thick aortic valve Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness (Mammalian Phenotype Ontology, MP_0010594)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010594
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Genes

15 gene mutations causing the thick aortic valve phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACKR3 atypical chemokine receptor 3
ADAM17 ADAM metallopeptidase domain 17
ADAM19 ADAM metallopeptidase domain 19
EFNA1 ephrin-A1
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
FOXC1 forkhead box C1
GATA4 GATA binding protein 4
GJA1 gap junction protein, alpha 1, 43kDa
KLF3 Kruppel-like factor 3 (basic)
NKX2-5 NK2 homeobox 5
NTF3 neurotrophin 3
PLCE1 phospholipase C, epsilon 1
SOS1 son of sevenless homolog 1 (Drosophila)
TGFB2 transforming growth factor, beta 2