL3

ALPQTL2 Gene

Alkaline phosphatase, plasma level of, QTL 2

NANP Gene

N-acetylneuraminic acid phosphatase

DUSP28 Gene

dual specificity phosphatase 28

DUSP21 Gene

dual specificity phosphatase 21

This gene encodes a member of the dual specificity phosphatase family, specifically the low molecular weight dual specificity phosphatase family. The encoded protein localizes to both the cytoplasm and the nucleus and functions to remove phosphate groups from phosphotyrosine and phosphothreonine residues.[provided by RefSeq, Mar 2009]

DUSP22 Gene

dual specificity phosphatase 22

DUSP23 Gene

dual specificity phosphatase 23

DUSP26 Gene

dual specificity phosphatase 26 (putative)

This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

DUSP27 Gene

dual specificity phosphatase 27 (putative)

PTPRZ2 Gene

protein tyrosine phosphatase, receptor-type, Z polypeptide 2

PTPRZ1 Gene

protein tyrosine phosphatase, receptor-type, Z polypeptide 1

This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

PPP1R8P1 Gene

protein phosphatase 1, regulatory subunit 8 pseudogene 1

PHOSPHO2 Gene

phosphatase, orphan 2

PHOSPHO1 Gene

phosphatase, orphan 1

LOC100131448 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 pseudogene

PTPN3 Gene

protein tyrosine phosphatase, non-receptor type 3

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

PPP2R1B Gene

protein phosphatase 2, regulatory subunit A, beta

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

PPP1R26P4 Gene

protein phosphatase 1, regulatory subunit 26 pseudogene 4

TIGAR Gene

TP53 induced glycolysis regulatory phosphatase

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]

SSU72 Gene

SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)

LOC100422495 Gene

protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) pseudogene

PPP2R4 Gene

protein phosphatase 2A activator, regulatory subunit 4

Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

LOC400927 Gene

TPTE and PTEN homologous inositol lipid phosphatase pseudogene

LOC100132773 Gene

serine/threonine-protein phosphatase 4 regulatory subunit 2-like

PPEF2 Gene

protein phosphatase, EF-hand calcium binding domain 2

This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein, which is expressed specifically in photoreceptors and the pineal, has been suggested to play a role in the visual system. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. [provided by RefSeq, Jul 2008]

PPEF1 Gene

protein phosphatase, EF-hand calcium binding domain 1

This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described. [provided by RefSeq, Jul 2008]

PTPN2P2 Gene

protein tyrosine phosphatase, non-receptor type 2 pseudogene 2

DUSP5P2 Gene

dual specificity phosphatase 5 pseudogene 2

DUSP5P1 Gene

dual specificity phosphatase 5 pseudogene 1

LOC643605 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 pseudogene

PPP2CBP1 Gene

protein phosphatase 2, catalytic subunit, beta isozyme pseudogene 1

PPP1R14BP5 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 5

LOC442263 Gene

protein tyrosine phosphatase, non-receptor type 11 pseudogene

PTPN9 Gene

protein tyrosine phosphatase, non-receptor type 9

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]

PTPN2 Gene

protein tyrosine phosphatase, non-receptor type 2

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

PTPN1 Gene

protein tyrosine phosphatase, non-receptor type 1

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

PTPN7 Gene

protein tyrosine phosphatase, non-receptor type 7

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]

PTPN6 Gene

protein tyrosine phosphatase, non-receptor type 6

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

PTPN5 Gene

protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)

PTPN4 Gene

protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]

LOC390760 Gene

protein phosphatase inhibitor 2-like

PPP1R14BP4 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 4

PPP1R14BP2 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 2

PPP1R14BP3 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 3

PPP1R14BP1 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 1

PPP1R3G Gene

protein phosphatase 1, regulatory subunit 3G

PPP1R3F Gene

protein phosphatase 1, regulatory subunit 3F

This gene encodes a protein that has been identified as one of several type-1 protein phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulatory subunit functions to regulate substrate specificity and/or targeting to a particular cellular compartment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

PPP1R3E Gene

protein phosphatase 1, regulatory subunit 3E

PPP1R3D Gene

protein phosphatase 1, regulatory subunit 3D

Phosphorylation of serine and threonine residues in proteins is a crucial step in the regulation of many cellular functions ranging from hormonal regulation to cell division and even short-term memory. The level of phosphorylation is controlled by the opposing actions of protein kinases and protein phosphatases. Protein phosphatase 1 (PP1) is 1 of 4 major serine/threonine-specific protein phosphatases which have been identified in eukaryotic cells. PP1 associates with various regulatory subunits that dictate its subcellular localization and modulate its substrate specificity. Several subunits that target PP1 to glycogen have been identified. This gene encodes a glycogen-targeting subunit of PP1. [provided by RefSeq, Jul 2008]

PPP1R3C Gene

protein phosphatase 1, regulatory subunit 3C

This gene encodes a regulatory subunit of protein phosphatase-1 (PP1). PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities: neuronal, muscular, RNA splicing, protein synthesis, cell death, and glycogen metabolism, to name just a few. By interacting with different regulatory subunits, PP1 is directed to different parts of the cell, to different substrates, or to respond to extracellular signals. [provided by RefSeq, Oct 2011]

PPP1R3B Gene

protein phosphatase 1, regulatory subunit 3B

This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]

PPP1R3A Gene

protein phosphatase 1, regulatory subunit 3A

The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase. [provided by RefSeq, Jul 2008]

PPP1R37 Gene

protein phosphatase 1, regulatory subunit 37

PPP1R36 Gene

protein phosphatase 1, regulatory subunit 36

PPP1R35 Gene

protein phosphatase 1, regulatory subunit 35

PPP1R32 Gene

protein phosphatase 1, regulatory subunit 32

INPP5A Gene

inositol polyphosphate-5-phosphatase, 40kDa

The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]

INPP5B Gene

inositol polyphosphate-5-phosphatase, 75kDa

This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]

INPP5D Gene

inositol polyphosphate-5-phosphatase, 145kDa

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

INPP5E Gene

inositol polyphosphate-5-phosphatase, 72 kDa

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.[provided by RefSeq, Feb 2011]

INPP5F Gene

inositol polyphosphate-5-phosphatase F

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

INPP5J Gene

inositol polyphosphate-5-phosphatase J

INPP5K Gene

inositol polyphosphate-5-phosphatase K

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

PPP1R12A Gene

protein phosphatase 1, regulatory subunit 12A

Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

PPP1R12B Gene

protein phosphatase 1, regulatory subunit 12B

Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]

PPP1R12C Gene

protein phosphatase 1, regulatory subunit 12C

The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

LOC102724677 Gene

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 pseudogene

PPP6R2 Gene

protein phosphatase 6, regulatory subunit 2

Protein phosphatase regulatory subunits, such as SAPS2, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS2 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

PPP6R3 Gene

protein phosphatase 6, regulatory subunit 3

Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

PPP6R1 Gene

protein phosphatase 6, regulatory subunit 1

Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

LOC344593 Gene

protein tyrosine phosphatase, non-receptor type 11 pseudogene

PPP1R26P1 Gene

protein phosphatase 1, regulatory subunit 26 pseudogene 1

PSTPIP2 Gene

proline-serine-threonine phosphatase interacting protein 2

PSTPIP1 Gene

proline-serine-threonine phosphatase interacting protein 1

The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome. [provided by RefSeq, Jul 2008]

CTDSP1 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1

This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

CTDSP2 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2

CTDSPL Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

LOC100131868 Gene

serine/threonine-protein phosphatase 4 regulatory subunit 2-like

PPP5C Gene

protein phosphatase 5, catalytic subunit

This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

EYA4 Gene

EYA transcriptional coactivator and phosphatase 4

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

EYA1 Gene

EYA transcriptional coactivator and phosphatase 1

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2013]

EYA3 Gene

EYA transcriptional coactivator and phosphatase 3

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, where this gene is up-regulated via a micro-RNA that binds to the 3' UTR of the transcript. A similar protein in mice acts as a transcriptional activator. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]

EYA2 Gene

EYA transcriptional coactivator and phosphatase 2

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined. [provided by RefSeq, Jul 2009]

LOC100129526 Gene

protein tyrosine phosphatase, receptor type, D pseudogene

G6PC3 Gene

glucose 6 phosphatase, catalytic, 3

This gene encodes the catalytic subunit of glucose-6-phosphatase (G6Pase). G6Pase is located in the endoplasmic reticulum (ER) and catalyzes the hydrolysis of glucose-6-phosphate to glucose and phosphate in the last step of the gluconeogenic and glycogenolytic pathways. Mutations in this gene result in autosomal recessive severe congenital neutropenia. Multiple transcript variants have been found for this gene, only one of which is expected to express a protein.[provided by RefSeq, Sep 2009]

G6PC2 Gene

glucose-6-phosphatase, catalytic, 2

This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

PPM1AP1 Gene

protein phosphatase, Mg2+/Mn2+ dependent 1A, pseudogene 1

PPP4R4 Gene

protein phosphatase 4, regulatory subunit 4

The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The function of this particular gene product has not been determined. Alternative splicing has been observed for this gene and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

PPP4R1 Gene

protein phosphatase 4, regulatory subunit 1

This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

PPP4R2 Gene

protein phosphatase 4, regulatory subunit 2

CTDNEP1 Gene

CTD nuclear envelope phosphatase 1

SSH2 Gene

slingshot protein phosphatase 2

This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

SSH3 Gene

slingshot protein phosphatase 3

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]

SSH1 Gene

slingshot protein phosphatase 1

The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

PSPHP1 Gene

phosphoserine phosphatase pseudogene 1

This gene is significantly upregulated in Fanconi's anemia fibroblasts but downregulated or absent in fibroblasts from normal donors. It is also highly expressed in FA B-cells of complementation group A. [provided by RefSeq, Jul 2008]

ALPQTL4 Gene

Alkaline phosphatase, plasma level of, QTL4

LOC102724822 Gene

carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 pseudogene

PPP1R1AP1 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 1A pseudogene 1

ILKAP Gene

integrin-linked kinase-associated serine/threonine phosphatase

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]

PTP4A1P2 Gene

protein tyrosine phosphatase type IVA, member 1 pseudogene 2

PTP4A1P3 Gene

protein tyrosine phosphatase type IVA, member 1 pseudogene 3

PTP4A1P1 Gene

protein tyrosine phosphatase type IVA, member 1 pseudogene 1

PTP4A1P6 Gene

protein tyrosine phosphatase type IVA, member 1 pseudogene 6

PTP4A1P7 Gene

protein tyrosine phosphatase type IVA, member 1 pseudogene 7

PTP4A1P4 Gene

protein tyrosine phosphatase type IVA, member 1 pseudogene 4

PTP4A1P5 Gene

protein tyrosine phosphatase type IVA, member 1 pseudogene 5

PHPT1 Gene

phosphohistidine phosphatase 1

This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

PPP1R7 Gene

protein phosphatase 1, regulatory subunit 7

This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

PPP1R2 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2

LOC100131360 Gene

serine/threonine-protein phosphatase 4 regulatory subunit 2-like

RNGTTP1 Gene

RNA guanylyltransferase and 5'-phosphatase pseudogene 1

TPTEP1 Gene

transmembrane phosphatase with tensin homology pseudogene 1

LOC647299 Gene

enolase-phosphatase 1 pseudogene

G6PC Gene

glucose-6-phosphatase, catalytic subunit

Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011]

G6PR Gene

glucose-6-phosphatase regulator

MINPP1 Gene

multiple inositol-polyphosphate phosphatase 1

This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]

PPP2R3B Gene

protein phosphatase 2, regulatory subunit B'', beta

Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]

PPP2R3C Gene

protein phosphatase 2, regulatory subunit B'', gamma

This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

PPP2R3A Gene

protein phosphatase 2, regulatory subunit B'', alpha

This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]

PNKP Gene

polynucleotide kinase 3'-phosphatase

This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010]

CTDP1 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1

This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

LPPR3 Gene

lipid phosphate phosphatase-related protein type 3

The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]

PPAP2C Gene

phosphatidic acid phosphatase type 2C

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

PPAP2B Gene

phosphatidic acid phosphatase type 2B

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

PPAP2A Gene

phosphatidic acid phosphatase type 2A

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

LOC102725179 Gene

tyrosine-protein phosphatase non-receptor type 20-like

LOC391771 Gene

protein tyrosine phosphatase, non-receptor type 11 pseudogene

PPP1R8 Gene

protein phosphatase 1, regulatory subunit 8

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]

PAPL Gene

iron/zinc purple acid phosphatase-like protein

Purple acid phosphatases (PAPs), including PAPL, are a family of binuclear metallohydrolases that have been identified in plants, animals, and fungi (Flanagan et al., 2006 [PubMed 16793224]).[supplied by OMIM, Mar 2008]

LOC283922 Gene

pyruvate dehydrogenase phosphatase regulatory subunit pseudogene

MPRIPP1 Gene

myosin phosphatase Rho interacting protein pseudogene 1

PALD1 Gene

phosphatase domain containing, paladin 1

PTPN2P1 Gene

protein tyrosine phosphatase, non-receptor type 2 pseudogene 1

PPTC7 Gene

PTC7 protein phosphatase homolog (S. cerevisiae)

LOC100418682 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene

LOC100418683 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene

LOC100418684 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene

PTP4A2P1 Gene

protein tyrosine phosphatase type IVA, member 2 pseudogene 1

PTP4A2P2 Gene

protein tyrosine phosphatase type IVA, member 2 pseudogene 2

LOC100129155 Gene

phosphatase, orphan 1 pseudogene

LOC100288016 Gene

serine/threonine-protein phosphatase 4 regulatory subunit 2-like

LOC100128076 Gene

protein tyrosine phosphatase pseudogene

DUSP19 Gene

dual specificity phosphatase 19

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

DUSP15 Gene

dual specificity phosphatase 15

The protein encoded by this gene belongs to the non-receptor class of the protein-tyrosine phosphatase family. The encoded protein has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DUSP14 Gene

dual specificity phosphatase 14

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

DUSP16 Gene

dual specificity phosphatase 16

This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]

DUSP11 Gene

dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]

DUSP10 Gene

dual specificity phosphatase 10

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

DUSP12 Gene

dual specificity phosphatase 12

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]

SGPP2 Gene

sphingosine-1-phosphate phosphatase 2

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP2 catalyzes the degradation of S1P (Ogawa et al., 2003 [PubMed 12411432]).[supplied by OMIM, Jun 2009]

SGPP1 Gene

sphingosine-1-phosphate phosphatase 1

Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]

PPP1R1A Gene

protein phosphatase 1, regulatory (inhibitor) subunit 1A

PPP1R1C Gene

protein phosphatase 1, regulatory (inhibitor) subunit 1C

Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010]

PPP1R1B Gene

protein phosphatase 1, regulatory (inhibitor) subunit 1B

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

PPP1R11 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 11

This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]

PPP1R10 Gene

protein phosphatase 1, regulatory subunit 10

This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

PPP1R18 Gene

protein phosphatase 1, regulatory subunit 18

Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008]

PPFIA2 Gene

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mammals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

PPFIA3 Gene

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones. [provided by RefSeq, Jul 2008]

PPFIA1 Gene

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

LOC100128362 Gene

protein phosphatase 2, catalytic subunit, alpha isozyme pseudogene

PPP1R2P3 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 3

ENOPH1 Gene

enolase-phosphatase 1

PPP1R9A Gene

protein phosphatase 1, regulatory subunit 9A

This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

PPP1R9B Gene

protein phosphatase 1, regulatory subunit 9B

This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]

INPPL1 Gene

inositol polyphosphate phosphatase-like 1

The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]

PPP3R2 Gene

protein phosphatase 3, regulatory subunit B, beta

PPP3R1 Gene

protein phosphatase 3, regulatory subunit B, alpha

LOC100420528 Gene

CTD nuclear envelope phosphatase 1 pseudogene

PPP6R2P1 Gene

protein phosphatase 6, regulatory subunit 2 pseudogene 1

PPAPDC1B Gene

phosphatidic acid phosphatase type 2 domain containing 1B

PPAPDC1A Gene

phosphatidic acid phosphatase type 2 domain containing 1A

LPPR5 Gene

lipid phosphate phosphatase-related protein type 5

The protein encoded by this gene is a type 2 member of the phosphatidic acid phosphatase (PAP) family. All type 2 members of this protein family contain 6 transmembrane regions, and a consensus N-glycosylation site. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

LPPR4 Gene

lipid phosphate phosphatase-related protein type 4

The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

LPPR2 Gene

lipid phosphate phosphatase-related protein type 2

LPPR1 Gene

lipid phosphate phosphatase-related protein type 1

This gene encodes a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

PTPRVP Gene

protein tyrosine phosphatase, receptor type, V, pseudogene

DUPD1 Gene

dual specificity phosphatase and pro isomerase domain containing 1

MDP1 Gene

magnesium-dependent phosphatase 1

PPP1R15A Gene

protein phosphatase 1, regulatory subunit 15A

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]

PPP1R15B Gene

protein phosphatase 1, regulatory subunit 15B

PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1; MIM 603907) through recruitment of protein phosphatase-1 (PP1) catalytic subunits (see MIM 176875) (Harding et al., 2009 [PubMed 19181853]).[supplied by OMIM, Feb 2010]

PTPRR Gene

protein tyrosine phosphatase, receptor type, R

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]

PPP1R2P1 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 1

PPP1R2P2 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 2

PPP1R2P5 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 5

PPP1R2P4 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 4

PPP1R2P6 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 6

PPP1R2P9 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9

PPP1R2P8 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 8

PTEN Gene

phosphatase and tensin homolog

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

PHACTR2P1 Gene

phosphatase and actin regulator 2 pseudogene 1

PPP2R5D Gene

protein phosphatase 2, regulatory subunit B', delta

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PPP2R5E Gene

protein phosphatase 2, regulatory subunit B', epsilon isoform

The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

PPP2R5A Gene

protein phosphatase 2, regulatory subunit B', alpha

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

PPP2R5B Gene

protein phosphatase 2, regulatory subunit B', beta

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]

PPP2R5C Gene

protein phosphatase 2, regulatory subunit B', gamma

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

MPRIP Gene

myosin phosphatase Rho interacting protein

PTPRU Gene

protein tyrosine phosphatase, receptor type, U

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]

PTPRT Gene

protein tyrosine phosphatase, receptor type, T

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

PTPRS Gene

protein tyrosine phosphatase, receptor type, S

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

PTPRQ Gene

protein tyrosine phosphatase, receptor type, Q

This locus encodes a member of the type III receptor-like protein-tyrosine phosphatase family. The encoded protein catalyzes the dephosphorylation of phosphotyrosine and phosphatidylinositol and plays roles in cellular proliferation and differentiation. Mutations at this locus have been linked to autosomal recessive deafness. [provided by RefSeq, Mar 2014]

PTPRG Gene

protein tyrosine phosphatase, receptor type, G

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]

PTPRF Gene

protein tyrosine phosphatase, receptor type, F

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

PTPRE Gene

protein tyrosine phosphatase, receptor type, E

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Jul 2008]

PTPRD Gene

protein tyrosine phosphatase, receptor type, D

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]

PTPRC Gene

protein tyrosine phosphatase, receptor type, C

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

PTPRB Gene

protein tyrosine phosphatase, receptor type, B

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

PTPRA Gene

protein tyrosine phosphatase, receptor type, A

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

PTPRO Gene

protein tyrosine phosphatase, receptor type, O

This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]

PTPRN Gene

protein tyrosine phosphatase, receptor type, N

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

PTPRM Gene

protein tyrosine phosphatase, receptor type, M

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

PTPRK Gene

protein tyrosine phosphatase, receptor type, K

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]

PTPRJ Gene

protein tyrosine phosphatase, receptor type, J

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PTPRH Gene

protein tyrosine phosphatase, receptor type, H

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

FIG4 Gene

FIG4 phosphoinositide 5-phosphatase

The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]

PPP1R42 Gene

protein phosphatase 1, regulatory subunit 42

PPP4R1L Gene

protein phosphatase 4, regulatory subunit 1-like (pseudogene)

TPTE2P5 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 5

PPP4C Gene

protein phosphatase 4, catalytic subunit

PTP4A1 Gene

protein tyrosine phosphatase type IVA, member 1

This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

PTP4A3 Gene

protein tyrosine phosphatase type IVA, member 3

This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PTP4A2 Gene

protein tyrosine phosphatase type IVA, member 2

The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]

LOC101060304 Gene

protein phosphatase 1 regulatory subunit 26-like

ACP5 Gene

acid phosphatase 5, tartrate resistant

This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]

ACP6 Gene

acid phosphatase 6, lysophosphatidic

ACP1 Gene

acid phosphatase 1, soluble

The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]

ACP2 Gene

acid phosphatase 2, lysosomal

This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. LAP-deficiencies in mice cause multiple defects including bone structure alterations, lysosomal storage defects in the kidneys and central nervous system, and an increased tendency towards seizures. An enzymatically-inactive allele of LAP in mice exhibited a more severe phenotype than the null allele, and defects included cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

ACPT Gene

acid phosphatase, testicular

Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

ACPP Gene

acid phosphatase, prostate

This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]

UBLCP1 Gene

ubiquitin-like domain containing CTD phosphatase 1

PHLPP2 Gene

PH domain and leucine rich repeat protein phosphatase 2

PPP1R26P3 Gene

protein phosphatase 1, regulatory subunit 26 pseudogene 3

TPTE Gene

transmembrane phosphatase with tensin homology

This gene encodes a PTEN-related tyrosine phosphatase which may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

PPP2R1A Gene

protein phosphatase 2, regulatory subunit A, alpha

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

PPP1R11P2 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 11 pseudogene 2

PPP1R11P1 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 11 pseudogene 1

PGP Gene

phosphoglycolate phosphatase

LOC154937 Gene

protein phosphatase 2, regulatory subunit B', epsilon isoform pseudogene

LOC100422645 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 pseudogene

PPAPDC3 Gene

phosphatidic acid phosphatase type 2 domain containing 3

PPAPDC2 Gene

phosphatidic acid phosphatase type 2 domain containing 2

PPME1 Gene

protein phosphatase methylesterase 1

This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

PTPRN2 Gene

protein tyrosine phosphatase, receptor type, N polypeptide 2

This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

LOC101060852 Gene

protein phosphatase 1 regulatory subunit 26-like

PPM1G Gene

protein phosphatase, Mg2+/Mn2+ dependent, 1G

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]

PPM1F Gene

protein phosphatase, Mg2+/Mn2+ dependent, 1F

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

PPM1E Gene

protein phosphatase, Mg2+/Mn2+ dependent, 1E

This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

PPM1D Gene

protein phosphatase, Mg2+/Mn2+ dependent, 1D

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]

PPM1B Gene

protein phosphatase, Mg2+/Mn2+ dependent, 1B

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]

PPM1A Gene

protein phosphatase, Mg2+/Mn2+ dependent, 1A

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

PPM1N Gene

protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)

PPM1M Gene

protein phosphatase, Mg2+/Mn2+ dependent, 1M

PPM1L Gene

protein phosphatase, Mg2+/Mn2+ dependent, 1L

PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. PP2Cs regulate stress-activated protein kinase (SAPK; see MIM 601158) signaling cascades that respond to extracellular stimuli (Jin et al., 2004 [PubMed 15560375]).[supplied by OMIM, Apr 2008]

PPM1K Gene

protein phosphatase, Mg2+/Mn2+ dependent, 1K

This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012]

PPM1J Gene

protein phosphatase, Mg2+/Mn2+ dependent, 1J

This gene encodes the serine/threonine protein phosphatase. The mouse homolog of this gene apparently belongs to the protein phosphatase 2C family of genes. The exact function of this gene is not yet known. [provided by RefSeq, Jul 2008]

PPM1H Gene

protein phosphatase, Mg2+/Mn2+ dependent, 1H

PP2D1 Gene

protein phosphatase 2C-like domain containing 1

PPP1CB Gene

protein phosphatase 1, catalytic subunit, beta isozyme

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

PPP1CC Gene

protein phosphatase 1, catalytic subunit, gamma isozyme

The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

PPP1CA Gene

protein phosphatase 1, catalytic subunit, alpha isozyme

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PPP1R16A Gene

protein phosphatase 1, regulatory subunit 16A

PPP1R16B Gene

protein phosphatase 1, regulatory subunit 16B

The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

PPP2CA Gene

protein phosphatase 2, catalytic subunit, alpha isozyme

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

PPP2CB Gene

protein phosphatase 2, catalytic subunit, beta isozyme

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]

PTPN20CP Gene

protein tyrosine phosphatase, non-receptor type 20C, pseudogene

LOC102724991 Gene

serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

LOC100286973 Gene

protein phosphatase 1, catalytic subunit, alpha isozyme pseudogene

LOC100128052 Gene

protein phosphatase 2, regulatory subunit B', gamma pseudogene

LOC100128056 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 pseudogene

LOC102724526 Gene

protein phosphatase 1 regulatory subunit 26-like

DUSP18 Gene

dual specificity phosphatase 18

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

DUSP13 Gene

dual specificity phosphatase 13

Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]

LOC101059962 Gene

serine/threonine-protein phosphatase 1 regulatory subunit 10-like

DUSP8P4 Gene

dual specificity phosphatase 8 pseudogene 4

DUSP8P3 Gene

dual specificity phosphatase 8 pseudogene 3

PPP2R2D Gene

protein phosphatase 2, regulatory subunit B, delta

PPP2R2A Gene

protein phosphatase 2, regulatory subunit B, alpha

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

PPP2R2C Gene

protein phosphatase 2, regulatory subunit B, gamma

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PPP2R2B Gene

protein phosphatase 2, regulatory subunit B, beta

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq, Jul 2008]

PPP1R17 Gene

protein phosphatase 1, regulatory subunit 17

The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

PPP1R2P10 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 10

LOC100421822 Gene

protein tyrosine phosphatase, non-receptor type 11 pseudogene

PPP2R5CP Gene

protein phosphatase 2, regulatory subunit B', gamma pseudogene

ALPQTL1 Gene

Alkaline phosphatase, plasma level of, QTL1

DUSP9 Gene

dual specificity phosphatase 9

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus. [provided by RefSeq, Jul 2008]

DUSP8 Gene

dual specificity phosphatase 8

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]

DUSP5 Gene

dual specificity phosphatase 5

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

DUSP4 Gene

dual specificity phosphatase 4

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]

DUSP7 Gene

dual specificity phosphatase 7

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

DUSP6 Gene

dual specificity phosphatase 6

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]

DUSP1 Gene

dual specificity phosphatase 1

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008]

DUSP3 Gene

dual specificity phosphatase 3

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]

DUSP2 Gene

dual specificity phosphatase 2

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

TPTE2P2 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 2

TPTE2P3 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 3

TPTE2P1 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 1

TPTE2P6 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 6

TPTE2P4 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 4

PTPDC1 Gene

protein tyrosine phosphatase domain containing 1

The protein encoded by this gene contains a characteristic motif of protein tyrosine phosphatases (PTPs). PTPs regulate activities of phosphoproteins through dephosphorylation. They are signaling molecules involved in the regulation of a wide variety of biological processes. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

CTDSPL2 Gene

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2

CNEP1R1 Gene

CTD nuclear envelope phosphatase 1 regulatory subunit 1

This gene encodes a transmembrane protein that belongs to the Tmemb_18A family. A similar protein in yeast is a component of an endoplasmic reticulum-associated protein phosphatase complex and is thought to play a role in the synthesis of triacylglycerol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

PSPH Gene

phosphoserine phosphatase

The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]

phosphoethanolamine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphoethanolamine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

O-Phosphoethanolamine Gene Set

From DrugBank Drug Targets

interacting proteins for the O-Phosphoethanolamine drug from the curated DrugBank Drug Targets dataset.

1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine Gene Set

From DrugBank Drug Targets

interacting proteins for the 1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine drug from the curated DrugBank Drug Targets dataset.

phosphoethanolamine Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term phosphoethanolamine in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

sn-glycero-3-Phosphoethanolamine Gene Set

From HMDB Metabolites of Enzymes

interacting proteins for the sn-glycero-3-Phosphoethanolamine metabolite from the curated HMDB Metabolites of Enzymes dataset.

O-Phosphoethanolamine Gene Set

From HMDB Metabolites of Enzymes

interacting proteins for the O-Phosphoethanolamine metabolite from the curated HMDB Metabolites of Enzymes dataset.

N-palmitoyl-phosphoethanolamine Gene Set

From HMDB Metabolites of Enzymes

interacting proteins for the N-palmitoyl-phosphoethanolamine metabolite from the curated HMDB Metabolites of Enzymes dataset.

Tensin phosphatase, lipid phosphatase domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tensin phosphatase, lipid phosphatase domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

FCP1-like phosphatase, phosphatase domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the FCP1-like phosphatase, phosphatase domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN protein domain from the InterPro Predicted Protein Domain Annotations dataset.

regulation of inositol-polyphosphate 5-phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of inositol-polyphosphate 5-phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of fructose 1,6-bisphosphate 1-phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of fructose 1,6-bisphosphate 1-phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of protein phosphatase type 2a activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of protein phosphatase type 2a activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of alkaline phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of alkaline phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of protein phosphatase type 2b activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of protein phosphatase type 2b activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of protein phosphatase type 2b activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of protein phosphatase type 2b activity biological process from the curated GO Biological Process Annotations dataset.

regulation of carbohydrate phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of carbohydrate phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of alkaline phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of alkaline phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of alkaline phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of alkaline phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of protein phosphatase type 2b activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of protein phosphatase type 2b activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of myosin-light-chain-phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of myosin-light-chain-phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of myosin-light-chain-phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of myosin-light-chain-phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of protein serine/threonine phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of protein serine/threonine phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of inositol-polyphosphate 5-phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of inositol-polyphosphate 5-phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of protein phosphatase type 2a activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of protein phosphatase type 2a activity biological process from the curated GO Biological Process Annotations dataset.

regulation of phosphoprotein phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of phosphoprotein phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of phosphoprotein phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of phosphoprotein phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of phosphoprotein phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of phosphoprotein phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of phosphatase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of phosphatase activity biological process from the curated GO Biological Process Annotations dataset.

lysophosphatidic acid phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the lysophosphatidic acid phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

thiamine phosphate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the thiamine phosphate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein phosphatase type 4 regulator activity Gene Set

From GO Molecular Function Annotations

genes performing the protein phosphatase type 4 regulator activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphohistidine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphohistidine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol phosphate 5-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol phosphate 5-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein phosphatase type 1 activator activity Gene Set

From GO Molecular Function Annotations

genes performing the protein phosphatase type 1 activator activity molecular function from the curated GO Molecular Function Annotations dataset.

bisphosphoglycerate 3-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the bisphosphoglycerate 3-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol phosphate 4-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol phosphate 4-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol monophosphate 1-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol monophosphate 1-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol tetrakisphosphate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol tetrakisphosphate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphoglycolate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphoglycolate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol pentakisphosphate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol pentakisphosphate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

magnesium-dependent protein serine/threonine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the magnesium-dependent protein serine/threonine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

receptor signaling protein tyrosine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the receptor signaling protein tyrosine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

calcium-dependent protein serine/threonine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the calcium-dependent protein serine/threonine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

map kinase phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the map kinase phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphoprotein phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphoprotein phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

prenylated protein tyrosine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the prenylated protein tyrosine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

transmembrane receptor protein tyrosine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the transmembrane receptor protein tyrosine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein phosphatase type 1 regulator activity Gene Set

From GO Molecular Function Annotations

genes performing the protein phosphatase type 1 regulator activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol monophosphate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol monophosphate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol-1,3,4-trisphosphate 1-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol-1,3,4-trisphosphate 1-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

[pyruvate dehydrogenase (lipoamide)] phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the [pyruvate dehydrogenase (lipoamide)] phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol trisphosphate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol trisphosphate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein serine/threonine phosphatase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the protein serine/threonine phosphatase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol-3-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol-3-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein serine/threonine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the protein serine/threonine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

myosin phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the myosin phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

lipid phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the lipid phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

n-acylneuraminate-9-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the n-acylneuraminate-9-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

map kinase tyrosine/serine/threonine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the map kinase tyrosine/serine/threonine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol-polyphosphate 5-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol-polyphosphate 5-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

8-hydroxy-dadp phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the 8-hydroxy-dadp phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

receptor signaling protein serine/threonine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the receptor signaling protein serine/threonine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

myosin-light-chain-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the myosin-light-chain-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

bisphosphoglycerate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the bisphosphoglycerate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatase regulator activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatase regulator activity molecular function from the curated GO Molecular Function Annotations dataset.

ctd phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the ctd phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol-4-phosphate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol-4-phosphate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

jun kinase phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the jun kinase phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatase activator activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatase activator activity molecular function from the curated GO Molecular Function Annotations dataset.

protein phosphatase regulator activity Gene Set

From GO Molecular Function Annotations

genes performing the protein phosphatase regulator activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol hexakisphosphate 2-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol hexakisphosphate 2-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol monophosphate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol monophosphate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

polynucleotide 5'-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the polynucleotide 5'-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol-1,4,5-trisphosphate 5-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol-1,4,5-trisphosphate 5-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

fructose-2,6-bisphosphate 2-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the fructose-2,6-bisphosphate 2-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol-hexakisphosphate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol-hexakisphosphate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

carbohydrate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the carbohydrate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

myosin phosphatase regulator activity Gene Set

From GO Molecular Function Annotations

genes performing the myosin phosphatase regulator activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol trisphosphate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol trisphosphate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

acid phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the acid phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

8-oxo-dgdp phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the 8-oxo-dgdp phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

polynucleotide 3'-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the polynucleotide 3'-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein phosphatase type 2a regulator activity Gene Set

From GO Molecular Function Annotations

genes performing the protein phosphatase type 2a regulator activity molecular function from the curated GO Molecular Function Annotations dataset.

fructose 1,6-bisphosphate 1-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the fructose 1,6-bisphosphate 1-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

sugar-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the sugar-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

pyridoxal phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the pyridoxal phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol monophosphate 4-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol monophosphate 4-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein tyrosine phosphatase activator activity Gene Set

From GO Molecular Function Annotations

genes performing the protein tyrosine phosphatase activator activity molecular function from the curated GO Molecular Function Annotations dataset.

protein phosphatase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the protein phosphatase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

sugar-terminal-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the sugar-terminal-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

bisphosphoglycerate 2-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the bisphosphoglycerate 2-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein tyrosine/serine/threonine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the protein tyrosine/serine/threonine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

calcium-dependent protein serine/threonine phosphatase regulator activity Gene Set

From GO Molecular Function Annotations

genes performing the calcium-dependent protein serine/threonine phosphatase regulator activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol phosphate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol phosphate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphoserine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphoserine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein tyrosine/threonine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the protein tyrosine/threonine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein phosphatase activator activity Gene Set

From GO Molecular Function Annotations

genes performing the protein phosphatase activator activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol bisphosphate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol bisphosphate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

8-oxo-gdp phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the 8-oxo-gdp phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

sphingosine-1-phosphate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the sphingosine-1-phosphate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

calmodulin-dependent protein phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the calmodulin-dependent protein phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein tyrosine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the protein tyrosine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

polynucleotide phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the polynucleotide phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphocholine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphocholine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol monophosphate 3-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol monophosphate 3-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

transmembrane receptor protein phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the transmembrane receptor protein phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

non-membrane spanning protein tyrosine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the non-membrane spanning protein tyrosine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol-1,4-bisphosphate 1-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol-1,4-bisphosphate 1-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

inositol phosphate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol phosphate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

glucose-6-phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the glucose-6-phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

alkaline phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the alkaline phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

nucleotide phosphatase activity, acting on free nucleotides Gene Set

From GO Molecular Function Annotations

genes performing the nucleotide phosphatase activity, acting on free nucleotides molecular function from the curated GO Molecular Function Annotations dataset.

inositol bisphosphate phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the inositol bisphosphate phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

abnormality of alkaline phosphatase activity Gene Set

From HPO Gene-Disease Associations

genes associated with the abnormality of alkaline phosphatase activity phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

abnormal alkaline phosphatase activity Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal alkaline phosphatase activity phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

increased alkaline phosphatase activity Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the increased alkaline phosphatase activity phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase Gene Set

From Biocarta Pathways

proteins participating in the pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase pathway from the Biocarta Pathways dataset.

Deficiency of phosphoserine phosphatase Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Deficiency of phosphoserine phosphatase phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Pyruvate dehydrogenase phosphatase deficiency Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Pyruvate dehydrogenase phosphatase deficiency phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

nem1-spo7 phosphatase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the nem1-spo7 phosphatase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

phosphatase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the phosphatase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

ptw/pp1 phosphatase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the ptw/pp1 phosphatase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

protein phosphatase 4 complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protein phosphatase 4 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

protein phosphatase type 2a complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protein phosphatase type 2a complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

protein serine/threonine phosphatase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protein serine/threonine phosphatase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

protein phosphatase type 1 complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protein phosphatase type 1 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

phosphatase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the phosphatase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

myosin phosphatase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the myosin phosphatase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

ptw/pp1 phosphatase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the ptw/pp1 phosphatase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

protein phosphatase 4 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the protein phosphatase 4 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

protein serine/threonine phosphatase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the protein serine/threonine phosphatase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Protein phosphatase 4 complex Gene Set

From CORUM Protein Complexes

proteins in the Protein phosphatase 4 complex protein complex from the CORUM Protein Complexes dataset.

Kinase-scaffold-phosphatase complex, PKA-AKAP79-CaN Gene Set

From CORUM Protein Complexes

proteins in the Kinase-scaffold-phosphatase complex, PKA-AKAP79-CaN protein complex from the CORUM Protein Complexes dataset.

Pyruvate dehydrogenase phosphatase deficiency Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Pyruvate dehydrogenase phosphatase deficiency from the curated CTD Gene-Disease Associations dataset.

Alkaline Phosphatase Gene Set

From dbGAP Gene-Trait Associations

genes associated with the trait Alkaline Phosphatase in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

alkaline phosphatase Gene Set

From GAD Gene-Disease Associations

genes associated with the disease alkaline phosphatase in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

phosphatase Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term phosphatase in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

transmembrane receptor protein tyrosine phosphatase signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the transmembrane receptor protein tyrosine phosphatase signaling pathway biological process from the curated GO Biological Process Annotations dataset.

mapk phosphatase export from nucleus, leptomycin b sensitive Gene Set

From GO Biological Process Annotations

genes participating in the mapk phosphatase export from nucleus, leptomycin b sensitive biological process from the curated GO Biological Process Annotations dataset.

mapk phosphatase export from nucleus Gene Set

From GO Biological Process Annotations

genes participating in the mapk phosphatase export from nucleus biological process from the curated GO Biological Process Annotations dataset.

nem1-spo7 phosphatase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the nem1-spo7 phosphatase complex cellular component from the curated GO Cellular Component Annotations dataset.

phosphatase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the phosphatase complex cellular component from the curated GO Cellular Component Annotations dataset.

ptw/pp1 phosphatase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the ptw/pp1 phosphatase complex cellular component from the curated GO Cellular Component Annotations dataset.

protein serine/threonine phosphatase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protein serine/threonine phosphatase complex cellular component from the curated GO Cellular Component Annotations dataset.

protein phosphatase 4 complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protein phosphatase 4 complex cellular component from the curated GO Cellular Component Annotations dataset.

protein phosphatase type 2a complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protein phosphatase type 2a complex cellular component from the curated GO Cellular Component Annotations dataset.

protein phosphatase type 1 complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protein phosphatase type 1 complex cellular component from the curated GO Cellular Component Annotations dataset.

protein phosphatase 2a binding Gene Set

From GO Molecular Function Annotations

genes performing the protein phosphatase 2a binding molecular function from the curated GO Molecular Function Annotations dataset.

protein phosphatase binding Gene Set

From GO Molecular Function Annotations

genes performing the protein phosphatase binding molecular function from the curated GO Molecular Function Annotations dataset.

protein phosphatase 1 binding Gene Set

From GO Molecular Function Annotations

genes performing the protein phosphatase 1 binding molecular function from the curated GO Molecular Function Annotations dataset.

protein phosphatase 2b binding Gene Set

From GO Molecular Function Annotations

genes performing the protein phosphatase 2b binding molecular function from the curated GO Molecular Function Annotations dataset.

phosphatase binding Gene Set

From GO Molecular Function Annotations

genes performing the phosphatase binding molecular function from the curated GO Molecular Function Annotations dataset.

Serum alkaline phosphatase levels Gene Set

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Serum alkaline phosphatase levels phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

Liver enzyme levels (alkaline phosphatase) Gene Set

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Liver enzyme levels (alkaline phosphatase) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

low alkaline phosphatase Gene Set

From HPO Gene-Disease Associations

genes associated with the low alkaline phosphatase phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

elevated leukocyte alkaline phosphatase Gene Set

From HPO Gene-Disease Associations

genes associated with the elevated leukocyte alkaline phosphatase phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

elevated alkaline phosphatase Gene Set

From HPO Gene-Disease Associations

genes associated with the elevated alkaline phosphatase phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

elevated serum acid phosphatase Gene Set

From HPO Gene-Disease Associations

genes associated with the elevated serum acid phosphatase phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

elevated tissue non-specific alkaline phosphatase Gene Set

From HPO Gene-Disease Associations

genes associated with the elevated tissue non-specific alkaline phosphatase phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

elevated alkaline phosphatase of bone origin Gene Set

From HPO Gene-Disease Associations

genes associated with the elevated alkaline phosphatase of bone origin phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Dual specificity protein phosphatase 12 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Dual specificity protein phosphatase 12 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 4 core regulatory subunit R2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 4 core regulatory subunit R2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 1, regulatory subunit 16A/B Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 1, regulatory subunit 16A/B protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Atypical dual specificity phosphatase, subfamily B Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Atypical dual specificity phosphatase, subfamily B protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Atypical dual specificity phosphatase, subfamily A Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Atypical dual specificity phosphatase, subfamily A protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Polynucleotide kinase 3 phosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Polynucleotide kinase 3 phosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phosphotyrosine protein phosphatase I superfamily Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphotyrosine protein phosphatase I superfamily protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein tyrosine phosphatase, receptor type, N-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein tyrosine phosphatase, receptor type, N-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 1 regulatory subunit 36 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 1 regulatory subunit 36 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Alkaline phosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Alkaline phosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Polynucleotide kinase 3-phosphatase, metazoan Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Polynucleotide kinase 3-phosphatase, metazoan protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tensin phosphatase, C2 domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tensin phosphatase, C2 domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Histidine acid phosphatase, eukaryotic Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Histidine acid phosphatase, eukaryotic protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase-like, PTPLA Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase-like, PTPLA protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Alkaline phosphatase, active site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Alkaline phosphatase, active site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phosphatase PHOSPHO-type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphatase PHOSPHO-type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, non-receptor type-3, -4 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, non-receptor type-3, -4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Mitogen-activated protein (MAP) kinase phosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Mitogen-activated protein (MAP) kinase phosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, non-receptor type-6, -11 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, non-receptor type-6, -11 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, non-receptor type-1/2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, non-receptor type-1/2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Non-canonical purine NTP phosphatase/PRRC1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Non-canonical purine NTP phosphatase/PRRC1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Inositol polyphosphate-related phosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Inositol polyphosphate-related phosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

M-phase inducer phosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the M-phase inducer phosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Receptor tyrosine-protein phosphatase, alpha/epsilon-type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Receptor tyrosine-protein phosphatase, alpha/epsilon-type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 2C, manganese/magnesium aspartate binding site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 2C, manganese/magnesium aspartate binding site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Histidine phosphatase superfamily Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Histidine phosphatase superfamily protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Alkaline-phosphatase-like, core domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Alkaline-phosphatase-like, core domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 1 binding domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 1 binding domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 1 regulatory subunit 35, C-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 1 regulatory subunit 35, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phosphoserine phosphatase SerB Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphoserine phosphatase SerB protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase/arsenate reductase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase/arsenate reductase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

14kDa phosphohistidine phosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the 14kDa phosphohistidine phosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, receptor/non-receptor type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, receptor/non-receptor type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine/Dual specificity phosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine/Dual specificity phosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase Slingshot homologue 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase Slingshot homologue 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phosphatidate phosphatase LPIN1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphatidate phosphatase LPIN1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phosphatidate phosphatase LPIN2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphatidate phosphatase LPIN2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Non-receptor tyrosine-protein phosphatase 22 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Non-receptor tyrosine-protein phosphatase 22 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

SIT4 phosphatase-associated protein family Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the SIT4 phosphatase-associated protein family protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, KIM-containing Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, KIM-containing protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase receptor IA-2 ectodomain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase receptor IA-2 ectodomain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Lipid phosphate phosphatase-related protein type 3 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Lipid phosphate phosphatase-related protein type 3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Lipid phosphate phosphatase-related protein type 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Lipid phosphate phosphatase-related protein type 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Lipid phosphate phosphatase-related protein type 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Lipid phosphate phosphatase-related protein type 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Lipid phosphate phosphatase-related protein type 5 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Lipid phosphate phosphatase-related protein type 5 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Lipid phosphate phosphatase-related protein type 4 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Lipid phosphate phosphatase-related protein type 4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein phosphatase non-receptor type 23 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein phosphatase non-receptor type 23 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, non-receptor type-12 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, non-receptor type-12 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Inositol phosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Inositol phosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 2A, regulatory subunit PR55 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 2A, regulatory subunit PR55 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, low molecular weight Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, low molecular weight protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proline-serine-threonine phosphatase-interacting protein 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proline-serine-threonine phosphatase-interacting protein 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 2A, regulatory B subunit, B56 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 2A, regulatory B subunit, B56 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Dual specificity phosphatase, subgroup, catalytic domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Dual specificity phosphatase, subgroup, catalytic domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Histidine phosphatase superfamily, clade-2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Histidine phosphatase superfamily, clade-2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Histidine phosphatase superfamily, clade-1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Histidine phosphatase superfamily, clade-1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 1 regulatory subunit 3B/C/D, Metazoa Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 1 regulatory subunit 3B/C/D, Metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Magnesium-dependent phosphatase-1, eukaryotic type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Magnesium-dependent phosphatase-1, eukaryotic type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Iron/zinc purple acid phosphatase-like C-terminal domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Iron/zinc purple acid phosphatase-like C-terminal domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Acid phosphatase, type 5 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Acid phosphatase, type 5 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

FCP1-like phosphatase, C-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the FCP1-like phosphatase, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Nucleoside phosphatase GDA1/CD39 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Nucleoside phosphatase GDA1/CD39 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase-like Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Polynucleotide 3'-phosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Polynucleotide 3'-phosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 1 regulatory subunit 26 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 1 regulatory subunit 26 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein serine/threonine phosphatase 2C, C-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein serine/threonine phosphatase 2C, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase methylesterase, eukaryotic Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase methylesterase, eukaryotic protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Receptor tyrosine-protein phosphatase alpha Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Receptor tyrosine-protein phosphatase alpha protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Dual specificity protein phosphatase CDC14A Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Dual specificity protein phosphatase CDC14A protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Dullard phosphatase domain, eukaryotic Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Dullard phosphatase domain, eukaryotic protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Serine/threonine-protein phosphatase with EF-hands Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Serine/threonine-protein phosphatase with EF-hands protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phosphatidate phosphatase PPAPDC1A/PPAPDC1B Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphatidate phosphatase PPAPDC1A/PPAPDC1B protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Receptor tyrosine-protein phosphatase C-associated protein CD45-AP Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Receptor tyrosine-protein phosphatase C-associated protein CD45-AP protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 1 regulatory subunit 12A/B, chordates Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 1 regulatory subunit 12A/B, chordates protein domain from the InterPro Predicted Protein Domain Annotations dataset.

PKC-activated phosphatase-1 inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the PKC-activated phosphatase-1 inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, non-receptor type-14, -21 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, non-receptor type-14, -21 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, active site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, active site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phosphatase and actin regulator 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphatase and actin regulator 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phosphatase and actin regulator 4 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphatase and actin regulator 4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Purple acid phosphatase, N-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Purple acid phosphatase, N-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Dual specificity/tyrosine protein phosphatase, N-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Dual specificity/tyrosine protein phosphatase, N-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phosphoglycolate phosphatase, domain 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphoglycolate phosphatase, domain 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Dual specificity phosphatase, catalytic domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Dual specificity phosphatase, catalytic domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Nuclear envelope phosphatase-regulatory subunit 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Nuclear envelope phosphatase-regulatory subunit 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, low molecular weight, mammalian Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, low molecular weight, mammalian protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phosphatidic acid phosphatase type 2/haloperoxidase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphatidic acid phosphatase type 2/haloperoxidase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Metallo-dependent phosphatase-like Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Metallo-dependent phosphatase-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phosphotyrosyl phosphatase activator, PTPA Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphotyrosyl phosphatase activator, PTPA protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 2C (PP2C)-like domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 2C (PP2C)-like domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase inhibitor 2 (IPP-2) Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase inhibitor 2 (IPP-2) protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Endonuclease/exonuclease/phosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Endonuclease/exonuclease/phosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Dual specificity phosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Dual specificity phosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 1, regulatory subunit 15A/B, C-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 1, regulatory subunit 15A/B, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 2A, regulatory subunit PR55, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 2A, regulatory subunit PR55, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein phosphatase non-receptor type 13 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein phosphatase non-receptor type 13 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Enolase-phosphatase E1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Enolase-phosphatase E1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Purple acid phosphatase-like, N-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Purple acid phosphatase-like, N-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Receptor-type tyrosine-protein phosphatase C Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Receptor-type tyrosine-protein phosphatase C protein domain from the InterPro Predicted Protein Domain Annotations dataset.

2-phosphoglycolate phosphatase, eukaryotic Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the 2-phosphoglycolate phosphatase, eukaryotic protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, receptor type R/non-receptor type 5 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, receptor type R/non-receptor type 5 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Serine/threonine protein phosphatase 5 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Serine/threonine protein phosphatase 5 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase inhibitor, 1DARPP-32 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase inhibitor, 1DARPP-32 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phosphoserine phosphatase, domain 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphoserine phosphatase, domain 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Magnesium-dependent phosphatase-1, eukaryotic/arcaheal type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Magnesium-dependent phosphatase-1, eukaryotic/arcaheal type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Putative phosphatase regulatory subunit Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Putative phosphatase regulatory subunit protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase 2C Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase 2C protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Pyridoxal phosphate phosphatase-related Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Pyridoxal phosphate phosphatase-related protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Polymerase/histidinol phosphatase-like Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Polymerase/histidinol phosphatase-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Atypical dual specificity phosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Atypical dual specificity phosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Enolase-phosphatase E1, eukaryotes Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Enolase-phosphatase E1, eukaryotes protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Myotubularin-like phosphatase domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Myotubularin-like phosphatase domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phosphatase and actin regulator 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphatase and actin regulator 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phosphatase and actin regulator 3 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phosphatase and actin regulator 3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Glucose-6-phosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Glucose-6-phosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Alkaline phosphatase-like, alpha/beta/alpha Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Alkaline phosphatase-like, alpha/beta/alpha protein domain from the InterPro Predicted Protein Domain Annotations dataset.

HAD-superfamily phosphatase, subfamily IIIC Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the HAD-superfamily phosphatase, subfamily IIIC protein domain from the InterPro Predicted Protein Domain Annotations dataset.

BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_PC3_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_PC3_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_VCAP_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_HCC515_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

abnormal circulating alkaline phosphatase level Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal circulating alkaline phosphatase level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

increased circulating alkaline phosphatase level Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the increased circulating alkaline phosphatase level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

decreased circulating alkaline phosphatase level Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the decreased circulating alkaline phosphatase level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

{alkaline phosphatase, plasma level of, qtl4} Gene Set

From OMIM Gene-Disease Associations

genes associated with the {alkaline phosphatase, plasma level of, qtl4} phenotype from the curated OMIM Gene-Disease Associations dataset.

phosphoserine phosphatase deficiency Gene Set

From OMIM Gene-Disease Associations

genes associated with the phosphoserine phosphatase deficiency phenotype from the curated OMIM Gene-Disease Associations dataset.

pyruvate dehydrogenase phosphatase deficiency Gene Set

From OMIM Gene-Disease Associations

genes associated with the pyruvate dehydrogenase phosphatase deficiency phenotype from the curated OMIM Gene-Disease Associations dataset.

{alkaline phosphatase, plasma level of, qtl1} Gene Set

From OMIM Gene-Disease Associations

genes associated with the {alkaline phosphatase, plasma level of, qtl1} phenotype from the curated OMIM Gene-Disease Associations dataset.

{alkaline phosphatase, plasma level of, qtl3} Gene Set

From OMIM Gene-Disease Associations

genes associated with the {alkaline phosphatase, plasma level of, qtl3} phenotype from the curated OMIM Gene-Disease Associations dataset.

?lysosomal acid phosphatase deficiency Gene Set

From OMIM Gene-Disease Associations

genes associated with the ?lysosomal acid phosphatase deficiency phenotype from the curated OMIM Gene-Disease Associations dataset.

{alkaline phosphatase, plasma level of, qtl 2} Gene Set

From OMIM Gene-Disease Associations

genes associated with the {alkaline phosphatase, plasma level of, qtl 2} phenotype from the curated OMIM Gene-Disease Associations dataset.

phosphatase Gene Set

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term phosphatase in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

protein-phosphatase-1 Gene Set

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term protein-phosphatase-1 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

brca1 dependent ub ligase activity Gene Set

From Biocarta Pathways

proteins participating in the brca1 dependent ub ligase activity pathway from the Biocarta Pathways dataset.

mechanism of acetaminophen activity and toxicity Gene Set

From Biocarta Pathways

proteins participating in the mechanism of acetaminophen activity and toxicity pathway from the Biocarta Pathways dataset.

pelp1 modulation of estrogen receptor activity Gene Set

From Biocarta Pathways

proteins participating in the pelp1 modulation of estrogen receptor activity pathway from the Biocarta Pathways dataset.

regulation of transcriptional activity by pml Gene Set

From Biocarta Pathways

proteins participating in the regulation of transcriptional activity by pml pathway from the Biocarta Pathways dataset.

Impdh2 enzyme activity, variation in Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Impdh2 enzyme activity, variation in phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Kallikrein, decreased urinary activity of Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Kallikrein, decreased urinary activity of phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

GPI-GnT activity complex Gene Set

From CORUM Protein Complexes

proteins in the GPI-GnT activity complex protein complex from the CORUM Protein Complexes dataset.

factor 13 activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease factor 13 activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

neutral endopeptidase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease neutral endopeptidase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

tpmt activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease tpmt activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

substrate activity of udp-glucuronosyltransferase Gene Set

From GAD Gene-Disease Associations

genes associated with the disease substrate activity of udp-glucuronosyltransferase in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

temperature-sensitive enzymatic activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease temperature-sensitive enzymatic activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

triglycerides; blood pressure, arterial; antioxidant activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease triglycerides; blood pressure, arterial; antioxidant activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

erythrocyte histamine n-methyltransferase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease erythrocyte histamine n-methyltransferase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

histamine n-methyltransferase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease histamine n-methyltransferase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

autonomic nervous system activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease autonomic nervous system activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

diazonase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease diazonase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

event-related prefrontal activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease event-related prefrontal activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

erythrocyte catalase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease erythrocyte catalase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

enzyme activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease enzyme activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

brain activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease brain activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

endothelial nitric oxide activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease endothelial nitric oxide activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

11beta-hydroxylase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease 11beta-hydroxylase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

high plasma cetp activity. Gene Set

From GAD Gene-Disease Associations

genes associated with the disease high plasma cetp activity. in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

decreases transcriptional activity and responsiveness to interleukin-6 Gene Set

From GAD Gene-Disease Associations

genes associated with the disease decreases transcriptional activity and responsiveness to interleukin-6 in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

paraoxonase1 activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease paraoxonase1 activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

inflammatory bowel disease; colorectal cancer; ace activity; coronary atherosclerosis Gene Set

From GAD Gene-Disease Associations

genes associated with the disease inflammatory bowel disease; colorectal cancer; ace activity; coronary atherosclerosis in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cyp2c9 activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cyp2c9 activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cyp1a2 activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cyp1a2 activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cholesterol, hdl; paraoxonase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cholesterol, hdl; paraoxonase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

platelet monoamine oxidase b activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease platelet monoamine oxidase b activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cyp2c19 activity; cyp2d6 activitiy Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cyp2c19 activity; cyp2d6 activitiy in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

na/k atpase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease na/k atpase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

lower levels of hepatic lipase activity buoyant ldl and higher hdl2 cholesterol Gene Set

From GAD Gene-Disease Associations

genes associated with the disease lower levels of hepatic lipase activity buoyant ldl and higher hdl2 cholesterol in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

paraoxonase-1 specific activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease paraoxonase-1 specific activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

respiratory activity following radiotherapy Gene Set

From GAD Gene-Disease Associations

genes associated with the disease respiratory activity following radiotherapy in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

adrenomedullary hormone activity; sympathetic nervous function Gene Set

From GAD Gene-Disease Associations

genes associated with the disease adrenomedullary hormone activity; sympathetic nervous function in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

breast cancer; thiopurine methyltransferase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease breast cancer; thiopurine methyltransferase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cyp3a4 activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cyp3a4 activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

hiv; cyp3a activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease hiv; cyp3a activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

adipose tissue lipoprotein lipase activity and lipoprotein lipid and glucose concentrations Gene Set

From GAD Gene-Disease Associations

genes associated with the disease adipose tissue lipoprotein lipase activity and lipoprotein lipid and glucose concentrations in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

undetectable glucose-6-phosphate dehydrogenase enzyme activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease undetectable glucose-6-phosphate dehydrogenase enzyme activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

factor vii antigen; factor vii coagulant activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease factor vii antigen; factor vii coagulant activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cyp1a2 enzymatic activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cyp1a2 enzymatic activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

lower lipoprotein lipase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease lower lipoprotein lipase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

atrial natriuretic peptide activity after exercise Gene Set

From GAD Gene-Disease Associations

genes associated with the disease atrial natriuretic peptide activity after exercise in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

prefrontal activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease prefrontal activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

left ventricular mass; renin activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease left ventricular mass; renin activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

blood pressure, arterial; renin activity; aldosterone Gene Set

From GAD Gene-Disease Associations

genes associated with the disease blood pressure, arterial; renin activity; aldosterone in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

altered oatp-c transport activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease altered oatp-c transport activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

body mass; insulin; glucose; nervous system activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease body mass; insulin; glucose; nervous system activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

thiopurine methyltransferase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease thiopurine methyltransferase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

carboxylesterase 2 activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease carboxylesterase 2 activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cholinesterase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cholinesterase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

lower cyp2a6 activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease lower cyp2a6 activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

lower plasma triglyceride levels and increased promoter activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease lower plasma triglyceride levels and increased promoter activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

dopamine beta-hydroxylase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease dopamine beta-hydroxylase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

low hepatic lipase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease low hepatic lipase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

low cetp activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease low cetp activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

renin activity; aldosterone Gene Set

From GAD Gene-Disease Associations

genes associated with the disease renin activity; aldosterone in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cancer; hiv infection; gastrointestinal bleeding; thiopurine methyltransferase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cancer; hiv infection; gastrointestinal bleeding; thiopurine methyltransferase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

leisure physical activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease leisure physical activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cyp3a activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cyp3a activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

diminished debrisoquine hydroxylase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease diminished debrisoquine hydroxylase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

myeloperoxidase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease myeloperoxidase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

saha glucuronidation activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease saha glucuronidation activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

vascular nad(p)h oxidase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease vascular nad(p)h oxidase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

angiotensin-converting enzyme activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease angiotensin-converting enzyme activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

plasma factor vii activity and antigen levels Gene Set

From GAD Gene-Disease Associations

genes associated with the disease plasma factor vii activity and antigen levels in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

increased concentration of hdl-c and decreased promoter activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease increased concentration of hdl-c and decreased promoter activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

platelet aggregation; nitric oxide activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease platelet aggregation; nitric oxide activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

high or low factor xiii specific activity. Gene Set

From GAD Gene-Disease Associations

genes associated with the disease high or low factor xiii specific activity. in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

plasmatic pai-1 activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease plasmatic pai-1 activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

diabetes, type 2; hepatic lipase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease diabetes, type 2; hepatic lipase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

depression; thrombocyte mao activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease depression; thrombocyte mao activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

igf-i activity and lipid parameters Gene Set

From GAD Gene-Disease Associations

genes associated with the disease igf-i activity and lipid parameters in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

postprandial variations in fibrinolytic activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease postprandial variations in fibrinolytic activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

sulfotransferases enzyme activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease sulfotransferases enzyme activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

butyrylcholinesterase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease butyrylcholinesterase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

hypertension; kallikrein activity, urinary Gene Set

From GAD Gene-Disease Associations

genes associated with the disease hypertension; kallikrein activity, urinary in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

paraoxonase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease paraoxonase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

thiopurine s-methytransferase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease thiopurine s-methytransferase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

reduced cbs activity and elevated post-load homocysteine levels Gene Set

From GAD Gene-Disease Associations

genes associated with the disease reduced cbs activity and elevated post-load homocysteine levels in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

physical activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease physical activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

ace activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease ace activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

higher n-acetylation activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease higher n-acetylation activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

hiv; cyp3a activity; prostate cancer Gene Set

From GAD Gene-Disease Associations

genes associated with the disease hiv; cyp3a activity; prostate cancer in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

pon1 activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease pon1 activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

activityindependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term activityindependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

activitybased Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term activitybased in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

activityloss Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term activityloss in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

activityassociated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term activityassociated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

activityreducing Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term activityreducing in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

activityof Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term activityof in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

activityinduced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term activityinduced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

activitymodifying Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term activitymodifying in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

activitydependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term activitydependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

activityreview Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term activityreview in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

activityrelated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term activityrelated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

regulation of high voltage-gated calcium channel activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of high voltage-gated calcium channel activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of deacetylase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of deacetylase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of superoxide dismutase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of superoxide dismutase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of acid-sensing ion channel activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of acid-sensing ion channel activity biological process from the curated GO Biological Process Annotations dataset.

regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of guanylate cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of guanylate cyclase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of sequence-specific dna binding transcription factor activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of sequence-specific dna binding transcription factor activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of cysteine-type endopeptidase activity involved in apoptotic process biological process from the curated GO Biological Process Annotations dataset.

regulation of transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of map kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of map kinase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction biological process from the curated GO Biological Process Annotations dataset.

positive regulation of ubiquitin-protein transferase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of ubiquitin-protein transferase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of proteinase activated receptor activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of proteinase activated receptor activity biological process from the curated GO Biological Process Annotations dataset.

regulation of 1-phosphatidylinositol 4-kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of 1-phosphatidylinositol 4-kinase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of cytokine activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cytokine activity biological process from the curated GO Biological Process Annotations dataset.

regulation of monooxygenase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of monooxygenase activity biological process from the curated GO Biological Process Annotations dataset.

activation of protein kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the activation of protein kinase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of monooxygenase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of monooxygenase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of lipase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of lipase activity biological process from the curated GO Biological Process Annotations dataset.

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of lipoprotein lipase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of lipoprotein lipase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of 1-phosphatidylinositol 4-kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of 1-phosphatidylinositol 4-kinase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of transporter activity biological process from the curated GO Biological Process Annotations dataset.

inhibition of cysteine-type endopeptidase activity Gene Set

From GO Biological Process Annotations

genes participating in the inhibition of cysteine-type endopeptidase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of serine-type peptidase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of serine-type peptidase activity biological process from the curated GO Biological Process Annotations dataset.

activation of jnkk activity Gene Set

From GO Biological Process Annotations

genes participating in the activation of jnkk activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of transporter activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of ryanodine-sensitive calcium-release channel activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of ryanodine-sensitive calcium-release channel activity biological process from the curated GO Biological Process Annotations dataset.

regulation of cysteine-type endopeptidase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cysteine-type endopeptidase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of sodium ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of sodium ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway biological process from the curated GO Biological Process Annotations dataset.

negative regulation of transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of transporter activity biological process from the curated GO Biological Process Annotations dataset.

regulation of cysteine-type endopeptidase activity involved in apoptotic process Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cysteine-type endopeptidase activity involved in apoptotic process biological process from the curated GO Biological Process Annotations dataset.

positive regulation of endopeptidase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of endopeptidase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of cyclic-nucleotide phosphodiesterase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of cyclic-nucleotide phosphodiesterase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of superoxide dismutase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of superoxide dismutase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of cyclase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of deoxyribonuclease activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of deoxyribonuclease activity biological process from the curated GO Biological Process Annotations dataset.

regulation of n-methyl-d-aspartate selective glutamate receptor activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of n-methyl-d-aspartate selective glutamate receptor activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in g1/s transition of mitotic cell cycle Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in g1/s transition of mitotic cell cycle biological process from the curated GO Biological Process Annotations dataset.

activation of cysteine-type endopeptidase activity involved in apoptotic process Gene Set

From GO Biological Process Annotations

genes participating in the activation of cysteine-type endopeptidase activity involved in apoptotic process biological process from the curated GO Biological Process Annotations dataset.

positive regulation of tyrosine 3-monooxygenase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of tyrosine 3-monooxygenase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of calcium ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of calcium ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

regulation of peptidase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of peptidase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of rna-directed rna polymerase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of rna-directed rna polymerase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of calcium:sodium antiporter activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of calcium:sodium antiporter activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of endoribonuclease activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of endoribonuclease activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of lyase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of lyase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of metalloenzyme activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of metalloenzyme activity biological process from the curated GO Biological Process Annotations dataset.

regulation of gtp cyclohydrolase i activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of gtp cyclohydrolase i activity biological process from the curated GO Biological Process Annotations dataset.

regulation of cholesterol transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cholesterol transporter activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of gtp cyclohydrolase i activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of gtp cyclohydrolase i activity biological process from the curated GO Biological Process Annotations dataset.

regulation of nad(p)h oxidase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of nad(p)h oxidase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of cyclase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of nitric-oxide synthase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of nitric-oxide synthase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of cation channel activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cation channel activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of activation of jak2 kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of activation of jak2 kinase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of rho-dependent protein serine/threonine kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of rho-dependent protein serine/threonine kinase activity biological process from the curated GO Biological Process Annotations dataset.

activation of phospholipase c activity Gene Set

From GO Biological Process Annotations

genes participating in the activation of phospholipase c activity biological process from the curated GO Biological Process Annotations dataset.

regulation of camp-dependent protein kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of camp-dependent protein kinase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cyclase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of tau-protein kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of tau-protein kinase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of lyase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of lyase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of guanylate cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of guanylate cyclase activity biological process from the curated GO Biological Process Annotations dataset.

modulation by host of viral catalytic activity Gene Set

From GO Biological Process Annotations

genes participating in the modulation by host of viral catalytic activity biological process from the curated GO Biological Process Annotations dataset.

regulation of corticotropin-releasing hormone receptor activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of corticotropin-releasing hormone receptor activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of transferase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of transferase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of creb transcription factor activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of creb transcription factor activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of deoxyribonuclease activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of deoxyribonuclease activity biological process from the curated GO Biological Process Annotations dataset.

regulation of lipid kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of lipid kinase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of vitamin d 24-hydroxylase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of vitamin d 24-hydroxylase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of hexokinase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of hexokinase activity biological process from the curated GO Biological Process Annotations dataset.

activation of anaphase-promoting complex activity Gene Set

From GO Biological Process Annotations

genes participating in the activation of anaphase-promoting complex activity biological process from the curated GO Biological Process Annotations dataset.

regulation of endopeptidase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of endopeptidase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of activation of jak2 kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of activation of jak2 kinase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of sumo transferase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of sumo transferase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of corticotropin-releasing hormone receptor activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of corticotropin-releasing hormone receptor activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of histone deacetylase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of histone deacetylase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of catalytic activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of catalytic activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of creb transcription factor activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of creb transcription factor activity biological process from the curated GO Biological Process Annotations dataset.

regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

activation of mapk activity by adrenergic receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the activation of mapk activity by adrenergic receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

positive regulation of atpase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of atpase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of ribonuclease activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of ribonuclease activity biological process from the curated GO Biological Process Annotations dataset.

regulation of androgen receptor activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of androgen receptor activity biological process from the curated GO Biological Process Annotations dataset.