testicular neoplasm Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description The presence of a neoplasm of the testis. (Human Phenotype Ontology, HP_0010788)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0010788
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Genes

333 genes associated with the testicular neoplasm phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
KITLG KIT ligand 1.70448
BAK1 BCL2-antagonist/killer 1 1.55568
DMRT1 doublesex and mab-3 related transcription factor 1 1.51005
CLPTM1L CLPTM1-like 1.48314
ATF7IP activating transcription factor 7 interacting protein 1.37549
TERT telomerase reverse transcriptase 1.3174
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 1.1789
NBAS neuroblastoma amplified sequence 1.08614
PDE3A phosphodiesterase 3A, cGMP-inhibited 1.05912
PCDH11X protocadherin 11 X-linked 1.05134
IFNLR1 interferon, lambda receptor 1 1.04468
LINC00336 long intergenic non-protein coding RNA 336 1.02319
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 1.01683
ADD2 adducin 2 (beta) 1.00841
AKAP9 A kinase (PRKA) anchor protein 9 1.00627
EYS eyes shut homolog (Drosophila) 1.00627
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 1.00059
CDK14 cyclin-dependent kinase 14 0.993873
RFWD3 ring finger and WD repeat domain 3 0.99234
PCDH9 protocadherin 9 0.966449
LPP LIM domain containing preferred translocation partner in lipoma 0.949544
RARS arginyl-tRNA synthetase 0.932233
CALCR calcitonin receptor 0.928309
MALRD1 MAM and LDL receptor class A domain containing 1 0.919744
SLC51A solute carrier family 51, alpha subunit 0.903602
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 0.897244
ARHGAP35 Rho GTPase activating protein 35 0.886585
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.884602
DTNB dystrobrevin, beta 0.875746
ZFAND4 zinc finger, AN1-type domain 4 0.870998
CNTNAP2 contactin associated protein-like 2 0.868241
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.861012
SMAD6 SMAD family member 6 0.855449
AKAP13 A kinase (PRKA) anchor protein 13 0.849886
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.845192
KLHL32 kelch-like family member 32 0.844241
TRAPPC9 trafficking protein particle complex 9 0.844241
PTPRJ protein tyrosine phosphatase, receptor type, J 0.844241
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.844241
APP amyloid beta (A4) precursor protein 0.844241
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) 0.818279
IL7R interleukin 7 receptor 0.81601
CENPE centromere protein E, 312kDa 0.808951
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.805703
HSP90AA6P heat shock protein 90kDa alpha (cytosolic), class A member 6, pseudogene 0.805703
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 0.791675
FRMD5 FERM domain containing 5 0.784165
LOC339975 uncharacterized LOC339975 0.782964
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.778885
METTL2A methyltransferase like 2A 0.778885
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.778318
CHN2 chimerin 2 0.777194
GPR149 G protein-coupled receptor 149 0.777194
BSG basigin (Ok blood group) 0.775536
DERA deoxyribose-phosphate aldolase (putative) 0.77499
EGFR epidermal growth factor receptor 0.772842
AIG1 androgen-induced 1 0.772842
C4ORF45 chromosome 4 open reading frame 45 0.772842
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.772842
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.772842
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.772842
C20ORF196 chromosome 20 open reading frame 196 0.772842
RYR2 ryanodine receptor 2 (cardiac) 0.772842
MAP2 microtubule-associated protein 2 0.772842
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.772842
SLC26A3 solute carrier family 26 (anion exchanger), member 3 0.771787
MCTP1 multiple C2 domains, transmembrane 1 0.767696
CADM1 cell adhesion molecule 1 0.758275
PLK3 polo-like kinase 3 0.756252
RNF144B ring finger protein 144B 0.752816
DNAH6 dynein, axonemal, heavy chain 6 0.752335
CASZ1 castor zinc finger 1 0.751857
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.750439
FAM71D family with sequence similarity 71, member D 0.745864
CDK8 cyclin-dependent kinase 8 0.732783
UBASH3B ubiquitin associated and SH3 domain containing B 0.729791
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 0.729372
ADAMTSL3 ADAMTS-like 3 0.726078
ERBB4 erb-b2 receptor tyrosine kinase 4 0.726078
TPK1 thiamin pyrophosphokinase 1 0.726078
BMPR1B bone morphogenetic protein receptor, type IB 0.726078
CHD9 chromodomain helicase DNA binding protein 9 0.726078
ZNF385D zinc finger protein 385D 0.726078
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.726078
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 0.726078
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.726078
NRXN3 neurexin 3 0.726078
ELMO1 engulfment and cell motility 1 0.726078
PXDNL peroxidasin-like 0.726078
SMAD3 SMAD family member 3 0.724872
MCM3AP minichromosome maintenance complex component 3 associated protein 0.719731
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.717942
USH2A Usher syndrome 2A (autosomal recessive, mild) 0.714661
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.713947
SUSD5 sushi domain containing 5 0.713947
COL25A1 collagen, type XXV, alpha 1 0.712886
PRICKLE1 prickle homolog 1 (Drosophila) 0.709765
CDH13 cadherin 13 0.708638
NOL8 nucleolar protein 8 0.706055
KIAA1671 KIAA1671 0.703184
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.700738
USP45 ubiquitin specific peptidase 45 0.700393
CAPSL calcyphosine-like 0.698689
PAX2 paired box 2 0.697013
DSE dermatan sulfate epimerase 0.695366
P3H2 prolyl 3-hydroxylase 2 0.695366
FAM207A family with sequence similarity 207, member A 0.693745
CSMD1 CUB and Sushi multiple domains 1 0.693745
FAM179B family with sequence similarity 179, member B 0.693425
NRG3 neuregulin 3 0.690584
LPA lipoprotein, Lp(a) 0.690584
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 0.690584
PTPRD protein tyrosine phosphatase, receptor type, D 0.690584
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.690584
ALPK3 alpha-kinase 3 0.690584
CCDC67 coiled-coil domain containing 67 0.690584
AOX2P aldehyde oxidase 2 pseudogene 0.690584
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.690584
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.690584
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.690584
FGF12 fibroblast growth factor 12 0.690584
VIT vitrin 0.685142
RHD Rh blood group, D antigen 0.684556
CLCN6 chloride channel, voltage-sensitive 6 0.682247
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.681396
KCNIP1 Kv channel interacting protein 1 0.680272
SECTM1 secreted and transmembrane 1 0.676017
TMEM248 transmembrane protein 248 0.675718
ZBTB7C zinc finger and BTB domain containing 7C 0.673945
MYLK myosin light chain kinase 0.672779
SCFD2 sec1 family domain containing 2 0.672202
ZNF652 zinc finger protein 652 0.672202
CENPP centromere protein P 0.671341
ZNF407 zinc finger protein 407 0.671056
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 0.66742
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.664175
FMN2 formin 2 0.663645
SOX5 SRY (sex determining region Y)-box 5 0.661809
FRMD4A FERM domain containing 4A 0.661809
LINC00540 long intergenic non-protein coding RNA 540 0.661809
MEMO1 mediator of cell motility 1 0.661809
ARMC8 armadillo repeat containing 8 0.661809
DCLK1 doublecortin-like kinase 1 0.661809
AGBL1 ATP/GTP binding protein-like 1 0.661291
SPAG16 sperm associated antigen 16 0.659244
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.659244
ADGRA3 adhesion G protein-coupled receptor A3 0.658487
CLSTN2 calsyntenin 2 0.656005
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.65576
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 0.655029
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.653584
CCSER1 coiled-coil serine-rich protein 1 0.652395
CAMTA1 calmodulin binding transcription activator 1 0.651923
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.65006
CFAP43 cilia and flagella associated protein 43 0.649139
NEGR1 neuronal growth regulator 1 0.646119
DENND4B DENN/MADD domain containing 4B 0.644641
PTPRS protein tyrosine phosphatase, receptor type, S 0.644153
PTPRK protein tyrosine phosphatase, receptor type, K 0.640797
PTCH2 patched 2 0.638004
FBLN1 fibulin 1 0.637546
SRD5A3 steroid 5 alpha-reductase 3 0.637546
LDB2 LIM domain binding 2 0.637546
ESRRG estrogen-related receptor gamma 0.637546
NGEF neuronal guanine nucleotide exchange factor 0.637546
EIF3E eukaryotic translation initiation factor 3, subunit E 0.637546
COL13A1 collagen, type XIII, alpha 1 0.637546
C6ORF89 chromosome 6 open reading frame 89 0.637546
SEZ6L seizure related 6 homolog (mouse)-like 0.637546
TFEC transcription factor EC 0.637546
ASS1 argininosuccinate synthase 1 0.637546
TMEM87A transmembrane protein 87A 0.635061
TSPAN15 tetraspanin 15 0.634172
BRD1 bromodomain containing 1 0.631549
PTPRM protein tyrosine phosphatase, receptor type, M 0.631333
HDAC4 histone deacetylase 4 0.631333
TNIK TRAF2 and NCK interacting kinase 0.631118
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 0.629707
LOC344887 NmrA-like family domain containing 1 pseudogene 0.623659
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.621485
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.621094
TBC1D22A TBC1 domain family, member 22A 0.620705
MTUS2 microtubule associated tumor suppressor candidate 2 0.619739
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.619547
CLASP2 cytoplasmic linker associated protein 2 0.618973
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.617835
DOPEY1 dopey family member 1 0.616892
MACROD1 MACRO domain containing 1 0.616892
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 0.616892
KIF13B kinesin family member 13B 0.616892
KIAA1217 KIAA1217 0.616892
MLPH melanophilin 0.616892
LIMCH1 LIM and calponin homology domains 1 0.616892
PRR16 proline rich 16 0.616892
OSBPL5 oxysterol binding protein-like 5 0.611597
RERG RAS-like, estrogen-regulated, growth inhibitor 0.611229
GATAD2B GATA zinc finger domain containing 2B 0.611045
MIS18BP1 MIS18 binding protein 1 0.610862
ZFPM2 zinc finger protein, FOG family member 2 0.610133
ECM2 extracellular matrix protein 2, female organ and adipocyte specific 0.608689
RGS7 regulator of G-protein signaling 7 0.608689
SLC39A1 solute carrier family 39 (zinc transporter), member 1 0.608153
PPAP2B phosphatidic acid phosphatase type 2B 0.607266
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.603452
AKNAD1 AKNA domain containing 1 0.599122
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.599122
SCHIP1 schwannomin interacting protein 1 0.599122
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 0.599122
FAM71F1 family with sequence similarity 71, member F1 0.599122
UMODL1 uromodulin-like 1 0.599122
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.599122
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.599122
PCDH15 protocadherin-related 15 0.599122
LOC339862 uncharacterized LOC339862 0.599122
CADM2 cell adhesion molecule 2 0.599122
NAV2 neuron navigator 2 0.597345
PRKCB protein kinase C, beta 0.595757
WDR72 WD repeat domain 72 0.594349
PRKG1 protein kinase, cGMP-dependent, type I 0.594193
DMPK dystrophia myotonica-protein kinase 0.592045
PLD5 phospholipase D family, member 5 0.588321
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.586726
DFNB31 deafness, autosomal recessive 31 0.585507
MRPL47 mitochondrial ribosomal protein L47 0.585136
LAMA2 laminin, alpha 2 0.584275
NTM neurotrimin 0.584275
LUZP2 leucine zipper protein 2 0.584275
ASPA aspartoacylase 0.584275
UBE2W ubiquitin-conjugating enzyme E2W (putative) 0.584275
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.584275
SBF2 SET binding factor 2 0.584275
LOC728755 uncharacterized LOC728755 0.584275
IQCJ IQ motif containing J 0.584275
GLIS3 GLIS family zinc finger 3 0.584275
ELOVL6 ELOVL fatty acid elongase 6 0.584275
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 0.584275
TMEM132D transmembrane protein 132D 0.584275
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.584275
ASTN2 astrotactin 2 0.584275
SMAD7 SMAD family member 7 0.58403
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.583059
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.582219
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.580913
TMEM183A transmembrane protein 183A 0.579049
SPIDR scaffolding protein involved in DNA repair 0.578934
SCLT1 sodium channel and clathrin linker 1 0.578132
SEZ6 seizure related 6 homolog (mouse) 0.577677
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.577563
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.577563
MYO3B myosin IIIB 0.576661
GRM7 glutamate receptor, metabotropic 7 0.576661
ERN2 endoplasmic reticulum to nucleus signaling 2 0.576214
LINC00687 long intergenic non-protein coding RNA 687 0.575326
FAT4 FAT atypical cadherin 4 0.574776
RANBP1 RAN binding protein 1 0.57412
RAD21 RAD21 homolog (S. pombe) 0.573577
MACROD2 MACRO domain containing 2 0.572823
CTIF CBP80/20-dependent translation initiation factor 0.572823
TOX thymocyte selection-associated high mobility group box 0.572823
FAM111B family with sequence similarity 111, member B 0.572823
RELN reelin 0.572823
CCDC174 coiled-coil domain containing 174 0.572823
TMEM165 transmembrane protein 165 0.572823
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.572823
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.572823
FGF6 fibroblast growth factor 6 0.572823
CLOCK clock circadian regulator 0.572823
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.572823
LYN LYN proto-oncogene, Src family tyrosine kinase 0.572823
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.572823
CNTN5 contactin 5 0.572823
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.572823
SCUBE1 signal peptide, CUB domain, EGF-like 1 0.572823
ARHGAP15 Rho GTPase activating protein 15 0.572823
CFAP61 cilia and flagella associated protein 61 0.572823
CD38 CD38 molecule 0.572823
HPGDS hematopoietic prostaglandin D synthase 0.572823
KIAA1456 KIAA1456 0.572823
SAMD3 sterile alpha motif domain containing 3 0.572823
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.572823
LINC00578 long intergenic non-protein coding RNA 578 0.572823
FAM163A family with sequence similarity 163, member A 0.572823
PARD3B par-3 family cell polarity regulator beta 0.572823
CLIC5 chloride intracellular channel 5 0.572823
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.572823
ATXN1 ataxin 1 0.572823
OSBPL1A oxysterol binding protein-like 1A 0.572823
THADA thyroid adenoma associated 0.572823
PELP1 proline, glutamate and leucine rich protein 1 0.572823
MAN2B2 mannosidase, alpha, class 2B, member 2 0.572823
IRAK3 interleukin-1 receptor-associated kinase 3 0.572823
C6ORF7 chromosome 6 open reading frame 7 0.572823
SPTBN1 spectrin, beta, non-erythrocytic 1 0.572823
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.572823
NXPH1 neurexophilin 1 0.572823
NUP160 nucleoporin 160kDa 0.572823
LRP5L low density lipoprotein receptor-related protein 5-like 0.572823
SNAP25 synaptosomal-associated protein, 25kDa 0.572823
CSPP1 centrosome and spindle pole associated protein 1 0.572823
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.572823
KIF16B kinesin family member 16B 0.572823
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.572823
PDZRN3 PDZ domain containing ring finger 3 0.572823
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.572823
MINOS1-NBL1 MINOS1-NBL1 readthrough 0.572823
SGK1 serum/glucocorticoid regulated kinase 1 0.572823
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.572823
SLIT1 slit homolog 1 (Drosophila) 0.572823
SCN3A sodium channel, voltage gated, type III alpha subunit 0.572823
PADI3 peptidyl arginine deiminase, type III 0.572823
FRMD6 FERM domain containing 6 0.572823
DCAF4 DDB1 and CUL4 associated factor 4 0.572823
C4ORF22 chromosome 4 open reading frame 22 0.572823
FAM189A1 family with sequence similarity 189, member A1 0.572823
UCK2 uridine-cytidine kinase 2 0.542759
PITX1 paired-like homeodomain 1 0.542759
PDCL2 phosducin-like 2 0.531556
SLC25A44 solute carrier family 25, member 44 0.530444
CHD2 chromodomain helicase DNA binding protein 2 0.528162
APAF1 apoptotic peptidase activating factor 1 0.522136
IKBIP IKBKB interacting protein 0.522136
PRDM14 PR domain containing 14 0.515847
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.514254
ZFYVE1 zinc finger, FYVE domain containing 1 0.511765
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.509391
TCF3 transcription factor 3 0.50495
CACHD1 cache domain containing 1 0.496801
CPM carboxypeptidase M 0.496801
NBEA neurobeachin 0.476506
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.470822
RGS5 regulator of G-protein signaling 5 0.44484
TEX14 testis expressed 14 0.442877
LIPG lipase, endothelial 0.406588