waist-hip ratio Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description The waist circumference measurement divided by the hip circumference measurement. For both men and women, a waist-to-hip ratio (WHR) of 1.0 or higher is considered at risk for undesirable health consequences, such as heart disease and ailments associated with OVERWEIGHT. A healthy WHR is 0.90 or less for men, and 0.80 or less for women. (National Center for Chronic Disease Prevention and Health Promotion, 2004) (Experimental Factor Ontology, EFO_0004343)
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89 genes associated with the disease waist-hip ratio in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
AADACL4 arylacetamide deacetylase-like 4
ACOT13 acyl-CoA thioesterase 13
AKAP12 A kinase (PRKA) anchor protein 12
ALPI alkaline phosphatase, intestinal
ANLN anillin, actin binding protein
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
BBX bobby sox homolog (Drosophila)
BTNL2 butyrophilin-like 2
CCND3 cyclin D3
CNTNAP2 contactin associated protein-like 2
COL4A1 collagen, type IV, alpha 1
CPEB4 cytoplasmic polyadenylation element binding protein 4
CSMD3 CUB and Sushi multiple domains 3
CTNNA2 catenin (cadherin-associated protein), alpha 2
DNM3 dynamin 3
DPY19L2 dpy-19-like 2 (C. elegans)
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
EVA1A eva-1 homolog A (C. elegans)
FAM13A family with sequence similarity 13, member A
FRMD3 FERM domain containing 3
FTO fat mass and obesity associated
FYN FYN proto-oncogene, Src family tyrosine kinase
GABPB1 GA binding protein transcription factor, beta subunit 1
GMDS GDP-mannose 4,6-dehydratase
GPC6 glypican 6
GRID1 glutamate receptor, ionotropic, delta 1
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4
IL12A interleukin 12A
IL6 interleukin 6
IMPG1 interphotoreceptor matrix proteoglycan 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
JAKMIP1 janus kinase and microtubule interacting protein 1
JAM3 junctional adhesion molecule 3
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KIAA0895 KIAA0895
KIF13B kinesin family member 13B
KIF5B kinesin family member 5B
LRP1B low density lipoprotein receptor-related protein 1B
MACROD2 MACRO domain containing 2
MED20 mediator complex subunit 20
MTSS1 metastasis suppressor 1
MYO7B myosin VIIB
NEB nebulin
NISCH nischarin
NPTN neuroplastin
NRG2 neuregulin 2
NT5DC4 5'-nucleotidase domain containing 4
OPCML opioid binding protein/cell adhesion molecule-like
OR51I2 olfactory receptor, family 51, subfamily I, member 2
PACRG PARK2 co-regulated
PAMR1 peptidase domain containing associated with muscle regeneration 1
PAQR4 progestin and adipoQ receptor family member IV
PCDH7 protocadherin 7
PCNXL2 pecanex-like 2 (Drosophila)
PITRM1 pitrilysin metallopeptidase 1
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLA2G2E phospholipase A2, group IIE
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLB1 phospholipase B1
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1
PNPLA1 patatin-like phospholipase domain containing 1
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTPRR protein tyrosine phosphatase, receptor type, R
RNF13 ring finger protein 13
RSPO3 R-spondin 3
SCFD2 sec1 family domain containing 2
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SIK3 SIK family kinase 3
SIPA1L2 signal-induced proliferation-associated 1 like 2
SIRPA signal-regulatory protein alpha
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
STXBP6 syntaxin binding protein 6 (amisyn)
SYN2 synapsin II
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBX15 T-box 15
TCEA2 transcription elongation factor A (SII), 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM108 transmembrane protein 108
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TOB1 transducer of ERBB2, 1
VAV3 vav 3 guanine nucleotide exchange factor
VWDE von Willebrand factor D and EGF domains
ZNF521 zinc finger protein 521
ZNRF3 zinc and ring finger 3