urethral stenosis Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Abnormal narrowing of the urethra. (Human Phenotype Ontology, HP_0008661)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0008661
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Genes

365 genes associated with the urethral stenosis phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
HLA-DRA major histocompatibility complex, class II, DR alpha 3.58248
IL23R interleukin 23 receptor 2.70176
STAT4 signal transducer and activator of transcription 4 2.45852
C6ORF10 chromosome 6 open reading frame 10 2.41337
LPP LIM domain containing preferred translocation partner in lipoma 2.40453
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.2832
NOTCH4 notch 4 2.26447
TNXB tenascin XB 2.18646
KIAA1109 KIAA1109 2.15575
OTUD3 OTU deubiquitinase 3 2.03027
ATXN2 ataxin 2 1.99969
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.97257
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 1.97023
ERBB3 erb-b2 receptor tyrosine kinase 3 1.97023
BAG6 BCL2-associated athanogene 6 1.93767
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 1.91341
MCCD1 mitochondrial coiled-coil domain 1 1.88979
C5ORF56 chromosome 5 open reading frame 56 1.88157
HLA-F-AS1 HLA-F antisense RNA 1 1.85741
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.8253
CLEC16A C-type lectin domain family 16, member A 1.82094
HLA-DMB major histocompatibility complex, class II, DM beta 1.80534
C2 complement component 2 1.7963
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 1.79316
CD58 CD58 molecule 1.77862
NKX2-3 NK2 homeobox 3 1.77797
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 1.76279
CTSH cathepsin H 1.73304
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.72862
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 1.72225
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 1.71244
IL13 interleukin 13 1.71244
EVI5 ecotropic viral integration site 5 1.70448
TAGAP T-cell activation RhoGTPase activating protein 1.69824
ZGPAT zinc finger, CCCH-type with G patch domain 1.68928
CFB complement factor B 1.67895
TRAF1 TNF receptor-associated factor 1 1.65584
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.65584
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 1.63535
AHI1 Abelson helper integration site 1 1.63258
TNPO3 transportin 3 1.61591
LACC1 laccase (multicopper oxidoreductase) domain containing 1 1.61479
BTNL2 butyrophilin-like 2 1.60965
PUS10 pseudouridylate synthase 10 1.59602
TNIP1 TNFAIP3 interacting protein 1 1.59516
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.58949
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.58272
GSDMB gasdermin B 1.58149
FGFR1OP FGFR1 oncogene partner 1.5635
MST1 macrophage stimulating 1 1.56093
MMEL1 membrane metallo-endopeptidase-like 1 1.55262
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.52822
GLIS3 GLIS family zinc finger 3 1.5264
ANKRD55 ankyrin repeat domain 55 1.51142
CD86 CD86 molecule 1.51005
SIRPG signal-regulatory protein gamma 1.5037
IL2RA interleukin 2 receptor, alpha 1.49777
HLA-DMA major histocompatibility complex, class II, DM alpha 1.49616
CCR6 chemokine (C-C motif) receptor 6 1.49511
CD69 CD69 molecule 1.48604
IFIH1 interferon induced with helicase C domain 1 1.48419
PRKD2 protein kinase D2 1.47408
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.47083
METTL1 methyltransferase like 1 1.45654
CDSN corneodesmosin 1.45613
PSORS1C1 psoriasis susceptibility 1 candidate 1 1.44489
POU5F1 POU class 5 homeobox 1 1.44469
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.44286
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase 1.41863
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.41863
SP140 SP140 nuclear body protein 1.41863
PTPN2 protein tyrosine phosphatase, non-receptor type 2 1.40853
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 1.4071
TCF19 transcription factor 19 1.40555
SLC30A7 solute carrier family 30 (zinc transporter), member 7 1.40061
KIF1B kinesin family member 1B 1.40061
BANK1 B-cell scaffold protein with ankyrin repeats 1 1.39169
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 1.38086
BRD2 bromodomain containing 2 1.38039
NCOA5 nuclear receptor coactivator 5 1.37994
SPRED2 sprouty-related, EVH1 domain containing 2 1.37782
PPT2 palmitoyl-protein thioesterase 2 1.36169
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 1.35917
ZMIZ1 zinc finger, MIZ-type containing 1 1.35865
STAT2 signal transducer and activator of transcription 2, 113kDa 1.35521
LOC100506459 uncharacterized LOC100506459 1.34987
ITLN1 intelectin 1 (galactofuranose binding) 1.34137
JAZF1 JAZF zinc finger 1 1.34034
C1ORF106 chromosome 1 open reading frame 106 1.32793
ATXN2L ataxin 2-like 1.32793
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 1.32793
HORMAD2 HORMA domain containing 2 1.32793
SBNO2 strawberry notch homolog 2 (Drosophila) 1.32521
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 1.31934
ICOSLG inducible T-cell co-stimulator ligand 1.31768
AGER advanced glycosylation end product-specific receptor 1.31377
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 1.30781
MALT1 MALT1 paracaspase 1.30781
CD247 CD247 molecule 1.30781
CD6 CD6 molecule 1.29386
IGF2 insulin-like growth factor 2 1.29386
PHRF1 PHD and ring finger domains 1 1.28383
DKKL1 dickkopf-like 1 1.28282
MAPK1 mitogen-activated protein kinase 1 1.28282
ZNF767P zinc finger family member 767, pseudogene 1.28282
SKAP2 src kinase associated phosphoprotein 2 1.27994
ICOS inducible T-cell co-stimulator 1.27533
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 1.27347
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 1.27109
PXK PX domain containing serine/threonine kinase 1.2647
PLEK pleckstrin 1.25984
PVT1 Pvt1 oncogene (non-protein coding) 1.25845
ARHGAP31 Rho GTPase activating protein 31 1.25826
CD40 CD40 molecule, TNF receptor superfamily member 5 1.25717
CLECL1 C-type lectin-like 1 1.24751
CD226 CD226 molecule 1.24751
SPATA2 spermatogenesis associated 2 1.24751
MPV17L2 MPV17 mitochondrial membrane protein-like 2 1.24751
MERTK MER proto-oncogene, tyrosine kinase 1.24751
C6ORF15 chromosome 6 open reading frame 15 1.22362
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 1.2216
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 1.21853
UBASH3A ubiquitin associated and SH3 domain containing A 1.21853
BATF basic leucine zipper transcription factor, ATF-like 1.21853
ODF3B outer dense fiber of sperm tails 3B 1.21853
IL7R interleukin 7 receptor 1.21853
CTNNA3 catenin (cadherin-associated protein), alpha 3 1.21046
MLANA melan-A 1.19958
ZFP90 ZFP90 zinc finger protein 1.19958
LOC100506047 uncharacterized LOC100506047 1.19958
SLC44A4 solute carrier family 44, member 4 1.19708
IL17REL interleukin 17 receptor E-like 1.18704
C5ORF30 chromosome 5 open reading frame 30 1.18603
FAM107A family with sequence similarity 107, member A 1.18141
HLA-F major histocompatibility complex, class I, F 1.16436
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.15743
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 1.155
ZBTB46 zinc finger and BTB domain containing 46 1.15352
MANBA mannosidase, beta A, lysosomal 1.15352
SOX5 SRY (sex determining region Y)-box 5 1.15352
PRRC2A proline-rich coiled-coil 2A 1.15067
HSPA1L heat shock 70kDa protein 1-like 1.13723
STK19 serine/threonine kinase 19 1.13194
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 1.12851
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 1.12851
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 1.11976
HCG22 HLA complex group 22 1.11443
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 1.11203
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 1.11203
SPEF2 sperm flagellar 2 1.09906
LOC100294145 uncharacterized LOC100294145 1.09758
NELFE negative elongation factor complex member E 1.08951
SAE1 SUMO1 activating enzyme subunit 1 1.08774
AK5 adenylate kinase 5 1.07971
SUMF1 sulfatase modifying factor 1 1.07729
MSH5 mutS homolog 5 1.07173
MPHOSPH9 M-phase phosphoprotein 9 1.0674
MYNN myoneurin 1.0674
C1ORF204 chromosome 1 open reading frame 204 1.0674
TMEM39A transmembrane protein 39A 1.0674
CLSTN2 calsyntenin 2 1.05869
SYK spleen tyrosine kinase 1.05066
GRB10 growth factor receptor-bound protein 10 1.04365
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 1.04365
GPC5 glypican 5 1.04365
PVR poliovirus receptor 1.04365
ZNF433 zinc finger protein 433 1.04365
KIF21B kinesin family member 21B 1.04365
VAV2 vav 2 guanine nucleotide exchange factor 1.04365
TRIM31 tripartite motif containing 31 1.02683
KANK1 KN motif and ankyrin repeat domains 1 1.01065
DPCR1 diffuse panbronchiolitis critical region 1 1.00557
LINC01551 long intergenic non-protein coding RNA 1551 1.00059
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 1.00059
PDZRN4 PDZ domain containing ring finger 4 1.00059
CSMD1 CUB and Sushi multiple domains 1 1.00059
LEKR1 leucine, glutamate and lysine rich 1 1.00059
NDFIP1 Nedd4 family interacting protein 1 1.00059
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.998051
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.971092
RPL5 ribosomal protein L5 0.969142
RREB1 ras responsive element binding protein 1 0.969142
RELN reelin 0.969142
FCRL3 Fc receptor-like 3 0.969142
NRXN1 neurexin 1 0.965141
MOG myelin oligodendrocyte glycoprotein 0.95642
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.942765
ALPK2 alpha-kinase 2 0.942765
TRIM2 tripartite motif containing 2 0.942765
EGFL6 EGF-like-domain, multiple 6 0.942765
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 0.942765
PLCL2 phospholipase C-like 2 0.942765
NLRP11 NLR family, pyrin domain containing 11 0.942765
LRRC16A leucine rich repeat containing 16A 0.941615
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.936101
TIAM1 T-cell lymphoma invasion and metastasis 1 0.928083
FAM179A family with sequence similarity 179, member A 0.919947
TLL1 tolloid-like 1 0.919744
PCSK5 proprotein convertase subtilisin/kexin type 5 0.919744
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.899912
MET MET proto-oncogene, receptor tyrosine kinase 0.899912
AXDND1 axonemal dynein light chain domain containing 1 0.899912
OPCML opioid binding protein/cell adhesion molecule-like 0.896546
TG thyroglobulin 0.896372
KPNB1 karyopherin (importin) beta 1 0.884114
IL12A interleukin 12A 0.882984
LOC100506023 uncharacterized LOC100506023 0.882984
NCKAP5 NCK-associated protein 5 0.882984
GPR75-ASB3 GPR75-ASB3 readthrough 0.881236
SAMD12 sterile alpha motif domain containing 12 0.868241
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.868241
POPDC3 popeye domain containing 3 0.868241
POU2F3 POU class 2 homeobox 3 0.867296
FHIT fragile histidine triad 0.865437
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.85216
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.849104
HSDL1 hydroxysteroid dehydrogenase like 1 0.849104
ETV6 ets variant 6 0.845831
CDH18 cadherin 18, type 2 0.840142
PCDH7 protocadherin 7 0.839148
DYSF dysferlin 0.836232
FAM69A family with sequence similarity 69, member A 0.835282
ELMO1 engulfment and cell motility 1 0.834343
ERBB4 erb-b2 receptor tyrosine kinase 4 0.828053
PHACTR2 phosphatase and actin regulator 2 0.82634
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 0.824663
TRIM10 tripartite motif containing 10 0.823019
HDAC9 histone deacetylase 9 0.82221
SDCBP2 syndecan binding protein (syntenin) 2 0.81905
NXN nucleoredoxin 0.816759
TBC1D4 TBC1 domain family, member 4 0.807106
CLDN14 claudin 14 0.805703
RNF213 ring finger protein 213 0.802966
PARD3B par-3 family cell polarity regulator beta 0.799025
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.7965
SMAD3 SMAD family member 3 0.793451
EFNA5 ephrin-A5 0.791087
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.78662
MCTP2 multiple C2 domains, transmembrane 2 0.784773
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 0.784165
GRM7 glutamate receptor, metabotropic 7 0.776638
DGKQ diacylglycerol kinase, theta 110kDa 0.773374
DPPA2 developmental pluripotency associated 2 0.772842
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.771265
HEMK1 HemK methyltransferase family member 1 0.770746
RBMS3 RNA binding motif, single stranded interacting protein 3 0.769717
CCHCR1 coiled-coil alpha-helical rod protein 1 0.765722
MAML3 mastermind-like 3 (Drosophila) 0.765722
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C 0.762996
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.762996
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.762996
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.759303
EVA1A eva-1 homolog A (C. elegans) 0.755257
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.753784
CD300A CD300a molecule 0.753299
ZNF423 zinc finger protein 423 0.748122
NSD1 nuclear receptor binding SET domain protein 1 0.744976
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.744535
COL27A1 collagen, type XXVII, alpha 1 0.743226
SLIT3 slit homolog 3 (Drosophila) 0.731918
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.731062
DENND1A DENN/MADD domain containing 1A 0.726484
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.726078
TGFBR3 transforming growth factor, beta receptor III 0.725675
LRRC4C leucine rich repeat containing 4C 0.724474
PSORS1C2 psoriasis susceptibility 1 candidate 2 0.723288
ANKRD26P3 ankyrin repeat domain 26 pseudogene 3 0.722896
GRIK1 glutamate receptor, ionotropic, kainate 1 0.721344
NRG1 neuregulin 1 0.719817
WBSCR17 Williams-Beuren syndrome chromosome region 17 0.718314
CTNND2 catenin (cadherin-associated protein), delta 2 0.717203
STX8 syntaxin 8 0.716836
E2F5 E2F transcription factor 5, p130-binding 0.71538
MAGEB10 melanoma antigen family B10 0.714303
TNP2 transition protein 2 (during histone to protamine replacement) 0.710801
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.70642
TRAPPC9 trafficking protein particle complex 9 0.704251
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.703894
LOC388210 0.703894
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.702479
CPVL carboxypeptidase, vitellogenic-like 0.701431
MUC22 mucin 22 0.699367
PTCHD1-AS PTCHD1 antisense RNA (head to head) 0.697013
CPE carboxypeptidase E 0.694067
KSR2 kinase suppressor of ras 2 0.682247
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.681679
CADM2 cell adhesion molecule 2 0.679668
MUC21 mucin 21, cell surface associated 0.679051
SYN3 synapsin III 0.677522
ZBTB20 zinc finger and BTB domain containing 20 0.67336
KIAA1211 KIAA1211 0.67307
CPNE4 copine IV 0.671627
AACS acetoacetyl-CoA synthetase 0.665514
RIN2 Ras and Rab interactor 2 0.660518
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.659244
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.656743
TRIM26 tripartite motif containing 26 0.656496
ASB3 ankyrin repeat and SOCS box containing 3 0.655272
APOM apolipoprotein M 0.650522
DYX1C1 dyslexia susceptibility 1 candidate 1 0.649599
A2ML1 alpha-2-macroglobulin-like 1 0.645377
PLXNA2 plexin A2 0.640092
CNTN6 contactin 6 0.636862
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.635284
OSBP2 oxysterol binding protein 2 0.631549
NCF4 neutrophil cytosolic factor 4, 40kDa 0.630903
IL6 interleukin 6 0.630903
EPHA6 EPH receptor A6 0.630689
SFSWAP splicing factor, suppressor of white-apricot family 0.630475
LOC158435 uncharacterized LOC158435 0.630049
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.628991
ARHGAP17 Rho GTPase activating protein 17 0.628153
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.626701
ZFP69 ZFP69 zinc finger protein 0.623859
IL7 interleukin 7 0.619356
RAB3B RAB3B, member RAS oncogene family 0.618593
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like 0.613833
RRP1B ribosomal RNA processing 1B 0.611966
ALK anaplastic lymphoma receptor tyrosine kinase 0.609951
ARMC9 armadillo repeat containing 9 0.60465
GFI1 growth factor independent 1 transcription repressor 0.603793
AGBL1 ATP/GTP binding protein-like 1 0.603112
KDM4C lysine (K)-specific demethylase 4C 0.603112
TSPAN16 tetraspanin 16 0.602605
IRAK2 interleukin-1 receptor-associated kinase 2 0.60143
GRIK4 glutamate receptor, ionotropic, kainate 4 0.600105
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough 0.598959
DSCAML1 Down syndrome cell adhesion molecule like 1 0.598797
NOL10 nucleolar protein 10 0.598311
TENM4 teneurin transmembrane protein 4 0.597185
CENPM centromere protein M 0.597026
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 0.596866
CHODL chondrolectin 0.594816
RSPO2 R-spondin 2 0.594193
NPAS3 neuronal PAS domain protein 3 0.593729
C1QB complement component 1, q subcomponent, B chain 0.58687
SUSD3 sushi domain containing 3 0.583301
DOCK2 dedicator of cytokinesis 2 0.582818
SORBS2 sorbin and SH3 domain containing 2 0.581861
CADPS2 Ca++-dependent secretion activator 2 0.580796
FBXO32 F-box protein 32 0.580561
USP8 ubiquitin specific peptidase 8 0.579744
HPGDS hematopoietic prostaglandin D synthase 0.578589
DNM3 dynamin 3 0.57745
LRRK1 leucine-rich repeat kinase 1 0.576437
UNC5B unc-5 homolog B (C. elegans) 0.573794
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.572823
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.560832
ICAM3 intercellular adhesion molecule 3 0.55536
PDZD2 PDZ domain containing 2 0.53868
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.537883
TTYH2 tweety family member 2 0.532619
IL12RB2 interleukin 12 receptor, beta 2 0.522995
HAPLN1 hyaluronan and proteoglycan link protein 1 0.522136
COL25A1 collagen, type XXV, alpha 1 0.522136
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 0.508017
FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 0.498792
MXD1 MAX dimerization protein 1 0.466305
HDGFRP3 hepatoma-derived growth factor, related protein 3 0.464433
DIAPH1 diaphanous-related formin 1 0.461356
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.458078
LOC440600 uncharacterized LOC440600 0.452371
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.445326
DSCAM Down syndrome cell adhesion molecule 0.436956
STK39 serine threonine kinase 39 0.429005