tetraethylenepentamine-457 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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194 genes differentially expressed following the tetraethylenepentamine-457 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
AP3M2 adaptor-related protein complex 3, mu 2 subunit
APAF1 apoptotic peptidase activating factor 1
AREG amphiregulin
ASB13 ankyrin repeat and SOCS box containing 13
ASB8 ankyrin repeat and SOCS box containing 8
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
C7ORF26 chromosome 7 open reading frame 26
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CBX4 chromobox homolog 4
CD58 CD58 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDYL chromodomain protein, Y-like
CFAP70 cilia and flagella associated protein 70
CLU clusterin
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
CNTD2 cyclin N-terminal domain containing 2
CPE carboxypeptidase E
CREB3L1 cAMP responsive element binding protein 3-like 1
CREBL2 cAMP responsive element binding protein-like 2
CROT carnitine O-octanoyltransferase
CSRP2 cysteine and glycine-rich protein 2
ELAVL2 ELAV like neuron-specific RNA binding protein 2
FAM188A family with sequence similarity 188, member A
FASTK Fas-activated serine/threonine kinase
FKBP8 FK506 binding protein 8, 38kDa
FUBP3 far upstream element (FUSE) binding protein 3
GAK cyclin G associated kinase
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GHR growth hormone receptor
GUSBP3 glucuronidase, beta pseudogene 3
HACD1 3-hydroxyacyl-CoA dehydratase 1
HADH hydroxyacyl-CoA dehydrogenase
HLA-C major histocompatibility complex, class I, C
HMOX2 heme oxygenase 2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INPP5K inositol polyphosphate-5-phosphatase K
KIAA0141 KIAA0141
KLF5 Kruppel-like factor 5 (intestinal)
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
MAPKBP1 mitogen-activated protein kinase binding protein 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MINPP1 multiple inositol-polyphosphate phosphatase 1
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
NACAP1 nascent-polypeptide-associated complex alpha polypeptide pseudogene 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NIPAL2 NIPA-like domain containing 2
NMB neuromedin B
NNT nicotinamide nucleotide transhydrogenase
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PAK1IP1 PAK1 interacting protein 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLA2G16 phospholipase A2, group XVI
PRRC2B proline-rich coiled-coil 2B
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBM25 RNA binding motif protein 25
RING1 ring finger protein 1
RPL13 ribosomal protein L13
RSL1D1 ribosomal L1 domain containing 1
SEC23B Sec23 homolog B (S. cerevisiae)
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SERBP1 SERPINE1 mRNA binding protein 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SPPL2B signal peptide peptidase like 2B
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRP72 signal recognition particle 72kDa
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STX2 syntaxin 2
SURF2 surfeit 2
SYNGR1 synaptogyrin 1
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TMC6 transmembrane channel-like 6
TMEM161A transmembrane protein 161A
TMEM38B transmembrane protein 38B
TMEM8B transmembrane protein 8B
TNS4 tensin 4
TREX1 three prime repair exonuclease 1
TSKU tsukushi, small leucine rich proteoglycan
U2SURP U2 snRNP-associated SURP domain containing
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)
VAC14 Vac14 homolog (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VRK3 vaccinia related kinase 3
WDR13 WD repeat domain 13
ZFX zinc finger protein, X-linked

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ACTN4 actinin, alpha 4
ADRA2B adrenoceptor alpha 2B
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
APCS amyloid P component, serum
APOC4 apolipoprotein C-IV
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
BDNF brain-derived neurotrophic factor
BEGAIN brain-enriched guanylate kinase-associated
BSPRY B-box and SPRY domain containing
C17ORF70 chromosome 17 open reading frame 70
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CAPG capping protein (actin filament), gelsolin-like
CCDC176 coiled-coil domain containing 176
CD83 CD83 molecule
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLEC1A C-type lectin domain family 1, member A
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CTRB2 chymotrypsinogen B2
DAAM1 dishevelled associated activator of morphogenesis 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ELAVL4 ELAV like neuron-specific RNA binding protein 4
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM153A family with sequence similarity 153, member A
FBXL2 F-box and leucine-rich repeat protein 2
FGL1 fibrinogen-like 1
FIG4 FIG4 phosphoinositide 5-phosphatase
FIP1L1 factor interacting with PAPOLA and CPSF1
FKBP10 FK506 binding protein 10, 65 kDa
FLT3 fms-related tyrosine kinase 3
FMO4 flavin containing monooxygenase 4
FRS3 fibroblast growth factor receptor substrate 3
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GAL3ST4 galactose-3-O-sulfotransferase 4
GALR3 galanin receptor 3
GK2 glycerol kinase 2
GLRA2 glycine receptor, alpha 2
GPATCH3 G patch domain containing 3
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GPS1 G protein pathway suppressor 1
GRWD1 glutamate-rich WD repeat containing 1
GUCA2A guanylate cyclase activator 2A (guanylin)
IFT20 intraflagellar transport 20
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL22RA1 interleukin 22 receptor, alpha 1
INO80D INO80 complex subunit D
JAM3 junctional adhesion molecule 3
KIAA0753 KIAA0753
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KLK6 kallikrein-related peptidase 6
KRT37 keratin 37, type I
LGALS13 lectin, galactoside-binding, soluble, 13
LRRC15 leucine rich repeat containing 15
LY86 lymphocyte antigen 86
MB myoglobin
MOCS3 molybdenum cofactor synthesis 3
MOGAT2 monoacylglycerol O-acyltransferase 2
NEUROD2 neuronal differentiation 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
OR2C1 olfactory receptor, family 2, subfamily C, member 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCSK7 proprotein convertase subtilisin/kexin type 7
PEX13 peroxisomal biogenesis factor 13
PF4 platelet factor 4
PGS1 phosphatidylglycerophosphate synthase 1
PIP prolactin-induced protein
PLCD1 phospholipase C, delta 1
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PRSS23 protease, serine, 23
PRSS8 protease, serine, 8
PSG4 pregnancy specific beta-1-glycoprotein 4
QSER1 glutamine and serine rich 1
R3HDM2 R3H domain containing 2
RAD9A RAD9 homolog A (S. pombe)
RNF185 ring finger protein 185
SECTM1 secreted and transmembrane 1
SEPW1 selenoprotein W, 1
SERTAD3 SERTA domain containing 3
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SSUH2 ssu-2 homolog (C. elegans)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUSD4 sushi domain containing 4
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
TMPRSS6 transmembrane protease, serine 6
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM66 tripartite motif containing 66
UPK2 uroplakin 2
VIPR1 vasoactive intestinal peptide receptor 1
YPEL1 yippee-like 1 (Drosophila)
ZBTB25 zinc finger and BTB domain containing 25
ZC3H3 zinc finger CCCH-type containing 3
ZNF175 zinc finger protein 175
ZNF280A zinc finger protein 280A