thioguanosine-2619 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the thioguanosine-2619 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
AIRE autoimmune regulator
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
APLP1 amyloid beta (A4) precursor-like protein 1
AQP4 aquaporin 4
ATF3 activating transcription factor 3
ATF6B activating transcription factor 6 beta
BLZF1 basic leucine zipper nuclear factor 1
BTG2 BTG family, member 2
C14ORF79 chromosome 14 open reading frame 79
C17ORF59 chromosome 17 open reading frame 59
CA4 carbonic anhydrase IV
CD3D CD3d molecule, delta (CD3-TCR complex)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL5A1 collagen, type V, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DICER1 dicer 1, ribonuclease type III
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EGR1 early growth response 1
ETV6 ets variant 6
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF2 fibroblast growth factor 2 (basic)
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLJ11292
FOXH1 forkhead box H1
GADD45A growth arrest and DNA-damage-inducible, alpha
GLG1 golgi glycoprotein 1
GLP1R glucagon-like peptide 1 receptor
GLRA1 glycine receptor, alpha 1
GLS glutaminase
GPR87 G protein-coupled receptor 87
HBS1L HBS1-like translational GTPase
HEMK1 HemK methyltransferase family member 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST2H2BE histone cluster 2, H2be
HNF4A hepatocyte nuclear factor 4, alpha
HOXC8 homeobox C8
HSPA13 heat shock protein 70kDa family, member 13
HSPG2 heparan sulfate proteoglycan 2
INHBA inhibin, beta A
ISG20 interferon stimulated exonuclease gene 20kDa
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KDM4C lysine (K)-specific demethylase 4C
KIAA0125 KIAA0125
KLHL20 kelch-like family member 20
LIF leukemia inhibitory factor
MAOA monoamine oxidase A
MARS methionyl-tRNA synthetase
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED6 mediator complex subunit 6
METTL7A methyltransferase like 7A
MKL1 megakaryoblastic leukemia (translocation) 1
MKRN1 makorin ring finger protein 1
MPZ myelin protein zero
MTA1 metastasis associated 1
MYF5 myogenic factor 5
MYOF myoferlin
N4BP2L2 NEDD4 binding protein 2-like 2
NACA nascent polypeptide-associated complex alpha subunit
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUMA1 nuclear mitotic apparatus protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PGAP1 post-GPI attachment to proteins 1
POMT2 protein-O-mannosyltransferase 2
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRO2964 uncharacterized protein PRO2964
PTPRU protein tyrosine phosphatase, receptor type, U
RBM34 RNA binding motif protein 34
RBM48 RNA binding motif protein 48
RPS4Y1 ribosomal protein S4, Y-linked 1
RRH retinal pigment epithelium-derived rhodopsin homolog
RSL1D1 ribosomal L1 domain containing 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SP100 SP100 nuclear antigen
SPTAN1 spectrin, alpha, non-erythrocytic 1
TAOK2 TAO kinase 2
TAZ tafazzin
TCP10L t-complex 10-like
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM53 transmembrane protein 53
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TRIB3 tribbles pseudokinase 3
TXNIP thioredoxin interacting protein
VAC14 Vac14 homolog (S. cerevisiae)
VEGFA vascular endothelial growth factor A
ZC3H13 zinc finger CCCH-type containing 13
ZFP64 ZFP64 zinc finger protein
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF3 zinc finger protein 3
ZNF337 zinc finger protein 337
ZRSR1 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1
ZSCAN31 zinc finger and SCAN domain containing 31
ZYX zyxin

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
AP3M2 adaptor-related protein complex 3, mu 2 subunit
ARHGAP11A Rho GTPase activating protein 11A
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP11B ATPase, class VI, type 11B
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BARD1 BRCA1 associated RING domain 1
BCORL1 BCL6 corepressor-like 1
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C10ORF88 chromosome 10 open reading frame 88
C2CD2 C2 calcium-dependent domain containing 2
C6ORF47 chromosome 6 open reading frame 47
CCNE2 cyclin E2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPE centromere protein E, 312kDa
CENPI centromere protein I
CENPQ centromere protein Q
CHMP7 charged multivesicular body protein 7
CKAP2 cytoskeleton associated protein 2
CLDND1 claudin domain containing 1
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUL1 cullin 1
DBR1 debranching RNA lariats 1
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
E2F8 E2F transcription factor 8
EGLN3 egl-9 family hypoxia-inducible factor 3
ERN2 endoplasmic reticulum to nucleus signaling 2
EXO1 exonuclease 1
EXOSC9 exosome component 9
FA2H fatty acid 2-hydroxylase
FASTKD1 FAST kinase domains 1
FBXL6 F-box and leucine-rich repeat protein 6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
INSIG2 insulin induced gene 2
IPO13 importin 13
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF16B kinesin family member 16B
KIF23 kinesin family member 23
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MED15 mediator complex subunit 15
METTL4 methyltransferase like 4
MSH2 mutS homolog 2
MTRF1 mitochondrial translational release factor 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCAM2 neural cell adhesion molecule 2
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NPIPB15 nuclear pore complex interacting protein family, member B15
OSBPL11 oxysterol binding protein-like 11
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLEKHA5 pleckstrin homology domain containing, family A member 5
PMM1 phosphomannomutase 1
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PPT2 palmitoyl-protein thioesterase 2
RBL1 retinoblastoma-like 1
RFWD3 ring finger and WD repeat domain 3
RIBC2 RIB43A domain with coiled-coils 2
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPAP3 RNA polymerase II associated protein 3
RPL13P5 ribosomal protein L13 pseudogene 5
SALL2 spalt-like transcription factor 2
SGK1 serum/glucocorticoid regulated kinase 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SMC3 structural maintenance of chromosomes 3
SMTN smoothelin
SPDL1 spindle apparatus coiled-coil protein 1
TBC1D31 TBC1 domain family, member 31
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TEFM transcription elongation factor, mitochondrial
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIPRL TOR signaling pathway regulator
TMEM110 transmembrane protein 110
TPST2 tyrosylprotein sulfotransferase 2
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
VAV1 vav 1 guanine nucleotide exchange factor
WDR44 WD repeat domain 44
XYLT2 xylosyltransferase II
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZC3H3 zinc finger CCCH-type containing 3
ZCCHC2 zinc finger, CCHC domain containing 2
ZDHHC18 zinc finger, DHHC-type containing 18
ZMYM3 zinc finger, MYM-type 3
ZNF573 zinc finger protein 573