type i diabetes mellitus Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas. (Human Disease Ontology, DOID_9744)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0100651
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Genes

170 genes associated with the type i diabetes mellitus phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
HLA-DRA major histocompatibility complex, class II, DR alpha 4.22996
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 3.42793
C6ORF10 chromosome 6 open reading frame 10 3.36862
INS insulin 3.3613
C6ORF47 chromosome 6 open reading frame 47 3.18201
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.17503
NOTCH4 notch 4 3.15683
PRRC2A proline-rich coiled-coil 2A 3.15231
BAG6 BCL2-associated athanogene 6 3.10521
PPT2 palmitoyl-protein thioesterase 2 3.09326
HSPA1L heat shock 70kDa protein 1-like 3.08941
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 3.07973
VWA7 von Willebrand factor A domain containing 7 3.07224
TNXB tenascin XB 3.0594
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 3.05574
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 3.04136
HLA-DOB major histocompatibility complex, class II, DO beta 2.99854
HSPA1B heat shock 70kDa protein 1B 2.99146
MICB MHC class I polypeptide-related sequence B 2.97699
STK19 serine/threonine kinase 19 2.91911
C2 complement component 2 2.91658
CFB complement factor B 2.91247
MSH5 mutS homolog 5 2.90147
SLC44A4 solute carrier family 44, member 4 2.89999
APOM apolipoprotein M 2.88977
BTNL2 butyrophilin-like 2 2.78204
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 2.77333
IL2RA interleukin 2 receptor, alpha 2.36859
SH2B3 SH2B adaptor protein 3 2.36099
RPS26 ribosomal protein S26 2.23511
ERBB3 erb-b2 receptor tyrosine kinase 3 2.14826
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.09848
GPANK1 G patch domain and ankyrin repeats 1 2.09341
IGF2 insulin-like growth factor 2 2.06646
CLEC16A C-type lectin domain family 16, member A 1.87544
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 1.86605
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.84688
TCF19 transcription factor 19 1.81736
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 1.81736
BRD2 bromodomain containing 2 1.81736
CUX2 cut-like homeobox 2 1.81736
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 1.81736
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.81736
HCP5 HLA complex P5 (non-protein coding) 1.81736
C6ORF15 chromosome 6 open reading frame 15 1.81736
MICA MHC class I polypeptide-related sequence A 1.7752
CTSH cathepsin H 1.73304
PTPN2 protein tyrosine phosphatase, non-receptor type 2 1.72215
HLA-C major histocompatibility complex, class I, C 1.70611
HLA-B major histocompatibility complex, class I, B 1.70025
IFIH1 interferon induced with helicase C domain 1 1.67051
FLOT1 flotillin 1 1.66588
HCG18 HLA complex group 18 (non-protein coding) 1.63287
ABHD16A abhydrolase domain containing 16A 1.61712
LOC100287329 uncharacterized LOC100287329 1.60771
KIAA1109 KIAA1109 1.58488
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 1.58458
GSDMB gasdermin B 1.57861
RNF39 ring finger protein 39 1.55942
DPCR1 diffuse panbronchiolitis critical region 1 1.54889
GPSM3 G-protein signaling modulator 3 1.54374
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 1.53753
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.52822
GLIS3 GLIS family zinc finger 3 1.52822
FCRL3 Fc receptor-like 3 1.51005
SIRPG signal-regulatory protein gamma 1.51005
CCDC101 coiled-coil domain containing 101 1.50337
CD69 CD69 molecule 1.48419
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.48127
PRKD2 protein kinase D2 1.47083
ZNRD1 zinc ribbon domain containing 1 1.46084
LY6G5B lymphocyte antigen 6 complex, locus G5B 1.45737
PSORS1C1 psoriasis susceptibility 1 candidate 1 1.45397
LMO7 LIM domain 7 1.45123
TRIM31 tripartite motif containing 31 1.4427
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 1.43825
TYK2 tyrosine kinase 2 1.43716
MEG3 maternally expressed 3 (non-protein coding) 1.43716
TRIM40 tripartite motif containing 40 1.4327
LY6G6E lymphocyte antigen 6 complex, locus G6E (pseudogene) 1.42039
AGER advanced glycosylation end product-specific receptor 1.41386
LOC100294145 uncharacterized LOC100294145 1.41086
HCG23 HLA complex group 23 (non-protein coding) 1.40488
PPP1R18 protein phosphatase 1, regulatory subunit 18 1.39271
MUC21 mucin 21, cell surface associated 1.37034
CD226 CD226 molecule 1.35521
VARS2 valyl-tRNA synthetase 2, mitochondrial 1.33402
UBASH3A ubiquitin associated and SH3 domain containing A 1.32793
TH tyrosine hydroxylase 1.31303
EFR3B EFR3 homolog B (S. cerevisiae) 1.29386
HCG9 HLA complex group 9 (non-protein coding) 1.29327
SKAP2 src kinase associated phosphoprotein 2 1.28282
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 1.26338
GAB3 GRB2-associated binding protein 3 1.25845
HCG26 HLA complex group 26 (non-protein coding) 1.24954
AFF3 AF4/FMR2 family, member 3 1.24751
POU5F1 POU class 5 homeobox 1 1.22817
COL1A2 collagen, type I, alpha 2 1.22554
IL10 interleukin 10 1.2183
LY6G5C lymphocyte antigen 6 complex, locus G5C 1.2121
BNC2 basonuclin 2 1.19025
LTA lymphotoxin alpha 1.18563
LST1 leukocyte specific transcript 1 1.1818
CLEC2D C-type lectin domain family 2, member D 1.1784
SNORD48 small nucleolar RNA, C/D box 48 1.16642
PSORS1C3 psoriasis susceptibility 1 candidate 3 (non-protein coding) 1.16579
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 1.16099
C1QTNF6 C1q and tumor necrosis factor related protein 6 1.16027
PRKCQ protein kinase C, theta 1.15352
ERBB4 erb-b2 receptor tyrosine kinase 4 1.12851
PGM1 phosphoglucomutase 1 1.09906
IL2 interleukin 2 1.08774
JAZF1-AS1 JAZF1 antisense RNA 1 1.08774
DNAH2 dynein, axonemal, heavy chain 2 1.08774
ZFP36L1 ZFP36 ring finger protein-like 1 1.06948
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 1.06929
HPSE2 heparanase 2 (inactive) 1.05869
AQP4-AS1 AQP4 antisense RNA 1 1.04564
CENPW centromere protein W 1.01065
RNF10 ring finger protein 10 1.00059
LPAR3 lysophosphatidic acid receptor 3 1.00059
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.985971
ADAD1 adenosine deaminase domain containing 1 (testis-specific) 0.969142
TENM2 teneurin transmembrane protein 2 0.943933
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.942765
FSTL4 follistatin-like 4 0.919744
NRIP1 nuclear receptor interacting protein 1 0.893306
CFDP1 craniofacial development protein 1 0.89067
DNAH8 dynein, axonemal, heavy chain 8 0.885094
IL7R interleukin 7 receptor 0.868241
CAPSL calcyphosine-like 0.868241
EFCAB8 EF-hand calcium binding domain 8 0.855449
MAPK14 mitogen-activated protein kinase 14 0.843198
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.820614
GRIK2 glutamate receptor, ionotropic, kainate 2 0.819829
AMZ1 archaelysin family metallopeptidase 1 0.817516
PDE4A phosphodiesterase 4A, cAMP-specific 0.814503
CTSB cathepsin B 0.81297
ZNF451 zinc finger protein 451 0.789144
CNTN6 contactin 6 0.78662
AGBL1 ATP/GTP binding protein-like 1 0.784165
STAT4 signal transducer and activator of transcription 4 0.781779
HORMAD2 HORMA domain containing 2 0.78061
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 0.777194
APLF aprataxin and PNKP like factor 0.758788
AP4B1 adaptor-related protein complex 4, beta 1 subunit 0.740245
OPCML opioid binding protein/cell adhesion molecule-like 0.733655
ACOXL acyl-CoA oxidase-like 0.726078
TENM4 teneurin transmembrane protein 4 0.719439
SAA2 serum amyloid A2 0.717942
ZNF536 zinc finger protein 536 0.703184
FLI1 Fli-1 proto-oncogene, ETS transcription factor 0.702831
FUT2 fucosyltransferase 2 (secretor status included) 0.683684
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.678131
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.671056
TULP4 tubby like protein 4 0.669642
TMEM170A transmembrane protein 170A 0.66233
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.657736
THADA thyroid adenoma associated 0.650522
NCALD neurocalcin delta 0.642701
CDKN2B-AS1 CDKN2B antisense RNA 1 0.635061
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.631333
KANSL1 KAT8 regulatory NSL complex subunit 1 0.627528
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 0.617835
DUSP16 dual specificity phosphatase 16 0.600766
VGLL4 vestigial-like family member 4 0.596548
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 0.587592
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 0.581386
ZPBP2 zona pellucida binding protein 2 0.481449
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 0.453147