weibel-palade body Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses. (Gene Ontology, GO_0033093)
Similar Terms
Downloads & Tools

Genes

87 proteins co-occuring with the weibel-palade body cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
VWF von Willebrand factor 2.85941
F8 coagulation factor VIII, procoagulant component 2.27675
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 2.20594
ANGPT2 angiopoietin 2 1.4198
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.35102
HBA2 hemoglobin, alpha 2 1.28409
HBA1 hemoglobin, alpha 1 1.27717
CD34 CD34 molecule 0.981959
RAB27A RAB27A, member RAS oncogene family 0.974198
CD63 CD63 molecule 0.943059
SELE selectin E 0.836433
STXBP5 syntaxin binding protein 5 (tomosyn) 0.82037
CXCL8 chemokine (C-X-C motif) ligand 8 0.777755
AFTPH aftiphilin 0.772275
PLAT plasminogen activator, tissue 0.764072
MMRN1 multimerin 1 0.734666
CDH5 cadherin 5, type 2 (vascular endothelium) 0.723026
ACE angiotensin I converting enzyme 0.720351
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.696026
MCAM melanoma cell adhesion molecule 0.68639
SELPLG selectin P ligand 0.675934
ECE1 endothelin converting enzyme 1 0.675499
PROM1 prominin 1 0.666827
VCAM1 vascular cell adhesion molecule 1 0.662503
MAMDC4 MAM domain containing 4 0.65388
ICAM1 intercellular adhesion molecule 1 0.635013
RALGDS ral guanine nucleotide dissociation stimulator 0.620954
FN1 fibronectin 1 0.593072
KDR kinase insert domain receptor 0.580086
KLF2 Kruppel-like factor 2 0.569664
RAB3D RAB3D, member RAS oncogene family 0.560528
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.557214
NOS3 nitric oxide synthase 3 (endothelial cell) 0.552251
ANGPT1 angiopoietin 1 0.52675
FLT1 fms-related tyrosine kinase 1 0.490944
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 0.476429
RAB37 RAB37, member RAS oncogene family 0.435775
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) 0.430253
IGFBP7 insulin-like growth factor binding protein 7 0.425924
SYTL4 synaptotagmin-like 4 0.418077
CCL26 chemokine (C-C motif) ligand 26 0.402859
RAP2B RAP2B, member of RAS oncogene family 0.401693
PDPN podoplanin 0.400527
SAR1A secretion associated, Ras related GTPase 1A 0.39471
ARF3 ADP-ribosylation factor 3 0.394323
RAB1B RAB1B, member RAS oncogene family 0.391615
THBD thrombomodulin 0.384665
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.376586
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.373516
VEGFA vascular endothelial growth factor A 0.37045
EDN1 endothelin 1 0.37045
STXBP3 syntaxin binding protein 3 0.367771
RAB15 RAB15, member RAS oncogene family 0.358609
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.354802
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.34645
STX2 syntaxin 2 0.343042
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 0.332848
ANXA8 annexin A8 0.332848
NSF N-ethylmaleimide-sensitive factor 0.331719
IL11 interleukin 11 0.32345
CLEC11A C-type lectin domain family 11, member A 0.321201
ENG endoglin 0.321201
PRKD2 protein kinase D2 0.319328
ECE2 endothelin converting enzyme 2 0.312597
PLG plasminogen 0.301797
PROX1 prospero homeobox 1 0.295119
F2R coagulation factor II (thrombin) receptor 0.288829
SYNRG synergin, gamma 0.287352
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.286983
STX4 syntaxin 4 0.285876
S100A10 S100 calcium binding protein A10 0.239197
C2 complement component 2 0.227041
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.21716
SNX17 sorting nexin 17 0.209513
TNF tumor necrosis factor 0.204039
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.203361
ECM1 extracellular matrix protein 1 0.197993
IGLL5 immunoglobulin lambda-like polypeptide 5 0.191456
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.179459
VEZF1 vascular endothelial zinc finger 1 0.171149
FGF1 fibroblast growth factor 1 (acidic) 0.167856
CLCN2 chloride channel, voltage-sensitive 2 0.164315
CD36 CD36 molecule (thrombospondin receptor) 0.162546
S1PR3 sphingosine-1-phosphate receptor 3 0.161905
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.159658
EDA ectodysplasin A 0.158882
APLNR apelin receptor 0.156863