synapse Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. (Gene Ontology, GO_0045202)
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Genes

171 genes co-occuring with the biological term synapse in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACP1 acid phosphatase 1, soluble
ACTA1 actin, alpha 1, skeletal muscle
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADGRB1 adhesion G protein-coupled receptor B1
ADGRB3 adhesion G protein-coupled receptor B3
ADGRL3 adhesion G protein-coupled receptor L3
AGRN agrin
AKAP9 A kinase (PRKA) anchor protein 9
ALCAM activated leukocyte cell adhesion molecule
ANO2 anoctamin 2, calcium activated chloride channel
BACE1 beta-site APP-cleaving enzyme 1
BCL10 B-cell CLL/lymphoma 10
BDNF brain-derived neurotrophic factor
BST2 bone marrow stromal cell antigen 2
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD151 CD151 molecule (Raph blood group)
CD19 CD19 molecule
CD2 CD2 molecule
CD226 CD226 molecule
CD244 CD244 molecule, natural killer cell receptor 2B4
CD274 CD274 molecule
CD28 CD28 molecule
CD2AP CD2-associated protein
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD4 CD4 molecule
CD40LG CD40 ligand
CD47 CD47 molecule
CD5 CD5 molecule
CD6 CD6 molecule
CD80 CD80 molecule
CD9 CD9 molecule
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKL5 cyclin-dependent kinase-like 5
CHRND cholinergic receptor, nicotinic, delta (muscle)
CSK c-src tyrosine kinase
CTBP2 C-terminal binding protein 2
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYTIP cytohesin 1 interacting protein
DBNL drebrin-like
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DFNB31 deafness, autosomal recessive 31
DGKZ diacylglycerol kinase, zeta
DIAPH1 diaphanous-related formin 1
DISC1 disrupted in schizophrenia 1
DLG1 discs, large homolog 1 (Drosophila)
DLG3 discs, large homolog 3 (Drosophila)
DNALI1 dynein, axonemal, light intermediate chain 1
DOCK8 dedicator of cytokinesis 8
DOK7 docking protein 7
EEA1 early endosome antigen 1
EFHD2 EF-hand domain family, member D2
EZR ezrin
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FLNA filamin A, alpha
FLRT3 fibronectin leucine rich transmembrane protein 3
FMR1 fragile X mental retardation 1
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
GDNF glial cell derived neurotrophic factor
GNLY granulysin
GPR50 G protein-coupled receptor 50
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIA2 glutamate receptor, ionotropic, AMPA 2
HCST hematopoietic cell signal transducer
HLA-C major histocompatibility complex, class I, C
HLA-G major histocompatibility complex, class I, G
HMGB1 high mobility group box 1
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL15RA interleukin 15 receptor, alpha
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB7 integrin, beta 7
KALRN kalirin, RhoGEF kinase
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KLRC1 killer cell lectin-like receptor subfamily C, member 1
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
L1CAM L1 cell adhesion molecule
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LGALS1 lectin, galactoside-binding, soluble, 1
LGI1 leucine-rich, glioma inactivated 1
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MEN1 multiple endocrine neoplasia I
MICB MHC class I polypeptide-related sequence B
MIR221 microRNA 221
MUSK muscle, skeletal, receptor tyrosine kinase
MYH9 myosin, heavy chain 9, non-muscle
NBEA neurobeachin
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLGN1 neuroligin 1
NLGN2 neuroligin 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NPTX1 neuronal pentraxin I
NRP1 neuropilin 1
NRTN neurturin
NRXN1 neurexin 1
NYX nyctalopin
OTOF otoferlin
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PANX1 pannexin 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEK2 pleckstrin 2
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PRF1 perforin 1 (pore forming protein)
PRKCQ protein kinase C, theta
PRNP prion protein
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1
PTK2B protein tyrosine kinase 2 beta
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRS protein tyrosine phosphatase, receptor type, S
PTPRT protein tyrosine phosphatase, receptor type, T
RAB27A RAB27A, member RAS oncogene family
RAB35 RAB35, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RELN reelin
REM2 RAS (RAD and GEM)-like GTP binding 2
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIRPA signal-regulatory protein alpha
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX27 sorting nexin family member 27
SPN sialophorin
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STK24 serine/threonine kinase 24
STX7 syntaxin 7
SYTL1 synaptotagmin-like 1
SYTL2 synaptotagmin-like 2
TBC1D10A TBC1 domain family, member 10A
TERF2 telomeric repeat binding factor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
UNC119 unc-119 homolog (C. elegans)
UTRN utrophin
VAV1 vav 1 guanine nucleotide exchange factor
VTI1B vesicle transport through interaction with t-SNAREs 1B
WAS Wiskott-Aldrich syndrome
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZNF804A zinc finger protein 804A