thrombosis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements (Mammalian Phenotype Ontology, MP_0005048)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005048
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Genes

70 gene mutations causing the thrombosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ACKR3 atypical chemokine receptor 3
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
AHR aryl hydrocarbon receptor
ALOX12 arachidonate 12-lipoxygenase
ANK1 ankyrin 1, erythrocytic
ANXA2 annexin A2
APOE apolipoprotein E
ARNTL aryl hydrocarbon receptor nuclear translocator-like
CD36 CD36 molecule (thrombospondin receptor)
CD40LG CD40 ligand
CTSD cathepsin D
E2F3 E2F transcription factor 3
EPCAM epithelial cell adhesion molecule
F2RL2 coagulation factor II (thrombin) receptor-like 2
F2RL3 coagulation factor II (thrombin) receptor-like 3
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FBLN5 fibulin 5
FBN1 fibrillin 1
FERMT3 fermitin family member 3
FGG fibrinogen gamma chain
FLNA filamin A, alpha
FOXP3 forkhead box P3
FSHR follicle stimulating hormone receptor
GDF15 growth differentiation factor 15
GOLM1 golgi membrane protein 1
GP1BB glycoprotein Ib (platelet), beta polypeptide
GPX3 glutathione peroxidase 3
HMOX1 heme oxygenase 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JUP junction plakoglobin
KNG1 kininogen 1
LAT linker for activation of T cells
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NT5E 5'-nucleotidase, ecto (CD73)
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDLIM1 PDZ and LIM domain 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PF4 platelet factor 4
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLG plasminogen
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRDX6 peroxiredoxin 6
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROCR protein C receptor, endothelial
PROS1 protein S (alpha)
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAP1B RAP1B, member of RAS oncogene family
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SMAD6 SMAD family member 6
SPTA1 spectrin, alpha, erythrocytic 1
SPTB spectrin, beta, erythrocytic
STIM1 stromal interaction molecule 1
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TREX1 three prime repair exonuclease 1
TUSC2 tumor suppressor candidate 2
WRN Werner syndrome, RecQ helicase-like