syrosingopine-6213 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the syrosingopine-6213 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
AMOTL2 angiomotin like 2
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
B9D1 B9 protein domain 1
BAG4 BCL2-associated athanogene 4
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD44 CD44 molecule (Indian blood group)
CD6 CD6 molecule
CDC25C cell division cycle 25C
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHKB choline kinase beta
CORO1A coronin, actin binding protein, 1A
CPD carboxypeptidase D
CREM cAMP responsive element modulator
CSHL1 chorionic somatomammotropin hormone-like 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DTNA dystrobrevin, alpha
FADS3 fatty acid desaturase 3
FGF23 fibroblast growth factor 23
FTH1 ferritin, heavy polypeptide 1
GAB1 GRB2-associated binding protein 1
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HIST1H2AJ histone cluster 1, H2aj
ICAM1 intercellular adhesion molecule 1
ING4 inhibitor of growth family, member 4
INHBE inhibin, beta E
INSIG1 insulin induced gene 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDSR 3-ketodihydrosphingosine reductase
KIF5C kinesin family member 5C
KLHL24 kelch-like family member 24
LARP6 La ribonucleoprotein domain family, member 6
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LIME1 Lck interacting transmembrane adaptor 1
LINC00341 long intergenic non-protein coding RNA 341
LMBR1L limb development membrane protein 1-like
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFAP3L microfibrillar-associated protein 3-like
MID1 midline 1
MMP19 matrix metallopeptidase 19
MXRA7 matrix-remodelling associated 7
NADK NAD kinase
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NUP214 nucleoporin 214kDa
NUP62CL nucleoporin 62kDa C-terminal like
NUPR1 nuclear protein, transcriptional regulator, 1
PAX2 paired box 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PHF21A PHD finger protein 21A
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PRKCA protein kinase C, alpha
PROL1 proline rich, lacrimal 1
PRPH peripherin
RCAN3 RCAN family member 3
RNF39 ring finger protein 39
RRAGD Ras-related GTP binding D
SALL2 spalt-like transcription factor 2
SAMD4A sterile alpha motif domain containing 4A
SAPCD1 suppressor APC domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOS2 son of sevenless homolog 2 (Drosophila)
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SYBU syntabulin (syntaxin-interacting)
TAGLN transgelin
TBC1D16 TBC1 domain family, member 16
TBC1D22A TBC1 domain family, member 22A
TDRKH tudor and KH domain containing
TTC33 tetratricopeptide repeat domain 33
TXNIP thioredoxin interacting protein
USB1 U6 snRNA biogenesis 1
VEGFA vascular endothelial growth factor A
VPRBP Vpr (HIV-1) binding protein
WIPI1 WD repeat domain, phosphoinositide interacting 1
WSB1 WD repeat and SOCS box containing 1
ZFAND6 zinc finger, AN1-type domain 6
ZNF197 zinc finger protein 197
ZNF250 zinc finger protein 250
ZNF37BP zinc finger protein 37B, pseudogene
ZNF440 zinc finger protein 440
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ADGRA3 adhesion G protein-coupled receptor A3
ADGRL2 adhesion G protein-coupled receptor L2
AGR2 anterior gradient 2
AKTIP AKT interacting protein
ARHGAP10 Rho GTPase activating protein 10
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BCL7B B-cell CLL/lymphoma 7B
BLM Bloom syndrome, RecQ helicase-like
C10ORF88 chromosome 10 open reading frame 88
C3ORF52 chromosome 3 open reading frame 52
C4ORF19 chromosome 4 open reading frame 19
C5 complement component 5
CCNE2 cyclin E2
CHMP6 charged multivesicular body protein 6
CLASP1 cytoplasmic linker associated protein 1
CLEC16A C-type lectin domain family 16, member A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DGKD diacylglycerol kinase, delta 130kDa
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ESRP2 epithelial splicing regulatory protein 2
FASTKD5 FAST kinase domains 5
FBRS fibrosin
FJX1 four jointed box 1 (Drosophila)
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GFRA1 GDNF family receptor alpha 1
GLI3 GLI family zinc finger 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTF2I general transcription factor IIi
HIRA histone cell cycle regulator
HIRIP3 HIRA interacting protein 3
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KAT2A K(lysine) acetyltransferase 2A
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KIAA1551 KIAA1551
KLHL21 kelch-like family member 21
KLHL36 kelch-like family member 36
KPTN kaptin (actin binding protein)
MANBA mannosidase, beta A, lysosomal
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MARC1 mitochondrial amidoxime reducing component 1
MCRS1 microspherule protein 1
MEPCE methylphosphate capping enzyme
METTL1 methyltransferase like 1
MPHOSPH8 M-phase phosphoprotein 8
MSL1 male-specific lethal 1 homolog (Drosophila)
MSX1 msh homeobox 1
NDC1 NDC1 transmembrane nucleoporin
NOL9 nucleolar protein 9
NSD1 nuclear receptor binding SET domain protein 1
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PC pyruvate carboxylase
PEX12 peroxisomal biogenesis factor 12
PLD3 phospholipase D family, member 3
PLEKHJ1 pleckstrin homology domain containing, family J member 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRR3 proline rich 3
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM4B RNA binding motif protein 4B
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RINT1 RAD50 interactor 1
RNF121 ring finger protein 121
RNF31 ring finger protein 31
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC35A5 solute carrier family 35, member A5
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SMG9 SMG9 nonsense mediated mRNA decay factor
STARD13 StAR-related lipid transfer (START) domain containing 13
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TMEM115 transmembrane protein 115
TMEM164 transmembrane protein 164
TMEM62 transmembrane protein 62
TMEM80 transmembrane protein 80
TOE1 target of EGR1, member 1 (nuclear)
TRIM25 tripartite motif containing 25
TTC4 tetratricopeptide repeat domain 4
UBIAD1 UbiA prenyltransferase domain containing 1
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
WWC3 WWC family member 3
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZC3H3 zinc finger CCCH-type containing 3
ZNF276 zinc finger protein 276
ZNF394 zinc finger protein 394
ZNF408 zinc finger protein 408
ZNF430 zinc finger protein 430