synapse Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. (Gene Ontology, GO_0045202)
External Link http://amigo.geneontology.org/amigo/term/GO:0045202
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Genes

230 proteins localized to the synapse cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
ACHE acetylcholinesterase (Yt blood group)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADGRL1 adhesion G protein-coupled receptor L1
ADORA1 adenosine A1 receptor
ADRA2A adrenoceptor alpha 2A
AGRN agrin
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APP amyloid beta (A4) precursor protein
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGAP44 Rho GTPase activating protein 44
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARR3 arrestin 3, retinal (X-arrestin)
ASIC2 acid sensing (proton gated) ion channel 2
ATCAY ataxia, cerebellar, Cayman type
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BSN bassoon presynaptic cytomatrix protein
CABP4 calcium binding protein 4
CADM2 cell adhesion molecule 2
CADPS Ca++-dependent secretion activator
CALB1 calbindin 1, 28kDa
CAV3 caveolin 3
CBLN3 cerebellin 3 precursor
CBLN4 cerebellin 4 precursor
CCL2 chemokine (C-C motif) ligand 2
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CHRM4 cholinergic receptor, muscarinic 4
CHRM5 cholinergic receptor, muscarinic 5
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CIB2 calcium and integrin binding family member 2
CNTN2 contactin 2 (axonal)
COL4A5 collagen, type IV, alpha 5
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CPEB3 cytoplasmic polyadenylation element binding protein 3
CPLX1 complexin 1
CPLX2 complexin 2
CPLX3 complexin 3
CPLX4 complexin 4
CPT1C carnitine palmitoyltransferase 1C
CTBP2 C-terminal binding protein 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DACT1 dishevelled-binding antagonist of beta-catenin 1
DES desmin
DGKI diacylglycerol kinase, iota
DLG1 discs, large homolog 1 (Drosophila)
DLG4 discs, large homolog 4 (Drosophila)
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DMD dystrophin
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNMBP dynamin binding protein
DOK7 docking protein 7
DTNA dystrobrevin, alpha
DTNB dystrobrevin, beta
DVL1 dishevelled segment polarity protein 1
EFNA2 ephrin-A2
EFNB1 ephrin-B1
EGFLAM EGF-like, fibronectin type III and laminin G domains
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1
EMB embigin
ENAH enabled homolog (Drosophila)
EPHA4 EPH receptor A4
EPHA7 EPH receptor A7
ERC1 ELKS/RAB6-interacting/CAST family member 1
F2R coagulation factor II (thrombin) receptor
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FGFR2 fibroblast growth factor receptor 2
FMR1 fragile X mental retardation 1
FRRS1L ferric-chelate reductase 1-like
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GLRA1 glycine receptor, alpha 1
GPHN gephyrin
GRID2 glutamate receptor, ionotropic, delta 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRM7 glutamate receptor, metabotropic 7
GSG1L GSG1-like
HDAC4 histone deacetylase 4
HOMER1 homer scaffolding protein 1
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IGSF8 immunoglobulin superfamily, member 8
IGSF9 immunoglobulin superfamily, member 9
IGSF9B immunoglobulin superfamily, member 9B
IQSEC3 IQ motif and Sec7 domain 3
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA7 integrin, alpha 7
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITSN1 intersectin 1 (SH3 domain protein)
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4
LAMB2 laminin, beta 2 (laminin S)
LGI1 leucine-rich, glioma inactivated 1
LIN7A lin-7 homolog A (C. elegans)
LIN7B lin-7 homolog B (C. elegans)
LIN7C lin-7 homolog C (C. elegans)
LRP4 low density lipoprotein receptor-related protein 4
LRP6 low density lipoprotein receptor-related protein 6
LRRC4 leucine rich repeat containing 4
LRRTM1 leucine rich repeat transmembrane neuronal 1
LRRTM2 leucine rich repeat transmembrane neuronal 2
MAF1 MAF1 homolog (S. cerevisiae)
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAP1S microtubule-associated protein 1S
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MGLL monoglyceride lipase
MME membrane metallo-endopeptidase
MPST mercaptopyruvate sulfurtransferase
MUSK muscle, skeletal, receptor tyrosine kinase
MYH10 myosin, heavy chain 10, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
MYO7A myosin VIIA
MYRIP myosin VIIA and Rab interacting protein
NEFM neurofilament, medium polypeptide
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1
NLGN1 neuroligin 1
NLGN2 neuroligin 2
NLGN3 neuroligin 3
NLGN4X neuroligin 4, X-linked
NLGN4Y neuroligin 4, Y-linked
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NOS1 nitric oxide synthase 1 (neuronal)
NPHP4 nephronophthisis 4
NRCAM neuronal cell adhesion molecule
NRG1 neuregulin 1
NRN1 neuritin 1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM1 olfactomedin 1
OLFM2 olfactomedin 2
OLFM3 olfactomedin 3
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PACSIN1 protein kinase C and casein kinase substrate in neurons 1
PCDH15 protocadherin-related 15
PCLO piccolo presynaptic cytomatrix protein
PDZD11 PDZ domain containing 11
PDZRN3 PDZ domain containing ring finger 3
PFN1 profilin 1
PHACTR1 phosphatase and actin regulator 1
PIAS3 protein inhibitor of activated STAT, 3
PICK1 protein interacting with PRKCA 1
PLAT plasminogen activator, tissue
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PRIMA1 proline rich membrane anchor 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRRT1 proline-rich transmembrane protein 1
PRRT2 proline-rich transmembrane protein 2
PSEN1 presenilin 1
PSEN2 presenilin 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RAPSN receptor-associated protein of the synapse
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RIMBP2 RIMS binding protein 2
RPH3A rabphilin 3A
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SAMD4A sterile alpha motif domain containing 4A
SARM1 sterile alpha and TIR motif containing 1
SDC2 syndecan 2
SEPT11 septin 11
SEPT2 septin 2
SEPT3 septin 3
SEPT7 septin 7
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3KBP1 SH3-domain kinase binding protein 1
SHANK1 SH3 and multiple ankyrin repeat domains 1
SHISA9 shisa family member 9
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SNAP23 synaptosomal-associated protein, 23kDa
SNAP29 synaptosomal-associated protein, 29kDa
SNAPIN SNAP-associated protein
SNTA1 syntrophin, alpha 1
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRCIN1 SRC kinase signaling inhibitor 1
SRPX2 sushi-repeat containing protein, X-linked 2
STX4 syntaxin 4
SUMO1 small ubiquitin-like modifier 1
SV2A synaptic vesicle glycoprotein 2A
SYN2 synapsin II
SYNC syncoilin, intermediate filament protein
SYNDIG1 synapse differentiation inducing 1
SYNGR1 synaptogyrin 1
SYNGR2 synaptogyrin 2
SYNGR3 synaptogyrin 3
SYNGR4 synaptogyrin 4
SYP synaptophysin
SYT1 synaptotagmin I
TBC1D24 TBC1 domain family, member 24
TLN2 talin 2
TMEM57 transmembrane protein 57
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRAPPC4 trafficking protein particle complex 4
TULP1 tubby like protein 1
UBE2I ubiquitin-conjugating enzyme E2I
UNC13A unc-13 homolog A (C. elegans)
UNC13B unc-13 homolog B (C. elegans)
USH1C Usher syndrome 1C (autosomal recessive, severe)
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
UTRN utrophin
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VAMP7 vesicle-associated membrane protein 7
VWC2 von Willebrand factor C domain containing 2
VWC2L von Willebrand factor C domain containing protein 2-like
WASF1 WAS protein family, member 1
ZMYND19 zinc finger, MYND-type containing 19