tridihexethyl-5067 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the tridihexethyl-5067 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADGB androglobin
ADGRB1 adhesion G protein-coupled receptor B1
AKAP8L A kinase (PRKA) anchor protein 8-like
APAF1 apoptotic peptidase activating factor 1
APOC1 apolipoprotein C-I
ARHGAP44 Rho GTPase activating protein 44
ATP10A ATPase, class V, type 10A
ATP10B ATPase, class V, type 10B
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
AVPR1A arginine vasopressin receptor 1A
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BEAN1 brain expressed, associated with NEDD4, 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASS4 Cas scaffolding protein family member 4
CDHR2 cadherin-related family member 2
CDK10 cyclin-dependent kinase 10
CEL carboxyl ester lipase
CHN2 chimerin 2
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CLEC2D C-type lectin domain family 2, member D
CNTFR ciliary neurotrophic factor receptor
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CYBB cytochrome b-245, beta polypeptide
DCTN2 dynactin 2 (p50)
DNAH9 dynein, axonemal, heavy chain 9
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DSCAM Down syndrome cell adhesion molecule
EGFL7 EGF-like-domain, multiple 7
EML2 echinoderm microtubule associated protein like 2
EPS8L1 EPS8-like 1
EYA3 EYA transcriptional coactivator and phosphatase 3
F5 coagulation factor V (proaccelerin, labile factor)
FLJ11710 uncharacterized protein FLJ11710
FRMD1 FERM domain containing 1
FRMPD1 FERM and PDZ domain containing 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GAL galanin/GMAP prepropeptide
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GJA4 gap junction protein, alpha 4, 37kDa
GPR21 G protein-coupled receptor 21
GRAMD1C GRAM domain containing 1C
HHAT hedgehog acyltransferase
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
IGFALS insulin-like growth factor binding protein, acid labile subunit
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL36A interleukin 36, alpha
INO80D INO80 complex subunit D
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCTD17 potassium channel tetramerization domain containing 17
KLF4 Kruppel-like factor 4 (gut)
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYRM9 LYR motif containing 9
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MMP9 matrix metallopeptidase 9
MSR1 macrophage scavenger receptor 1
MYO1B myosin IB
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OMD osteomodulin
OTOR otoraplin
PER1 period circadian clock 1
PHC3 polyhomeotic homolog 3 (Drosophila)
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLA2G5 phospholipase A2, group V
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PYHIN1 pyrin and HIN domain family, member 1
RANBP1 RAN binding protein 1
RGS12 regulator of G-protein signaling 12
RYR2 ryanodine receptor 2 (cardiac)
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN4A sodium channel, voltage gated, type IV alpha subunit
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIX3 SIX homeobox 3
SNCG synuclein, gamma (breast cancer-specific protein 1)
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SPINK5 serine peptidase inhibitor, Kazal type 5
SRRT serrate, RNA effector molecule
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TBCD tubulin folding cofactor D
TEX11 testis expressed 11
TFDP3 transcription factor Dp family, member 3
TP63 tumor protein p63
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF710 zinc finger protein 710
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABHD8 abhydrolase domain containing 8
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
APOLD1 apolipoprotein L domain containing 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BNC1 basonuclin 1
BOLA1 bolA family member 1
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CD82 CD82 molecule
CENPQ centromere protein Q
CFAP44 cilia and flagella associated protein 44
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CIDEC cell death-inducing DFFA-like effector c
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNN1 calponin 1, basic, smooth muscle
CPNE7 copine VII
CSF1R colony stimulating factor 1 receptor
CXORF56 chromosome X open reading frame 56
DEPTOR DEP domain containing MTOR-interacting protein
DTX4 deltex 4, E3 ubiquitin ligase
EFNA3 ephrin-A3
EHF ets homologous factor
EN1 engrailed homeobox 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXOSC1 exosome component 1
FAM160B2 family with sequence similarity 160, member B2
FGGY FGGY carbohydrate kinase domain containing
GAL3ST4 galactose-3-O-sulfotransferase 4
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPC3 glypican 3
HAUS6 HAUS augmin-like complex, subunit 6
HIST1H2AG histone cluster 1, H2ag
HIST1H2AM histone cluster 1, H2am
HIST1H2BN histone cluster 1, H2bn
HIST1H2BO histone cluster 1, H2bo
HIST1H3C histone cluster 1, H3c
HIST1H4C histone cluster 1, H4c
IL15RA interleukin 15 receptor, alpha
IL22 interleukin 22
INF2 inverted formin, FH2 and WH2 domain containing
ISYNA1 inositol-3-phosphate synthase 1
ITK IL2-inducible T-cell kinase
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF3A kinesin family member 3A
KRT34 keratin 34, type I
LATS1 large tumor suppressor kinase 1
LOC257152 uncharacterized LOC257152
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGEA6 melanoma antigen family A6
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MUC2 mucin 2, oligomeric mucus/gel-forming
MYLIP myosin regulatory light chain interacting protein
NDRG4 NDRG family member 4
NXPH4 neurexophilin 4
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PDZK1 PDZ domain containing 1
PER3 period circadian clock 3
PHEX phosphate regulating endopeptidase homolog, X-linked
RAB3A RAB3A, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
REPS2 RALBP1 associated Eps domain containing 2
SCARA3 scavenger receptor class A, member 3
SERGEF secretion regulating guanine nucleotide exchange factor
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOD3 superoxide dismutase 3, extracellular
SPIDR scaffolding protein involved in DNA repair
SPTBN2 spectrin, beta, non-erythrocytic 2
SSBP3 single stranded DNA binding protein 3
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STBD1 starch binding domain 1
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TESK1 testis-specific kinase 1
THBS3 thrombospondin 3
TMC7 transmembrane channel-like 7
TMEM120B transmembrane protein 120B
TMEM242 transmembrane protein 242
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM66 tripartite motif containing 66
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TSPAN8 tetraspanin 8
ZNF165 zinc finger protein 165
ZNF205 zinc finger protein 205
ZNF253 zinc finger protein 253
ZNF358 zinc finger protein 358
ZNF37BP zinc finger protein 37B, pseudogene
ZNF639 zinc finger protein 639
ZNF667 zinc finger protein 667