yolk sac Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description A membranous sac that is attached to an embryo and encloses food yolk, that is continuous in most forms through the yolk stalk with the intestinal cavity of the embryo, that being abundantly supplied with blood vessels is throughout embryonic life and in some forms later the chief organ of nutrition, and that in placental mammals is nearly vestigial and functions chiefly prior to the elaboration of the placenta. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001471)
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Genes

388 proteins co-occuring with the tissue yolk sac in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
AFP alpha-fetoprotein 3.15653
FRY furry homolog (Drosophila) 1.98578
LRP2 low density lipoprotein receptor-related protein 2 1.90706
CUBN cubilin (intrinsic factor-cobalamin receptor) 1.78992
SALL4 spalt-like transcription factor 4 1.77983
GPC3 glypican 3 1.68703
FCRLB Fc receptor-like B 1.59275
TAL1 T-cell acute lymphocytic leukemia 1 1.53382
KLF1 Kruppel-like factor 1 (erythroid) 1.51807
RUNX1 runt-related transcription factor 1 1.42322
GATA2 GATA binding protein 2 1.42183
FCGRT Fc fragment of IgG, receptor, transporter, alpha 1.33817
CDH5 cadherin 5, type 2 (vascular endothelium) 1.29804
ALB albumin 1.2922
NMT1 N-myristoyltransferase 1 1.26039
TF transferrin 1.24833
TTR transthyretin 1.24744
LMO2 LIM domain only 2 (rhombotin-like 1) 1.23807
CD34 CD34 molecule 1.19756
HBE1 hemoglobin, epsilon 1 1.12394
SOX17 SRY (sex determining region Y)-box 17 1.12305
MYB v-myb avian myeloblastosis viral oncogene homolog 1.11243
ALPPL2 alkaline phosphatase, placental-like 2 1.09916
GATA6 GATA binding protein 6 1.09827
ALPP alkaline phosphatase, placental 1.0912
HBG2 hemoglobin, gamma G 1.08987
ALPL alkaline phosphatase, liver/bone/kidney 1.0806
GATA4 GATA binding protein 4 1.04577
SPTA1 spectrin, alpha, erythrocytic 1 1.03653
IHH indian hedgehog 1.02995
EMCN endomucin 1.00196
ETV2 ets variant 2 0.956859
SLC39A4 solute carrier family 39 (zinc transporter), member 4 0.937917
BMP4 bone morphogenetic protein 4 0.932337
NANOG Nanog homeobox 0.890101
CSF1R colony stimulating factor 1 receptor 0.881627
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.880781
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.879089
IGF2 insulin-like growth factor 2 0.871061
ERICH1 glutamate-rich 1 0.862206
HOXB4 homeobox B4 0.859258
SLC23A3 solute carrier family 23, member 3 0.85505
FN1 fibronectin 1 0.848325
NID1 nidogen 1 0.845805
NOTCH1 notch 1 0.842867
SMAD5 SMAD family member 5 0.831129
CGRRF1 cell growth regulator with ring finger domain 1 0.829872
SOX2 SRY (sex determining region Y)-box 2 0.821085
EPOR erythropoietin receptor 0.816068
FTH1 ferritin, heavy polypeptide 1 0.814397
AHR aryl hydrocarbon receptor 0.803961
KITLG KIT ligand 0.801042
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.800208
FTL ferritin, light polypeptide 0.798958
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.792709
MDFIC MyoD family inhibitor domain containing 0.79146
PSG9 pregnancy specific beta-1-glycoprotein 9 0.774419
SLC39A5 solute carrier family 39 (zinc transporter), member 5 0.773174
CDX2 caudal type homeobox 2 0.770685
ECEL1 endothelin converting enzyme-like 1 0.770685
RNF141 ring finger protein 141 0.765711
SPTB spectrin, beta, erythrocytic 0.762811
RHBG Rh family, B glycoprotein (gene/pseudogene) 0.757845
EFNB2 ephrin-B2 0.755777
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.755364
HBA2 hemoglobin, alpha 2 0.749992
GIF gastric intrinsic factor (vitamin B synthesis) 0.749992
FLT1 fms-related tyrosine kinase 1 0.746277
IGLJ2 immunoglobulin lambda joining 2 0.745039
HBA1 hemoglobin, alpha 1 0.739266
FOXF1 forkhead box F1 0.728563
TGFB1 transforming growth factor, beta 1 0.727741
KDR kinase insert domain receptor 0.726097
GLB1 galactosidase, beta 1 0.724863
MNX1 motor neuron and pancreas homeobox 1 0.71501
SNX13 sorting nexin 13 0.713779
ASCL2 achaete-scute family bHLH transcription factor 2 0.711729
HBB hemoglobin, beta 0.703127
SNX2 sorting nexin 2 0.699444
GPI glucose-6-phosphate isomerase 0.696581
TTC12 tetratricopeptide repeat domain 12 0.691676
PNPLA1 patatin-like phospholipase domain containing 1 0.691268
CP ceruloplasmin (ferroxidase) 0.691268
FLT3 fms-related tyrosine kinase 3 0.689226
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 0.68188
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.670878
HAND1 heart and neural crest derivatives expressed 1 0.670471
GFI1B growth factor independent 1B transcription repressor 0.667215
IGKV1D-42 immunoglobulin kappa variable 1D-42 (non-functional) 0.664368
CLEC4F C-type lectin domain family 4, member F 0.662336
THSD1 thrombospondin, type I, domain containing 1 0.659085
GC group-specific component (vitamin D binding protein) 0.657054
VEGFA vascular endothelial growth factor A 0.644479
ACPP acid phosphatase, prostate 0.642048
QKI QKI, KH domain containing, RNA binding 0.637999
IGLJ3 immunoglobulin lambda joining 3 0.637594
KRT7 keratin 7, type II 0.637594
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.631931
POU5F1 POU class 5 homeobox 1 0.629101
NRP1 neuropilin 1 0.623043
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.617796
MTTP microsomal triglyceride transfer protein 0.614974
CSH2 chorionic somatomammotropin hormone 2 0.614974
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.611346
SEPT7P2 septin 7 pseudogene 2 0.609735
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.608124
DOT1L DOT1-like histone H3K79 methyltransferase 0.606514
HAND2 heart and neural crest derivatives expressed 2 0.602088
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.598469
APOA1 apolipoprotein A-I 0.597263
AGTR2 angiotensin II receptor, type 2 0.595656
INS insulin 0.589635
CGNL1 cingulin-like 1 0.58322
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.574816
EPO erythropoietin 0.574017
HMGA1 high mobility group AT-hook 1 0.573616
PNPLA4 patatin-like phospholipase domain containing 4 0.572018
TSPY1 testis specific protein, Y-linked 1 0.572018
HPX hemopexin 0.568823
KDM8 lysine (K)-specific demethylase 8 0.568823
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.563637
ANGPTL1 angiopoietin-like 1 0.56284
THPO thrombopoietin 0.560847
CD44 CD44 molecule (Indian blood group) 0.56005
EGFL8 EGF-like-domain, multiple 8 0.56005
APOB apolipoprotein B 0.558457
WDR20 WD repeat domain 20 0.556467
IL34 interleukin 34 0.554478
ACVRL1 activin A receptor type II-like 1 0.553683
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 0.548914
CGGBP1 CGG triplet repeat binding protein 1 0.547326
TP53 tumor protein p53 0.544549
HBZ hemoglobin, zeta 0.543756
TAGLN transgelin 0.539793
CDX4 caudal type homeobox 4 0.536229
MECOM MDS1 and EVI1 complex locus 0.536229
SAGE1 sarcoma antigen 1 0.533856
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 0.53267
RASGEF1A RasGEF domain family, member 1A 0.528323
LDLR low density lipoprotein receptor 0.527928
MPL MPL proto-oncogene, thrombopoietin receptor 0.52556
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.525166
SEPT4 septin 4 0.524771
KLF10 Kruppel-like factor 10 0.524377
GDF3 growth differentiation factor 3 0.518465
PRDM6 PR domain containing 6 0.516497
TTPA tocopherol (alpha) transfer protein 0.510599
LCN8 lipocalin 8 0.50942
AHCTF1 AT hook containing transcription factor 1 0.506279
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.50079
GAGE12G G antigen 12G 0.499223
SNRPN small nuclear ribonucleoprotein polypeptide N 0.498832
USP29 ubiquitin specific peptidase 29 0.496874
TSPY3 testis specific protein, Y-linked 3 0.496092
TSPY10 testis specific protein, Y-linked 10 0.496092
S100G S100 calcium binding protein G 0.495701
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 0.492963
WNT16 wingless-type MMTV integration site family, member 16 0.489057
UTF1 undifferentiated embryonic cell transcription factor 1 0.487106
SKP1 S-phase kinase-associated protein 1 0.484766
POU5F1B POU class 5 homeobox 1B 0.481648
STK3 serine/threonine kinase 3 0.480091
FGF4 fibroblast growth factor 4 0.480091
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.478145
EPHB4 EPH receptor B4 0.477756
ATF7IP activating transcription factor 7 interacting protein 0.47348
PAX8 paired box 8 0.472315
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.472315
CIAO1 cytosolic iron-sulfur assembly component 1 0.470375
HOXB9 homeobox B9 0.469987
SPRY4 sprouty homolog 4 (Drosophila) 0.469211
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 0.466498
HNF1A HNF1 homeobox A 0.4634
HLA-B major histocompatibility complex, class I, B 0.461465
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.459918
RPL6 ribosomal protein L6 0.459145
CDK9 cyclin-dependent kinase 9 0.458952
IGF1 insulin-like growth factor 1 (somatomedin C) 0.457987
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.457214
ESAM endothelial cell adhesion molecule 0.457214
SMAD2 SMAD family member 2 0.456828
PAXBP1 PAX3 and PAX7 binding protein 1 0.456442
LPA lipoprotein, Lp(a) 0.454126
JAG1 jagged 1 0.45374
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.453355
TRIM47 tripartite motif containing 47 0.452584
ANGPTL5 angiopoietin-like 5 0.443731
ZFYVE27 zinc finger, FYVE domain containing 27 0.440274
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 0.438739
IFITM2 interferon induced transmembrane protein 2 0.438356
DLK1 delta-like 1 homolog (Drosophila) 0.432608
THAP11 THAP domain containing 11 0.431843
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.43146
SLC30A4 solute carrier family 30 (zinc transporter), member 4 0.428401
TMPO thymopoietin 0.425344
STK26 serine/threonine protein kinase 26 0.424963
TGFBR1 transforming growth factor, beta receptor 1 0.424199
IRX3 iroquois homeobox 3 0.416576
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 0.411631
AURKB aurora kinase B 0.411631
TNRC6A trinucleotide repeat containing 6A 0.410111
RHOJ ras homolog family member J 0.408592
MDFI MyoD family inhibitor 0.407832
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.406315
ALCAM activated leukocyte cell adhesion molecule 0.405176
MRPL49 mitochondrial ribosomal protein L49 0.40328
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 0.402901
VEZF1 vascular endothelial zinc finger 1 0.400628
NEK2 NIMA-related kinase 2 0.399114
GMFG glia maturation factor, gamma 0.398735
PEX13 peroxisomal biogenesis factor 13 0.396465
PEX3 peroxisomal biogenesis factor 3 0.393064
ARNT aryl hydrocarbon receptor nuclear translocator 0.391553
ERLIN2 ER lipid raft associated 2 0.390044
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.388912
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 0.388158
SMAD9 SMAD family member 9 0.38665
TBP TATA box binding protein 0.385143
NOTCH4 notch 4 0.379499
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 0.379123
MRC1 mannose receptor, C type 1 0.378748
DOK4 docking protein 4 0.374993
SOD2 superoxide dismutase 2, mitochondrial 0.374243
DNAH8 dynein, axonemal, heavy chain 8 0.37087
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.369747
CRB3 crumbs family member 3 0.368624
RUNX3 runt-related transcription factor 3 0.36825
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.367502
MEF2C myocyte enhancer factor 2C 0.366381
SHH sonic hedgehog 0.365633
TUBA4A tubulin, alpha 4a 0.364139
PTPRB protein tyrosine phosphatase, receptor type, B 0.36302
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.360409
KLF2 Kruppel-like factor 2 0.35743
ABHD2 abhydrolase domain containing 2 0.352969
FZD1 frizzled class receptor 1 0.352227
CAT catalase 0.350743
HP haptoglobin 0.350001
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.348519
DPPA4 developmental pluripotency associated 4 0.348519
REM1 RAS (RAD and GEM)-like GTP-binding 1 0.348148
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.347778
COLEC10 collectin sub-family member 10 (C-type lectin) 0.347408
HIPK1 homeodomain interacting protein kinase 1 0.346668
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.344818
CSNK2B casein kinase 2, beta polypeptide 0.344449
AZIN1 antizyme inhibitor 1 0.344079
BMP2 bone morphogenetic protein 2 0.341126
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.340757
HPR haptoglobin-related protein 0.33965
TRPV6 transient receptor potential cation channel, subfamily V, member 6 0.338914
FES FES proto-oncogene, tyrosine kinase 0.338545
UNC45B unc-45 homolog B (C. elegans) 0.332661
FGF2 fibroblast growth factor 2 (basic) 0.331194
APOE apolipoprotein E 0.328994
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 0.32753
SYNPO2 synaptopodin 2 0.32753
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.32497
HHEX hematopoietically expressed homeobox 0.323874
ZFP36L2 ZFP36 ring finger protein-like 2 0.323509
HEMGN hemogen 0.322414
EMB embigin 0.321685
C1R complement component 1, r subcomponent 0.319134
SOX15 SRY (sex determining region Y)-box 15 0.31877
INHA inhibin, alpha 0.317679
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 0.317315
CD79A CD79a molecule, immunoglobulin-associated alpha 0.316951
COBL cordon-bleu WH2 repeat protein 0.315498
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 0.314772
YAP1 Yes-associated protein 1 0.312957
HOXA9 homeobox A9 0.312595
SSRP1 structure specific recognition protein 1 0.312232
SALL2 spalt-like transcription factor 2 0.31187
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.311145
EPAS1 endothelial PAS domain protein 1 0.308251
DHDH dihydrodiol dehydrogenase (dimeric) 0.307889
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.306083
BAK1 BCL2-antagonist/killer 1 0.305361
PGK1 phosphoglycerate kinase 1 0.303198
ABHD5 abhydrolase domain containing 5 0.302478
CHRD chordin 0.302478
H3F3A H3 histone, family 3A 0.301758
H3F3B H3 histone, family 3B (H3.3B) 0.301758
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.301398
RNF4 ring finger protein 4 0.30032
CXXC1 CXXC finger protein 1 0.297806
PODXL podocalyxin-like 0.297447
ZNF331 zinc finger protein 331 0.296372
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 0.294581
C1S complement component 1, s subcomponent 0.291365
VAV1 vav 1 guanine nucleotide exchange factor 0.290652
LCTL lactase-like 0.289939
MT4 metallothionein 4 0.28887
ZFAT zinc finger and AT hook domain containing 0.287092
ANGPT1 angiopoietin 1 0.283899
SRY sex determining region Y 0.283191
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 0.282837
EGOT eosinophil granule ontogeny transcript (non-protein coding) 0.282483
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 0.28213
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.28213
SNX1 sorting nexin 1 0.281423
DGCR8 DGCR8 microprocessor complex subunit 0.280012
CALB2 calbindin 2 0.276495
NFE2L3 nuclear factor, erythroid 2-like 3 0.276145
ENG endoglin 0.276145
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.275794
MKL2 MKL/myocardin-like 2 0.273346
OTP orthopedia homeobox 0.2723
EP400 E1A binding protein p400 0.271952
GGT1 gamma-glutamyltransferase 1 0.269867
PGF placental growth factor 0.269867
GTF2IRD1 GTF2I repeat domain containing 1 0.269521
GAGE12F G antigen 12F 0.267791
PDPN podoplanin 0.264011
PGLYRP2 peptidoglycan recognition protein 2 0.263327
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.260267
RBP1 retinol binding protein 1, cellular 0.260267
FOXL2 forkhead box L2 0.258917
CD19 CD19 molecule 0.258243
ZNF148 zinc finger protein 148 0.257572
PCDH7 protocadherin 7 0.256568
NOTCH2NL notch 2 N-terminal like 0.256568
G6PD glucose-6-phosphate dehydrogenase 0.2559
NOTCH2 notch 2 0.253908
CT45A1 cancer/testis antigen family 45, member A1 0.25259
DROSHA drosha, ribonuclease type III 0.252261
SMAD6 SMAD family member 6 0.251279
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 0.250953
WNK1 WNK lysine deficient protein kinase 1 0.250953
HPN hepsin 0.249653
RFK riboflavin kinase 0.247399
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa 0.245807
NPHP4 nephronophthisis 4 0.24486
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.244232
NFIB nuclear factor I/B 0.243918
HNF1B HNF1 homeobox B 0.243294
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.240826
CNN1 calponin 1, basic, smooth muscle 0.238706
PRDM1 PR domain containing 1, with ZNF domain 0.238406
NFIA nuclear factor I/A 0.238406
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.236921
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 0.236921
CALB1 calbindin 1, 28kDa 0.236627
FOS FBJ murine osteosarcoma viral oncogene homolog 0.234878
KRT20 keratin 20, type I 0.234302
KLF6 Kruppel-like factor 6 0.234016
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.232599
HAUS3 HAUS augmin-like complex, subunit 3 0.232599
ZMIZ1 zinc finger, MIZ-type containing 1 0.232039
KLF3 Kruppel-like factor 3 (basic) 0.232039
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.231482
KRT18 keratin 18, type I 0.231482
TUBA1C tubulin, alpha 1c 0.230656
ADCY7 adenylate cyclase 7 0.229839
HBD hemoglobin, delta 0.229032
UBP1 upstream binding protein 1 (LBP-1a) 0.225144
LATS1 large tumor suppressor kinase 1 0.225144
JUN jun proto-oncogene 0.224893
DMTN dematin actin binding protein 0.22415
PTPRC protein tyrosine phosphatase, receptor type, C 0.223906
SLC26A7 solute carrier family 26 (anion exchanger), member 7 0.223419
DMRTA1 DMRT-like family A1 0.223419
GSTA3 glutathione S-transferase alpha 3 0.223419
G6PC glucose-6-phosphatase, catalytic subunit 0.222699
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.22246
IGLV7-43 immunoglobulin lambda variable 7-43 0.222224
GSTA4 glutathione S-transferase alpha 4 0.222224
GSTA2 glutathione S-transferase alpha 2 0.221989
RAG1 recombination activating gene 1 0.221989
HRAS Harvey rat sarcoma viral oncogene homolog 0.221755
GPER1 G protein-coupled estrogen receptor 1 0.221755
OTC ornithine carbamoyltransferase 0.221291
MTF1 metal-regulatory transcription factor 1 0.221061
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.220152
RNASEH2A ribonuclease H2, subunit A 0.219928
GSTA1 glutathione S-transferase alpha 1 0.219485
ITGB8 integrin, beta 8 0.217139
YY1 YY1 transcription factor 0.21673
TCL1A T-cell leukemia/lymphoma 1A 0.215928
LAMA1 laminin, alpha 1 0.215534
GGT6 gamma-glutamyltransferase 6 0.215534
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.215534
LEPR leptin receptor 0.215341
BIRC6 baculoviral IAP repeat containing 6 0.214388
PTH parathyroid hormone 0.213833
GGTLC1 gamma-glutamyltransferase light chain 1 0.213291
CLEC12A C-type lectin domain family 12, member A 0.213112
RELN reelin 0.192272