thyroid nodule Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Pathological nodule in the thyroid gland, often filled with colloid; some are indicative of adenoma or carcinoma. (BRENDA Tissue and Enzyme Source Ontology, BTO_0002617)
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Genes

145 proteins co-occuring with the tissue thyroid nodule in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
TG thyroglobulin 2.81977
TSHR thyroid stimulating hormone receptor 2.28213
LGALS3 lectin, galactoside-binding, soluble, 3 2.23416
CALCA calcitonin-related polypeptide alpha 2.20454
RET ret proto-oncogene 2.11233
PAX8 paired box 8 2.01452
CTNS cystinosin, lysosomal cystine transporter 1.86255
TPO thyroid peroxidase 1.80768
PTH parathyroid hormone 1.60564
DDI2 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 1.38505
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 1.37043
GNAS GNAS complex locus 1.34361
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1.31694
TRH thyrotropin-releasing hormone 1.31244
OTUD1 OTU deubiquitinase 1 1.28367
TNS1 tensin 1 1.22069
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 1.18912
TFF3 trefoil factor 3 (intestinal) 1.05589
HRAS Harvey rat sarcoma viral oncogene homolog 1.02425
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 1.0085
KRT19 keratin 19, type I 1.00589
SYNGR2 synaptogyrin 2 0.988466
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 0.952978
MIR197 microRNA 197 0.868107
PTCH1 patched 1 0.856732
FAM129A family with sequence similarity 129, member A 0.851266
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.823175
ECM1 extracellular matrix protein 1 0.821921
LRRC6 leucine rich repeat containing 6 0.80563
MPPED2 metallophosphoesterase domain containing 2 0.774834
CHGA chromogranin A 0.772344
MIR221 microRNA 221 0.768197
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.763226
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.761155
TERT telomerase reverse transcriptase 0.742976
KRAS Kirsten rat sarcoma viral oncogene homolog 0.726918
MIR190A microRNA 190a 0.725685
NKX2-1 NK2 homeobox 1 0.721166
TMPRSS4 transmembrane protease, serine 4 0.717472
PCSK2 proprotein convertase subtilisin/kexin type 2 0.699853
IGF1 insulin-like growth factor 1 (somatomedin C) 0.698625
MIR222 microRNA 222 0.689634
GSTO1 glutathione S-transferase omega 1 0.688
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.671692
MEMO1 mediator of cell motility 1 0.666402
QPCT glutaminyl-peptide cyclotransferase 0.666402
SYP synaptophysin 0.657054
MIR187 microRNA 187 0.644479
DAPK1 death-associated protein kinase 1 0.639214
ATG4C autophagy related 4C, cysteine peptidase 0.637999
PGK1 phosphoglycerate kinase 1 0.634762
ZNF165 zinc finger protein 165 0.634358
GDF15 growth differentiation factor 15 0.633549
FOXE1 forkhead box E1 0.631931
HK3 hexokinase 3 (white cell) 0.627081
LYPD1 LY6/PLAUR domain containing 1 0.59405
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 0.584022
HMGA2 high mobility group AT-hook 2 0.58322
C8ORF4 chromosome 8 open reading frame 4 0.564035
PTEN phosphatase and tensin homolog 0.557661
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 0.539
ENO2 enolase 2 (gamma, neuronal) 0.535438
GMDS GDP-mannose 4,6-dehydratase 0.521617
ZNHIT2 zinc finger, HIT-type containing 2 0.519647
PPARG peroxisome proliferator-activated receptor gamma 0.519253
MIR130B microRNA 130b 0.512564
THY1 Thy-1 cell surface antigen 0.50942
SLC26A4 solute carrier family 26 (anion exchanger), member 4 0.507849
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.505887
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.499223
FCGBP Fc fragment of IgG binding protein 0.498048
CELA2A chymotrypsin-like elastase family, member 2A 0.485545
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.483596
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.477367
IYD iodotyrosine deiodinase 0.470375
TTN titin 0.468048
KLHL21 kelch-like family member 21 0.465335
WDR1 WD repeat domain 1 0.457987
FBXO2 F-box protein 2 0.449886
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.448731
HAUS3 HAUS augmin-like complex, subunit 3 0.440658
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.439123
SERP1 stress-associated endoplasmic reticulum protein 1 0.433757
MIRLET7E microRNA let-7e 0.433757
AKAP9 A kinase (PRKA) anchor protein 9 0.428018
ARG2 arginase 2 0.419242
NUMBL numb homolog (Drosophila)-like 0.419242
DNPEP aspartyl aminopeptidase 0.412391
HLTF helicase-like transcription factor 0.405176
VILL villin-like 0.402144
RGS6 regulator of G-protein signaling 6 0.3976
MET MET proto-oncogene, receptor tyrosine kinase 0.38439
QPRT quinolinate phosphoribosyltransferase 0.380627
RGS10 regulator of G-protein signaling 10 0.378748
FGF13 fibroblast growth factor 13 0.378372
PGRMC1 progesterone receptor membrane component 1 0.377996
PGPEP1 pyroglutamyl-peptidase I 0.374618
GAGE1 G antigen 1 0.371619
TRIB1 tribbles pseudokinase 1 0.364513
MUC1 mucin 1, cell surface associated 0.354084
NASP nuclear autoantigenic sperm protein (histone-binding) 0.35334
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 0.352969
ADGRG1 adhesion G protein-coupled receptor G1 0.345928
TP53 tumor protein p53 0.33744
RAD9A RAD9 homolog A (S. pombe) 0.336336
SPAG7 sperm associated antigen 7 0.333763
TIMP3 TIMP metallopeptidase inhibitor 3 0.326432
MRC2 mannose receptor, C type 2 0.32497
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 0.312595
MCM5 minichromosome maintenance complex component 5 0.312595
RGS3 regulator of G-protein signaling 3 0.305001
GNPDA1 glucosamine-6-phosphate deaminase 1 0.29996
TPT1 tumor protein, translationally-controlled 1 0.296372
PCNA proliferating cell nuclear antigen 0.282483
ARRB1 arrestin, beta 1 0.281776
SEPT7 septin 7 0.28107
DUOX1 dual oxidase 1 0.278251
GAGE12I G antigen 12I 0.277549
ACOT13 acyl-CoA thioesterase 13 0.275794
MIR100 microRNA 100 0.266413
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.264696
DUOX2 dual oxidase 2 0.264353
SHD Src homology 2 domain containing transforming protein D 0.262304
FCN3 ficolin (collagen/fibrinogen domain containing) 3 0.256902
FOSL1 FOS-like antigen 1 0.25457
RAB2A RAB2A, member RAS oncogene family 0.25457
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 0.253248
HBA1 hemoglobin, alpha 1 0.248361
EPS8 epidermal growth factor receptor pathway substrate 8 0.243294
PER2 period circadian clock 2 0.241438
HBA2 hemoglobin, alpha 2 0.238108
VEGFA vascular endothelial growth factor A 0.23604
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.232039
EFNB2 ephrin-B2 0.231206
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.231206
SST somatostatin 0.231206
IL31 interleukin 31 0.230656
GSTP1 glutathione S-transferase pi 1 0.229568
NCAM1 neural cell adhesion molecule 1 0.226411
BIRC5 baculoviral IAP repeat containing 5 0.222699
SSTR2 somatostatin receptor 2 0.220378
MED1 mediator complex subunit 1 0.220152
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.219047
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.218398
APOC1 apolipoprotein C-I 0.216325