tanespimycin-450 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the tanespimycin-450 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AFF1 AF4/FMR2 family, member 1
AHCYL2 adenosylhomocysteinase-like 2
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AKAP9 A kinase (PRKA) anchor protein 9
AMBRA1 autophagy/beclin-1 regulator 1
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BAG3 BCL2-associated athanogene 3
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
CACYBP calcyclin binding protein
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD2BP2 CD2 (cytoplasmic tail) binding protein 2
CD5 CD5 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CIITA class II, major histocompatibility complex, transactivator
CLU clusterin
CPOX coproporphyrinogen oxidase
CREB3L1 cAMP responsive element binding protein 3-like 1
CTH cystathionine gamma-lyase
CUL4B cullin 4B
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DXO decapping exoribonuclease
E2F5 E2F transcription factor 5, p130-binding
EGFR epidermal growth factor receptor
EID1 EP300 interacting inhibitor of differentiation 1
EML2 echinoderm microtubule associated protein like 2
ENGASE endo-beta-N-acetylglucosaminidase
FAM222B family with sequence similarity 222, member B
FBXO38 F-box protein 38
FKBP4 FK506 binding protein 4, 59kDa
FOXA2 forkhead box A2
GLRA2 glycine receptor, alpha 2
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GRK5 G protein-coupled receptor kinase 5
GRWD1 glutamate-rich WD repeat containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPB11 heat shock protein family B (small), member 11
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IFRD1 interferon-related developmental regulator 1
IL19 interleukin 19
IL7R interleukin 7 receptor
KIAA0513 KIAA0513
KIF23 kinesin family member 23
KTN1 kinectin 1 (kinesin receptor)
LAMP2 lysosomal-associated membrane protein 2
LUZP1 leucine zipper protein 1
MBNL2 muscleblind-like splicing regulator 2
N4BP2L2 NEDD4 binding protein 2-like 2
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NAP1L2 nucleosome assembly protein 1-like 2
NBL1 neuroblastoma 1, DAN family BMP antagonist
NOTCH1 notch 1
NPY1R neuropeptide Y receptor Y1
NUCB2 nucleobindin 2
PDIA4 protein disulfide isomerase family A, member 4
PDZD2 PDZ domain containing 2
PICALM phosphatidylinositol binding clathrin assembly protein
PLEKHO2 pleckstrin homology domain containing, family O member 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RBKS ribokinase
RPL23AP7 ribosomal protein L23a pseudogene 7
RPS2 ribosomal protein S2
SAP18 Sin3A-associated protein, 18kDa
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIAH2 siah E3 ubiquitin protein ligase 2
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPTBN1 spectrin, beta, non-erythrocytic 1
SSR1 signal sequence receptor, alpha
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
TES testin LIM domain protein
TMED7 transmembrane emp24 protein transport domain containing 7
TMEM127 transmembrane protein 127
TOB2 transducer of ERBB2, 2
TSKU tsukushi, small leucine rich proteoglycan
ZBTB40 zinc finger and BTB domain containing 40
ZFR zinc finger RNA binding protein

decreased expression

Symbol Name
AKTIP AKT interacting protein
AMT aminomethyltransferase
ART3 ADP-ribosyltransferase 3
ASCC1 activating signal cointegrator 1 complex subunit 1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BEAN1 brain expressed, associated with NEDD4, 1
BEX1 brain expressed, X-linked 1
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CA6 carbonic anhydrase VI
CARD8 caspase recruitment domain family, member 8
CCDC132 coiled-coil domain containing 132
CCDC176 coiled-coil domain containing 176
CCDC82 coiled-coil domain containing 82
CD177 CD177 molecule
CD19 CD19 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD82 CD82 molecule
CDK20 cyclin-dependent kinase 20
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHRM4 cholinergic receptor, muscarinic 4
CPB1 carboxypeptidase B1 (tissue)
CSK c-src tyrosine kinase
DAGLA diacylglycerol lipase, alpha
DCC DCC netrin 1 receptor
ENO3 enolase 3 (beta, muscle)
EVPL envoplakin
FBRS fibrosin
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FOXF1 forkhead box F1
FOXJ1 forkhead box J1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GBX2 gastrulation brain homeobox 2
GMPPA GDP-mannose pyrophosphorylase A
GMPR guanosine monophosphate reductase
GPR3 G protein-coupled receptor 3
GUCA2A guanylate cyclase activator 2A (guanylin)
HDAC5 histone deacetylase 5
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFNA4 interferon, alpha 4
IL13 interleukin 13
IL17RA interleukin 17 receptor A
INTS8 integrator complex subunit 8
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KLHL25 kelch-like family member 25
LEMD3 LEM domain containing 3
LGALS4 lectin, galactoside-binding, soluble, 4
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LOC441601 septin 7 pseudogene
LRRC49 leucine rich repeat containing 49
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGEC1 melanoma antigen family C1
MPPED1 metallophosphoesterase domain containing 1
MTERF4 mitochondrial transcription termination factor 4
MTG1 mitochondrial ribosome-associated GTPase 1
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
NDRG4 NDRG family member 4
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NLK nemo-like kinase
NT5C 5', 3'-nucleotidase, cytosolic
NTHL1 nth endonuclease III-like 1 (E. coli)
NTSR1 neurotensin receptor 1 (high affinity)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OLFML2A olfactomedin-like 2A
OR12D3 olfactory receptor, family 12, subfamily D, member 3
PAGR1 PAXIP1 associated glutamate-rich protein 1
PAK1IP1 PAK1 interacting protein 1
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PENK proenkephalin
PFAS phosphoribosylformylglycinamidine synthase
PICK1 protein interacting with PRKCA 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PNOC prepronociceptin
PPARG peroxisome proliferator-activated receptor gamma
PPP1R26 protein phosphatase 1, regulatory subunit 26
PRODH2 proline dehydrogenase (oxidase) 2
PRSS21 protease, serine, 21 (testisin)
RBM15 RNA binding motif protein 15
RMI1 RecQ mediated genome instability 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12
SPTBN5 spectrin, beta, non-erythrocytic 5
SSTR4 somatostatin receptor 4
STRA6 stimulated by retinoic acid 6
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TMPRSS5 transmembrane protease, serine 5
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRAIP TRAF interacting protein
TST thiosulfate sulfurtransferase (rhodanese)
TULP2 tubby like protein 2
U2AF1 U2 small nuclear RNA auxiliary factor 1
ZNF280A zinc finger protein 280A
ZNF606 zinc finger protein 606