|Dataset||GO Molecular Function Annotations|
|Category||structural or functional annotations|
|Description||Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate. (Gene Ontology, GO_0004839)|
|Downloads & Tools|
4 genes performing the ubiquitin activating enzyme activity molecular function from the curated GO Molecular Function Annotations dataset.