Name

MIR221 Gene

microRNA 221

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

mir221 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mir221 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

mir2213p Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mir2213p in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

mir2212timp3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mir2212timp3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

mir221222 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mir221222 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

mir221mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mir221mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MIR221_KD_GDS4054_455_human_MCF7 breast cancer cells (fulvestrant-resistant) Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the MIR221_KD_GDS4054_455_human_MCF7 breast cancer cells (fulvestrant-resistant) gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.