tetracycline-6233 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the tetracycline-6233 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADAM7 ADAM metallopeptidase domain 7
ADGRE5 adhesion G protein-coupled receptor E5
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ATAD5 ATPase family, AAA domain containing 5
ATM ATM serine/threonine kinase
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BIRC7 baculoviral IAP repeat containing 7
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BTD biotinidase
C19ORF73 chromosome 19 open reading frame 73
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CLCF1 cardiotrophin-like cytokine factor 1
CNGB3 cyclic nucleotide gated channel beta 3
COPS7B COP9 signalosome subunit 7B
CRYBB2P1 crystallin, beta B2 pseudogene 1
CUL4B cullin 4B
CXCL8 chemokine (C-X-C motif) ligand 8
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCAF15 DDB1 and CUL4 associated factor 15
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ECE1 endothelin converting enzyme 1
ELSPBP1 epididymal sperm binding protein 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
ERAP1 endoplasmic reticulum aminopeptidase 1
F3 coagulation factor III (thromboplastin, tissue factor)
FKBP8 FK506 binding protein 8, 38kDa
GAMT guanidinoacetate N-methyltransferase
GANAB glucosidase, alpha; neutral AB
GAS7 growth arrest-specific 7
GJB3 gap junction protein, beta 3, 31kDa
GUSBP3 glucuronidase, beta pseudogene 3
IFT27 intraflagellar transport 27
IGHA1 immunoglobulin heavy constant alpha 1
IRF6 interferon regulatory factor 6
KDM5A lysine (K)-specific demethylase 5A
KLF9 Kruppel-like factor 9
LEPR leptin receptor
LMBR1L limb development membrane protein 1-like
LPP LIM domain containing preferred translocation partner in lipoma
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MAP4 microtubule-associated protein 4
MCM3AP minichromosome maintenance complex component 3 associated protein
MED1 mediator complex subunit 1
MLF1 myeloid leukemia factor 1
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NDRG2 NDRG family member 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEK1 NIMA-related kinase 1
NEK11 NIMA-related kinase 11
NFRKB nuclear factor related to kappaB binding protein
NRGN neurogranin (protein kinase C substrate, RC3)
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OSMR oncostatin M receptor
PARG poly (ADP-ribose) glycohydrolase
PDGFA platelet-derived growth factor alpha polypeptide
PDS5B PDS5 cohesin associated factor B
PLCH1 phospholipase C, eta 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRMT2 protein arginine methyltransferase 2
PYCRL pyrroline-5-carboxylate reductase-like
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RFX7 regulatory factor X, 7
RIN1 Ras and Rab interactor 1
RNF122 ring finger protein 122
RNF39 ring finger protein 39
RP2 retinitis pigmentosa 2 (X-linked recessive)
RPL13P5 ribosomal protein L13 pseudogene 5
SAPCD1 suppressor APC domain containing 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SLC19A1 solute carrier family 19 (folate transporter), member 1
SOGA1 suppressor of glucose, autophagy associated 1
SOX4 SRY (sex determining region Y)-box 4
SPIDR scaffolding protein involved in DNA repair
SPTBN1 spectrin, beta, non-erythrocytic 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
SUGP1 SURP and G patch domain containing 1
SYNGR1 synaptogyrin 1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TMEM63A transmembrane protein 63A
TRAV8-3 T cell receptor alpha variable 8-3
TRIM62 tripartite motif containing 62
USF2 upstream transcription factor 2, c-fos interacting
VAC14 Vac14 homolog (S. cerevisiae)
VAX2 ventral anterior homeobox 2
WFDC2 WAP four-disulfide core domain 2
ZBTB43 zinc finger and BTB domain containing 43
ZNF468 zinc finger protein 468
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ANKRD36 ankyrin repeat domain 36
ANXA2P3 annexin A2 pseudogene 3
BAX BCL2-associated X protein
BTF3P11 basic transcription factor 3 pseudogene 11
C11ORF95 chromosome 11 open reading frame 95
C21ORF91 chromosome 21 open reading frame 91
CCDC186 coiled-coil domain containing 186
CD302 CD302 molecule
CDKL3 cyclin-dependent kinase-like 3
CEP131 centrosomal protein 131kDa
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CUL9 cullin 9
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DSPP dentin sialophosphoprotein
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EFNA3 ephrin-A3
ERCC5 excision repair cross-complementation group 5
EVPL envoplakin
FAM114A2 family with sequence similarity 114, member A2
FAM118A family with sequence similarity 118, member A
FCHO1 FCH domain only 1
FKBP10 FK506 binding protein 10, 65 kDa
FLT4 fms-related tyrosine kinase 4
FSTL3 follistatin-like 3 (secreted glycoprotein)
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GAN gigaxonin
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GPR19 G protein-coupled receptor 19
HIST1H2BC histone cluster 1, H2bc
HMHA1 histocompatibility (minor) HA-1
HOXC10 homeobox C10
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
INO80D INO80 complex subunit D
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCTD20 potassium channel tetramerization domain containing 20
KIZ kizuna centrosomal protein
KLHL21 kelch-like family member 21
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC730101 uncharacterized LOC730101
LRP5L low density lipoprotein receptor-related protein 5-like
LRP6 low density lipoprotein receptor-related protein 6
LZTR1 leucine-zipper-like transcription regulator 1
MAMLD1 mastermind-like domain containing 1
MBNL3 muscleblind-like splicing regulator 3
MICALL2 MICAL-like 2
MRPL44 mitochondrial ribosomal protein L44
MTMR12 myotubularin related protein 12
MUM1 melanoma associated antigen (mutated) 1
MYO1E myosin IE
NR1D2 nuclear receptor subfamily 1, group D, member 2
NT5C 5', 3'-nucleotidase, cytosolic
ONECUT2 one cut homeobox 2
PARD6A par-6 family cell polarity regulator alpha
PEX26 peroxisomal biogenesis factor 26
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PILRB paired immunoglobin-like type 2 receptor beta
PLD2 phospholipase D2
RAB33B RAB33B, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RCOR3 REST corepressor 3
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
S100A4 S100 calcium binding protein A4
SKA1 spindle and kinetochore associated complex subunit 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC46A3 solute carrier family 46, member 3
SOX12 SRY (sex determining region Y)-box 12
SOX3 SRY (sex determining region Y)-box 3
SUN2 Sad1 and UNC84 domain containing 2
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TEAD3 TEA domain family member 3
THBS3 thrombospondin 3
TMC7 transmembrane channel-like 7
TMEM159 transmembrane protein 159
TMEM180 transmembrane protein 180
TMEM184B transmembrane protein 184B
TRAF2 TNF receptor-associated factor 2
TRAPPC13 trafficking protein particle complex 13
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSPAN15 tetraspanin 15
TSPAN5 tetraspanin 5
TUBA3D tubulin, alpha 3d
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UPK3B uroplakin 3B
ZC3H12A zinc finger CCCH-type containing 12A
ZDHHC18 zinc finger, DHHC-type containing 18
ZFP69B ZFP69 zinc finger protein B
ZNF205 zinc finger protein 205
ZNF573 zinc finger protein 573
ZNF574 zinc finger protein 574
ZNF586 zinc finger protein 586
ZNHIT2 zinc finger, HIT-type containing 2