troglitazone-5592 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the troglitazone-5592 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ADAM22 ADAM metallopeptidase domain 22
ALS2CL ALS2 C-terminal like
AMH anti-Mullerian hormone
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANO2 anoctamin 2, calcium activated chloride channel
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARRB1 arrestin, beta 1
ATAT1 alpha tubulin acetyltransferase 1
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
ATXN7L1 ataxin 7-like 1
BEST2 bestrophin 2
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
C2ORF27A chromosome 2 open reading frame 27A
CAPG capping protein (actin filament), gelsolin-like
CD47 CD47 molecule
CD8A CD8a molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CEND1 cell cycle exit and neuronal differentiation 1
COL11A1 collagen, type XI, alpha 1
COL6A1 collagen, type VI, alpha 1
CPB1 carboxypeptidase B1 (tissue)
CPEB3 cytoplasmic polyadenylation element binding protein 3
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DRD1 dopamine receptor D1
EGF epidermal growth factor
EGR1 early growth response 1
EPHX2 epoxide hydrolase 2, cytoplasmic
ERO1LB ERO1-like beta (S. cerevisiae)
FAM46C family with sequence similarity 46, member C
FBLN1 fibulin 1
FH fumarate hydratase
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FSCN1 fascin actin-bundling protein 1
GK glycerol kinase
GK2 glycerol kinase 2
GSK3A glycogen synthase kinase 3 alpha
HIST1H1B histone cluster 1, H1b
HIST1H1T histone cluster 1, H1t
HIST1H3B histone cluster 1, H3b
HOXB7 homeobox B7
HOXD1 homeobox D1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HUS1 HUS1 checkpoint homolog (S. pombe)
IFT27 intraflagellar transport 27
INE1 inactivation escape 1 (non-protein coding)
ING2 inhibitor of growth family, member 2
ING4 inhibitor of growth family, member 4
ISG20 interferon stimulated exonuclease gene 20kDa
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCTD17 potassium channel tetramerization domain containing 17
KIF1C kinesin family member 1C
LAMB4 laminin, beta 4
LAMP1 lysosomal-associated membrane protein 1
LAT2 linker for activation of T cells family, member 2
LOC100131510 uncharacterized LOC100131510
LRP12 low density lipoprotein receptor-related protein 12
LRRC75B leucine rich repeat containing 75B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2 microtubule-associated protein 2
MYH14 myosin, heavy chain 14, non-muscle
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
NCOR2 nuclear receptor corepressor 2
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NEK9 NIMA-related kinase 9
NF1 neurofibromin 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
OR1F2P olfactory receptor, family 1, subfamily F, member 2, pseudogene
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PLCB2 phospholipase C, beta 2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PVR poliovirus receptor
RAB6A RAB6A, member RAS oncogene family
RASL11B RAS-like, family 11, member B
RBM12B RNA binding motif protein 12B
RPLP2 ribosomal protein, large, P2
RUNDC3A RUN domain containing 3A
RXRB retinoid X receptor, beta
SCN11A sodium channel, voltage gated, type XI alpha subunit
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SSX3 synovial sarcoma, X breakpoint 3
TADA3 transcriptional adaptor 3
TAL1 T-cell acute lymphocytic leukemia 1
TAS2R1 taste receptor, type 2, member 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THTPA thiamine triphosphatase
TLR2 toll-like receptor 2
TMOD2 tropomodulin 2 (neuronal)
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TRIM10 tripartite motif containing 10
VIPR2 vasoactive intestinal peptide receptor 2
ZFP64 ZFP64 zinc finger protein
ZNF428 zinc finger protein 428
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADAP2 ArfGAP with dual PH domains 2
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARPIN actin-related protein 2/3 complex inhibitor
BIK BCL2-interacting killer (apoptosis-inducing)
BMP4 bone morphogenetic protein 4
C17ORF53 chromosome 17 open reading frame 53
C1ORF105 chromosome 1 open reading frame 105
C1QTNF3 C1q and tumor necrosis factor related protein 3
C5AR2 complement component 5a receptor 2
CA11 carbonic anhydrase XI
CBX7 chromobox homolog 7
CCDC71 coiled-coil domain containing 71
CCDC9 coiled-coil domain containing 9
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD1A CD1a molecule
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CEP112 centrosomal protein 112kDa
CRIP1 cysteine-rich protein 1 (intestinal)
CRLF1 cytokine receptor-like factor 1
CUZD1 CUB and zona pellucida-like domains 1
DGKE diacylglycerol kinase, epsilon 64kDa
DMTN dematin actin binding protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EAF2 ELL associated factor 2
EDAR ectodysplasin A receptor
EFHD2 EF-hand domain family, member D2
EGFL7 EGF-like-domain, multiple 7
EN2 engrailed homeobox 2
ERN2 endoplasmic reticulum to nucleus signaling 2
ETNK2 ethanolamine kinase 2
FADS2 fatty acid desaturase 2
FAM110B family with sequence similarity 110, member B
FAM155B family with sequence similarity 155, member B
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF6 fibroblast growth factor 6
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HOXC8 homeobox C8
HOXD11 homeobox D11
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
INPP5J inositol polyphosphate-5-phosphatase J
IQCC IQ motif containing C
IQSEC2 IQ motif and Sec7 domain 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KREMEN2 kringle containing transmembrane protein 2
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIN7A lin-7 homolog A (C. elegans)
LMTK2 lemur tyrosine kinase 2
LRRC37A3 leucine rich repeat containing 37, member A3
MAPKBP1 mitogen-activated protein kinase binding protein 1
MCOLN1 mucolipin 1
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
NOL6 nucleolar protein 6 (RNA-associated)
NRGN neurogranin (protein kinase C substrate, RC3)
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OSGIN1 oxidative stress induced growth inhibitor 1
OVGP1 oviductal glycoprotein 1, 120kDa
OVOL1 ovo-like zinc finger 1
PARG poly (ADP-ribose) glycohydrolase
PAX9 paired box 9
PDE8B phosphodiesterase 8B
PGBD5 piggyBac transposable element derived 5
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLSCR4 phospholipid scramblase 4
PRODH proline dehydrogenase (oxidase) 1
RAB30 RAB30, member RAS oncogene family
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFPL3 ret finger protein-like 3
RPAP1 RNA polymerase II associated protein 1
RPL13P5 ribosomal protein L13 pseudogene 5
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SETD1A SET domain containing 1A
SLC12A8 solute carrier family 12, member 8
SLC12A9 solute carrier family 12, member 9
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
STX1A syntaxin 1A (brain)
TCHH trichohyalin
TGFBR3 transforming growth factor, beta receptor III
TMEM180 transmembrane protein 180
TMEM45A transmembrane protein 45A
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TTBK2 tau tubulin kinase 2
USB1 U6 snRNA biogenesis 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VIM vimentin
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
XYLT2 xylosyltransferase II
ZNF484 zinc finger protein 484
ZNF574 zinc finger protein 574