very-low-density lipoprotein particle Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm. It is found in blood and transports endogenous products (newly synthesized cholesterol and triglycerides) from the liver. (Gene Ontology, GO_0034361)
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260 proteins co-occuring with the very-low-density lipoprotein particle cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
APOB apolipoprotein B 4.42745
LPL lipoprotein lipase 3.70192
APOE apolipoprotein E 3.52326
APOC3 apolipoprotein C-III 2.90856
LPA lipoprotein, Lp(a) 2.88964
COG2 component of oligomeric golgi complex 2 2.65768
APOA1 apolipoprotein A-I 2.61375
CETP cholesteryl ester transfer protein, plasma 2.52485
INS insulin 2.50294
LCAT lecithin-cholesterol acyltransferase 2.42333
APOA2 apolipoprotein A-II 2.34321
MTTP microsomal triglyceride transfer protein 2.27363
MYDGF myeloid-derived growth factor 2.1654
LDLR low density lipoprotein receptor 2.12385
APOC2 apolipoprotein C-II 1.86762
LIPC lipase, hepatic 1.86211
ALB albumin 1.8266
VLDLR very low density lipoprotein receptor 1.72307
PLTP phospholipid transfer protein 1.63123
APOC1 apolipoprotein C-I 1.60301
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.59257
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 1.58679
APOA5 apolipoprotein A-V 1.58334
USF1 upstream transcription factor 1 1.37243
CRP C-reactive protein, pentraxin-related 1.34065
SREBF1 sterol regulatory element binding transcription factor 1 1.27664
SCARB1 scavenger receptor class B, member 1 1.26445
DGAT2 diacylglycerol O-acyltransferase 2 1.25232
CSN1S1 casein alpha s1 1.25075
FASN fatty acid synthase 1.24341
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.2314
TGM4 transglutaminase 4 1.19623
CHD1L chromodomain helicase DNA binding protein 1-like 1.17055
LEP leptin 1.16184
PPARA peroxisome proliferator-activated receptor alpha 1.15109
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.12296
PON1 paraoxonase 1 1.11021
ANGPTL3 angiopoietin-like 3 1.07308
DGAT1 diacylglycerol O-acyltransferase 1 1.06549
GCG glucagon 1.06347
APOD apolipoprotein D 1.06347
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.05387
LIPG lipase, endothelial 1.04532
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.02082
GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 1.01387
F7 coagulation factor VII (serum prothrombin conversion accelerator) 1.0109
APOF apolipoprotein F 1.00744
SHBG sex hormone-binding globulin 1.0035
CES1 carboxylesterase 1 0.963588
SREBF2 sterol regulatory element binding transcription factor 2 0.960707
ANGPTL4 angiopoietin-like 4 0.955917
HCAR2 hydroxycarboxylic acid receptor 2 0.935488
COG1 component of oligomeric golgi complex 1 0.932658
PEMT phosphatidylethanolamine N-methyltransferase 0.927483
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 0.921386
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.914842
PPARG peroxisome proliferator-activated receptor gamma 0.905531
TGFA transforming growth factor, alpha 0.905067
SOD2 superoxide dismutase 2, mitochondrial 0.894868
MANF mesencephalic astrocyte-derived neurotrophic factor 0.891169
CD36 CD36 molecule (thrombospondin receptor) 0.863528
CEL carboxyl ester lipase 0.863528
TTPA tocopherol (alpha) transfer protein 0.845155
SOAT1 sterol O-acyltransferase 1 0.835974
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.833679
LIPE lipase, hormone-sensitive 0.824041
PCSK9 proprotein convertase subtilisin/kexin type 9 0.814864
APOBR apolipoprotein B receptor 0.813946
PNLIP pancreatic lipase 0.803396
SDC2 syndecan 2 0.788733
ALPPL2 alkaline phosphatase, placental-like 2 0.787817
ALPL alkaline phosphatase, liver/bone/kidney 0.787359
ALPP alkaline phosphatase, placental 0.786902
GPX4 glutathione peroxidase 4 0.782784
GPX5 glutathione peroxidase 5 0.78004
PLG plasminogen 0.775014
PNPLA3 patatin-like phospholipase domain containing 3 0.770451
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.764072
CIDEB cell death-inducing DFFA-like effector b 0.763162
GPX1 glutathione peroxidase 1 0.760887
SCARB2 scavenger receptor class B, member 2 0.758161
FABP2 fatty acid binding protein 2, intestinal 0.755891
GGT1 gamma-glutamyltransferase 1 0.752716
CAT catalase 0.747737
NPC1L1 NPC1-like 1 0.733768
PCYOX1 prenylcysteine oxidase 1 0.732422
SOAT2 sterol O-acyltransferase 2 0.722134
APOA4 apolipoprotein A-IV 0.714126
AADAC arylacetamide deacetylase 0.696465
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.689451
HMGA2 high mobility group AT-hook 2 0.68639
IGLV5-48 immunoglobulin lambda variable 5-48 (non-functional) 0.685954
RETN resistin 0.682463
ACSS2 acyl-CoA synthetase short-chain family member 2 0.679849
F3 coagulation factor III (thromboplastin, tissue factor) 0.675934
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 0.675065
ACLY ATP citrate lyase 0.668559
PCSK7 proprotein convertase subtilisin/kexin type 7 0.647862
LPIN2 lipin 2 0.647433
SAA1 serum amyloid A1 0.645287
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.635868
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.629892
TNF tumor necrosis factor 0.625206
RBP4 retinol binding protein 4, plasma 0.62393
IL6 interleukin 6 0.623079
MLXIPL MLX interacting protein-like 0.617557
CES3 carboxylesterase 3 0.605284
IRF6 interferon regulatory factor 6 0.604017
PLIN2 perilipin 2 0.603596
PLAT plasminogen activator, tissue 0.596855
G6PD glucose-6-phosphate dehydrogenase 0.587199
PLA2G1B phospholipase A2, group IB (pancreas) 0.585105
LRP2 low density lipoprotein receptor-related protein 2 0.584686
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.583849
SCARF1 scavenger receptor class F, member 1 0.579251
DLL1 delta-like 1 (Drosophila) 0.577999
LTF lactotransferrin 0.572162
PNPLA2 patatin-like phospholipase domain containing 2 0.566754
INSR insulin receptor 0.545648
HBA2 hemoglobin, alpha 2 0.544
NR1H4 nuclear receptor subfamily 1, group H, member 4 0.543176
LPIN1 lipin 1 0.53413
VCAM1 vascular cell adhesion molecule 1 0.525113
HBA1 hemoglobin, alpha 1 0.518981
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.518573
F2 coagulation factor II (thrombin) 0.515716
FOXO1 forkhead box O1 0.503099
SAA2 serum amyloid A2 0.502288
ACE angiotensin I converting enzyme 0.500664
CP ceruloplasmin (ferroxidase) 0.499042
PLA2G12B phospholipase A2, group XIIB 0.499042
LYPLA1 lysophospholipase I 0.486096
TTR transthyretin 0.485289
APOH apolipoprotein H (beta-2-glycoprotein I) 0.471208
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 0.4676
SUGP1 SURP and G patch domain containing 1 0.453621
FADS1 fatty acid desaturase 1 0.452427
GLT8D2 glycosyltransferase 8 domain containing 2 0.452029
SRR serine racemase 0.447259
GSR glutathione reductase 0.446862
PON2 paraoxonase 2 0.445275
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.443689
TF transferrin 0.438542
CTSC cathepsin C 0.437356
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 0.431829
CPT1A carnitine palmitoyltransferase 1A (liver) 0.428678
SAA4 serum amyloid A4, constitutive 0.420428
FADS2 fatty acid desaturase 2 0.41886
APOM apolipoprotein M 0.418468
NR1H3 nuclear receptor subfamily 1, group H, member 3 0.415337
IRS1 insulin receptor substrate 1 0.414555
CCDC92 coiled-coil domain containing 92 0.413773
LPIN3 lipin 3 0.409869
IGF1 insulin-like growth factor 1 (somatomedin C) 0.406361
APOC4 apolipoprotein C-IV 0.400916
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.392001
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.391615
HP haptoglobin 0.386593
MGAM maltase-glucoamylase 0.382354
HPR haptoglobin-related protein 0.369684
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 0.35899
PROS1 protein S (alpha) 0.354422
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.349863
ACACA acetyl-CoA carboxylase alpha 0.347967
ALLC allantoicase 0.347587
LMF1 lipase maturation factor 1 0.346829
FGF21 fibroblast growth factor 21 0.346829
CBY1 chibby homolog 1 (Drosophila) 0.343799
GGT2 gamma-glutamyltransferase 2 0.338884
RELN reelin 0.333979
APOO apolipoprotein O 0.330589
LRP1B low density lipoprotein receptor-related protein 1B 0.330589
ICAM1 intercellular adhesion molecule 1 0.319702
SDC1 syndecan 1 0.317082
CCL2 chemokine (C-C motif) ligand 2 0.314465
ZNF664 zinc finger protein 664 0.312971
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.312971
PTH parathyroid hormone 0.312597
TRIB1 tribbles pseudokinase 1 0.306632
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 0.298455
LDLRAP1 low density lipoprotein receptor adaptor protein 1 0.291787
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 0.290678
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 0.288829
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.285138
APOL1 apolipoprotein L, 1 0.284769
PON3 paraoxonase 3 0.283663
METTL7B methyltransferase like 7B 0.278509
SULF2 sulfatase 2 0.278141
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 0.277774
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 0.277406
STARD8 StAR-related lipid transfer (START) domain containing 8 0.276304
GPBAR1 G protein-coupled bile acid receptor 1 0.273367
LRP10 low density lipoprotein receptor-related protein 10 0.272267
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.272267
IRS2 insulin receptor substrate 2 0.271167
REN renin 0.268237
TM6SF2 transmembrane 6 superfamily member 2 0.267139
STAP2 signal transducing adaptor family member 2 0.256561
CD44 CD44 molecule (Indian blood group) 0.256197
CROT carnitine O-octanoyltransferase 0.255107
SAR1B secretion associated, Ras related GTPase 1B 0.251839
IL1B interleukin 1, beta 0.248578
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.248216
G6PC glucose-6-phosphatase, catalytic subunit 0.246046
IFNL3 interferon, lambda 3 0.243519
C3 complement component 3 0.238837
SORT1 sortilin 1 0.238119
GLP1R glucagon-like peptide 1 receptor 0.237401
LTB4R leukotriene B4 receptor 0.234174
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.232744
F9 coagulation factor IX 0.230958
PPARD peroxisome proliferator-activated receptor delta 0.230601
P4HB prolyl 4-hydroxylase, beta polypeptide 0.229532
AMY2A amylase, alpha 2A (pancreatic) 0.227752
POMC proopiomelanocortin 0.22385
PCSK5 proprotein convertase subtilisin/kexin type 5 0.222083
ACACB acetyl-CoA carboxylase beta 0.22173
FABP4 fatty acid binding protein 4, adipocyte 0.219969
SELE selectin E 0.214017
TSC22D4 TSC22 domain family, member 4 0.212627
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.209858
TCHH trichohyalin 0.205059
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.203361
LSR lipolysis stimulated lipoprotein receptor 0.202684
VAT1 vesicle amine transport 1 0.198991
GCK glucokinase (hexokinase 4) 0.196669
CER1 cerberus 1, DAN family BMP antagonist 0.194371
CSTB cystatin B (stefin B) 0.191777
ZNHIT1 zinc finger, HIT-type containing 1 0.191456
THADA thyroid adenoma associated 0.188905
HNF4A hepatocyte nuclear factor 4, alpha 0.18859
TXNL4B thioredoxin-like 4B 0.18702
STX8 syntaxin 8 0.186708
SPINK5 serine peptidase inhibitor, Kazal type 5 0.186397
GSTA3 glutathione S-transferase alpha 3 0.186087
NOS3 nitric oxide synthase 3 (endothelial cell) 0.185777
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 0.184853
GSTA2 glutathione S-transferase alpha 2 0.184547
GSTA4 glutathione S-transferase alpha 4 0.184547
GSTA1 glutathione S-transferase alpha 1 0.182723
A1CF APOBEC1 complementation factor 0.18093
DAND5 DAN domain family member 5, BMP antagonist 0.18093
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.179752
DHRS7 dehydrogenase/reductase (SDR family) member 7 0.179167
BHMT betaine--homocysteine S-methyltransferase 0.178011
LEPR leptin receptor 0.177724
GPX3 glutathione peroxidase 3 0.175745
ACSL1 acyl-CoA synthetase long-chain family member 1 0.174911
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.173814
DNAH10 dynein, axonemal, heavy chain 10 0.173003
ACSL3 acyl-CoA synthetase long-chain family member 3 0.173003
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.171937
TGM5 transglutaminase 5 0.170371
REPIN1 replication initiator 1 0.166643
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 0.165231
MLX MLX, MAX dimerization protein 0.164315
CD81 CD81 molecule 0.162117
GIP gastric inhibitory polypeptide 0.160863
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.159658
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.156863