tanespimycin-5223 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the tanespimycin-5223 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY7 adenylate cyclase 7
ADM adrenomedullin
AMPD3 adenosine monophosphate deaminase 3
ANXA1 annexin A1
ASPH aspartate beta-hydroxylase
BAG2 BCL2-associated athanogene 2
BIN1 bridging integrator 1
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BST2 bone marrow stromal cell antigen 2
BTN2A2 butyrophilin, subfamily 2, member A2
C11ORF73 chromosome 11 open reading frame 73
CACYBP calcyclin binding protein
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCDC186 coiled-coil domain containing 186
CCNG2 cyclin G2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLCN4 chloride channel, voltage-sensitive 4
CLU clusterin
CSRP2 cysteine and glycine-rich protein 2
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIO2 deiodinase, iodothyronine, type II
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EGF epidermal growth factor
ERP44 endoplasmic reticulum protein 44
FGFR2 fibroblast growth factor receptor 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GEM GTP binding protein overexpressed in skeletal muscle
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
HBEGF heparin-binding EGF-like growth factor
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HFE hemochromatosis
HMOX1 heme oxygenase 1
HOXB2 homeobox B2
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IL6R interleukin 6 receptor
IRS2 insulin receptor substrate 2
JAG1 jagged 1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KLHL25 kelch-like family member 25
KLK6 kallikrein-related peptidase 6
LAMP1 lysosomal-associated membrane protein 1
MAP1B microtubule-associated protein 1B
MICB MHC class I polypeptide-related sequence B
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MXD4 MAX dimerization protein 4
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NAP1L2 nucleosome assembly protein 1-like 2
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
NOTCH4 notch 4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUP214 nucleoporin 214kDa
NUPR1 nuclear protein, transcriptional regulator, 1
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PLA2G3 phospholipase A2, group III
POPDC3 popeye domain containing 3
PRKCE protein kinase C, epsilon
RABGGTB Rab geranylgeranyltransferase, beta subunit
RCAN1 regulator of calcineurin 1
RFPL2 ret finger protein-like 2
RFPL3 ret finger protein-like 3
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RUNDC3A RUN domain containing 3A
SAMD4A sterile alpha motif domain containing 4A
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGR SH3 domain binding glutamate-rich protein
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNAI2 snail family zinc finger 2
SNAP23 synaptosomal-associated protein, 23kDa
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STYK1 serine/threonine/tyrosine kinase 1
TBX3 T-box 3
TES testin LIM domain protein
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIM2 tripartite motif containing 2
UNKL unkempt family zinc finger-like
VLDLR very low density lipoprotein receptor
ZMYND8 zinc finger, MYND-type containing 8
ZNF10 zinc finger protein 10
ZNF165 zinc finger protein 165
ZNF227 zinc finger protein 227
ZNF230 zinc finger protein 230
ZNF329 zinc finger protein 329
ZSCAN26 zinc finger and SCAN domain containing 26

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADAM15 ADAM metallopeptidase domain 15
ADGRA3 adhesion G protein-coupled receptor A3
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BYSL bystin-like
CD3EAP CD3e molecule, epsilon associated protein
CENPO centromere protein O
CENPT centromere protein T
CFAP44 cilia and flagella associated protein 44
CLDN7 claudin 7
COA7 cytochrome c oxidase assembly factor 7 (putative)
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
EGR3 early growth response 3
EPN3 epsin 3
ERCC4 excision repair cross-complementation group 4
EXOSC9 exosome component 9
FAAH fatty acid amide hydrolase
FAM65A family with sequence similarity 65, member A
FURIN furin (paired basic amino acid cleaving enzyme)
GFOD1 glucose-fructose oxidoreductase domain containing 1
GNL1 guanine nucleotide binding protein-like 1
GPR19 G protein-coupled receptor 19
HOXC13 homeobox C13
HTRA2 HtrA serine peptidase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IL17RB interleukin 17 receptor B
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM5C lysine (K)-specific demethylase 5C
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
LIG4 ligase IV, DNA, ATP-dependent
LINC00339 long intergenic non-protein coding RNA 339
MAPKBP1 mitogen-activated protein kinase binding protein 1
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MMP9 matrix metallopeptidase 9
MNX1 motor neuron and pancreas homeobox 1
MOCS3 molybdenum cofactor synthesis 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP3 NEDD4 binding protein 3
NARFL nuclear prelamin A recognition factor-like
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPL2 nucleoporin like 2
NXT1 nuclear transport factor 2-like export factor 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PCDHA6 protocadherin alpha 6
PCF11 PCF11 cleavage and polyadenylation factor subunit
PGBD5 piggyBac transposable element derived 5
PRKCD protein kinase C, delta
PTCD2 pentatricopeptide repeat domain 2
PTDSS2 phosphatidylserine synthase 2
PUS1 pseudouridylate synthase 1
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
PYCRL pyrroline-5-carboxylate reductase-like
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RECQL4 RecQ protein-like 4
RGS16 regulator of G-protein signaling 16
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIBC2 RIB43A domain with coiled-coils 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF25 ring finger protein 25
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCO2 SCO2 cytochrome c oxidase assembly protein
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMAD7 SMAD family member 7
SOX12 SRY (sex determining region Y)-box 12
SPATA2L spermatogenesis associated 2-like
SPRY2 sprouty homolog 2 (Drosophila)
STBD1 starch binding domain 1
SYTL2 synaptotagmin-like 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCHH trichohyalin
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFRC transferrin receptor
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIM45 tripartite motif containing 45
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBQLN4 ubiquilin 4
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VEGFC vascular endothelial growth factor C
WDR91 WD repeat domain 91
ZCCHC6 zinc finger, CCHC domain containing 6
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZXDC ZXD family zinc finger C