weight loss Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Reduction inexisting body weight. (Human Phenotype Ontology, HP_0001824)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001263
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Genes

244 gene mutations causing the weight loss phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTN4 actinin, alpha 4
ADAM17 ADAM metallopeptidase domain 17
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AHR aryl hydrocarbon receptor
AIRE autoimmune regulator
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALOXE3 arachidonate lipoxygenase 3
ALPL alkaline phosphatase, liver/bone/kidney
ANXA1 annexin A1
APLN apelin
APRT adenine phosphoribosyltransferase
AQP2 aquaporin 2 (collecting duct)
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2
ATR ATR serine/threonine kinase
ATXN1 ataxin 1
ATXN1L ataxin 1-like
ATXN7 ataxin 7
BACE1 beta-site APP-cleaving enzyme 1
BAG3 BCL2-associated athanogene 3
BCL2 B-cell CLL/lymphoma 2
BCR breakpoint cluster region
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like
BDNF brain-derived neurotrophic factor
BHLHA15 basic helix-loop-helix family, member a15
BTD biotinidase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC88A coiled-coil domain containing 88A
CCR2 chemokine (C-C motif) receptor 2
CD151 CD151 molecule (Raph blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CERS1 ceramide synthase 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHD2 chromodomain helicase DNA binding protein 2
CHRM3 cholinergic receptor, muscarinic 3
CLDN1 claudin 1
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CNR1 cannabinoid receptor 1 (brain)
CNTN1 contactin 1
COL10A1 collagen, type X, alpha 1
COL19A1 collagen, type XIX, alpha 1
COL5A3 collagen, type V, alpha 3
COQ9 coenzyme Q9
CTSC cathepsin C
CTSF cathepsin F
CTSV cathepsin V
CUX1 cut-like homeobox 1
CYCS cytochrome c, somatic
CYLD cylindromatosis (turban tumor syndrome)
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DCR Down syndrome chromosome region
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DERL2 derlin 2
DGAT2 diacylglycerol O-acyltransferase 2
DMBX1 diencephalon/mesencephalon homeobox 1
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5
DSG3 desmoglein 3
DST dystonin
DUSP1 dual specificity phosphatase 1
EDNRB endothelin receptor type B
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGFR epidermal growth factor receptor
EGR2 early growth response 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELOVL4 ELOVL fatty acid elongase 4
ENG endoglin
ERCC2 excision repair cross-complementation group 2
EREG epiregulin
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FOXJ1 forkhead box J1
FOXN1 forkhead box N1
FOXP3 forkhead box P3
FSHR follicle stimulating hormone receptor
FTO fat mass and obesity associated
FZD4 frizzled class receptor 4
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GAL galanin/GMAP prepropeptide
GALC galactosylceramidase
GAN gigaxonin
GBP3 guanylate binding protein 3
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GLB1 galactosidase, beta 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLM1 golgi membrane protein 1
GPR132 G protein-coupled receptor 132
GSTZ1 glutathione S-transferase zeta 1
HAMP hepcidin antimicrobial peptide
HELLS helicase, lymphoid-specific
HEXA hexosaminidase A (alpha polypeptide)
HEXB hexosaminidase B (beta polypeptide)
HIP1 huntingtin interacting protein 1
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HOXC13 homeobox C13
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRC histidine rich calcium binding protein
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTT huntingtin
HYDIN HYDIN, axonemal central pair apparatus protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHMBP2 immunoglobulin mu binding protein 2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL10 interleukin 10
IL1R1 interleukin 1 receptor, type I
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL4R interleukin 4 receptor
INHA inhibin, alpha
INHBA inhibin, beta A
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRS2 insulin receptor substrate 2
KCNQ1OT1 KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)
KIF26A kinesin family member 26A
KITLG KIT ligand
KRT1 keratin 1, type II
LAMA2 laminin, alpha 2
LEPR leptin receptor
LHX3 LIM homeobox 3
LMNA lamin A/C
LTB lymphotoxin beta (TNF superfamily, member 3)
MAPT microtubule-associated protein tau
MBD5 methyl-CpG binding domain protein 5
MCHR1 melanin-concentrating hormone receptor 1
MECP2 methyl CpG binding protein 2
MED30 mediator complex subunit 30
MEFV Mediterranean fever
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP7 matrix metallopeptidase 7
MPV17 MpV17 mitochondrial inner membrane protein
MPZL3 myelin protein zero-like 3
MTM1 myotubularin 1
NAGLU N-acetylglucosaminidase, alpha
NAV2 neuron navigator 2
NCOA3 nuclear receptor coactivator 3
NDFIP1 Nedd4 family interacting protein 1
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NFE2L2 nuclear factor, erythroid 2-like 2
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NKX2-3 NK2 homeobox 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOTCH3 notch 3
NPC1 Niemann-Pick disease, type C1
NPC2 Niemann-Pick disease, type C2
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR3C2 nuclear receptor subfamily 3, group C, member 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRG1 neuregulin 1
OSTM1 osteopetrosis associated transmembrane protein 1
OTC ornithine carbamoyltransferase
PARK7 parkinson protein 7
PARL presenilin associated, rhomboid-like
PAX7 paired box 7
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PDYN prodynorphin
PFDN1 prefoldin subunit 1
PGLYRP1 peptidoglycan recognition protein 1
PGLYRP2 peptidoglycan recognition protein 2
PGLYRP3 peptidoglycan recognition protein 3
PGLYRP4 peptidoglycan recognition protein 4
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKP3 plakophilin 3
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLAU plasminogen activator, urokinase
PLG plasminogen
POLG polymerase (DNA directed), gamma
POU4F3 POU class 4 homeobox 3
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRF1 perforin 1 (pore forming protein)
PRKCDBP protein kinase C, delta binding protein
PRX periaxin
PSAP prosaposin
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
PTPRS protein tyrosine phosphatase, receptor type, S
PTRH2 peptidyl-tRNA hydrolase 2
PURA purine-rich element binding protein A
RAB27A RAB27A, member RAS oncogene family
RAB8A RAB8A, member RAS oncogene family
RAG2 recombination activating gene 2
RB1 retinoblastoma 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGN regucalcin
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RND3 Rho family GTPase 3
RORC RAR-related orphan receptor C
RYK receptor-like tyrosine kinase
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN2A sodium channel, voltage gated, type II alpha subunit
SCNN1G sodium channel, non voltage gated 1 gamma subunit
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFTPC surfactant protein C
SFTPD surfactant protein D
SHARPIN SHANK-associated RH domain interactor
SKIL SKI-like proto-oncogene
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC19A3 solute carrier family 19 (thiamine transporter), member 3
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOCS3 suppressor of cytokine signaling 3
STX11 syntaxin 11
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TERC telomerase RNA component
TET2 tet methylcytosine dioxygenase 2
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLR2 toll-like receptor 2
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TP73 tumor protein p73
TPMT thiopurine S-methyltransferase
TPP2 tripeptidyl peptidase II
TRAF2 TNF receptor-associated factor 2
TRPV5 transient receptor potential cation channel, subfamily V, member 5
TSLP thymic stromal lymphopoietin
TWIST2 twist family bHLH transcription factor 2
TWSG1 twisted gastrulation BMP signaling modulator 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WASF1 WAS protein family, member 1
WWOX WW domain containing oxidoreductase
ZDHHC13 zinc finger, DHHC-type containing 13
ZMPSTE24 zinc metallopeptidase STE24