trichostatin A-4565 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the trichostatin A-4565 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
ATG2A autophagy related 2A
AVPI1 arginine vasopressin-induced 1
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
BIRC3 baculoviral IAP repeat containing 3
BMP4 bone morphogenetic protein 4
BMP6 bone morphogenetic protein 6
C1ORF116 chromosome 1 open reading frame 116
CCDC68 coiled-coil domain containing 68
CCNA1 cyclin A1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COBL cordon-bleu WH2 repeat protein
CORO1A coronin, actin binding protein, 1A
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CYR61 cysteine-rich, angiogenic inducer, 61
DENND3 DENN/MADD domain containing 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
EGR2 early growth response 2
ESRRG estrogen-related receptor gamma
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FAM69A family with sequence similarity 69, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FYN FYN proto-oncogene, Src family tyrosine kinase
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GLS glutaminase
GMPR guanosine monophosphate reductase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
H1FX H1 histone family, member X
HOXA1 homeobox A1
IRF6 interferon regulatory factor 6
ITGA7 integrin, alpha 7
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIF5C kinesin family member 5C
LINC00341 long intergenic non-protein coding RNA 341
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
MAP1A microtubule-associated protein 1A
MMP17 matrix metallopeptidase 17 (membrane-inserted)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
PAIP2B poly(A) binding protein interacting protein 2B
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI2 pellino E3 ubiquitin protein ligase family member 2
PLK2 polo-like kinase 2
PLSCR4 phospholipid scramblase 4
PPL periplakin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTCH1 patched 1
PTK2B protein tyrosine kinase 2 beta
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI2 retinoic acid induced 2
REPS2 RALBP1 associated Eps domain containing 2
RGCC regulator of cell cycle
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RND1 Rho family GTPase 1
RNF24 ring finger protein 24
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SIRT4 sirtuin 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SORBS1 sorbin and SH3 domain containing 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STOM stomatin
SYT1 synaptotagmin I
TAOK3 TAO kinase 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPMT thiopurine S-methyltransferase
TRAFD1 TRAF-type zinc finger domain containing 1
TRIM29 tripartite motif containing 29
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
USP2 ubiquitin specific peptidase 2
VGLL3 vestigial-like family member 3
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARSJ arylsulfatase family, member J
ATF1 activating transcription factor 1
BCAR3 breast cancer anti-estrogen resistance 3
BNC2 basonuclin 2
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CLCF1 cardiotrophin-like cytokine factor 1
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
COA7 cytochrome c oxidase assembly factor 7 (putative)
COG7 component of oligomeric golgi complex 7
COIL coilin
CPEB1 cytoplasmic polyadenylation element binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
CUL1 cullin 1
DEPDC1 DEP domain containing 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FADD Fas (TNFRSF6)-associated via death domain
FAIM Fas apoptotic inhibitory molecule
FAM57A family with sequence similarity 57, member A
FAN1 FANCD2/FANCI-associated nuclease 1
FJX1 four jointed box 1 (Drosophila)
FOXA1 forkhead box A1
FST follistatin
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 GA binding protein transcription factor, beta subunit 1
GBX2 gastrulation brain homeobox 2
GTF2I general transcription factor IIi
H2AFY2 H2A histone family, member Y2
HAS2 hyaluronan synthase 2
HIRIP3 HIRA interacting protein 3
HMGA2 high mobility group AT-hook 2
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
INHBB inhibin, beta B
KAT6B K(lysine) acetyltransferase 6B
KEAP1 kelch-like ECH-associated protein 1
KLHL12 kelch-like family member 12
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LIF leukemia inhibitory factor
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRRC37A3 leucine rich repeat containing 37, member A3
LRRC41 leucine rich repeat containing 41
LUC7L2 LUC7-like 2 (S. cerevisiae)
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MED24 mediator complex subunit 24
MEPCE methylphosphate capping enzyme
MSL1 male-specific lethal 1 homolog (Drosophila)
NHEJ1 nonhomologous end-joining factor 1
NLRX1 NLR family member X1
NME6 NME/NM23 nucleoside diphosphate kinase 6
NMI N-myc (and STAT) interactor
NUPR1 nuclear protein, transcriptional regulator, 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PALMD palmdelphin
PHF11 PHD finger protein 11
PPAP2B phosphatidic acid phosphatase type 2B
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RBM23 RNA binding motif protein 23
RBM4B RNA binding motif protein 4B
RIN2 Ras and Rab interactor 2
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SETD1B SET domain containing 1B
SFMBT1 Scm-like with four mbt domains 1
SIM2 single-minded family bHLH transcription factor 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SMAGP small cell adhesion glycoprotein
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMG9 SMG9 nonsense mediated mRNA decay factor
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SMYD5 SMYD family member 5
SNX5 sorting nexin 5
SRSF4 serine/arginine-rich splicing factor 4
SRSF8 serine/arginine-rich splicing factor 8
STBD1 starch binding domain 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB3 tribbles pseudokinase 3
UBTF upstream binding transcription factor, RNA polymerase I
UBXN8 UBX domain protein 8
UNKL unkempt family zinc finger-like
USP21 ubiquitin specific peptidase 21
VEGFC vascular endothelial growth factor C
ZBED1 zinc finger, BED-type containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZNF165 zinc finger protein 165
ZNF32 zinc finger protein 32
ZNF532 zinc finger protein 532
ZNF668 zinc finger protein 668
ZNF692 zinc finger protein 692