wortmannin-6959 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the wortmannin-6959 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADCK3 aarF domain containing kinase 3
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ASB1 ankyrin repeat and SOCS box containing 1
ATG13 autophagy related 13
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C14ORF93 chromosome 14 open reading frame 93
C21ORF91 chromosome 21 open reading frame 91
C22ORF46 chromosome 22 open reading frame 46
C6ORF47 chromosome 6 open reading frame 47
CALHM2 calcium homeostasis modulator 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CDC25C cell division cycle 25C
CDH8 cadherin 8, type 2
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CLCN7 chloride channel, voltage-sensitive 7
CLIC2 chloride intracellular channel 2
COL9A3 collagen, type IX, alpha 3
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CTNND2 catenin (cadherin-associated protein), delta 2
CYLD cylindromatosis (turban tumor syndrome)
DCAF11 DDB1 and CUL4 associated factor 11
DCX doublecortin
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DTX2 deltex 2, E3 ubiquitin ligase
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR1 early growth response 1
EHBP1L1 EH domain binding protein 1-like 1
FAS Fas cell surface death receptor
FCMR Fc fragment of IgM receptor
FGGY FGGY carbohydrate kinase domain containing
FKBP1B FK506 binding protein 1B, 12.6 kDa
FRMPD1 FERM and PDZ domain containing 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
G6PC3 glucose 6 phosphatase, catalytic, 3
GLRX glutaredoxin (thioltransferase)
HBP1 HMG-box transcription factor 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HPN hepsin
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGL immunoglobulin lambda locus
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INPP5K inositol polyphosphate-5-phosphatase K
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
JRK Jrk homolog (mouse)
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIAA0141 KIAA0141
KIZ kizuna centrosomal protein
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT19P2 keratin 19 pseudogene 2
LPCAT3 lysophosphatidylcholine acyltransferase 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MED25 mediator complex subunit 25
METTL7A methyltransferase like 7A
MSMB microseminoprotein, beta-
N4BP2L2 NEDD4 binding protein 2-like 2
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NDE1 nudE neurodevelopment protein 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
ORAI3 ORAI calcium release-activated calcium modulator 3
PCDHB17P protocadherin beta 17 pseudogene
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPAP2B phosphatidic acid phosphatase type 2B
RAB2A RAB2A, member RAS oncogene family
RAD51B RAD51 paralog B
RCAN1 regulator of calcineurin 1
RFTN1 raftlin, lipid raft linker 1
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RTN2 reticulon 2
SBNO1 strawberry notch homolog 1 (Drosophila)
SF3A2 splicing factor 3a, subunit 2, 66kDa
SLAMF8 SLAM family member 8
ST7 suppression of tumorigenicity 7
STON1 stonin 1
TK2 thymidine kinase 2, mitochondrial
TMOD1 tropomodulin 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VASH1 vasohibin 1
VIPR1 vasoactive intestinal peptide receptor 1
WDR62 WD repeat domain 62
YLPM1 YLP motif containing 1
YPEL5 yippee-like 5 (Drosophila)
ZBTB40 zinc finger and BTB domain containing 40
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
ARMC6 armadillo repeat containing 6
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ATG7 autophagy related 7
BAGE B melanoma antigen
BCCIP BRCA2 and CDKN1A interacting protein
BCORL1 BCL6 corepressor-like 1
BYSL bystin-like
C12ORF29 chromosome 12 open reading frame 29
C19ORF40 chromosome 19 open reading frame 40
C5ORF30 chromosome 5 open reading frame 30
C9ORF40 chromosome 9 open reading frame 40
CAMKMT calmodulin-lysine N-methyltransferase
CAPN15 calpain 15
CCDC25 coiled-coil domain containing 25
CCDC86 coiled-coil domain containing 86
CENPJ centromere protein J
CERK ceramide kinase
CHST10 carbohydrate sulfotransferase 10
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CTSC cathepsin C
CXORF56 chromosome X open reading frame 56
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAL4 dynein, axonemal, light chain 4
EDC4 enhancer of mRNA decapping 4
ELOVL4 ELOVL fatty acid elongase 4
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOC5 exocyst complex component 5
EYA2 EYA transcriptional coactivator and phosphatase 2
FICD FIC domain containing
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HCFC2 host cell factor C2
HEATR3 HEAT repeat containing 3
HIST1H2BC histone cluster 1, H2bc
IFRD1 interferon-related developmental regulator 1
INF2 inverted formin, FH2 and WH2 domain containing
IRAK4 interleukin-1 receptor-associated kinase 4
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KPNA4 karyopherin alpha 4 (importin alpha 3)
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAMLD1 mastermind-like domain containing 1
MCOLN3 mucolipin 3
METTL8 methyltransferase like 8
MMP15 matrix metallopeptidase 15 (membrane-inserted)
NCS1 neuronal calcium sensor 1
NECAB3 N-terminal EF-hand calcium binding protein 3
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUPL2 nucleoporin like 2
NVL nuclear VCP-like
OXTR oxytocin receptor
PARD6A par-6 family cell polarity regulator alpha
PER3 period circadian clock 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
PROS1 protein S (alpha)
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RBM42 RNA binding motif protein 42
RIBC2 RIB43A domain with coiled-coils 2
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RWDD3 RWD domain containing 3
SCYL2 SCY1-like 2 (S. cerevisiae)
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC46A3 solute carrier family 46, member 3
SNHG3 small nucleolar RNA host gene 3
SPAG7 sperm associated antigen 7
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TMEM104 transmembrane protein 104
TMEM183A transmembrane protein 183A
TMEM57 transmembrane protein 57
TP53BP2 tumor protein p53 binding protein 2
TUBGCP5 tubulin, gamma complex associated protein 5
TXLNA taxilin alpha
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP36 ubiquitin specific peptidase 36
VASH2 vasohibin 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB38 zinc finger and BTB domain containing 38
ZNF205 zinc finger protein 205
ZNF253 zinc finger protein 253
ZNF324 zinc finger protein 324
ZNF675 zinc finger protein 675
ZNF767P zinc finger family member 767, pseudogene