tanespimycin-2666 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the tanespimycin-2666 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACSM3 acyl-CoA synthetase medium-chain family member 3
AFF3 AF4/FMR2 family, member 3
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ANXA1 annexin A1
BAG3 BCL2-associated athanogene 3
BLZF1 basic leucine zipper nuclear factor 1
CA5B carbonic anhydrase VB, mitochondrial
CACYBP calcyclin binding protein
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCNG2 cyclin G2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLK1 CDC-like kinase 1
COPE coatomer protein complex, subunit epsilon
CPM carboxypeptidase M
CREM cAMP responsive element modulator
CRY2 cryptochrome circadian clock 2
CRYZ crystallin, zeta (quinone reductase)
CTRC chymotrypsin C (caldecrin)
DDAH2 dimethylarginine dimethylaminohydrolase 2
DNAH17 dynein, axonemal, heavy chain 17
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNMBP dynamin binding protein
DRICH1 aspartate-rich 1
EMILIN2 elastin microfibril interfacer 2
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAM13A family with sequence similarity 13, member A
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FKBP4 FK506 binding protein 4, 59kDa
FMO5 flavin containing monooxygenase 5
FOXG1 forkhead box G1
FRMD8 FERM domain containing 8
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA10 homeobox A10
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IGL immunoglobulin lambda locus
IL10RA interleukin 10 receptor, alpha
KIAA0513 KIAA0513
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MBNL2 muscleblind-like splicing regulator 2
MBOAT7 membrane bound O-acyltransferase domain containing 7
MKL2 MKL/myocardin-like 2
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MT1F metallothionein 1F
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
NINJ2 ninjurin 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PHACTR1 phosphatase and actin regulator 1
PIR pirin (iron-binding nuclear protein)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPID peptidylprolyl isomerase D
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRMT2 protein arginine methyltransferase 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SHOX2 short stature homeobox 2
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC31A2 solute carrier family 31 (copper transporter), member 2
SNAP23 synaptosomal-associated protein, 23kDa
SNX13 sorting nexin 13
SPATS2L spermatogenesis associated, serine-rich 2-like
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STARD13 StAR-related lipid transfer (START) domain containing 13
STIP1 stress-induced phosphoprotein 1
STS steroid sulfatase (microsomal), isozyme S
TEX40 testis expressed 40
THBS1 thrombospondin 1
TMCC1 transmembrane and coiled-coil domain family 1
ZBTB38 zinc finger and BTB domain containing 38
ZER1 zyg-11 related, cell cycle regulator
ZNF337 zinc finger protein 337
ZNF451 zinc finger protein 451
ZSCAN26 zinc finger and SCAN domain containing 26

decreased expression

Symbol Name
AEN apoptosis enhancing nuclease
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
APOC4 apolipoprotein C-IV
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
BATF3 basic leucine zipper transcription factor, ATF-like 3
BHLHE41 basic helix-loop-helix family, member e41
C10ORF2 chromosome 10 open reading frame 2
C5 complement component 5
C7ORF69 chromosome 7 open reading frame 69
C9ORF91 chromosome 9 open reading frame 91
CCDC86 coiled-coil domain containing 86
CCDC88C coiled-coil domain containing 88C
CCL27 chemokine (C-C motif) ligand 27
CD14 CD14 molecule
CD3EAP CD3e molecule, epsilon associated protein
CD9 CD9 molecule
CEL carboxyl ester lipase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHML choroideremia-like (Rab escort protein 2)
CHST10 carbohydrate sulfotransferase 10
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
DDN dendrin
DENND2D DENN/MADD domain containing 2D
DSPP dentin sialophosphoprotein
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EHD4 EH-domain containing 4
EPHB6 EPH receptor B6
EXOSC5 exosome component 5
FLT3 fms-related tyrosine kinase 3
FLT4 fms-related tyrosine kinase 4
FOSL1 FOS-like antigen 1
GEMIN8 gem (nuclear organelle) associated protein 8
GPR22 G protein-coupled receptor 22
HIST1H2AJ histone cluster 1, H2aj
HMGA2 high mobility group AT-hook 2
HPR haptoglobin-related protein
IER2 immediate early response 2
IFT81 intraflagellar transport 81
INHBE inhibin, beta E
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KIF21B kinesin family member 21B
KLF1 Kruppel-like factor 1 (erythroid)
MAT2A methionine adenosyltransferase II, alpha
MBL1P mannose-binding lectin (protein A) 1, pseudogene
METTL16 methyltransferase like 16
METTL8 methyltransferase like 8
MID1IP1 MID1 interacting protein 1
MKS1 Meckel syndrome, type 1
MNT MAX network transcriptional repressor
MOCS3 molybdenum cofactor synthesis 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPS18C mitochondrial ribosomal protein S18C
MXD3 MAX dimerization protein 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NAG18 NAG18 mRNA
NIP7 NIP7, nucleolar pre-rRNA processing protein
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
NT5M 5',3'-nucleotidase, mitochondrial
NTSR1 neurotensin receptor 1 (high affinity)
NXT1 nuclear transport factor 2-like export factor 1
OCLN occludin
ODF2 outer dense fiber of sperm tails 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PKD2L2 polycystic kidney disease 2-like 2
PRDM13 PR domain containing 13
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RFXAP regulatory factor X-associated protein
RGS16 regulator of G-protein signaling 16
RPP25 ribonuclease P/MRP 25kDa subunit
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RSAD1 radical S-adenosyl methionine domain containing 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPATA1 spermatogenesis associated 1
SPATA2L spermatogenesis associated 2-like
SRD5A3 steroid 5 alpha-reductase 3
STC2 stanniocalcin 2
STRA13 stimulated by retinoic acid 13
TERT telomerase reverse transcriptase
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIGD6 tigger transposable element derived 6
TMEM120B transmembrane protein 120B
TMEM212 transmembrane protein 212
TNF tumor necrosis factor
TRIB3 tribbles pseudokinase 3
USP36 ubiquitin specific peptidase 36
VEGFB vascular endothelial growth factor B
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBED1 zinc finger, BED-type containing 1
ZCWPW1 zinc finger, CW type with PWWP domain 1