thiostrepton-4563 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the thiostrepton-4563 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ACTA1 actin, alpha 1, skeletal muscle
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALOXE3 arachidonate lipoxygenase 3
ANTXR1 anthrax toxin receptor 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGAP28 Rho GTPase activating protein 28
ATF3 activating transcription factor 3
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
CADM3 cell adhesion molecule 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CNTNAP2 contactin associated protein-like 2
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYTH4 cytohesin 4
DCSTAMP dendrocyte expressed seven transmembrane protein
DDIT4 DNA-damage-inducible transcript 4
DIDO1 death inducer-obliterator 1
DMP1 dentin matrix acidic phosphoprotein 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DYM dymeclin
EGLN3 egl-9 family hypoxia-inducible factor 3
EYA3 EYA transcriptional coactivator and phosphatase 3
F5 coagulation factor V (proaccelerin, labile factor)
FGB fibrinogen beta chain
FLJ11292
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GRM8 glutamate receptor, metabotropic 8
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HGFAC HGF activator
HLA-DMB major histocompatibility complex, class II, DM beta
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IL4 interleukin 4
INSIG1 insulin induced gene 1
JPH3 junctophilin 3
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KLHL20 kelch-like family member 20
KLK11 kallikrein-related peptidase 11
KRT31 keratin 31, type I
KRT33A keratin 33A, type I
LAX1 lymphocyte transmembrane adaptor 1
LRRTM2 leucine rich repeat transmembrane neuronal 2
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR22HG MIR22 host gene
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MYBPC3 myosin binding protein C, cardiac
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NFIB nuclear factor I/B
NPIPB15 nuclear pore complex interacting protein family, member B15
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUP160 nucleoporin 160kDa
OR7E24 olfactory receptor, family 7, subfamily E, member 24
OSGIN1 oxidative stress induced growth inhibitor 1
PCDHGB5 protocadherin gamma subfamily B, 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PDCD2 programmed cell death 2
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLAG1 pleiomorphic adenoma gene 1
PTGDR2 prostaglandin D2 receptor 2
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RBM34 RNA binding motif protein 34
RBMS2 RNA binding motif, single stranded interacting protein 2
RETN resistin
RGCC regulator of cell cycle
RIBC2 RIB43A domain with coiled-coils 2
RND1 Rho family GTPase 1
RPS3A ribosomal protein S3A
SENP6 SUMO1/sentrin specific peptidase 6
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC19A3 solute carrier family 19 (thiamine transporter), member 3
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SORBS1 sorbin and SH3 domain containing 1
STK3 serine/threonine kinase 3
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TTC38 tetratricopeptide repeat domain 38
UBE2I ubiquitin-conjugating enzyme E2I
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAT1 adenosine deaminase, tRNA-specific 1
ADCY6 adenylate cyclase 6
ADGRG6 adhesion G protein-coupled receptor G6
AHNAK2 AHNAK nucleoprotein 2
AMDHD2 amidohydrolase domain containing 2
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANP32A-IT1 ANP32A intronic transcript 1
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BAK1 BCL2-antagonist/killer 1
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BHLHE41 basic helix-loop-helix family, member e41
C1QTNF1 C1q and tumor necrosis factor related protein 1
C7ORF43 chromosome 7 open reading frame 43
CENPB centromere protein B, 80kDa
CEP112 centrosomal protein 112kDa
CFAP44 cilia and flagella associated protein 44
CLEC16A C-type lectin domain family 16, member A
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRNP3 cysteine-serine-rich nuclear protein 3
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DNAL4 dynein, axonemal, light chain 4
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EPN3 epsin 3
ERF Ets2 repressor factor
FADD Fas (TNFRSF6)-associated via death domain
FAM131B family with sequence similarity 131, member B
FAM50B family with sequence similarity 50, member B
FANCF Fanconi anemia, complementation group F
FJX1 four jointed box 1 (Drosophila)
FZD8 frizzled class receptor 8
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPR87 G protein-coupled receptor 87
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H1F0 H1 histone family, member 0
HAS2 hyaluronan synthase 2
HOXC8 homeobox C8
INCENP inner centromere protein antigens 135/155kDa
KRCC1 lysine-rich coiled-coil 1
LIME1 Lck interacting transmembrane adaptor 1
LMNB1 lamin B1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC6 leucine rich repeat containing 6
MAVS mitochondrial antiviral signaling protein
MCM3AP-AS1 MCM3AP antisense RNA 1
MEIS3P1 Meis homeobox 3 pseudogene 1
MITF microphthalmia-associated transcription factor
NDP Norrie disease (pseudoglioma)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NIT1 nitrilase 1
NLRX1 NLR family member X1
NME5 NME/NM23 family member 5
NMRK1 nicotinamide riboside kinase 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
OSMR oncostatin M receptor
PARD6A par-6 family cell polarity regulator alpha
PARP3 poly (ADP-ribose) polymerase family, member 3
PLAT plasminogen activator, tissue
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PSRC1 proline/serine-rich coiled-coil 1
PYCRL pyrroline-5-carboxylate reductase-like
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
RUNX1-IT1 RUNX1 intronic transcript 1
RWDD2B RWD domain containing 2B
SAYSD1 SAYSVFN motif domain containing 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
STK16 serine/threonine kinase 16
STON1 stonin 1
SYTL2 synaptotagmin-like 2
TENM4 teneurin transmembrane protein 4
TERF2 telomeric repeat binding factor 2
TMEM209 transmembrane protein 209
TMEM242 transmembrane protein 242
TRIM66 tripartite motif containing 66
TRIM9 tripartite motif containing 9
TRIOBP TRIO and F-actin binding protein
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA3C tubulin, alpha 3c
UBTF upstream binding transcription factor, RNA polymerase I
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
ZHX2 zinc fingers and homeoboxes 2
ZNF32 zinc finger protein 32
ZNF629 zinc finger protein 629
ZNF667 zinc finger protein 667
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76