tropine-6264 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the tropine-6264 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACVR1B activin A receptor, type IB
ARHGAP4 Rho GTPase activating protein 4
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATG3 autophagy related 3
AVL9 AVL9 homolog (S. cerevisiase)
BMP4 bone morphogenetic protein 4
CALHM2 calcium homeostasis modulator 2
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX8 chromobox homolog 8
CD79B CD79b molecule, immunoglobulin-associated beta
CDH5 cadherin 5, type 2 (vascular endothelium)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
COL6A1 collagen, type VI, alpha 1
COPS7B COP9 signalosome subunit 7B
DAPK3 death-associated protein kinase 3
DGAT1 diacylglycerol O-acyltransferase 1
EPS8L1 EPS8-like 1
FRMD4B FERM domain containing 4B
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GON4L gon-4-like (C. elegans)
GRIP2 glutamate receptor interacting protein 2
HLA-DOA major histocompatibility complex, class II, DO alpha
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IDI2-AS1 IDI2 antisense RNA 1
IDS iduronate 2-sulfatase
IGHM immunoglobulin heavy constant mu
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL22 interleukin 22
IL4R interleukin 4 receptor
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNIP1 Kv channel interacting protein 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLHL24 kelch-like family member 24
KREMEN2 kringle containing transmembrane protein 2
KSR1 kinase suppressor of ras 1
LINC00115 long intergenic non-protein coding RNA 115
LMBR1L limb development membrane protein 1-like
LPPR2 lipid phosphate phosphatase-related protein type 2
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK7 mitogen-activated protein kinase 7
MCOLN3 mucolipin 3
MED6 mediator complex subunit 6
MST1L macrophage stimulating 1-like
MYL5 myosin, light chain 5, regulatory
NF2 neurofibromin 2 (merlin)
NT5E 5'-nucleotidase, ecto (CD73)
NUMA1 nuclear mitotic apparatus protein 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OGFR opioid growth factor receptor
ONECUT2 one cut homeobox 2
PDLIM7 PDZ and LIM domain 7 (enigma)
PENK proenkephalin
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G3 phospholipase A2, group III
PLTP phospholipid transfer protein
PLXNA1 plexin A1
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPN11 protein tyrosine phosphatase, non-receptor type 11
QKI QKI, KH domain containing, RNA binding
RBM19 RNA binding motif protein 19
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RFXAP regulatory factor X-associated protein
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAFB2 scaffold attachment factor B2
SCN11A sodium channel, voltage gated, type XI alpha subunit
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SORBS1 sorbin and SH3 domain containing 1
SP100 SP100 nuclear antigen
SPPL2B signal peptide peptidase like 2B
STAG3 stromal antigen 3
STK38L serine/threonine kinase 38 like
TBX6 T-box 6
TJAP1 tight junction associated protein 1 (peripheral)
TRAK1 trafficking protein, kinesin binding 1
TRIM29 tripartite motif containing 29
TRIM5 tripartite motif containing 5
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TSC22D3 TSC22 domain family, member 3
UBE3A ubiquitin protein ligase E3A
VAC14 Vac14 homolog (S. cerevisiae)
VAX2 ventral anterior homeobox 2
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WDR25 WD repeat domain 25
WDTC1 WD and tetratricopeptide repeats 1
ZFP30 ZFP30 zinc finger protein
ZNF675 zinc finger protein 675

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
AGO1 argonaute RISC catalytic component 1
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANKRD28 ankyrin repeat domain 28
ASB7 ankyrin repeat and SOCS box containing 7
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
AUH AU RNA binding protein/enoyl-CoA hydratase
BCAR3 breast cancer anti-estrogen resistance 3
CAPN15 calpain 15
CBX4 chromobox homolog 4
CCDC88C coiled-coil domain containing 88C
CDK3 cyclin-dependent kinase 3
CDR2L cerebellar degeneration-related protein 2-like
CFD complement factor D (adipsin)
CHMP7 charged multivesicular body protein 7
COBL cordon-bleu WH2 repeat protein
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CRYL1 crystallin, lambda 1
CTNNBIP1 catenin, beta interacting protein 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYBA cytochrome b-245, alpha polypeptide
DBR1 debranching RNA lariats 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNM1 dynamin 1
DNMBP dynamin binding protein
DOCK1 dedicator of cytokinesis 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EXOC5 exocyst complex component 5
FAM192A family with sequence similarity 192, member A
FAM222B family with sequence similarity 222, member B
FANCF Fanconi anemia, complementation group F
FBXL4 F-box and leucine-rich repeat protein 4
FBXO46 F-box protein 46
FBXW12 F-box and WD repeat domain containing 12
FPGS folylpolyglutamate synthase
GRAMD4 GRAM domain containing 4
HOOK1 hook microtubule-tethering protein 1
HS1BP3 HCLS1 binding protein 3
HYOU1 hypoxia up-regulated 1
IRF6 interferon regulatory factor 6
ITPKC inositol-trisphosphate 3-kinase C
KIAA0556 KIAA0556
KIAA0895 KIAA0895
KIF14 kinesin family member 14
KIZ kizuna centrosomal protein
L2HGDH L-2-hydroxyglutarate dehydrogenase
LYPLA2P1 lysophospholipase II pseudogene 1
MAPK12 mitogen-activated protein kinase 12
MED15 mediator complex subunit 15
MED22 mediator complex subunit 22
MOGS mannosyl-oligosaccharide glucosidase
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NOL6 nucleolar protein 6 (RNA-associated)
NPIPB15 nuclear pore complex interacting protein family, member B15
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PARD6A par-6 family cell polarity regulator alpha
PCOLCE2 procollagen C-endopeptidase enhancer 2
POLH polymerase (DNA directed), eta
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PQLC1 PQ loop repeat containing 1
PROCR protein C receptor, endothelial
REEP4 receptor accessory protein 4
RETSAT retinol saturase (all-trans-retinol 13,14-reductase)
RNF25 ring finger protein 25
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL23AP7 ribosomal protein L23a pseudogene 7
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SECISBP2 SECIS binding protein 2
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SNAI2 snail family zinc finger 2
SUSD6 sushi domain containing 6
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCTA T-cell leukemia translocation altered
THYN1 thymocyte nuclear protein 1
TM7SF3 transmembrane 7 superfamily member 3
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMOD3 tropomodulin 3 (ubiquitous)
TRAPPC13 trafficking protein particle complex 13
TSPAN1 tetraspanin 1
TTC23 tetratricopeptide repeat domain 23
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZC3H3 zinc finger CCCH-type containing 3
ZFHX3 zinc finger homeobox 3
ZNF205 zinc finger protein 205
ZNF226 zinc finger protein 226
ZNF271P zinc finger protein 271, pseudogene
ZNF623 zinc finger protein 623
ZNF7 zinc finger protein 7