weibel-palade body Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses. (Gene Ontology, GO_0033093)
External Link http://amigo.geneontology.org/amigo/term/GO:0033093
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Genes

4 proteins localized to the weibel-palade body cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
ECE1 endothelin converting enzyme 1
EDN1 endothelin 1
UNC13D unc-13 homolog D (C. elegans)
VWF von Willebrand factor