visceral leishmaniasis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver. (Human Disease Ontology, DOID_9146)
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Genes

187 genes co-occuring with the disease visceral leishmaniasis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PKD2L1 polycystic kidney disease 2-like 1 1.98017
KRT39 keratin 39, type I 1.80066
CD4 CD4 molecule 1.75868
MON2 MON2 homolog (S. cerevisiae) 1.46583
ERMARD ER membrane-associated RNA degradation 1.37774
IL10 interleukin 10 1.35986
PGD phosphogluconate dehydrogenase 1.34504
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 1.16179
FAM120B family with sequence similarity 120B 1.09167
PHF10 PHD finger protein 10 1.08999
NELFCD negative elongation factor complex member C/D 1.0753
NOS2 nitric oxide synthase 2, inducible 1.05597
EZR ezrin 1.05387
TNF tumor necrosis factor 1.03872
LONP1 lon peptidase 1, mitochondrial 1.00963
IL4 interleukin 4 0.984321
ALB albumin 0.966244
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 0.920498
HAMP hepcidin antimicrobial peptide 0.910199
LHCGR luteinizing hormone/choriogonadotropin receptor 0.89582
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.88393
LMLN leishmanolysin-like (metallopeptidase M8 family) 0.876966
TGFB1 transforming growth factor, beta 1 0.873281
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.869187
NUTF2 nuclear transport factor 2 0.866321
MGAT4C MGAT4 family, member C 0.863456
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.863046
LRRC25 leucine rich repeat containing 25 0.857724
ARG1 arginase 1 0.823308
TNP1 transition protein 1 (during histone to protamine replacement) 0.816745
GPI glucose-6-phosphate isomerase 0.796642
RRAGC Ras-related GTP binding C 0.795411
IFNG interferon, gamma 0.790492
IL2 interleukin 2 0.781479
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 0.757378
MAF1 MAF1 homolog (S. cerevisiae) 0.739894
TCHH trichohyalin 0.725716
FABP9 fatty acid binding protein 9, testis 0.724098
FOXP3 forkhead box P3 0.706351
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) 0.680697
TLR2 toll-like receptor 2 0.674713
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) 0.658422
TIMELESS timeless circadian clock 0.650903
MRC1 mannose receptor, C type 1 0.644192
GSX1 GS homeobox 1 0.641039
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.624927
CD79A CD79a molecule, immunoglobulin-associated alpha 0.624927
CCL21 chemokine (C-C motif) ligand 21 0.617877
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) 0.607714
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.593285
APOE apolipoprotein E 0.592116
RPS3A ribosomal protein S3A 0.583552
ODC1 ornithine decarboxylase 1 0.569941
DOHH deoxyhypusine hydroxylase/monooxygenase 0.566054
TBX21 T-box 21 0.565277
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 0.560227
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 0.55518
IFNGR1 interferon gamma receptor 1 0.54393
CXCL10 chemokine (C-X-C motif) ligand 10 0.540829
ANXA5 annexin A5 0.535022
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.520346
MBL2 mannose-binding lectin (protein C) 2, soluble 0.514571
TLR9 toll-like receptor 9 0.514186
CCL16 chemokine (C-C motif) ligand 16 0.509576
CYLD cylindromatosis (turban tumor syndrome) 0.503824
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.484364
CCL4 chemokine (C-C motif) ligand 4 0.480945
CCL1 chemokine (C-C motif) ligand 1 0.474119
CCL5 chemokine (C-C motif) ligand 5 0.468819
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.463149
DHFR dihydrofolate reductase 0.463149
TSPO translocator protein (18kDa) 0.455224
CCL24 chemokine (C-C motif) ligand 24 0.45447
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.448817
DUSP6 dual specificity phosphatase 6 0.443547
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.440914
MAPK1 mitogen-activated protein kinase 1 0.434524
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 0.433021
BDKRB2 bradykinin receptor B2 0.418019
LECT2 leukocyte cell-derived chemotaxin 2 0.416896
ZNF79 zinc finger protein 79 0.404557
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.398589
CSN2 casein beta 0.397843
CXCR4 chemokine (C-X-C motif) receptor 4 0.392257
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.390397
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 0.390397
CRP C-reactive protein, pentraxin-related 0.389653
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.375179
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.374438
CLEC4M C-type lectin domain family 4, member M 0.371477
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.36741
CD1D CD1d molecule 0.362978
SRM spermidine synthase 0.362609
STAT1 signal transducer and activator of transcription 1, 91kDa 0.361502
DBT dihydrolipoamide branched chain transacylase E2 0.359657
ATP2A3 ATPase, Ca++ transporting, ubiquitous 0.359657
CCL19 chemokine (C-C motif) ligand 19 0.358183
CAT catalase 0.358183
PRF1 perforin 1 (pore forming protein) 0.354868
DNAH8 dynein, axonemal, heavy chain 8 0.351555
CCL2 chemokine (C-C motif) ligand 2 0.348614
XDH xanthine dehydrogenase 0.342372
PEPD peptidase D 0.33944
IRF1 interferon regulatory factor 1 0.337608
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.33651
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.334315
ZBTB17 zinc finger and BTB domain containing 17 0.331025
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.325916
FASLG Fas ligand (TNF superfamily, member 6) 0.323002
TLR4 toll-like receptor 4 0.319363
SRI sorcin 0.317182
TMPRSS13 transmembrane protease, serine 13 0.316819
G6PD glucose-6-phosphate dehydrogenase 0.315729
IREB2 iron-responsive element binding protein 2 0.311739
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 0.31029
STIP1 stress-induced phosphoprotein 1 0.308842
IL27 interleukin 27 0.305948
VIL1 villin 1 0.302698
CD28 CD28 molecule 0.302337
PGLYRP1 peptidoglycan recognition protein 1 0.301976
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 0.300894
CCR3 chemokine (C-C motif) receptor 3 0.297651
CXCR2 chemokine (C-X-C motif) receptor 2 0.287952
CCL3 chemokine (C-C motif) ligand 3 0.287952
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 0.284728
SPAG7 sperm associated antigen 7 0.281868
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.280796
SKP1 S-phase kinase-associated protein 1 0.280439
IL4R interleukin 4 receptor 0.276514
LAMP2 lysosomal-associated membrane protein 2 0.275801
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 0.274376
HSPA1L heat shock 70kDa protein 1-like 0.272953
PPA1 pyrophosphatase (inorganic) 1 0.270464
TLR7 toll-like receptor 7 0.269753
KRT84 keratin 84, type II 0.266558
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.26266
MGAM maltase-glucoamylase 0.259124
ALYREF Aly/REF export factor 0.251015
TBP TATA box binding protein 0.249257
HDAC11 histone deacetylase 11 0.249257
LPO lactoperoxidase 0.248203
CD209 CD209 molecule 0.246799
SNORA29 small nucleolar RNA, H/ACA box 29 0.246098
CCR7 chemokine (C-C motif) receptor 7 0.246098
AURKAIP1 aurora kinase A interacting protein 1 0.243995
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.241546
STX11 syntaxin 11 0.240497
CD40 CD40 molecule, TNF receptor superfamily member 5 0.240497
ADA adenosine deaminase 0.239101
SRGN serglycin 0.237706
IL2RB interleukin 2 receptor, beta 0.237357
GPANK1 G patch domain and ankyrin repeats 1 0.23666
THY1 Thy-1 cell surface antigen 0.233878
MDH1 malate dehydrogenase 1, NAD (soluble) 0.228679
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.226262
IL6 interleukin 6 0.225229
LMAN1 lectin, mannose-binding, 1 0.223853
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.222822
C1QA complement component 1, q subcomponent, A chain 0.212271
HLA-B major histocompatibility complex, class I, B 0.211261
TOP1 topoisomerase (DNA) I 0.211261
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 0.209248
IL18 interleukin 18 0.207578
MYD88 myeloid differentiation primary response 88 0.199033
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 0.19742
STAT4 signal transducer and activator of transcription 4 0.194548
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 0.1936
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 0.189859
HLA-G major histocompatibility complex, class I, G 0.180367
CXCL3 chemokine (C-X-C motif) ligand 3 0.180084
TREH trehalase (brush-border membrane glycoprotein) 0.179239
LY75 lymphocyte antigen 75 0.178403
UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) 0.177576
CTRL chymotrypsin-like 0.177301
PDPN podoplanin 0.176485
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.175947
UNC13D unc-13 homolog D (C. elegans) 0.175411
CSN1S1 casein alpha s1 0.171785
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.170054
CTSL cathepsin L 0.170054
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.169571
CCL26 chemokine (C-C motif) ligand 26 0.165655
CD5 CD5 molecule 0.162908
CD86 CD86 molecule 0.162908
IRF2 interferon regulatory factor 2 0.162306
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.159302
LPA lipoprotein, Lp(a) 0.158097