tetrandrine-5821 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the tetrandrine-5821 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ACOT11 acyl-CoA thioesterase 11
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARNTL aryl hydrocarbon receptor nuclear translocator-like
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
C1R complement component 1, r subcomponent
C8ORF60 chromosome 8 open reading frame 60
CCNG2 cyclin G2
CD79B CD79b molecule, immunoglobulin-associated beta
CDC42 cell division cycle 42
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTH cystathionine gamma-lyase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EFHC2 EF-hand domain (C-terminal) containing 2
ETAA1 Ewing tumor-associated antigen 1
FAM13A family with sequence similarity 13, member A
FBN1 fibrillin 1
FBXO38 F-box protein 38
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFBP1 fibroblast growth factor binding protein 1
FLJ11292
GABARAPL1 GABA(A) receptor-associated protein like 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GLG1 golgi glycoprotein 1
GM2A GM2 ganglioside activator
GPR176 G protein-coupled receptor 176
GREB1L growth regulation by estrogen in breast cancer-like
GTPBP4 GTP binding protein 4
HIRA histone cell cycle regulator
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IFT122 intraflagellar transport 122
IL1RN interleukin 1 receptor antagonist
INSIG1 insulin induced gene 1
IQSEC2 IQ motif and Sec7 domain 2
ISG20 interferon stimulated exonuclease gene 20kDa
LDLR low density lipoprotein receptor
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIPG lipase, endothelial
LMAN1 lectin, mannose-binding, 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MON1B MON1 secretory trafficking family member B
MRPS11 mitochondrial ribosomal protein S11
MSMO1 methylsterol monooxygenase 1
MST1 macrophage stimulating 1
MT1M metallothionein 1M
MTAP methylthioadenosine phosphorylase
MTM1 myotubularin 1
NAT6 N-acetyltransferase 6 (GCN5-related)
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NGLY1 N-glycanase 1
NPC1 Niemann-Pick disease, type C1
NRN1 neuritin 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OVGP1 oviductal glycoprotein 1, 120kDa
PASK PAS domain containing serine/threonine kinase
PBOV1 prostate and breast cancer overexpressed 1
PHACTR2 phosphatase and actin regulator 2
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLEK pleckstrin
PVT1 Pvt1 oncogene (non-protein coding)
RAD23B RAD23 homolog B (S. cerevisiae)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A14 solute carrier family 22, member 14
SLC22A18 solute carrier family 22, member 18
SLC43A3 solute carrier family 43, member 3
SMAD5 SMAD family member 5
SMC1A structural maintenance of chromosomes 1A
SQLE squalene epoxidase
SSH3 slingshot protein phosphatase 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STC1 stanniocalcin 1
STK3 serine/threonine kinase 3
SUGCT succinyl-CoA:glutarate-CoA transferase
SUSD5 sushi domain containing 5
SYT1 synaptotagmin I
TAGLN3 transgelin 3
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TBL2 transducin (beta)-like 2
TENM1 teneurin transmembrane protein 1
TLDC1 TBC/LysM-associated domain containing 1
TMEM183A transmembrane protein 183A
TMEM19 transmembrane protein 19
TNC tenascin C
TRD T cell receptor delta locus
TSFM Ts translation elongation factor, mitochondrial
TSKU tsukushi, small leucine rich proteoglycan
TSPAN1 tetraspanin 1
UTRN utrophin
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
WSB1 WD repeat and SOCS box containing 1
ZNF407 zinc finger protein 407

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALPK1 alpha-kinase 1
ASS1 argininosuccinate synthase 1
ATP13A2 ATPase type 13A2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCCIP BRCA2 and CDKN1A interacting protein
C16ORF59 chromosome 16 open reading frame 59
CBY1 chibby homolog 1 (Drosophila)
CCNE1 cyclin E1
CDADC1 cytidine and dCMP deaminase domain containing 1
CDC37L1 cell division cycle 37-like 1
CDKL3 cyclin-dependent kinase-like 3
CEP131 centrosomal protein 131kDa
COBL cordon-bleu WH2 repeat protein
CPEB1 cytoplasmic polyadenylation element binding protein 1
CRIP2 cysteine-rich protein 2
CRYL1 crystallin, lambda 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ELOVL4 ELOVL fatty acid elongase 4
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERCC2 excision repair cross-complementation group 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FDXR ferredoxin reductase
FOXK2 forkhead box K2
FURIN furin (paired basic amino acid cleaving enzyme)
GLCE glucuronic acid epimerase
GLDC glycine dehydrogenase (decarboxylating)
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GRWD1 glutamate-rich WD repeat containing 1
HIST1H2AG histone cluster 1, H2ag
HIST1H2BI histone cluster 1, H2bi
HIST2H2BE histone cluster 2, H2be
HYAL3 hyaluronoglucosaminidase 3
IL15RA interleukin 15 receptor, alpha
IMPACT impact RWD domain protein
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITPKB inositol-trisphosphate 3-kinase B
JMJD4 jumonji domain containing 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1
KDM5C lysine (K)-specific demethylase 5C
KIAA1549L KIAA1549-like
KLK5 kallikrein-related peptidase 5
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MED9 mediator complex subunit 9
MYL5 myosin, light chain 5, regulatory
NARFL nuclear prelamin A recognition factor-like
NDE1 nudE neurodevelopment protein 1
NHEJ1 nonhomologous end-joining factor 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NSD1 nuclear receptor binding SET domain protein 1
NT5E 5'-nucleotidase, ecto (CD73)
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAQR6 progestin and adipoQ receptor family member VI
PDE8B phosphodiesterase 8B
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCD1 phospholipase C, delta 1
PLK2 polo-like kinase 2
PMPCA peptidase (mitochondrial processing) alpha
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRR15L proline rich 15-like
PTDSS2 phosphatidylserine synthase 2
PTGFR prostaglandin F receptor (FP)
RAB8B RAB8B, member RAS oncogene family
SCAMP5 secretory carrier membrane protein 5
SCN1B sodium channel, voltage gated, type I beta subunit
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SECISBP2 SECIS binding protein 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SETBP1 SET binding protein 1
SH2B2 SH2B adaptor protein 2
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC12A8 solute carrier family 12, member 8
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SOX12 SRY (sex determining region Y)-box 12
STEAP4 STEAP family member 4
STK25 serine/threonine kinase 25
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TMEM212 transmembrane protein 212
TMEM62 transmembrane protein 62
TMOD3 tropomodulin 3 (ubiquitous)
TNK1 tyrosine kinase, non-receptor, 1
TRABD TraB domain containing
TTBK2 tau tubulin kinase 2
UNKL unkempt family zinc finger-like
USP27X ubiquitin specific peptidase 27, X-linked
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
WDR41 WD repeat domain 41
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF696 zinc finger protein 696
ZNF747 zinc finger protein 747
ZNHIT2 zinc finger, HIT-type containing 2