trichostatin A-6222 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the trichostatin A-6222 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRE5 adhesion G protein-coupled receptor E5
AFF4 AF4/FMR2 family, member 4
AKR1C1 aldo-keto reductase family 1, member C1
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGAP35 Rho GTPase activating protein 35
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARRB1 arrestin, beta 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD5 ATPase family, AAA domain containing 5
B9D1 B9 protein domain 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C22ORF46 chromosome 22 open reading frame 46
C7ORF43 chromosome 7 open reading frame 43
CALCOCO1 calcium binding and coiled-coil domain 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNO cyclin O
CD44 CD44 molecule (Indian blood group)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDY1 chromodomain protein, Y-linked, 1
CGA glycoprotein hormones, alpha polypeptide
CLCN7 chloride channel, voltage-sensitive 7
CLSPN claspin
DLC1 DLC1 Rho GTPase activating protein
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
ERAP1 endoplasmic reticulum aminopeptidase 1
ERCC4 excision repair cross-complementation group 4
EXTL3 exostosin-like glycosyltransferase 3
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GON4L gon-4-like (C. elegans)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPSM3 G-protein signaling modulator 3
GRB7 growth factor receptor-bound protein 7
GRM8 glutamate receptor, metabotropic 8
GSPT1 G1 to S phase transition 1
GUSBP3 glucuronidase, beta pseudogene 3
HLA-C major histocompatibility complex, class I, C
HLA-G major histocompatibility complex, class I, G
HTATSF1 HIV-1 Tat specific factor 1
ING4 inhibitor of growth family, member 4
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
KLF9 Kruppel-like factor 9
KRIT1 KRIT1, ankyrin repeat containing
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LRRC23 leucine rich repeat containing 23
LY6D lymphocyte antigen 6 complex, locus D
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MAPK14 mitogen-activated protein kinase 14
MATK megakaryocyte-associated tyrosine kinase
NDE1 nudE neurodevelopment protein 1
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NOP16 NOP16 nucleolar protein
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUMA1 nuclear mitotic apparatus protein 1
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OGFR opioid growth factor receptor
OLFM1 olfactomedin 1
OSBP2 oxysterol binding protein 2
OTUD4 OTU deubiquitinase 4
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDGFA platelet-derived growth factor alpha polypeptide
PHC3 polyhomeotic homolog 3 (Drosophila)
PLCH1 phospholipase C, eta 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRB1 proline-rich protein BstNI subfamily 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PXN paxillin
QKI QKI, KH domain containing, RNA binding
RANBP3 RAN binding protein 3
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RNF19B ring finger protein 19B
RPS3A ribosomal protein S3A
SECISBP2L SECIS binding protein 2-like
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUGP1 SURP and G patch domain containing 1
SYNGR1 synaptogyrin 1
TAS2R10 taste receptor, type 2, member 10
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TMPO thymopoietin
TRIB2 tribbles pseudokinase 2
UBE3B ubiquitin protein ligase E3B
ULBP2 UL16 binding protein 2
USF2 upstream transcription factor 2, c-fos interacting
VDAC3 voltage-dependent anion channel 3
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
XAB2 XPA binding protein 2
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZMYM2 zinc finger, MYM-type 2
ZNF219 zinc finger protein 219

decreased expression

Symbol Name
AMBRA1 autophagy/beclin-1 regulator 1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGAP11A Rho GTPase activating protein 11A
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BBS7 Bardet-Biedl syndrome 7
BTF3P11 basic transcription factor 3 pseudogene 11
C1ORF115 chromosome 1 open reading frame 115
C1ORF56 chromosome 1 open reading frame 56
C22ORF29 chromosome 22 open reading frame 29
C2ORF44 chromosome 2 open reading frame 44
C5 complement component 5
C6ORF47 chromosome 6 open reading frame 47
CAPG capping protein (actin filament), gelsolin-like
CASKIN2 CASK interacting protein 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBX4 chromobox homolog 4
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CDK3 cyclin-dependent kinase 3
CENPT centromere protein T
CISH cytokine inducible SH2-containing protein
CPPED1 calcineurin-like phosphoesterase domain containing 1
CUL9 cullin 9
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DTWD1 DTW domain containing 1
EFNA3 ephrin-A3
ELMO3 engulfment and cell motility 3
FAM118A family with sequence similarity 118, member A
FBXO22 F-box protein 22
FKBP10 FK506 binding protein 10, 65 kDa
FOXA1 forkhead box A1
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GAB2 GRB2-associated binding protein 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GLI3 GLI family zinc finger 3
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
H2AFY2 H2A histone family, member Y2
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IL17RA interleukin 17 receptor A
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
ISG15 ISG15 ubiquitin-like modifier
JADE1 jade family PHD finger 1
JMJD4 jumonji domain containing 4
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KLF7 Kruppel-like factor 7 (ubiquitous)
KRT13 keratin 13, type I
LAMA3 laminin, alpha 3
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
MAN2B1 mannosidase, alpha, class 2B, member 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED15 mediator complex subunit 15
MRPL44 mitochondrial ribosomal protein L44
MTMR12 myotubularin related protein 12
MVD mevalonate (diphospho) decarboxylase
NPY5R neuropeptide Y receptor Y5
NSD1 nuclear receptor binding SET domain protein 1
ONECUT2 one cut homeobox 2
PC pyruvate carboxylase
PCSK7 proprotein convertase subtilisin/kexin type 7
PLD2 phospholipase D2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLIN3 perilipin 3
PRSS22 protease, serine, 22
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPS17P5 ribosomal protein S17 pseudogene 5
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCAI suppressor of cancer cell invasion
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SOX12 SRY (sex determining region Y)-box 12
STAG3 stromal antigen 3
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STARD13 StAR-related lipid transfer (START) domain containing 13
STX5 syntaxin 5
TCTN2 tectonic family member 2
TEAD3 TEA domain family member 3
THBS3 thrombospondin 3
TRAPPC2 trafficking protein particle complex 2
TRIM25 tripartite motif containing 25
TRNAU1AP tRNA selenocysteine 1 associated protein 1
UBXN6 UBX domain protein 6
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VAV1 vav 1 guanine nucleotide exchange factor
VGF VGF nerve growth factor inducible
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WDR19 WD repeat domain 19
YEATS2 YEATS domain containing 2
ZNF165 zinc finger protein 165
ZNF211 zinc finger protein 211
ZNF432 zinc finger protein 432
ZNF573 zinc finger protein 573
ZNF675 zinc finger protein 675
ZXDC ZXD family zinc finger C