synoviocyte Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Located in the synovial membrane, there are two types. Type A cells are more numerous, have phagocytic characteristics and produce degradative enzymes. Type B cells produce synovial fluid, which lubricates the joint and nurtures nourishes the articular cartilage. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003742)
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Genes

347 proteins co-occuring with the tissue synoviocyte in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
IL1B interleukin 1, beta 2.18715
MMP3 matrix metallopeptidase 3 2.03321
MMP1 matrix metallopeptidase 1 1.88788
TNF tumor necrosis factor 1.83785
MMP13 matrix metallopeptidase 13 1.77429
CD68 CD68 molecule 1.50433
IL6 interleukin 6 1.39376
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.35041
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 1.34995
PRG4 proteoglycan 4 1.32506
CCL2 chemokine (C-C motif) ligand 2 1.2461
IL17A interleukin 17A 1.24565
TIMP1 TIMP metallopeptidase inhibitor 1 1.24163
VCAM1 vascular cell adhesion molecule 1 1.22603
UGDH UDP-glucose 6-dehydrogenase 1.21757
JUN jun proto-oncogene 1.18823
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.17447
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.15983
ACAN aggrecan 1.12217
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.10889
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.10624
ICAM1 intercellular adhesion molecule 1 1.08722
TGM4 transglutaminase 4 1.05985
IL17RC interleukin 17 receptor C 1.04885
TGFB1 transforming growth factor, beta 1 1.04269
IL1RN interleukin 1 receptor antagonist 1.01331
IL1A interleukin 1, alpha 1.00938
MMP9 matrix metallopeptidase 9 1.0085
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 1.00807
CXCL8 chemokine (C-X-C motif) ligand 8 0.998473
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.98977
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.982386
IL32 interleukin 32 0.96809
HAS1 hyaluronan synthase 1 0.966793
PDCD5 programmed cell death 5 0.95384
MMP2 matrix metallopeptidase 2 0.943505
HAS2 hyaluronan synthase 2 0.934054
PHB2 prohibitin 2 0.932337
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.928478
MAPK8 mitogen-activated protein kinase 8 0.927621
ADGRE5 adhesion G protein-coupled receptor E5 0.924194
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.905831
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 0.905404
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.891374
TLR2 toll-like receptor 2 0.876129
CXCL10 chemokine (C-X-C motif) ligand 10 0.873172
TP53 tumor protein p53 0.870639
FN1 fibronectin 1 0.869794
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.869373
CD44 CD44 molecule (Indian blood group) 0.857995
HAS3 hyaluronan synthase 3 0.839091
FPR2 formyl peptide receptor 2 0.835737
MIR346 microRNA 346 0.835318
CCL20 chemokine (C-C motif) ligand 20 0.821921
ACP1 acid phosphatase 1, soluble 0.820666
CD163 CD163 molecule 0.819412
PADI4 peptidyl arginine deiminase, type IV 0.813144
ASIC3 acid sensing (proton gated) ion channel 3 0.811056
CHI3L2 chitinase 3-like 2 0.809386
MAP2K7 mitogen-activated protein kinase kinase 7 0.803127
TLR4 toll-like receptor 4 0.791877
CD4 CD4 molecule 0.780232
FGF2 fibroblast growth factor 2 (basic) 0.777325
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.775664
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.771514
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.770685
OLAH oleoyl-ACP hydrolase 0.77027
CRP C-reactive protein, pentraxin-related 0.768612
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.767783
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.75371
ACPP acid phosphatase, prostate 0.74834
ANXA5 annexin A5 0.731031
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.722809
DDR2 discoidin domain receptor tyrosine kinase 2 0.71583
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 0.699444
TLR3 toll-like receptor 3 0.690859
PLA2G2F phospholipase A2, group IIF 0.685959
MAP2K3 mitogen-activated protein kinase kinase 3 0.683103
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.680248
IL18 interleukin 18 0.661523
BAX BCL2-associated X protein 0.66071
TIMP2 TIMP metallopeptidase inhibitor 2 0.65543
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 0.655024
PARP1 poly (ADP-ribose) polymerase 1 0.651371
AP3D1 adaptor-related protein complex 3, delta 1 subunit 0.649344
BSG basigin (Ok blood group) 0.63719
ANPEP alanyl (membrane) aminopeptidase 0.633953
IL15 interleukin 15 0.631527
CCL5 chemokine (C-C motif) ligand 5 0.631123
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.6182
PLA2G10 phospholipase A2, group X 0.614167
TNIP1 TNFAIP3 interacting protein 1 0.602088
KAT5 K(lysine) acetyltransferase 5 0.595255
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.590437
CCL3 chemokine (C-C motif) ligand 3 0.587629
PTGES prostaglandin E synthase 0.581618
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.581218
JAK2 Janus kinase 2 0.580417
SAA1 serum amyloid A1 0.579617
FADD Fas (TNFRSF6)-associated via death domain 0.575216
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.574017
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.568424
TYMP thymidine phosphorylase 0.561644
CCR6 chemokine (C-C motif) receptor 6 0.56005
VEGFA vascular endothelial growth factor A 0.554876
DYNLRB1 dynein, light chain, roadblock-type 1 0.553286
IL17RB interleukin 17 receptor B 0.546929
IL4 interleukin 4 0.540585
CXCL12 chemokine (C-X-C motif) ligand 12 0.535438
IL10 interleukin 10 0.535042
PCNA proliferating cell nuclear antigen 0.524771
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.523588
SEBOX SEBOX homeobox 0.518072
PHOSPHO2 phosphatase, orphan 2 0.51571
FASLG Fas ligand (TNF superfamily, member 6) 0.51335
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.511778
LPAR1 lysophosphatidic acid receptor 1 0.509027
CTSK cathepsin K 0.507457
IL23A interleukin 23, alpha subunit p19 0.506672
IL17RA interleukin 17 receptor A 0.505887
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.505102
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.50471
CD40 CD40 molecule, TNF receptor superfamily member 5 0.501574
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.493354
KIAA1524 KIAA1524 0.491791
LAYN layilin 0.489838
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.489447
MAPK14 mitogen-activated protein kinase 14 0.487886
PLAU plasminogen activator, urokinase 0.487496
ICAM2 intercellular adhesion molecule 2 0.485545
PLA2G1B phospholipase A2, group IB (pancreas) 0.481648
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.476201
IL22 interleukin 22 0.469211
TAC1 tachykinin, precursor 1 0.468436
IL18RAP interleukin 18 receptor accessory protein 0.468048
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.465723
TADA1 transcriptional adaptor 1 0.462626
IRF3 interferon regulatory factor 3 0.461465
MKKS McKusick-Kaufman syndrome 0.460305
FSTL1 follistatin-like 1 0.459918
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.459145
SPAG16 sperm associated antigen 16 0.455284
BAIAP2L1 BAI1-associated protein 2-like 1 0.448346
COL2A1 collagen, type II, alpha 1 0.446807
GLS glutaminase 0.441042
CYR61 cysteine-rich, angiogenic inducer, 61 0.438739
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 0.436822
FOS FBJ murine osteosarcoma viral oncogene homolog 0.436055
WISP3 WNT1 inducible signaling pathway protein 3 0.432608
MGARP mitochondria-localized glutamic acid-rich protein 0.42993
TRIM2 tripartite motif containing 2 0.427636
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.42649
IL33 interleukin 33 0.424963
S100A8 S100 calcium binding protein A8 0.424581
MKI67 marker of proliferation Ki-67 0.422673
HGD homogentisate 1,2-dioxygenase 0.421529
XCR1 chemokine (C motif) receptor 1 0.413912
PADI2 peptidyl arginine deiminase, type II 0.413151
CTSL cathepsin L 0.411631
IL22RA1 interleukin 22 receptor, alpha 1 0.408972
MYDGF myeloid-derived growth factor 0.404797
AREG amphiregulin 0.402523
EZR ezrin 0.402523
MTX3 metaxin 3 0.401386
ANXA1 annexin A1 0.396844
CTSB cathepsin B 0.396087
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.392686
HOXD11 homeobox D11 0.392309
SOCS3 suppressor of cytokine signaling 3 0.390421
GLS2 glutaminase 2 (liver, mitochondrial) 0.388535
TXN thioredoxin 0.388158
IGF1 insulin-like growth factor 1 (somatomedin C) 0.385896
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.384013
HOXD9 homeobox D9 0.381003
SAA2 serum amyloid A2 0.378372
THY1 Thy-1 cell surface antigen 0.377245
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.375743
LGSN lengsin, lens protein with glutamine synthetase domain 0.374993
NRP1 neuropilin 1 0.374243
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.373868
CCR4 chemokine (C-C motif) receptor 4 0.369747
ADAM15 ADAM metallopeptidase domain 15 0.368998
KDM2A lysine (K)-specific demethylase 2A 0.367876
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.366754
NXT1 nuclear transport factor 2-like export factor 1 0.364513
SUMO1 small ubiquitin-like modifier 1 0.363766
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.361901
CX3CR1 chemokine (C-X3-C motif) receptor 1 0.35743
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.352969
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.347038
STAT1 signal transducer and activator of transcription 1, 91kDa 0.346298
CTSS cathepsin S 0.345558
MAPK9 mitogen-activated protein kinase 9 0.345188
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.344449
IER2 immediate early response 2 0.34334
CARD17 caspase recruitment domain family, member 17 0.341126
AHR aryl hydrocarbon receptor 0.338914
CHUK conserved helix-loop-helix ubiquitous kinase 0.334498
ANGPTL4 angiopoietin-like 4 0.333763
HSH2D hematopoietic SH2 domain containing 0.333028
CXCL5 chemokine (C-X-C motif) ligand 5 0.33156
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.33156
CCL13 chemokine (C-C motif) ligand 13 0.330827
WNT1 wingless-type MMTV integration site family, member 1 0.330827
CD40LG CD40 ligand 0.327896
CD58 CD58 molecule 0.32497
IRAK3 interleukin-1 receptor-associated kinase 3 0.324605
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.324605
TPST1 tyrosylprotein sulfotransferase 1 0.322414
CREB1 cAMP responsive element binding protein 1 0.321685
EARS2 glutamyl-tRNA synthetase 2, mitochondrial 0.320227
NOS2 nitric oxide synthase 2, inducible 0.319498
ADGRG2 adhesion G protein-coupled receptor G2 0.318042
RPS19 ribosomal protein S19 0.316588
VIP vasoactive intestinal peptide 0.312595
CABIN1 calcineurin binding protein 1 0.31187
IRAK1 interleukin-1 receptor-associated kinase 1 0.310421
IGFBP5 insulin-like growth factor binding protein 5 0.309335
CSF1R colony stimulating factor 1 receptor 0.307528
IL26 interleukin 26 0.306083
MAB21L2 mab-21-like 2 (C. elegans) 0.303919
BTK Bruton agammaglobulinemia tyrosine kinase 0.303559
TRPM8 transient receptor potential cation channel, subfamily M, member 8 0.301758
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.30032
IL18BP interleukin 18 binding protein 0.293508
CCL7 chemokine (C-C motif) ligand 7 0.289226
LTB lymphotoxin beta (TNF superfamily, member 3) 0.28887
GUSB glucuronidase, beta 0.288158
MSH3 mutS homolog 3 0.285316
PLG plasminogen 0.283899
CMKLR1 chemerin chemokine-like receptor 1 0.282483
IRF7 interferon regulatory factor 7 0.276145
MAPT microtubule-associated protein tau 0.274744
AQP1 aquaporin 1 (Colton blood group) 0.274744
STEAP4 STEAP family member 4 0.272649
CD19 CD19 molecule 0.268137
SV2C synaptic vesicle glycoprotein 2C 0.268137
CCL8 chemokine (C-C motif) ligand 8 0.267446
SELE selectin E 0.267102
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.264011
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 0.260267
RNF11 ring finger protein 11 0.259591
CD38 CD38 molecule 0.25259
DEFA6 defensin, alpha 6, Paneth cell-specific 0.250953
ANXA2 annexin A2 0.250627
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.250301
IRAK4 interleukin-1 receptor-associated kinase 4 0.249653
BBC3 BCL2 binding component 3 0.249006
IL7 interleukin 7 0.247719
HOXD13 homeobox D13 0.247399
HDAC1 histone deacetylase 1 0.241438
IL1R1 interleukin 1 receptor, type I 0.240216
FLT3LG fms-related tyrosine kinase 3 ligand 0.239007
ADGRE2 adhesion G protein-coupled receptor E2 0.238706
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.237216
NPS neuropeptide S 0.236921
IL2 interleukin 2 0.235457
MTX1 metaxin 1 0.23459
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.233446
NOTCH1 notch 1 0.233162
TACR1 tachykinin receptor 1 0.231206
NOTCH2NL notch 2 N-terminal like 0.229839
KNG1 kininogen 1 0.229568
NOTCH2 notch 2 0.227707
HMP19 HMP19 protein 0.225395
CTSD cathepsin D 0.224645
UBE2I ubiquitin-conjugating enzyme E2I 0.22448
B2M beta-2-microglobulin 0.222938
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.222699
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.222224
AIF1 allograft inflammatory factor 1 0.222224
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.221989
IL34 interleukin 34 0.220831
GDF10 growth differentiation factor 10 0.219338
CD34 CD34 molecule 0.219264
AICDA activation-induced cytidine deaminase 0.218902
CLEC12A C-type lectin domain family 12, member A 0.217001
ESR1 estrogen receptor 1 0.216528
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.214765
BCAN brevican 0.214765
SPRED1 sprouty-related, EVH1 domain containing 1 0.214263
DLL3 delta-like 3 (Drosophila) 0.214079
EGR1 early growth response 1 0.213833
BIRC5 baculoviral IAP repeat containing 5 0.212761
SNX9 sorting nexin 9 0.210447
BID BH3 interacting domain death agonist 0.20696
SENP1 SUMO1/sentrin specific peptidase 1 0.205241
SAA4 serum amyloid A4, constitutive 0.204795
CALCRL calcitonin receptor-like 0.203751
MIR19A microRNA 19a 0.203573
POU3F3 POU class 3 homeobox 3 0.203097
MDM4 MDM4, p53 regulator 0.202377
FAS Fas cell surface death receptor 0.202353
CNR2 cannabinoid receptor 2 (macrophage) 0.201932
EFNA3 ephrin-A3 0.200322
CLU clusterin 0.200047
FZD5 frizzled class receptor 5 0.199348
MIR22 microRNA 22 0.199242
LGALS8 lectin, galactoside-binding, soluble, 8 0.199108
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.189509
HOXD10 homeobox D10 0.189481
SFRP5 secreted frizzled-related protein 5 0.189267
CALCR calcitonin receptor 0.189238
IFNL1 interferon, lambda 1 0.18918
IL27RA interleukin 27 receptor, alpha 0.188796
EGLN2 egl-9 family hypoxia-inducible factor 2 0.188721
HAPLN1 hyaluronan and proteoglycan link protein 1 0.18821
ANXA11 annexin A11 0.187524
VILL villin-like 0.187474
TRAF2 TNF receptor-associated factor 2 0.187025
TGS1 trimethylguanosine synthase 1 0.186776
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.186595
ATF2 activating transcription factor 2 0.186577
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 0.186504
RGMB repulsive guidance molecule family member b 0.186168
ADM adrenomedullin 0.186111
AVIL advillin 0.186053
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 0.186034
TANK TRAF family member-associated NFKB activator 0.185899
THBS1 thrombospondin 1 0.185782
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.185644
POSTN periostin, osteoblast specific factor 0.185445
MIR146A microRNA 146a 0.185076
PARG poly (ADP-ribose) glycohydrolase 0.185014
EGLN3 egl-9 family hypoxia-inducible factor 3 0.184653
SFRP4 secreted frizzled-related protein 4 0.184588
COPS5 COP9 signalosome subunit 5 0.184414
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.184347
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.184325
UCN3 urocortin 3 0.184236
GNPDA1 glucosamine-6-phosphate deaminase 1 0.183781
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.183735
ALX4 ALX homeobox 4 0.183477
LPAR2 lysophosphatidic acid receptor 2 0.183214
MEFV Mediterranean fever 0.182593
ARRB1 arrestin, beta 1 0.182567
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.181697
ART3 ADP-ribosyltransferase 3 0.181449
LHX2 LIM homeobox 2 0.181366
PIR pirin (iron-binding nuclear protein) 0.181168
MYD88 myeloid differentiation primary response 88 0.181054
RFC2 replication factor C (activator 1) 2, 40kDa 0.181026
IL1RL1 interleukin 1 receptor-like 1 0.180997
FOXO1 forkhead box O1 0.180764
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.179979
AGER advanced glycosylation end product-specific receptor 0.179505
FGF5 fibroblast growth factor 5 0.179473