tight junction Gene Set

Dataset KEGG Pathways
Category structural or functional annotations
Type pathway
Description An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. (Gene Ontology, GO_0005923)
External Link http://www.genome.jp/kegg/pathway/hsa/hsa04530.html
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Genes

131 proteins participating in the tight junction pathway from the KEGG Pathways dataset.

Symbol Name
ACTB actin, beta
ACTG1 actin gamma 1
ACTN1 actinin, alpha 1
ACTN2 actinin, alpha 2
ACTN3 actinin, alpha 3 (gene/pseudogene)
ACTN4 actinin, alpha 4
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMOTL1 angiomotin like 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CDC42 cell division cycle 42
CDK4 cyclin-dependent kinase 4
CGN cingulin
CLDN1 claudin 1
CLDN10 claudin 10
CLDN11 claudin 11
CLDN14 claudin 14
CLDN15 claudin 15
CLDN16 claudin 16
CLDN17 claudin 17
CLDN18 claudin 18
CLDN19 claudin 19
CLDN2 claudin 2
CLDN20 claudin 20
CLDN22 claudin 22
CLDN23 claudin 23
CLDN3 claudin 3
CLDN4 claudin 4
CLDN5 claudin 5
CLDN6 claudin 6
CLDN7 claudin 7
CLDN8 claudin 8
CLDN9 claudin 9
CRB3 crumbs family member 3
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
EPB41 erythrocyte membrane protein band 4.1
EPB41L1 erythrocyte membrane protein band 4.1-like 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EXOC3 exocyst complex component 3
EXOC4 exocyst complex component 4
F11R F11 receptor
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
HCLS1 hematopoietic cell-specific Lyn substrate 1
HRAS Harvey rat sarcoma viral oncogene homolog
IGSF5 immunoglobulin superfamily, member 5
INADL InaD-like (Drosophila)
JAM2 junctional adhesion molecule 2
JAM3 junctional adhesion molecule 3
KRAS Kirsten rat sarcoma viral oncogene homolog
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LLGL2 lethal giant larvae homolog 2 (Drosophila)
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MPDZ multiple PDZ domain protein
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MRAS muscle RAS oncogene homolog
MYH1 myosin, heavy chain 1, skeletal muscle, adult
MYH10 myosin, heavy chain 10, non-muscle
MYH11 myosin, heavy chain 11, smooth muscle
MYH13 myosin, heavy chain 13, skeletal muscle
MYH14 myosin, heavy chain 14, non-muscle
MYH15 myosin, heavy chain 15
MYH2 myosin, heavy chain 2, skeletal muscle, adult
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic
MYH4 myosin, heavy chain 4, skeletal muscle
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYH7B myosin, heavy chain 7B, cardiac muscle, beta
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal
MYH9 myosin, heavy chain 9, non-muscle
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYL5 myosin, light chain 5, regulatory
MYL7 myosin, light chain 7, regulatory
MYL8P myosin, light chain 8, pseudogene
MYL9 myosin, light chain 9, regulatory
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OCLN occludin
PARD3 par-3 family cell polarity regulator
PARD6A par-6 family cell polarity regulator alpha
PARD6B par-6 family cell polarity regulator beta
PARD6G par-6 family cell polarity regulator gamma
PPM1J protein phosphatase, Mg2+/Mn2+ dependent, 1J
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PRKCH protein kinase C, eta
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PRKCZ protein kinase C, zeta
PTEN phosphatase and tensin homolog
RAB13 RAB13, member RAS oncogene family
RAB3B RAB3B, member RAS oncogene family
RHOA ras homolog family member A
RRAS related RAS viral (r-ras) oncogene homolog
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYMPK symplekin
TJAP1 tight junction associated protein 1 (peripheral)
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TJP3 tight junction protein 3
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZAK sterile alpha motif and leucine zipper containing kinase AZK