Name

MIR140 Gene

microRNA 140

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

mir140 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mir140 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

mir1405p Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mir1405p in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

mir1405pmmd Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mir1405pmmd in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

mir1403p Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mir1403p in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MIR140_OE_GDS3461_575_mouse_C3H10T1/2 fibroblast cell line Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the MIR140_OE_GDS3461_575_mouse_C3H10T1/2 fibroblast cell line gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

MIR140_Silencing_GDS3462_574_mouse_C3H10T1/2 fibroblast cell line Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the MIR140_Silencing_GDS3462_574_mouse_C3H10T1/2 fibroblast cell line gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.