tumor-necrosis-factor-alpha Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Tumor necrosis factor (TNF, cachexin or cachectin formerly known as tumor necrosis factor-alpha or TNF-α) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by other cell types as well. (Experimental Factor Ontology, EFO_0003271)
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Genes

215 proteins co-occuring with the biological term tumor-necrosis-factor-alpha in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ADAM17 ADAM metallopeptidase domain 17
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALOX5 arachidonate 5-lipoxygenase
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF1 activating transcription factor 1
ATF2 activating transcription factor 2
ATM ATM serine/threonine kinase
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
BAD BCL2-associated agonist of cell death
BANP BTG3 associated nuclear protein
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BLVRA biliverdin reductase A
BMX BMX non-receptor tyrosine kinase
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CARD11 caspase recruitment domain family, member 11
CARD9 caspase recruitment domain family, member 9
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CDC25C cell division cycle 25C
CDK1 cyclin-dependent kinase 1
CDK5 cyclin-dependent kinase 5
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHUK conserved helix-loop-helix ubiquitous kinase
COL17A1 collagen, type XVII, alpha 1
CREB1 cAMP responsive element binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYLD cylindromatosis (turban tumor syndrome)
DAB2IP DAB2 interacting protein
DAPK1 death-associated protein kinase 1
DAPK2 death-associated protein kinase 2
DAXX death-domain associated protein
DAZAP1 DAZ associated protein 1
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
EEF2 eukaryotic translation elongation factor 2
EEF2K eukaryotic elongation factor 2 kinase
EGFR epidermal growth factor receptor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EP300 E1A binding protein p300
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
FADD Fas (TNFRSF6)-associated via death domain
FBXL2 F-box and leucine-rich repeat protein 2
FOXA2 forkhead box A2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FOXP3 forkhead box P3
GJA1 gap junction protein, alpha 1, 43kDa
GLO1 glyoxalase I
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
GYS1 glycogen synthase 1 (muscle)
H3F3A H3 histone, family 3A
H3F3B H3 histone, family 3B (H3.3B)
HIST1H2BN histone cluster 1, H2bn
HIST1H3A histone cluster 1, H3a
HMGB1 high mobility group box 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSPB1 heat shock 27kDa protein 1
HSPB6 heat shock protein, alpha-crystallin-related, B6
ICAM1 intercellular adhesion molecule 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IP6K2 inositol hexakisphosphate kinase 2
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1
IRF3 interferon regulatory factor 3
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
IRS1 insulin receptor substrate 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JUN jun proto-oncogene
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LEPR leptin receptor
LRP6 low density lipoprotein receptor-related protein 6
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MEP1B meprin A, beta
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLKL mixed lineage kinase domain-like
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MSN moesin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL12B myosin, light chain 12B, regulatory
NCF1 neutrophil cytosolic factor 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NKX3-1 NK3 homeobox 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUAK1 NUAK family, SNF1-like kinase, 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PDPK1 3-phosphoinositide dependent protein kinase 1
PEA15 phosphoprotein enriched in astrocytes 15
PIAS1 protein inhibitor of activated STAT, 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLN phospholamban
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPARG peroxisome proliferator-activated receptor gamma
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PRKD1 protein kinase D1
PRKG1 protein kinase, cGMP-dependent, type I
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PSEN1 presenilin 1
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PXN paxillin
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBM4 RNA binding motif protein 4
RDX radixin
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS7 regulator of G-protein signaling 7
RIOK2 RIO kinase 2
RIPK3 receptor-interacting serine-threonine kinase 3
RPLP1 ribosomal protein, large, P1
RPLP2 ribosomal protein, large, P2
RPS6 ribosomal protein S6
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RYR2 ryanodine receptor 2 (cardiac)
S100A9 S100 calcium binding protein A9
SFPQ splicing factor proline/glutamine-rich
SIRPA signal-regulatory protein alpha
SIVA1 SIVA1, apoptosis-inducing factor
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLITRK1 SLIT and NTRK-like family, member 1
SOCS3 suppressor of cytokine signaling 3
SP1 Sp1 transcription factor
SPHK1 sphingosine kinase 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF10 serine/arginine-rich splicing factor 10
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STMN1 stathmin 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
THEMIS2 thymocyte selection associated family member 2
THRAP3 thyroid hormone receptor associated protein 3
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TP53 tumor protein p53
TP63 tumor protein p63
TRAF1 TNF receptor-associated factor 1
TRAF2 TNF receptor-associated factor 2
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
ULK1 unc-51 like autophagy activating kinase 1
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VIM vimentin
WASL Wiskott-Aldrich syndrome-like
WWOX WW domain containing oxidoreductase
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein