Name

CORUM Protein Complexes Dataset

From CORUM

proteins participating in complexes by manual literature curation

NURSA Protein Complexes Dataset

From Nuclear Receptor Signaling Atlas

proteins identified in complexes isolated from cultured cells

CUL4A Gene

cullin 4A

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]

UHRF2 Gene

ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]

RFWD2P1 Gene

ring finger and WD repeat domain 2, E3 ubiquitin protein ligase pseudogene 1

RFFL Gene

ring finger and FYVE-like domain containing E3 ubiquitin protein ligase

MARCH10 Gene

membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase

MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]

RNF128 Gene

ring finger protein 128, E3 ubiquitin protein ligase

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

RNF125 Gene

ring finger protein 125, E3 ubiquitin protein ligase

This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]

LOC100288437 Gene

ring finger and WD repeat domain 2, E3 ubiquitin protein ligase pseudogene

ZNRF1 Gene

zinc and ring finger 1, E3 ubiquitin protein ligase

This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]

ZNRF2 Gene

zinc and ring finger 2, E3 ubiquitin protein ligase

RNF138P1 Gene

ring finger protein 138, E3 ubiquitin protein ligase pseudogene 1

MGRN1 Gene

mahogunin ring finger 1, E3 ubiquitin protein ligase

Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004]

CHFR Gene

checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase

This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]

RNF19A Gene

ring finger protein 19A, RBR E3 ubiquitin protein ligase

This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RBX1 Gene

ring-box 1, E3 ubiquitin protein ligase

This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]

RNF138P2 Gene

ring finger protein 138, E3 ubiquitin protein ligase pseudogene 2

RNF34 Gene

ring finger protein 34, E3 ubiquitin protein ligase

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

RNF138 Gene

ring finger protein 138, E3 ubiquitin protein ligase

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

RNF8 Gene

ring finger protein 8, E3 ubiquitin protein ligase

The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

RNF5 Gene

ring finger protein 5, E3 ubiquitin protein ligase

The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008]

LOC100500934 Gene

ring-box 1, E3 ubiquitin protein ligase pseudogene

RNF5P1 Gene

ring finger protein 5, E3 ubiquitin protein ligase pseudogene 1

PJA1 Gene

praja ring finger 1, E3 ubiquitin protein ligase

This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked mental retardation disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

PJA2 Gene

praja ring finger 2, E3 ubiquitin protein ligase

RNF41 Gene

ring finger protein 41, E3 ubiquitin protein ligase

This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

MARCH4 Gene

membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase

MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]

MARCH7 Gene

membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase

MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Mar 2010]

MARCH6 Gene

membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase

This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

MARCH1 Gene

membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase

MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010]

MARCH3 Gene

membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase

This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]

MARCH2 Gene

membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase

MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010]

MARCH8 Gene

membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase

MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]

RCHY1 Gene

ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase

The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

RNF168 Gene

ring finger protein 168, E3 ubiquitin protein ligase

This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome. [provided by RefSeq, Sep 2011]

RNF40 Gene

ring finger protein 40, E3 ubiquitin protein ligase

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

RFWD2 Gene

ring finger and WD repeat domain 2, E3 ubiquitin protein ligase

RNF20 Gene

ring finger protein 20, E3 ubiquitin protein ligase

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]

SHPRH Gene

SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]

LOC100287985 Gene

ring-box 1, E3 ubiquitin protein ligase pseudogene

UHRF1 Gene

ubiquitin-like with PHD and ring finger domains 1

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]

LOC728688 Gene

ubiquitin-like, containing PHD and RING finger domains, 1 pseudogene

UHRF2P1 Gene

ubiquitin-like with PHD and ring finger domains 2 pseudogene 1

LTN1 Gene

listerin E3 ubiquitin protein ligase 1

Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]

ITCH Gene

itchy E3 ubiquitin protein ligase

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

CBLL1 Gene

Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase

This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011]

WWP2 Gene

WW domain containing E3 ubiquitin protein ligase 2

This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]

WWP1 Gene

WW domain containing E3 ubiquitin protein ligase 1

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

HACE1 Gene

HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1

LOC101927751 Gene

E3 ubiquitin-protein ligase RING1-like

LOC644909 Gene

ligand of numb-protein X 1, E3 ubiquitin protein ligase pseudogene

BTRCP1 Gene

beta-transducin repeat containing E3 ubiquitin protein ligase pseudogene 1

HERC1 Gene

HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

This gen encodes a member of the HERC protein family. This protein stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. [provided by RefSeq, Mar 2012]

HERC3 Gene

HECT and RLD domain containing E3 ubiquitin protein ligase 3

This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

HERC2 Gene

HECT and RLD domain containing E3 ubiquitin protein ligase 2

This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]

HERC5 Gene

HECT and RLD domain containing E3 ubiquitin protein ligase 5

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008]

HERC4 Gene

HECT and RLD domain containing E3 ubiquitin protein ligase 4

HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

HERC6 Gene

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

MYCBP2 Gene

MYC binding protein 2, E3 ubiquitin protein ligase

LOC101060191 Gene

E3 ubiquitin-protein ligase RING2-like

SIAH1 Gene

siah E3 ubiquitin protein ligase 1

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

SIAH2 Gene

siah E3 ubiquitin protein ligase 2

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]

SIAH3 Gene

siah E3 ubiquitin protein ligase family member 3

VHL Gene

von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

LOC100419574 Gene

HECT and RLD domain containing E3 ubiquitin protein ligase 2 pseudogene

UBE3B Gene

ubiquitin protein ligase E3B

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]

UBE3C Gene

ubiquitin protein ligase E3C

UBE3A Gene

ubiquitin protein ligase E3A

This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

UBE3D Gene

ubiquitin protein ligase E3D

LOC100421870 Gene

WW domain containing E3 ubiquitin protein ligase 2 pseudogene

ARIH2 Gene

ariadne RBR E3 ubiquitin protein ligase 2

ARIH1 Gene

ariadne RBR E3 ubiquitin protein ligase 1

UBE3AP1 Gene

ubiquitin protein ligase E3A pseudogene 1

UBE3AP2 Gene

ubiquitin protein ligase E3A pseudogene 2

AMFR Gene

autocrine motility factor receptor, E3 ubiquitin protein ligase

This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]

LOC100128122 Gene

Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase pseudogene

SKP2 Gene

S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]

LOC100996851 Gene

E3 ubiquitin-protein ligase XIAP pseudogene

NEURL1B Gene

neuralized E3 ubiquitin protein ligase 1B

HECW1 Gene

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1

HECW2 Gene

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

XIAP Gene

X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

LOC102723743 Gene

E3 ubiquitin-protein ligase RNF12-B-like

UBR3 Gene

ubiquitin protein ligase E3 component n-recognin 3 (putative)

UBR2 Gene

ubiquitin protein ligase E3 component n-recognin 2

This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

UBR1 Gene

ubiquitin protein ligase E3 component n-recognin 1

The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul 2008]

UBR7 Gene

ubiquitin protein ligase E3 component n-recognin 7 (putative)

UBR5 Gene

ubiquitin protein ligase E3 component n-recognin 5

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]

UBR4 Gene

ubiquitin protein ligase E3 component n-recognin 4

The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

NEDD4L Gene

neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

LOC100421248 Gene

siah E3 ubiquitin protein ligase family member 3 pseudogene

TRIM71 Gene

tripartite motif containing 71, E3 ubiquitin protein ligase

TOPORS Gene

topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase

This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]

TRAF6 Gene

TNF receptor-associated factor 6, E3 ubiquitin protein ligase

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012]

TRAF7 Gene

TNF receptor-associated factor 7, E3 ubiquitin protein ligase

Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]

MAP3K1 Gene

mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

LOC100631354 Gene

SMAD specific E3 ubiquitin protein ligase 2 pseudogene

WWP1P1 Gene

WW domain containing E3 ubiquitin protein ligase 1 pseudogene 1

CBL Gene

Cbl proto-oncogene, E3 ubiquitin protein ligase

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]

LOC100130500 Gene

S-phase kinase-associated protein 2, E3 ubiquitin protein ligase pseudogene

LOC100420509 Gene

X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase pseudogene

TMEM129 Gene

transmembrane protein 129, E3 ubiquitin protein ligase

SMURF1 Gene

SMAD specific E3 ubiquitin protein ligase 1

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]

SMURF2 Gene

SMAD specific E3 ubiquitin protein ligase 2

MDM2 Gene

MDM2 proto-oncogene, E3 ubiquitin protein ligase

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

FBXW7 Gene

F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

G2E3 Gene

G2/M-phase specific E3 ubiquitin protein ligase

DTX3L Gene

deltex 3 like, E3 ubiquitin ligase

DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

TRIM72 Gene

tripartite motif containing 72, E3 ubiquitin protein ligase

HECTD2 Gene

HECT domain containing E3 ubiquitin protein ligase 2

HECTD3 Gene

HECT domain containing E3 ubiquitin protein ligase 3

The protein encoded by this gene transfers ubiquitin from an E2 ubiquitin-conjugating enzyme to targeted substrates, leading to the degradation of those substrates. The encoded protein has been shown to transfer ubiquitin to TRIOBP to facilitate cell cycle progression, and to STX8. [provided by RefSeq, Dec 2012]

HECTD4 Gene

HECT domain containing E3 ubiquitin protein ligase 4

LOC391465 Gene

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase pseudogene

CBLC Gene

Cbl proto-oncogene C, E3 ubiquitin protein ligase

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

CBLB Gene

Cbl proto-oncogene B, E3 ubiquitin protein ligase

HECTD1 Gene

HECT domain containing E3 ubiquitin protein ligase 1

AREL1 Gene

apoptosis resistant E3 ubiquitin protein ligase 1

HUWE1 Gene

HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase

This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. [provided by RefSeq, Aug 2013]

LNX1 Gene

ligand of numb-protein X 1, E3 ubiquitin protein ligase

This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008]

LOC100419579 Gene

HECT and RLD domain containing E3 ubiquitin protein ligase 2 pseudogene

CCNB1IP1 Gene

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004]

DTL Gene

denticleless E3 ubiquitin protein ligase homolog (Drosophila)

LOC100128413 Gene

X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase pseudogene

LOC105369242 Gene

E3 ubiquitin-protein ligase HERC2-like

LOC100420641 Gene

TNF receptor-associated factor 7, E3 ubiquitin protein ligase pseudogene

TRIM63 Gene

tripartite motif containing 63, E3 ubiquitin protein ligase

This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]

PARK2 Gene

parkin RBR E3 ubiquitin protein ligase

The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]

LOC100130841 Gene

MDM2 oncogene, E3 ubiquitin protein ligase pseudogene

LOC100996379 Gene

E3 ubiquitin-protein ligase HERC2-like

MIB1 Gene

mindbomb E3 ubiquitin protein ligase 1

This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]

MIB2 Gene

mindbomb E3 ubiquitin protein ligase 2

BTRC Gene

beta-transducin repeat containing E3 ubiquitin protein ligase

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]

MUL1 Gene

mitochondrial E3 ubiquitin protein ligase 1

DTX4 Gene

deltex 4, E3 ubiquitin ligase

DTX1 Gene

deltex 1, E3 ubiquitin ligase

Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]

DTX2 Gene

deltex 2, E3 ubiquitin ligase

DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

DTX3 Gene

deltex 3, E3 ubiquitin ligase

DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

NHLRC1 Gene

NHL repeat containing E3 ubiquitin protein ligase 1

The protein encoded by this gene is a single subunit E3 ubiquitin ligase. Laforin is polyubiquitinated by the encoded protein. Defects in this intronless gene lead to an accumulation of laforin and onset of Lafora disease, also known as progressive myoclonic epilepsy type 2 (EPM2).[provided by RefSeq, Mar 2010]

LOC102723534 Gene

E3 ubiquitin-protein ligase HERC2-like

LOC100130550 Gene

g2/M phase-specific E3 ubiquitin-protein ligase-like

PELI1 Gene

pellino E3 ubiquitin protein ligase 1

PELI3 Gene

pellino E3 ubiquitin protein ligase family member 3

The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

PELI2 Gene

pellino E3 ubiquitin protein ligase family member 2

NEDD4 Gene

neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

NEURL1 Gene

neuralized E3 ubiquitin protein ligase 1

NEURL2 Gene

neuralized E3 ubiquitin protein ligase 2

This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]

NEURL3 Gene

neuralized E3 ubiquitin protein ligase 3

NEURL4 Gene

neuralized E3 ubiquitin protein ligase 4

The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]

ASB11 Gene

ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

RAD18 Gene

RAD18 E3 ubiquitin protein ligase

The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]

SIAH1P1 Gene

siah E3 ubiquitin protein ligase 1 pseudogene 1

STUB1 Gene

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]

LOC100128210 Gene

ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) pseudogene

UCHL1 Gene

ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]

UCHL3 Gene

ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

LOC100129607 Gene

ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) pseudogene

RNF175 Gene

ring finger protein 175

RNF170 Gene

ring finger protein 170

This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

MKRN6P Gene

makorin ring finger protein 6, pseudogene

MARCH11 Gene

membrane-associated ring finger (C3HC4) 11

MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]

RNF208 Gene

ring finger protein 208

RNF207 Gene

ring finger protein 207

RNF11P2 Gene

ring finger protein 11 pseudogene 2

RNF11P1 Gene

ring finger protein 11 pseudogene 1

LOC647253 Gene

ring finger protein 13 pseudogene

RNF19BPX Gene

ring finger protein 19B pseudogene, X-linked

RNF19BPY Gene

ring finger protein 19B pseudogene, Y-linked

LOC644006 Gene

ring finger protein 4 pseudogene

RNF126 Gene

ring finger protein 126

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]

RNF123 Gene

ring finger protein 123

The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. [provided by RefSeq, Feb 2012]

RNF122 Gene

ring finger protein 122

The encoded protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The encoded protein is localized to the endoplasmic reticulum and golgi apparatus, and may be associated with cell viability. [provided by RefSeq, Jul 2013]

RNF121 Gene

ring finger protein 121

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products. [provided by RefSeq, Sep 2008]

PDZRN4 Gene

PDZ domain containing ring finger 4

PDZRN3 Gene

PDZ domain containing ring finger 3

This gene encodes a member of the LNX (Ligand of Numb Protein-X) family of RING-type ubiquitin E3 ligases. This protein may function in vascular morphogenesis and the differentiation of adipocytes, osteoblasts and myoblasts. This protein may be targeted for degradation by the human papilloma virus E6 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

RNF225 Gene

ring finger protein 225

MKRN8P Gene

makorin ring finger protein 8, pseudogene

LOC441455 Gene

makorin ring finger protein 1 pseudogene

MKRN1 Gene

makorin ring finger protein 1

This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

MKRN3 Gene

makorin ring finger protein 3

The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene. [provided by RefSeq, Jul 2008]

MKRN2 Gene

makorin ring finger protein 2

This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

RNFT1 Gene

ring finger protein, transmembrane 1

LOC441711 Gene

RING finger protein 145-like

ZNRF4 Gene

zinc and ring finger 4

ZNRF3 Gene

zinc and ring finger 3

RSPRY1 Gene

ring finger and SPRY domain containing 1

This gene encodes a glycoprotein that contains a RING-type zinc finger domain and an SPRY domain of unknown function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]

LOC100631330 Gene

polycomb group ring finger 6 pseudogene

RNF115 Gene

ring finger protein 115

RNF112 Gene

ring finger protein 112

This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

RNF111 Gene

ring finger protein 111

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

RNF216P1 Gene

ring finger protein 216 pseudogene 1

CGRRF1 Gene

cell growth regulator with ring finger domain 1

RNF19B Gene

ring finger protein 19B

This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region. [provided by RefSeq, Jul 2014]

RNFT2 Gene

ring finger protein, transmembrane 2

LOC100421809 Gene

LON peptidase N-terminal domain and ring finger 2 pseudogene

RNFT1P1 Gene

ring finger protein, transmembrane 1 pseudogene 1

RNFT1P2 Gene

ring finger protein, transmembrane 1 pseudogene 2

LOC100419583 Gene

ring finger protein 4 pseudogene

RNF220 Gene

ring finger protein 220

RNF222 Gene

ring finger protein 222

RNF223 Gene

ring finger protein 223

RNF224 Gene

ring finger protein 224

LOC101929203 Gene

RING finger and transmembrane domain-containing protein 1-like

RNF148 Gene

ring finger protein 148

BARD1 Gene

BRCA1 associated RING domain 1

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

LOC100420347 Gene

polycomb group ring finger 3 pseudogene

RNF149 Gene

ring finger protein 149

RNF141 Gene

ring finger protein 141

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as a testis specific transcription factor during spermatogenesis. [provided by RefSeq, Jul 2008]

RNF145 Gene

ring finger protein 145

RNF146 Gene

ring finger protein 146

RNF6P1 Gene

ring finger protein (C3H2C3 type) 6 pseudogene 1

RNF126P1 Gene

ring finger protein 126 pseudogene 1

BMI1P1 Gene

BMI1 proto-oncogene, polycomb ring finger pseudogene 1

ZFP36 Gene

ZFP36 ring finger protein

LOC100129375 Gene

ring finger protein 14 pseudogene

RNF38 Gene

ring finger protein 38

This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

RNF39 Gene

ring finger protein 39

This gene lies within the major histocompatibility complex class I region on chromosome 6. Studies of a similar rat protein suggest that this gene encodes a protein that plays a role in an early phase of synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNF32 Gene

ring finger protein 32

The protein encoded by this gene contains two RING ring finger motifs. RING finger motifs are present in a variety of functionally distinct proteins and are known to be involved in protein-DNA or protein-protein interactions. This gene was found to be expressed during spermatogenesis, most likely in spermatocytes and/or in spermatids. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

RNF31 Gene

ring finger protein 31

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. [provided by RefSeq, Jul 2008]

RNF114 Gene

ring finger protein 114

RNF130 Gene

ring finger protein 130

The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

RNF133 Gene

ring finger protein 133

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene has no intron. [provided by RefSeq, Jul 2008]

RNF135 Gene

ring finger protein 135

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

RNF139 Gene

ring finger protein 139

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]

RNF7P1 Gene

ring finger protein 7 pseudogene 1

ZFP36L1 Gene

ZFP36 ring finger protein-like 1

This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

ZFP36L2 Gene

ZFP36 ring finger protein-like 2

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]

LONRF2P2 Gene

LON peptidase N-terminal domain and ring finger 2 pseudogene 2

LONRF2P1 Gene

LON peptidase N-terminal domain and ring finger 2 pseudogene 1

RNF6 Gene

ring finger protein (C3H2C3 type) 6

The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]

RNF7 Gene

ring finger protein 7

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

RNF4 Gene

ring finger protein 4

The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement of androgen receptor-dependent transcription mediated by this protein. Studies of the mouse and rat counterparts suggested a role of this protein in spermatogenesis. A pseudogene of this gene is found on chromosome 1.[provided by RefSeq, Jul 2010]

RNF2 Gene

ring finger protein 2

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008]

LONRF3 Gene

LON peptidase N-terminal domain and ring finger 3

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Multiple alternatively spliced transcript variants have been suggested, but their full length natures are not clear. [provided by RefSeq, Jul 2008]

LONRF2 Gene

LON peptidase N-terminal domain and ring finger 2

LONRF1 Gene

LON peptidase N-terminal domain and ring finger 1

PCGF1 Gene

polycomb group ring finger 1

PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008]

PCGF3 Gene

polycomb group ring finger 3

The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]

PCGF2 Gene

polycomb group ring finger 2

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]

PCGF5 Gene

polycomb group ring finger 5

PCGF6 Gene

polycomb group ring finger 6

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

LOC100420298 Gene

makorin ring finger protein 1 pseudogene

SH3RF2 Gene

SH3 domain containing ring finger 2

SH3RF3 Gene

SH3 domain containing ring finger 3

SH3RF1 Gene

SH3 domain containing ring finger 1

This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]

LOC346671 Gene

ring finger protein 14 pseudogene

LOC100131785 Gene

ring finger protein 181 pseudogene

RNF44 Gene

ring finger protein 44

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]

RNF43 Gene

ring finger protein 43

The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

MARCH5 Gene

membrane-associated ring finger (C3HC4) 5

MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008]

MARCH9 Gene

membrane-associated ring finger (C3HC4) 9

MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[supplied by OMIM, Apr 2010]

RNF167 Gene

ring finger protein 167

RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]

RNF166 Gene

ring finger protein 166

RNF165 Gene

ring finger protein 165

Encoded in regions involved in pericentric inversions in patients with bipolar affective disorder. [provided by RefSeq, Jul 2008]

RNF169 Gene

ring finger protein 169

PCGF7P Gene

polycomb group ring finger 7 pseudogene

MKRN7P Gene

makorin ring finger protein 7, pseudogene

LOC101060119 Gene

RING-box protein 2-like

RNF219 Gene

ring finger protein 219

RNF215 Gene

ring finger protein 215

RNF214 Gene

ring finger protein 214

RNF217 Gene

ring finger protein 217

RNF216 Gene

ring finger protein 216

This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]

RNF213 Gene

ring finger protein 213

This gene encodes a protein containing a C3HC4-type RING finger domain, which is a specialized type of Zn-finger that binds two atoms of zinc and is thought to be involved in mediating protein-protein interactions. The protein also contains an AAA domain, which is associated with ATPase activity. This gene is a susceptibility gene for Moyamoya disease, a vascular disorder of intracranial arteries. This gene is also a translocation partner in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor cases, where a t(2;17)(p23;q25) translocation has been identified with the anaplastic lymphoma kinase (ALK) gene on chromosome 2, and a t(8;17)(q24;q25) translocation has been identified with the MYC gene on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

RNF212 Gene

ring finger protein 212

This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

LOC100419643 Gene

ring finger protein 14 pseudogene

LOC100419645 Gene

ring finger protein 14 pseudogene

RNF14 Gene

ring finger protein 14

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]

RNF17 Gene

ring finger protein 17

This gene is similar to a mouse gene that encodes a testis-specific protein containing a RING finger domain. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, May 2010]

RNF10 Gene

ring finger protein 10

The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]

RNF11 Gene

ring finger protein 11

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]

RNF13 Gene

ring finger protein 13

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Alternatively spliced transcript variants that encode the same protein have been reported. A pseudogene, which is also located on chromosome 3, has been defined for this gene. [provided by RefSeq, Jul 2008]

PHRF1 Gene

PHD and ring finger domains 1

RNF152 Gene

ring finger protein 152

RNF150 Gene

ring finger protein 150

RNF151 Gene

ring finger protein 151

RNF157 Gene

ring finger protein 157

RC3H1 Gene

ring finger and CCCH-type domains 1

This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

RC3H2 Gene

ring finger and CCCH-type domains 2

MKRN4P Gene

makorin ring finger protein 4, pseudogene

MKRN5P Gene

makorin ring finger protein 5, pseudogene

RNF212B Gene

ring finger protein 212B

LOC100421810 Gene

LON peptidase N-terminal domain and ring finger 2 pseudogene

RNF10P1 Gene

ring finger protein 10 pseudogene 1

BMI1 Gene

BMI1 proto-oncogene, polycomb ring finger

RLIMP2 Gene

ring finger protein, LIM domain interacting pseudogene 2

RLIMP3 Gene

ring finger protein, LIM domain interacting pseudogene 3

RLIMP1 Gene

ring finger protein, LIM domain interacting pseudogene 1

RNF113B Gene

ring finger protein 113B

RNF113A Gene

ring finger protein 113A

This intronless gene encodes a protein which contains a C3H1-type zinc finger domain and a C3HC4 Ring-type (Really Interesting New Gene-type) zinc finger domain. The Ring-type zinc finger domain is identified in various tumor suppressors, DNA repair genes and cytokine receptor-associated molecules, and is probably involved in mediating protein-protein interactions. [provided by RefSeq, May 2010]

RFWD3 Gene

ring finger and WD repeat domain 3

RNF25 Gene

ring finger protein 25

The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]

RNF24 Gene

ring finger protein 24

The protein encoded by this gene contains similarity to the Drosophila goliath protein and thus may function as a transcription factor. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

RNF26 Gene

ring finger protein 26

The protein encoded by this intronless gene contains a C3HC5 type of RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. The expression of this gene was found to be upregulated in cancer cell lines derived from different types of cancer. [provided by RefSeq, Jul 2008]

RNF103 Gene

ring finger protein 103

The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011]

RING1 Gene

ring finger protein 1

This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4. [provided by RefSeq, Jul 2008]

RNF144A Gene

ring finger protein 144A

The protein encoded by this protein contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. The mouse counterpart of this protein has been shown to interact with Ube2l3/UbcM4, which is an ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Jul 2008]

LOC401805 Gene

ring finger protein 145 pseudogene

RNF185 Gene

ring finger protein 185

RNF187 Gene

ring finger protein 187

RNF186 Gene

ring finger protein 186

RNF181 Gene

ring finger protein 181

RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]

RNF180 Gene

ring finger protein 180

RNF183 Gene

ring finger protein 183

RNF182 Gene

ring finger protein 182

RNF152P1 Gene

ring finger protein 152 pseudogene 1

RNF2P1 Gene

ring finger protein 2 pseudogene 1

RLIM Gene

ring finger protein, LIM domain interacting

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]

RNF144B Gene

ring finger protein 144B

MKRN9P Gene

makorin ring finger protein 9, pseudogene

ZNRF2P1 Gene

zinc and ring finger 2 pseudogene 1

ZNRF2P3 Gene

zinc and ring finger 2 pseudogene 3

ZNRF2P2 Gene

zinc and ring finger 2 pseudogene 2

LOC100533945 Gene

succinate-CoA ligase, ADP-forming, beta subunit pseudogene

GLUL Gene

glutamate-ammonia ligase

The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

LOC100533944 Gene

succinate-CoA ligase, ADP-forming, beta subunit pseudogene

LOC100533948 Gene

succinate-CoA ligase, ADP-forming, beta subunit pseudogene

TTLL11 Gene

tubulin tyrosine ligase-like family member 11

TTLL10 Gene

tubulin tyrosine ligase-like family member 10

TTLL12 Gene

tubulin tyrosine ligase-like family member 12

LIG4 Gene

ligase IV, DNA, ATP-dependent

The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

LIG1 Gene

ligase I, DNA, ATP-dependent

This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

LIG3 Gene

ligase III, DNA, ATP-dependent

This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

SUCLA2P1 Gene

succinate-CoA ligase, ADP-forming, beta subunit pseudogene 1

SUCLA2P2 Gene

succinate-CoA ligase, ADP-forming, beta subunit pseudogene 2

SUCLA2P3 Gene

succinate-CoA ligase, ADP-forming, beta subunit pseudogene 3

TTLL13P Gene

tubulin tyrosine ligase-like family member 13, pseudogene

LOC101929744 Gene

phosphopantothenate--cysteine ligase pseudogene

LOC100533947 Gene

succinate-CoA ligase, ADP-forming, beta subunit pseudogene

LOC100533946 Gene

succinate-CoA ligase, ADP-forming, beta subunit pseudogene

MTHFS Gene

5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)

The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

TTLL5 Gene

tubulin tyrosine ligase-like family member 5

This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010]

TTLL4 Gene

tubulin tyrosine ligase-like family member 4

TTLL7 Gene

tubulin tyrosine ligase-like family member 7

TTLL6 Gene

tubulin tyrosine ligase-like family member 6

TTLL1 Gene

tubulin tyrosine ligase-like family member 1

TTLL3 Gene

tubulin tyrosine ligase-like family member 3

TTLL2 Gene

tubulin tyrosine ligase-like family member 2

TTLL9 Gene

tubulin tyrosine ligase-like family member 9

TTLL8 Gene

tubulin tyrosine ligase-like family member 8

LOC100418630 Gene

succinate-CoA ligase, ADP-forming, beta subunit pseudogene

TTL Gene

tubulin tyrosine ligase

TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]

GCLM Gene

glutamate-cysteine ligase, modifier subunit

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GCLC Gene

glutamate-cysteine ligase, catalytic subunit

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]

SUCLA2 Gene

succinate-CoA ligase, ADP-forming, beta subunit

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6. [provided by RefSeq, Jul 2008]

HLCS Gene

holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)

This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jun 2011]

RTCB Gene

RNA 2',3'-cyclic phosphate and 5'-OH ligase

SUCLG2P4 Gene

succinate-CoA ligase, GDP-forming, beta subunit pseudogene 4

SUCLG2P2 Gene

succinate-CoA ligase, GDP-forming, beta subunit pseudogene 2

SUCLG2P3 Gene

succinate-CoA ligase, GDP-forming, beta subunit pseudogene 3

SUCLG2P1 Gene

succinate-CoA ligase, GDP-forming, beta subunit pseudogene 1

GLULP1 Gene

glutamate-ammonia ligase (glutamine synthetase) pseudogene 1

GLULP2 Gene

glutamate-ammonia ligase (glutamine synthetase) pseudogene 2

GLULP3 Gene

glutamate-ammonia ligase (glutamine synthetase) pseudogene 3

GLULP4 Gene

glutamate-ammonia ligase (glutamine synthetase) pseudogene 4

GLULP5 Gene

glutamate-ammonia ligase (glutamine synthetase) pseudogene 5

GLULP6 Gene

glutamate-ammonia ligase (glutamine synthetase) pseudogene 6

LOC100418626 Gene

succinate-CoA ligase, ADP-forming, beta subunit pseudogene

LOC100418627 Gene

succinate-CoA ligase, ADP-forming, beta subunit pseudogene

LOC100418628 Gene

succinate-CoA ligase, ADP-forming, beta subunit pseudogene

LOC100418629 Gene

succinate-CoA ligase, ADP-forming, beta subunit pseudogene

UFL1 Gene

UFM1-specific ligase 1

SUCLG2 Gene

succinate-CoA ligase, GDP-forming, beta subunit

This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]

SUCLG1 Gene

succinate-CoA ligase, alpha subunit

This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]

LOC102724605 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene

UBE2Q2 Gene

ubiquitin-conjugating enzyme E2Q family member 2

USP17L30 Gene

ubiquitin specific peptidase 17-like family member 30

USP10P1 Gene

ubiquitin specific peptidase 10 pseudogene 1

USP10P2 Gene

ubiquitin specific peptidase10 pseudogene 2

UBE2J1 Gene

ubiquitin-conjugating enzyme E2, J1

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]

LOC100288170 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene

LOC100506633 Gene

ubiquitin-fold modifier 1 pseudogene

LOC100420351 Gene

ubiquitin specific peptidase 8 pseudogene

UFD1L Gene

ubiquitin fusion degradation 1 like (yeast)

The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Jun 2009]

LOC100422227 Gene

small ubiquitin-like modifier 1 pseudogene

USP32P1 Gene

ubiquitin specific peptidase 32 pseudogene 1

USP32P2 Gene

ubiquitin specific peptidase 32 pseudogene 2

USP32P4 Gene

ubiquitin specific peptidase 32 pseudogene 4

UBE2Q2P11 Gene

ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 11

UBE2Q2P12 Gene

ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 12

TMUB1 Gene

transmembrane and ubiquitin-like domain containing 1

TMUB2 Gene

transmembrane and ubiquitin-like domain containing 2

USP9X Gene

ubiquitin specific peptidase 9, X-linked

This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

USP9Y Gene

ubiquitin specific peptidase 9, Y-linked

This gene is a member of the peptidase C19 family. It encodes a protein that is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. [provided by RefSeq, Mar 2009]

USP9YP34 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 34

USP9YP30 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 30

USP17L3 Gene

ubiquitin specific peptidase 17-like family member 3

USP17L Gene

ubiquitin carboxyl-terminal hydrolase 17-like protein

UBA52 Gene

ubiquitin A-52 residue ribosomal protein fusion product 1

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008]

UBA6 Gene

ubiquitin-like modifier activating enzyme 6

Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin-activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE1L2 is an E1 enzyme that initiates the activation and conjugation of ubiquitin-like proteins (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008]

UBA5 Gene

ubiquitin-like modifier activating enzyme 5

This gene encodes a member of the E1-like ubiquitin-activating enzyme family. This protein activates ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein, via the formation of a high-energy thioester bond. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A pseudogene located on chromosome 1 has also been identified. [provided by RefSeq, Jul 2008]

UBA2 Gene

ubiquitin-like modifier activating enzyme 2

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

UBA3 Gene

ubiquitin-like modifier activating enzyme 3

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UBA1 Gene

ubiquitin-like modifier activating enzyme 1

The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

UBE2D3P3 Gene

ubiquitin-conjugating enzyme E2D 3 pseudogene 3

UBE2D3P2 Gene

ubiquitin-conjugating enzyme E2D 3 pseudogene 2

UBE2D3P1 Gene

ubiquitin-conjugating enzyme E2D 3 pseudogene 1

UBE2D3P4 Gene

ubiquitin-conjugating enzyme E2D 3 pseudogene 4

USP12 Gene

ubiquitin specific peptidase 12

USP10 Gene

ubiquitin specific peptidase 10

Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]

USP11 Gene

ubiquitin specific peptidase 11

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008]

USP16 Gene

ubiquitin specific peptidase 16

This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

USP14 Gene

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

USP15 Gene

ubiquitin specific peptidase 15

This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

USP18 Gene

ubiquitin specific peptidase 18

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]

USP19 Gene

ubiquitin specific peptidase 19

UBL4A Gene

ubiquitin-like 4A

USP35 Gene

ubiquitin specific peptidase 35

USP36 Gene

ubiquitin specific peptidase 36

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP36 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jan 2009]

UBE2V1P9 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene 9

UBE2V1P6 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene 6

UBE2V1P5 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene 5

UBE2V1P3 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene 3

UBE2V1P2 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene 2

UBE2V1P1 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene 1

UBE2R2 Gene

ubiquitin-conjugating enzyme E2R 2

Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]

USP8P1 Gene

ubiquitin specific peptidase 8 pseudogene 1

LOC100421094 Gene

ubiquitin specific peptidase 17-like family member 2 pseudogene

BAP1 Gene

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]

UBE2J2 Gene

ubiquitin-conjugating enzyme E2, J2

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

LOC100289193 Gene

ubiquitin-conjugating enzyme E2L 3 pseudogene

LOC102723977 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene

LOC100129586 Gene

ubiquitin-conjugating enzyme E2D 4 (putative) pseudogene

UBE2Q2P4Y Gene

ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 4, Y-linked

UBE2NP1 Gene

ubiquitin-conjugating enzyme E2N pseudogene 1

UBE2CP1 Gene

ubiquitin-conjugating enzyme E2C pseudogene 1

UBE2CP2 Gene

ubiquitin-conjugating enzyme E2C pseudogene 2

UBE2CP3 Gene

ubiquitin-conjugating enzyme E2C pseudogene 3

UBE2CP4 Gene

ubiquitin-conjugating enzyme E2C pseudogene 4

UBE2CP5 Gene

ubiquitin-conjugating enzyme E2C pseudogene 5

LOC100506576 Gene

ubiquitin-conjugating enzyme E2L 3 pseudogene

UBE2G2 Gene

ubiquitin-conjugating enzyme E2G 2

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

UBE2G1 Gene

ubiquitin-conjugating enzyme E2G 1

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]

LOC100289117 Gene

ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene

UBE2Q2P5Y Gene

ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 5, Y-linked

USP17L21 Gene

ubiquitin specific peptidase 17-like family member 21

OTUB1 Gene

OTU deubiquitinase, ubiquitin aldehyde binding 1

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

OTUB2 Gene

OTU deubiquitinase, ubiquitin aldehyde binding 2

This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]

USP9YP3 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 3

USP9YP5 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 5

USP9YP4 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 4

USP9YP1 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 1

USP9YP2 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 2

UBA52P8 Gene

ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 8

UBA52P9 Gene

ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 9

UBA52P1 Gene

ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 1

UBA52P2 Gene

ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 2

UBA52P3 Gene

ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 3

UBA52P4 Gene

ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 4

UBA52P6 Gene

ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 6

UBA52P7 Gene

ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 7

LOC105375665 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene

LOC101927789 Gene

putative ubiquitin-like protein FUBI-like protein ENSP00000310146

LOC101927785 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene

LOC100131962 Gene

ubiquitin-conjugating enzyme E2D 4 (putative) pseudogene

LOC402329 Gene

ubiquitin carboxyl-terminal hydrolase 17-like protein 2-like

UBL5 Gene

ubiquitin-like 5

This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

UBL7 Gene

ubiquitin-like 7

UBL3 Gene

ubiquitin-like 3

UBA52P5 Gene

ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 5

USP17L28 Gene

ubiquitin specific peptidase 17-like family member 28

USP17L22 Gene

ubiquitin specific peptidase 17-like family member 22

USP17L23 Gene

ubiquitin specific peptidase 17-like family member 23

USP17L20 Gene

ubiquitin specific peptidase 17-like family member 20

UBAP1L Gene

ubiquitin associated protein 1-like

UBE2L6 Gene

ubiquitin-conjugating enzyme E2L 6

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

UBE2L4 Gene

ubiquitin-conjugating enzyme E2L 4 (pseudogene)

UBE2L3 Gene

ubiquitin-conjugating enzyme E2L 3

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

UBE2L1 Gene

ubiquitin-conjugating enzyme E2L 1 (pseudogene)

LOC100421737 Gene

ubiquitin specific peptidase 4 (proto-oncogene) pseudogene

LOC100420435 Gene

ubiquitin specific peptidase 21 pseudogene

LOC440489 Gene

ubiquitin fusion degradation 1 like (yeast) pseudogene

UBFD1 Gene

ubiquitin family domain containing 1

UBE2E4P Gene

ubiquitin-conjugating enzyme E2E 4 pseudogene

UBE2L5P Gene

ubiquitin-conjugating enzyme E2L 5 (pseudogene)

UBE2D4 Gene

ubiquitin-conjugating enzyme E2D 4 (putative)

UBE2D2 Gene

ubiquitin-conjugating enzyme E2D 2

Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

UBE2D3 Gene

ubiquitin-conjugating enzyme E2D 3

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

UBE2D1 Gene

ubiquitin-conjugating enzyme E2D 1

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

UBE2Q2P10 Gene

ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 10

LOC345576 Gene

ubiquitin specific peptidase 7 (herpes virus-associated) pseudogene

UBDP1 Gene

ubiquitin D pseudogene 1

LOC102724706 Gene

ubiquitin-conjugating enzyme E2 variant 1-like

LOC101060189 Gene

ubiquitin-conjugating enzyme E2F (putative) pseudogene

USP9YP11 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 11

USP9YP10 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 10

USP9YP13 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 13

USP9YP12 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 12

LOC100420440 Gene

ubiquitin specific peptidase 12 pseudogene

LOC100420428 Gene

ubiquitin specific peptidase 21 pseudogene

USP22 Gene

ubiquitin specific peptidase 22

UFM1 Gene

ubiquitin-fold modifier 1

UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM 603173) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Dec 2008]

USP17L2 Gene

ubiquitin specific peptidase 17-like family member 2

DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.[supplied by OMIM, Mar 2008]

USP17L1 Gene

ubiquitin specific peptidase 17-like family member 1

USP17L7 Gene

ubiquitin specific peptidase 17-like family member 7

USP17L5 Gene

ubiquitin specific peptidase 17-like family member 5

USP17L4 Gene

ubiquitin specific peptidase 17-like family member 4

USP17L8 Gene

ubiquitin specific peptidase 17-like family member 8

LOC100533913 Gene

ubiquitin specific peptidase 8 pseudogene

LOC100533914 Gene

ubiquitin specific peptidase 8 pseudogene

USP38 Gene

ubiquitin specific peptidase 38

USP39 Gene

ubiquitin specific peptidase 39

USP30 Gene

ubiquitin specific peptidase 30

USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008]

USP31 Gene

ubiquitin specific peptidase 31

USP32 Gene

ubiquitin specific peptidase 32

USP33 Gene

ubiquitin specific peptidase 33

This gene encodes a deubiquinating enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 adrenergic receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

USP34 Gene

ubiquitin specific peptidase 34

USP37 Gene

ubiquitin specific peptidase 37

UBAP2L Gene

ubiquitin associated protein 2-like

ANKUB1 Gene

ankyrin repeat and ubiquitin domain containing 1

UBD Gene

ubiquitin D

UBB Gene

ubiquitin B

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

UBC Gene

ubiquitin C

This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]

USP17L29 Gene

ubiquitin specific peptidase 17-like family member 29

USP17L26 Gene

ubiquitin specific peptidase 17-like family member 26

USP17L27 Gene

ubiquitin specific peptidase 17-like family member 27

USP17L24 Gene

ubiquitin specific peptidase 17-like family member 24

USP17L25 Gene

ubiquitin specific peptidase 17-like family member 25

LOC100289623 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene

LOC100507422 Gene

ubiquitin-conjugating enzyme E2N pseudogene

LOC100533911 Gene

ubiquitin specific peptidase 8 pseudogene

LOC100533912 Gene

ubiquitin specific peptidase 8 pseudogene

LOC100533915 Gene

ubiquitin specific peptidase 8 pseudogene

LOC100533916 Gene

ubiquitin specific peptidase 8 pseudogene

UBTD2 Gene

ubiquitin domain containing 2

UBTD1 Gene

ubiquitin domain containing 1

The degradation of many proteins is carried out by the ubiquitin pathway in which proteins are targeted for degradation by covalent conjugation of the polypeptide ubiquitin. This gene encodes a protein that belongs to the ubiquitin family of proteins. The encoded protein is thought to regulate E2 ubiquitin conjugating enzymes belonging to the UBE2D family. [provided by RefSeq, Mar 2014]

USPL1 Gene

ubiquitin specific peptidase like 1

LOC102723952 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene

UCHL5 Gene

ubiquitin carboxyl-terminal hydrolase L5

LOC100128108 Gene

putative ubiquitin-conjugating enzyme E2Q2-like protein

USP9YP22 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 22

USP9YP23 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 23

LOC100887079 Gene

ubiquitin specific peptidase 17-like family member 22 pseudogene

LOC100128926 Gene

ubiquitin-conjugating enzyme E2 variant 1-like

LOC649352 Gene

ubiquitin carboxyl-terminal hydrolase 17-like protein 2-like

USP17L16P Gene

ubiquitin specific peptidase 17-like family member 16, pseudogene

LOC101060075 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene

LOC100506133 Gene

ubiquitin-conjugating enzyme E2N pseudogene

LOC100124402 Gene

ubiquitin-fold modifier conjugating enzyme 1 pseudogene

UBE2L2 Gene

ubiquitin-conjugating enzyme E2L 2 (pseudogene)

UBASH3A Gene

ubiquitin associated and SH3 domain containing A

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

UBASH3B Gene

ubiquitin associated and SH3 domain containing B

This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]

UBE2FP1 Gene

ubiquitin-conjugating enzyme E2F (putative) pseudogene 1

UBFD1P1 Gene

ubiquitin family domain containing 1 pseudogene 1

UBE2Q1 Gene

ubiquitin-conjugating enzyme E2Q family member 1

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to the mouse counterpart. [provided by RefSeq, Jul 2008]

UBE2NL Gene

ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)

This gene is intronless and encodes a member of the ubiquitin-conjugating enzyme family. The protein product is 91% identical to ubiquitin-conjugating enzyme E2N, a multi-exon gene product. This locus represents a polymorphic pseudogene, where some individuals contain an allele that can encode a full-length protein, while others have a non-functional allele containing a premature stop codon (reference SNP rs237520) that truncates the coding sequence. [provided by RefSeq, Jun 2014]

LOC780780 Gene

ubiquitin specific peptidase 10 pseudogene

LOC102724816 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene

UBE2WP1 Gene

ubiquitin-conjugating enzyme E2W pseudogene 1

UBE2I Gene

ubiquitin-conjugating enzyme E2I

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

UBE2O Gene

ubiquitin-conjugating enzyme E2O

UBE2B Gene

ubiquitin-conjugating enzyme E2B

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]

LOC105379587 Gene

putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23

UBE2MP1 Gene

ubiquitin-conjugating enzyme E2M pseudogene 1

USP13 Gene

ubiquitin specific peptidase 13 (isopeptidase T-3)

LOC100418572 Gene

ubiquitin specific peptidase 8 pseudogene

LOC100418571 Gene

ubiquitin specific peptidase 8 pseudogene

LOC100418576 Gene

ubiquitin specific peptidase 8 pseudogene

LOC100418577 Gene

ubiquitin specific peptidase 8 pseudogene

LOC100418574 Gene

ubiquitin specific peptidase 8 pseudogene

LOC100418575 Gene

ubiquitin specific peptidase 8 pseudogene

UBA7 Gene

ubiquitin-like modifier activating enzyme 7

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq, Jul 2008]

USP54 Gene

ubiquitin specific peptidase 54

USP53 Gene

ubiquitin specific peptidase 53

USP50 Gene

ubiquitin specific peptidase 50

USP51 Gene

ubiquitin specific peptidase 51

LOC100420429 Gene

ubiquitin specific peptidase 15 pseudogene

HERPUD1 Gene

homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]

LOC101618237 Gene

ubiquitin-conjugating enzyme E2F (putative) pseudogene

UBE2H Gene

ubiquitin-conjugating enzyme E2H

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]

UBE2K Gene

ubiquitin-conjugating enzyme E2K

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

UBE2M Gene

ubiquitin-conjugating enzyme E2M

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]

UBE2N Gene

ubiquitin-conjugating enzyme E2N

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]

UBE2A Gene

ubiquitin-conjugating enzyme E2A

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

UBE2C Gene

ubiquitin-conjugating enzyme E2C

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]

UBE2F Gene

ubiquitin-conjugating enzyme E2F (putative)

UBE2Z Gene

ubiquitin-conjugating enzyme E2Z

This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]

UBE2S Gene

ubiquitin-conjugating enzyme E2S

This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

UBE2U Gene

ubiquitin-conjugating enzyme E2U (putative)

UBE2T Gene

ubiquitin-conjugating enzyme E2T

The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 [PubMed 16916645]).[supplied by OMIM, Mar 2008]

UBE2W Gene

ubiquitin-conjugating enzyme E2W (putative)

This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

UFC1 Gene

ubiquitin-fold modifier conjugating enzyme 1

UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008]

USP17L19 Gene

ubiquitin specific peptidase 17-like family member 19

USP9YP7 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 7

USP9YP6 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 6

USP9YP9 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 9

USP9YP8 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 8

UBE2V2P3 Gene

ubiquitin-conjugating enzyme E2 variant 2 pseudogene 3

UBE2V1 Gene

ubiquitin-conjugating enzyme E2 variant 1

Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]

UBE2V2 Gene

ubiquitin-conjugating enzyme E2 variant 2

Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]

LOC100126822 Gene

ubiquitin-like modifier activating enzyme 5 pseudogene

UBE2Q2L Gene

ubiquitin-conjugating enzyme E2Q family member 2-like

LOC100421465 Gene

ubiquitin-like modifier activating enzyme 2 pseudogene

LOC100421468 Gene

ubiquitin-like modifier activating enzyme 2 pseudogene

USP27X Gene

ubiquitin specific peptidase 27, X-linked

UBE2DNL Gene

ubiquitin-conjugating enzyme E2D N-terminal like (pseudogene)

URM1 Gene

ubiquitin related modifier 1

UBL5P2 Gene

ubiquitin-like 5 pseudogene 2

UBL5P3 Gene

ubiquitin-like 5 pseudogene 3

UBL5P1 Gene

ubiquitin-like 5 pseudogene 1

LOC100420439 Gene

ubiquitin specific peptidase 12 pseudogene

LOC100420432 Gene

ubiquitin specific peptidase 26 pseudogene

LOC101929087 Gene

small ubiquitin-related modifier 2-like

LOC392196 Gene

ubiquitin specific peptidase 17-like family member 2 pseudogene

USP17L14P Gene

ubiquitin specific peptidase 17-like family member 14, pseudogene

USP32P3 Gene

ubiquitin specific peptidase 32 pseudogene 3

USP29 Gene

ubiquitin specific peptidase 29

USP28 Gene

ubiquitin specific peptidase 28

The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001).[supplied by OMIM, Mar 2008]

USP26 Gene

ubiquitin specific peptidase 26

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008]

USP25 Gene

ubiquitin specific peptidase 25

Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]

USP24 Gene

ubiquitin specific peptidase 24

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

USP21 Gene

ubiquitin specific peptidase 21

This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

USP20 Gene

ubiquitin specific peptidase 20

This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jan 2013]

LOC101929235 Gene

putative ubiquitin-conjugating enzyme E2Q2-like protein

USP17L17 Gene

ubiquitin specific peptidase 17-like family member 17

USP17L15 Gene

ubiquitin specific peptidase 17-like family member 15

USP17L13 Gene

ubiquitin specific peptidase 17-like family member 13

USP17L12 Gene

ubiquitin specific peptidase 17-like family member 12

USP17L11 Gene

ubiquitin specific peptidase 17-like family member 11

USP17L10 Gene

ubiquitin specific peptidase 17-like family member 10

USP17L18 Gene

ubiquitin specific peptidase 17-like family member 18

LOC392187 Gene

ubiquitin carboxyl-terminal hydrolase 17-like protein 2-like

LOC339966 Gene

ubiquitin family domain containing 1 pseudogene

LOC100996722 Gene

ubiquitin-conjugating enzyme E2 D4 pseudogene

UBE2V2P1 Gene

ubiquitin-conjugating enzyme E2 variant 2 pseudogene 1

USP17L9P Gene

ubiquitin specific peptidase 17-like family member 9, pseudogene

UBE2HP1 Gene

ubiquitin-conjugating enzyme E2H pseudogene 1

LOC100996911 Gene

putative ubiquitin-conjugating enzyme E2Q2-like protein

UBAP2 Gene

ubiquitin associated protein 2

The protein encoded by this gene contains a UBA (ubiquitin associated) domain, which is characteristic of proteins that function in the ubiquitination pathway. This gene may show increased expression in the adrenal gland and lymphatic tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

UBAP1 Gene

ubiquitin associated protein 1

This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

ISG15 Gene

ISG15 ubiquitin-like modifier

The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]

USP12P1 Gene

ubiquitin specific peptidase 12 pseudogene 1

UBE2Q2P7 Gene

ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 7

UBE2Q2P6 Gene

ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 6

UBE2Q2P1 Gene

ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 1

UBE2Q2P2 Gene

ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 2

UBE2Q2P8 Gene

ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 8

SUMO1 Gene

small ubiquitin-like modifier 1

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

SUMO2 Gene

small ubiquitin-like modifier 2

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

SUMO4 Gene

small ubiquitin-like modifier 4

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008]

UBLCP1 Gene

ubiquitin-like domain containing CTD phosphatase 1

UBL4B Gene

ubiquitin-like 4B

UIMC1 Gene

ubiquitin interaction motif containing 1

USP17L6P Gene

ubiquitin specific peptidase 17-like family member 6, pseudogene

LOC102443352 Gene

ubiquitin-fold modifier 1 pseudogene

LOC100505982 Gene

ubiquitin-conjugating enzyme E2 variant 1 pseudogene

NUB1 Gene

negative regulator of ubiquitin-like proteins 1

This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

USP24P1 Gene

ubiquitin specific peptidase 24 pseudogene 1

LOC101929053 Gene

ubiquitin-conjugating enzyme E2 variant 1-like

LOC100130682 Gene

ubiquitin specific peptidase 12 pseudogene

UBBP1 Gene

ubiquitin B pseudogene 1

UBBP2 Gene

ubiquitin B pseudogene 2

UBBP3 Gene

ubiquitin B pseudogene 3

UBBP4 Gene

ubiquitin B pseudogene 4

UBBP5 Gene

ubiquitin B pseudogene 5

UBE2E1 Gene

ubiquitin-conjugating enzyme E2E 1

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

UBE2E3 Gene

ubiquitin-conjugating enzyme E2E 3

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]

UBE2E2 Gene

ubiquitin-conjugating enzyme E2E 2

LOC100128739 Gene

ubiquitin domain containing 2 pseudogene

USP9YP19 Gene

ubiquitin specific peptidase 9, Y-linked pseudogene 19

UBE2QL1 Gene

ubiquitin-conjugating enzyme E2Q family-like 1

LOC729835 Gene

ubiquitin-fold modifier 1 pseudogene

LOC728825 Gene

small ubiquitin-like modifier 2

UBE2SP1 Gene

ubiquitin-conjugating enzyme E2S pseudogene 1

UBE2SP2 Gene

ubiquitin-conjugating enzyme E2S pseudogene 2

USP49 Gene

ubiquitin specific peptidase 49

USP48 Gene

ubiquitin specific peptidase 48

This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

USP45 Gene

ubiquitin specific peptidase 45

USP44 Gene

ubiquitin specific peptidase 44

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP44 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

USP47 Gene

ubiquitin specific peptidase 47

USP46 Gene

ubiquitin specific peptidase 46

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009]

USP41 Gene

ubiquitin specific peptidase 41

USP40 Gene

ubiquitin specific peptidase 40

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]

USP43 Gene

ubiquitin specific peptidase 43

USP42 Gene

ubiquitin specific peptidase 42

UBE2V2P2 Gene

ubiquitin-conjugating enzyme E2 variant 2 pseudogene 2

LOC100420438 Gene

ubiquitin specific peptidase 12 pseudogene

LOC100420437 Gene

ubiquitin specific peptidase 12 pseudogene

USP12PX Gene

ubiquitin specific peptidase 12 pseudogene, X-linked

USP12PY Gene

ubiquitin specific peptidase 12 pseudogene, Y-linked

IQUB Gene

IQ motif and ubiquitin domain containing

SUMO3 Gene

small ubiquitin-like modifier 3

This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]

USP8 Gene

ubiquitin specific peptidase 8

This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

USP1 Gene

ubiquitin specific peptidase 1

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

USP2 Gene

ubiquitin specific peptidase 2

This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

USP3 Gene

ubiquitin specific peptidase 3

USP4 Gene

ubiquitin specific peptidase 4 (proto-oncogene)

The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

USP5 Gene

ubiquitin specific peptidase 5 (isopeptidase T)

Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]

USP6 Gene

ubiquitin specific peptidase 6

USP7 Gene

ubiquitin specific peptidase 7 (herpes virus-associated)

cul4a-ring e3 ubiquitin ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the cul4a-ring e3 ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

cul4a-ring e3 ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cul4a-ring e3 ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cul4a-ring e3 ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the cul4a-ring e3 ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (CHEK1, CUL4A) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (CHEK1, CUL4A) protein complex from the CORUM Protein Complexes dataset.

cul5-ring ubiquitin ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the cul5-ring ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

cul4-ring e3 ubiquitin ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the cul4-ring e3 ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

cul2-ring ubiquitin ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the cul2-ring ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

cullin-ring ubiquitin ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the cullin-ring ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

cul3-ring ubiquitin ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the cul3-ring ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

cul4b-ring e3 ubiquitin ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the cul4b-ring e3 ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

cul7-ring ubiquitin ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the cul7-ring ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

cul4-ring e3 ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cul4-ring e3 ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cul2-ring ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cul2-ring ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cul5-ring ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cul5-ring ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cul4b-ring e3 ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cul4b-ring e3 ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cul7-ring ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cul7-ring ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cullin-ring ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cullin-ring ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cul3-ring ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cul3-ring ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cul5-ring ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the cul5-ring ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

cul4-ring e3 ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the cul4-ring e3 ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

cul2-ring ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the cul2-ring ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

cullin-ring ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the cullin-ring ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

cul4b-ring e3 ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the cul4b-ring e3 ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

cul7-ring ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the cul7-ring ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

cul3-ring ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the cul3-ring ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

ubiquitin-ubiquitin ligase activity Gene Set

From GO Molecular Function Annotations

genes performing the ubiquitin-ubiquitin ligase activity molecular function from the curated GO Molecular Function Annotations dataset.

E3 ubiquitin ligase EDD, ubiquitin-associated domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin ligase EDD, ubiquitin-associated domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

hrd1p ubiquitin ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the hrd1p ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

nuclear ubiquitin ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the nuclear ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

cytoplasmic ubiquitin ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the cytoplasmic ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

er ubiquitin ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the er ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

scf ubiquitin ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the scf ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

ubiquitin ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the ubiquitin ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

doa10p ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the doa10p ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

dsc e3 ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the dsc e3 ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

hrd1p ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the hrd1p ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

nuclear ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the nuclear ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

scf ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the scf ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cytoplasmic ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cytoplasmic ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cytoplasmic scf ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cytoplasmic scf ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

er ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the er ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

clrc ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the clrc ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

sumo-targeted ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the sumo-targeted ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

nuclear scf ubiquitin ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the nuclear scf ubiquitin ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex Gene Set

From CORUM Protein Complexes

proteins in the p27-cyclinE-Cdk2 - Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) complex protein complex from the CORUM Protein Complexes dataset.

Ubiquitin ligase complex (TRAF6, TAB2, MALT1, UEV1A, BCL10) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin ligase complex (TRAF6, TAB2, MALT1, UEV1A, BCL10) protein complex from the CORUM Protein Complexes dataset.

parkin-fbxw7-cul1 ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the parkin-fbxw7-cul1 ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

hrd1p ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the hrd1p ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

nuclear ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the nuclear ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

scf ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the scf ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

cytoplasmic ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the cytoplasmic ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

er ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the er ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

ubiquitin ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

Ubiquitin ligase, Det1/DDB1-complexing Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Ubiquitin ligase, Det1/DDB1-complexing protein domain from the InterPro Predicted Protein Domain Annotations dataset.

CAND1-CUL4A-RBX1 complex Gene Set

From CORUM Protein Complexes

proteins in the CAND1-CUL4A-RBX1 complex protein complex from the CORUM Protein Complexes dataset.

Ubiquitin/SUMO-activating enzyme ubiquitin-like domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Ubiquitin/SUMO-activating enzyme ubiquitin-like domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Ubiquitin E3 ligase (TRIM25, DDX58) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (TRIM25, DDX58) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin-protein ligase (UBE2N, UBE2V2/MMS2) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin-protein ligase (UBE2N, UBE2V2/MMS2) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (CRY1, SKP1A, CUL1, FBXL3) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (CRY1, SKP1A, CUL1, FBXL3) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (NFKBIA, FBXW11, BTRC, CUL1, SKP1A) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (NFKBIA, FBXW11, BTRC, CUL1, SKP1A) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SMAD3, BTRC, CUL1, SKP1A, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (CRY2, SKP1A, CUL1, FBXL3) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (CRY2, SKP1A, CUL1, FBXL3) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (FBXO18, SKP1A, CUL1, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (FBXO18, SKP1A, CUL1, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (NIPA, SKP1A, CUL1, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (NIPA, SKP1A, CUL1, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (Fbxo32, Skp1a, Cul1, Rbx1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (Fbxo32, Skp1a, Cul1, Rbx1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (Fbxl20, Skp1, Cul1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (Fbxl20, Skp1, Cul1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (CDC34, CUL1, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (CDC34, CUL1, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (FBXO31, SKP1A, CUL1, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (FBXO31, SKP1A, CUL1, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin-protein-ligase (UBE2N, UBE2V2/MMS2) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin-protein-ligase (UBE2N, UBE2V2/MMS2) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (SKP1A, FBXW2, CUL1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SKP1A, FBXW2, CUL1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SKP1A, SKP2, CUL1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (Fbxo15, Cul1, Skp1a) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (Fbxo15, Cul1, Skp1a) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (Fbxo2, Skp1a, Cul1, Rbx1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (Fbxo2, Skp1a, Cul1, Rbx1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (SKP1A, FBXW8, CUL7, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SKP1A, FBXW8, CUL7, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (NFKBIA, BTRC, CUL1, SKP1A) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (NFKBIA, BTRC, CUL1, SKP1A) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (H2AFY, SPOP, CUL3) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (H2AFY, SPOP, CUL3) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (SIAH1, SIP, SKP1A, TBL1X) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SIAH1, SIP, SKP1A, TBL1X) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (CDC34, NEDD8, BTRC, CUL1, SKP1A, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (NFKBIA, FBXW11, CUL1, SKP1A) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (NFKBIA, FBXW11, CUL1, SKP1A) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (SKP1A, BTRC, CUL1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SKP1A, BTRC, CUL1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, CKS1B, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (CUL1, RBX1, SKP1A) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (CUL1, RBX1, SKP1A) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (UBADC1, RNF123) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (UBADC1, RNF123) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (GLMN, FBXW8, SKP1A, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (GLMN, FBXW8, SKP1A, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (BMI1, SPOP, CUL3) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (BMI1, SPOP, CUL3) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (Skp1A, Skp2, Cul1, Rbx1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (Skp1A, Skp2, Cul1, Rbx1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (FBXW11, SKP1A, CUL1, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (FBXW11, SKP1A, CUL1, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (FBXW7, CUL1, SKP1A, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (CHEK1, CUL1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (CHEK1, CUL1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (SPOP, DAXX, CUL3) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (SPOP, DAXX, CUL3) protein complex from the CORUM Protein Complexes dataset.

Ubiquitin E3 ligase (Neurl2, Tceb1, Tceb2, Cul5, Rbx1) Gene Set

From CORUM Protein Complexes

proteins in the Ubiquitin E3 ligase (Neurl2, Tceb1, Tceb2, Cul5, Rbx1) protein complex from the CORUM Protein Complexes dataset.

regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Gene Set

From GO Biological Process Annotations

genes participating in the regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological process from the curated GO Biological Process Annotations dataset.

negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle biological process from the curated GO Biological Process Annotations dataset.

positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition biological process from the curated GO Biological Process Annotations dataset.

ubiquitin protein ligase binding Gene Set

From GO Molecular Function Annotations

genes performing the ubiquitin protein ligase binding molecular function from the curated GO Molecular Function Annotations dataset.

ubiquitin protein ligase activity Gene Set

From GO Molecular Function Annotations

genes performing the ubiquitin protein ligase activity molecular function from the curated GO Molecular Function Annotations dataset.

ubiquitin-like protein ligase binding Gene Set

From GO Molecular Function Annotations

genes performing the ubiquitin-like protein ligase binding molecular function from the curated GO Molecular Function Annotations dataset.

ubiquitin-like protein ligase activity Gene Set

From GO Molecular Function Annotations

genes performing the ubiquitin-like protein ligase activity molecular function from the curated GO Molecular Function Annotations dataset.

E3 ubiquitin ligase, domain of unknown function DUF908 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin ligase, domain of unknown function DUF908 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Putative E3 ubiquitin-protein ligase, makorin-related Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Putative E3 ubiquitin-protein ligase, makorin-related protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Probable E3 ubiquitin-protein ligase makorin-2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Probable E3 ubiquitin-protein ligase makorin-2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Ubiquitin-protein ligase E6-AP Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Ubiquitin-protein ligase E6-AP protein domain from the InterPro Predicted Protein Domain Annotations dataset.

E3 ubiquitin-protein ligase parkin Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin-protein ligase parkin protein domain from the InterPro Predicted Protein Domain Annotations dataset.

E3 ubiquitin-protein ligase RNF8 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin-protein ligase RNF8 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

E3 ubiquitin ligase, BRE1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin ligase, BRE1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

E3 ubiquitin-protein ligase Arkadia, N-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin-protein ligase Arkadia, N-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

E3 ubiquitin-protein ligase, SMURF1 type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin-protein ligase, SMURF1 type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

E3 ubiquitin ligase, domain of unknown function DUF913 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin ligase, domain of unknown function DUF913 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

E3 ubiquitin ligase, UBR4 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin ligase, UBR4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

E3 ubiquitin-protein ligase SINA like Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin-protein ligase SINA like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

E3 ubiquitin-protein ligase RNF31 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin-protein ligase RNF31 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

E3 ubiquitin-protein ligase Mdm2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin-protein ligase Mdm2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

E3 ubiquitin-protein ligase FANCL Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin-protein ligase FANCL protein domain from the InterPro Predicted Protein Domain Annotations dataset.

E3 ubiquitin-protein ligase Trim36 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin-protein ligase Trim36 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

E3 ubiquitin-protein ligase Highwire/Pam/Rpm-1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the E3 ubiquitin-protein ligase Highwire/Pam/Rpm-1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Mitochondrial ubiquitin ligase activator of NFKB 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Mitochondrial ubiquitin ligase activator of NFKB 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Ubiquitin-protein ligase E3 MDM2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Ubiquitin-protein ligase E3 MDM2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Autodegradation of the E3 ubiquitin ligase COP1 Gene Set

From Reactome Pathways

proteins participating in the Autodegradation of the E3 ubiquitin ligase COP1 pathway from the Reactome Pathways dataset.

cul4a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cul4a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

BL2388 (CUL4A) Gene Set

From NURSA Protein Complexes

proteins in the BL2388 (CUL4A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL2390 (CUL4A) Gene Set

From NURSA Protein Complexes

proteins in the BL2390 (CUL4A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL2389 (CUL4A) Gene Set

From NURSA Protein Complexes

proteins in the BL2389 (CUL4A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL2391 (CUL4A) Gene Set

From NURSA Protein Complexes

proteins in the BL2391 (CUL4A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

CUL4A Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for CUL4A from the NURSA Protein-Protein Interactions dataset.

CUL4A Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CUL4A from the Pathway Commons Protein-Protein Interactions dataset.

gamma-tubulin ring complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the gamma-tubulin ring complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

gamma-tubulin ring complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the gamma-tubulin ring complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

gamma-tubulin ring complex Gene Set

From GO Cellular Component Annotations

proteins localized to the gamma-tubulin ring complex cellular component from the curated GO Cellular Component Annotations dataset.

DNA ligase IV-XRCC4 complex (LX complex) Gene Set

From CORUM Protein Complexes

proteins in the DNA ligase IV-XRCC4 complex (LX complex) protein complex from the CORUM Protein Complexes dataset.

ubiquitin conjugating enzyme complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the ubiquitin conjugating enzyme complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

ubiquitin conjugating enzyme complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the ubiquitin conjugating enzyme complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

ubiquitin conjugating enzyme complex Gene Set

From GO Cellular Component Annotations

proteins localized to the ubiquitin conjugating enzyme complex cellular component from the curated GO Cellular Component Annotations dataset.

26S proteasome complex ubiquitin receptor, subunit Rpn13 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the 26S proteasome complex ubiquitin receptor, subunit Rpn13 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Ring dermoid of cornea Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Ring dermoid of cornea phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

contractile ring Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the contractile ring cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

nuclear pore outer ring Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the nuclear pore outer ring cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

actomyosin contractile ring Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the actomyosin contractile ring cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

contractile ring Gene Set

From COMPARTMENTS Experimental Protein Localization Evidence Scores

proteins localized to the contractile ring cellular component in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.

contractile ring Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the contractile ring cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

female germline ring canal Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the female germline ring canal cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

female germline ring canal inner rim Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the female germline ring canal inner rim cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

nuclear pore outer ring Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the nuclear pore outer ring cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

septin ring Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the septin ring cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

germline ring canal Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the germline ring canal cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

actomyosin contractile ring Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the actomyosin contractile ring cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

prospore contractile ring Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the prospore contractile ring cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Heterocyclic Compounds, 3-Ring Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Heterocyclic Compounds, 3-Ring from the curated CTD Gene-Chemical Interactions dataset.

Heterocyclic Compounds, 1-Ring Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Heterocyclic Compounds, 1-Ring from the curated CTD Gene-Chemical Interactions dataset.

Ring dermoid of cornea Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Ring dermoid of cornea from the curated CTD Gene-Disease Associations dataset.

breast signet ring cell adenocarcinoma Gene Set

From DISEASES Text-mining Gene-Disease Assocation Evidence Scores

genes co-occuring with the disease breast signet ring cell adenocarcinoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

gastric signet ring cell adenocarcinoma Gene Set

From DISEASES Text-mining Gene-Disease Assocation Evidence Scores

genes co-occuring with the disease gastric signet ring cell adenocarcinoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

signet ring basal cell carcinoma Gene Set

From DISEASES Text-mining Gene-Disease Assocation Evidence Scores

genes co-occuring with the disease signet ring basal cell carcinoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

prostate signet ring cell adenocarcinoma Gene Set

From DISEASES Text-mining Gene-Disease Assocation Evidence Scores

genes co-occuring with the disease prostate signet ring cell adenocarcinoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

signet ring cell adenocarcinoma Gene Set

From DISEASES Text-mining Gene-Disease Assocation Evidence Scores

genes co-occuring with the disease signet ring cell adenocarcinoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

1-3 Sugar Ring of Pentamannosyl 6-Phosphate Gene Set

From DrugBank Drug Targets

interacting proteins for the 1-3 Sugar Ring of Pentamannosyl 6-Phosphate drug from the curated DrugBank Drug Targets dataset.

ring sideroblasts Gene Set

From GAD Gene-Disease Associations

genes associated with the disease ring sideroblasts in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

carcinoma, signet ring cell; helicobacter infections; stomach neoplasms Gene Set

From GAD Gene-Disease Associations

genes associated with the disease carcinoma, signet ring cell; helicobacter infections; stomach neoplasms in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

adenocarcinoma; adenocarcinoma, mucinous; carcinoma, papillary; carcinoma, signet ring cell; intestinal neoplasms; stomach neoplasms Gene Set

From GAD Gene-Disease Associations

genes associated with the disease adenocarcinoma; adenocarcinoma, mucinous; carcinoma, papillary; carcinoma, signet ring cell; intestinal neoplasms; stomach neoplasms in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

ring Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ring in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

actomyosin contractile ring assembly Gene Set

From GO Biological Process Annotations

genes participating in the actomyosin contractile ring assembly biological process from the curated GO Biological Process Annotations dataset.

actomyosin contractile ring organization Gene Set

From GO Biological Process Annotations

genes participating in the actomyosin contractile ring organization biological process from the curated GO Biological Process Annotations dataset.

septin ring organization Gene Set

From GO Biological Process Annotations

genes participating in the septin ring organization biological process from the curated GO Biological Process Annotations dataset.

septin ring assembly Gene Set

From GO Biological Process Annotations

genes participating in the septin ring assembly biological process from the curated GO Biological Process Annotations dataset.

contractile ring Gene Set

From GO Cellular Component Annotations

proteins localized to the contractile ring cellular component from the curated GO Cellular Component Annotations dataset.

actomyosin contractile ring Gene Set

From GO Cellular Component Annotations

proteins localized to the actomyosin contractile ring cellular component from the curated GO Cellular Component Annotations dataset.

nuclear pore outer ring Gene Set

From GO Cellular Component Annotations

proteins localized to the nuclear pore outer ring cellular component from the curated GO Cellular Component Annotations dataset.

c3hc4-type ring finger domain binding Gene Set

From GO Molecular Function Annotations

genes performing the c3hc4-type ring finger domain binding molecular function from the curated GO Molecular Function Annotations dataset.

ring-like zinc finger domain binding Gene Set

From GO Molecular Function Annotations

genes performing the ring-like zinc finger domain binding molecular function from the curated GO Molecular Function Annotations dataset.

vascular ring Gene Set

From HPO Gene-Disease Associations

genes associated with the vascular ring phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

kayser-fleischer ring Gene Set

From HPO Gene-Disease Associations

genes associated with the kayser-fleischer ring phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

amniotic constriction ring Gene Set

From HPO Gene-Disease Associations

genes associated with the amniotic constriction ring phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

ring fibers Gene Set

From HPO Gene-Disease Associations

genes associated with the ring fibers phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Replication termination factor 2, RING-finger Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Replication termination factor 2, RING-finger protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Zinc finger, RING/FYVE/PHD-type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Zinc finger, RING/FYVE/PHD-type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Zinc finger, RING-CH-type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Zinc finger, RING-CH-type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Zinc finger, RING-like Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Zinc finger, RING-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Aromatic-ring hydroxylase-like Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Aromatic-ring hydroxylase-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

RING-type zinc-finger, LisH dimerisation motif Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the RING-type zinc-finger, LisH dimerisation motif protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Zinc finger, RING-type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Zinc finger, RING-type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Zinc finger, RING-type, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Zinc finger, RING-type, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

UNC-45/Ring assembly protein 3 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the UNC-45/Ring assembly protein 3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Zinc finger, C3HC4 RING-type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Zinc finger, C3HC4 RING-type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Zinc finger, RING-H2-type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Zinc finger, RING-H2-type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

decreased tympanic ring size Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the decreased tympanic ring size phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

vascular ring Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the vascular ring phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

absent tympanic ring Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the absent tympanic ring phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

decreased tracheal cartilage ring number Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the decreased tracheal cartilage ring number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

abnormal tympanic ring morphology Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal tympanic ring morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

ring dermoid of cornea Gene Set

From OMIM Gene-Disease Associations

genes associated with the ring dermoid of cornea phenotype from the curated OMIM Gene-Disease Associations dataset.

ring gland Gene Set

From TISSUES Text-mining Tissue Protein Expression Evidence Scores

proteins co-occuring with the tissue ring gland in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

ring stage Gene Set

From TISSUES Text-mining Tissue Protein Expression Evidence Scores

proteins co-occuring with the tissue ring stage in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

glutamate-cysteine ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the glutamate-cysteine ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

dna ligase iv complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the dna ligase iv complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

trna-splicing ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the trna-splicing ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

succinate-coa ligase complex (gdp-forming) Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the succinate-coa ligase complex (gdp-forming) cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

succinate-coa ligase complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the succinate-coa ligase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

dna-dependent protein kinase-dna ligase 4 complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the dna-dependent protein kinase-dna ligase 4 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

dna ligase iv complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the dna ligase iv complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

trna-splicing ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the trna-splicing ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

succinate-coa ligase complex (gdp-forming) Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the succinate-coa ligase complex (gdp-forming) cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

succinate-coa ligase complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the succinate-coa ligase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

succinate-coa ligase complex (adp-forming) Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the succinate-coa ligase complex (adp-forming) cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

dna ligase iii-xrcc1 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the dna ligase iii-xrcc1 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

DNA ligase IV-XRCC4-AHNK complex Gene Set

From CORUM Protein Complexes

proteins in the DNA ligase IV-XRCC4-AHNK complex protein complex from the CORUM Protein Complexes dataset.

DNA ligase IV-XRCC4 complex Gene Set

From CORUM Protein Complexes

proteins in the DNA ligase IV-XRCC4 complex protein complex from the CORUM Protein Complexes dataset.

DNA ligase IV-Xrcc4-DNA-protein kinase complex Gene Set

From CORUM Protein Complexes

proteins in the DNA ligase IV-Xrcc4-DNA-protein kinase complex protein complex from the CORUM Protein Complexes dataset.

DNA ligase IV-condensin complex Gene Set

From CORUM Protein Complexes

proteins in the DNA ligase IV-condensin complex protein complex from the CORUM Protein Complexes dataset.

DNA ligase IV-XRCC4-XLF complex Gene Set

From CORUM Protein Complexes

proteins in the DNA ligase IV-XRCC4-XLF complex protein complex from the CORUM Protein Complexes dataset.

DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex Gene Set

From CORUM Protein Complexes

proteins in the DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex protein complex from the CORUM Protein Complexes dataset.

DNA ligase IV-XRCC1 complex Gene Set

From CORUM Protein Complexes

proteins in the DNA ligase IV-XRCC1 complex protein complex from the CORUM Protein Complexes dataset.

PCNA-DNA ligase complex Gene Set

From CORUM Protein Complexes

proteins in the PCNA-DNA ligase complex protein complex from the CORUM Protein Complexes dataset.

DNA ligase III-XRCC1 complex Gene Set

From CORUM Protein Complexes

proteins in the DNA ligase III-XRCC1 complex protein complex from the CORUM Protein Complexes dataset.

DNA ligase IV-XRCC4-PNK complex Gene Set

From CORUM Protein Complexes

proteins in the DNA ligase IV-XRCC4-PNK complex protein complex from the CORUM Protein Complexes dataset.

dna ligase iv complex Gene Set

From GO Cellular Component Annotations

proteins localized to the dna ligase iv complex cellular component from the curated GO Cellular Component Annotations dataset.

trna-splicing ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the trna-splicing ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

succinate-coa ligase complex (gdp-forming) Gene Set

From GO Cellular Component Annotations

proteins localized to the succinate-coa ligase complex (gdp-forming) cellular component from the curated GO Cellular Component Annotations dataset.

succinate-coa ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the succinate-coa ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

dna-dependent protein kinase-dna ligase 4 complex Gene Set

From GO Cellular Component Annotations

proteins localized to the dna-dependent protein kinase-dna ligase 4 complex cellular component from the curated GO Cellular Component Annotations dataset.

glutamate-cysteine ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the glutamate-cysteine ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

sumoylated e2 ligase complex Gene Set

From GO Cellular Component Annotations

proteins localized to the sumoylated e2 ligase complex cellular component from the curated GO Cellular Component Annotations dataset.

role of parkin in ubiquitin-proteasomal pathway Gene Set

From Biocarta Pathways

proteins participating in the role of parkin in ubiquitin-proteasomal pathway pathway from the Biocarta Pathways dataset.

Frontotemporal dementia, ubiquitin-positive Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Frontotemporal dementia, ubiquitin-positive phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

ubiquitin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ubiquitin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

regulation of proteasomal ubiquitin-dependent protein catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the regulation of proteasomal ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

scf-dependent proteasomal ubiquitin-dependent protein catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the scf-dependent proteasomal ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

positive regulation of ubiquitin-protein transferase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of ubiquitin-protein transferase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of proteasomal ubiquitin-dependent protein catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of proteasomal ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

negative regulation of er-associated ubiquitin-dependent protein catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of er-associated ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

free ubiquitin chain polymerization Gene Set

From GO Biological Process Annotations

genes participating in the free ubiquitin chain polymerization biological process from the curated GO Biological Process Annotations dataset.

positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia biological process from the curated GO Biological Process Annotations dataset.

ubiquitin-dependent protein catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

regulation of er-associated ubiquitin-dependent protein catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the regulation of er-associated ubiquitin-dependent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

regulation of ubiquitin-dependent endocytosis Gene Set

From GO Biological Process Annotations

genes participating in the regulation of ubiquitin-dependent endocytosis biological process from the curated GO Biological Process Annotations dataset.

regulation of ubiquitin-protein transferase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of ubiquitin-protein transferase activity biological process from the curated GO Biological Process Annotations dataset.

protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Gene Set

From GO Biological Process Annotations

genes participating in the protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway biological process from the curated GO Biological Process Annotations dataset.

ubiquitin-dependent smad protein catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the ubiquitin-dependent smad protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

negative regulation of ubiquitin-specific protease activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of ubiquitin-specific protease activity biological process from the curated GO Biological Process Annotations dataset.

proteasomal ubiquitin-independent protein catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the proteasomal ubiquitin-independent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

positive regulation of ubiquitin-specific protease activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of ubiquitin-specific protease activity biological process from the curated GO Biological Process Annotations dataset.