thymus atrophy Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description acquired diminution of the size of the thymus associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes (Mammalian Phenotype Ontology, MP_0003644)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003644
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Genes

44 gene mutations causing the thymus atrophy phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AIRE autoimmune regulator
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
BCL2 B-cell CLL/lymphoma 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CD2AP CD2-associated protein
CDK6 cyclin-dependent kinase 6
CTSV cathepsin V
CYCS cytochrome c, somatic
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DHRS7B dehydrogenase/reductase (SDR family) member 7B
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
FAS Fas cell surface death receptor
FEN1 flap structure-specific endonuclease 1
FGF23 fibroblast growth factor 23
FZD9 frizzled class receptor 9
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GLRA1 glycine receptor, alpha 1
GNAS GNAS complex locus
HR hair growth associated
HYDIN HYDIN, axonemal central pair apparatus protein
KITLG KIT ligand
KL klotho
LCK LCK proto-oncogene, Src family tyrosine kinase
LMNA lamin A/C
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PARL presenilin associated, rhomboid-like
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RORA RAR-related orphan receptor A
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
SOCS1 suppressor of cytokine signaling 1
STK36 serine/threonine kinase 36
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TDP2 tyrosyl-DNA phosphodiesterase 2
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast)
TPP2 tripeptidyl peptidase II
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TWIST2 twist family bHLH transcription factor 2
TWSG1 twisted gastrulation BMP signaling modulator 1