tight junction Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. (Gene Ontology, GO_0005923)
External Link http://amigo.geneontology.org/amigo/term/GO:0005923
Similar Terms
Downloads & Tools

Genes

110 proteins localized to the tight junction cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
AMICA1 adhesion molecule, interacts with CXADR antigen 1
AMOT angiomotin
AMOTL1 angiomotin like 1
AMOTL2 angiomotin like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AOC1 amine oxidase, copper containing 1
APC adenomatous polyposis coli
ARHGAP17 Rho GTPase activating protein 17
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BVES blood vessel epicardial substance
CCDC85C coiled-coil domain containing 85C
CCND1 cyclin D1
CDH5 cadherin 5, type 2 (vascular endothelium)
CDK4 cyclin-dependent kinase 4
CGN cingulin
CGNL1 cingulin-like 1
CLDN1 claudin 1
CLDN10 claudin 10
CLDN11 claudin 11
CLDN12 claudin 12
CLDN14 claudin 14
CLDN15 claudin 15
CLDN16 claudin 16
CLDN17 claudin 17
CLDN18 claudin 18
CLDN19 claudin 19
CLDN2 claudin 2
CLDN20 claudin 20
CLDN22 claudin 22
CLDN23 claudin 23
CLDN24 claudin 24
CLDN25 claudin 25
CLDN3 claudin 3
CLDN4 claudin 4
CLDN5 claudin 5
CLDN6 claudin 6
CLDN7 claudin 7
CLDN8 claudin 8
CLDN9 claudin 9
CLMP CXADR-like membrane protein
CRB3 crumbs family member 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXADR coxsackie virus and adenovirus receptor
CYTH1 cytohesin 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DLG1 discs, large homolog 1 (Drosophila)
DLG3 discs, large homolog 3 (Drosophila)
ECT2 epithelial cell transforming 2
EPCAM epithelial cell adhesion molecule
ESAM endothelial cell adhesion molecule
F11R F11 receptor
FRMD4A FERM domain containing 4A
FRMPD2 FERM and PDZ domain containing 2
FZD5 frizzled class receptor 5
IGSF5 immunoglobulin superfamily, member 5
INADL InaD-like (Drosophila)
JAM2 junctional adhesion molecule 2
JAM3 junctional adhesion molecule 3
LIN7A lin-7 homolog A (C. elegans)
LIN7B lin-7 homolog B (C. elegans)
LIN7C lin-7 homolog C (C. elegans)
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MARVELD2 MARVEL domain containing 2
MARVELD3 MARVEL domain containing 3
MICALL2 MICAL-like 2
MPDZ multiple PDZ domain protein
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
MTDH metadherin
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
NPHP1 nephronophthisis 1 (juvenile)
NPHP4 nephronophthisis 4
OCLN occludin
PARD3 par-3 family cell polarity regulator
PARD3B par-3 family cell polarity regulator beta
PARD6A par-6 family cell polarity regulator alpha
PARD6B par-6 family cell polarity regulator beta
PARD6G par-6 family cell polarity regulator gamma
PLXDC1 plexin domain containing 1
PMP22 peripheral myelin protein 22
POF1B premature ovarian failure, 1B
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
RAB13 RAB13, member RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RAP2C RAP2C, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RPGRIP1L RPGRIP1-like
SHROOM2 shroom family member 2
STRN striatin, calmodulin binding protein
SYMPK symplekin
SYNPO synaptopodin
TBCD tubulin folding cofactor D
TGFBR1 transforming growth factor, beta receptor 1
TJAP1 tight junction associated protein 1 (peripheral)
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TJP3 tight junction protein 3
TMEM235 transmembrane protein 235
TRAF4 TNF receptor-associated factor 4
UBN1 ubinuclein 1
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VASP vasodilator-stimulated phosphoprotein
WNK3 WNK lysine deficient protein kinase 3
WNK4 WNK lysine deficient protein kinase 4
YBX3 Y box binding protein 3