sudden cardiac death Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description The heart suddenly and unexpectedly stops beating resulting in death within a short time period (generally within 1 h of symptom onset). (Human Phenotype Ontology, HP_0001645)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0001645
Similar Terms
Downloads & Tools

Genes

309 genes associated with the sudden cardiac death phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.50746
AGXT2 alanine--glyoxylate aminotransferase 2 2.43692
DDAH1 dimethylarginine dimethylaminohydrolase 1 2.43692
KIAA1755 KIAA1755 2.20934
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 2.13589
CCDC141 coiled-coil domain containing 141 2.12345
CD46 CD46 molecule, complement regulatory protein 2.12345
SYT10 synaptotagmin X 2.08106
FADS1 fatty acid desaturase 1 2.05673
BRIX1 BRX1, biogenesis of ribosomes 1.85192
RAD1 RAD1 checkpoint DNA exonuclease 1.78031
TTC23L tetratricopeptide repeat domain 23-like 1.68335
ZNF385B zinc finger protein 385B 1.6456
MAML2 mastermind-like 2 (Drosophila) 1.57026
CHRM2 cholinergic receptor, muscarinic 2 1.5645
NKX2-5 NK2 homeobox 5 1.54733
CEP85L centrosomal protein 85kDa-like 1.49916
SLC25A45 solute carrier family 25, member 45 1.41863
BAZ2B bromodomain adjacent to zinc finger domain, 2B 1.41863
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.40061
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) 1.39306
BCL10 B-cell CLL/lymphoma 10 1.37393
ESR1 estrogen receptor 1 1.36794
KCTD1 potassium channel tetramerization domain containing 1 1.36327
FNDC3B fibronectin type III domain containing 3B 1.35521
RFX4 regulatory factor X, 4 (influences HLA class II expression) 1.32793
CPNE8 copine VIII 1.29386
ACYP2 acylphosphatase 2, muscle type 1.18704
C1ORF52 chromosome 1 open reading frame 52 1.18428
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 1.1784
AP1G2 adaptor-related protein complex 1, gamma 2 subunit 1.17192
DEGS2 delta(4)-desaturase, sphingolipid 2 1.15352
LOC646626 uncharacterized LOC646626 1.13655
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 1.12851
FAM149B1 family with sequence similarity 149, member B1 1.12773
PDE11A phosphodiesterase 11A 1.11203
ATF1 activating transcription factor 1 1.11203
ARL5B ADP-ribosylation factor-like 5B 1.09906
MARCH10 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase 1.09906
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 1.09906
PLCE1 phospholipase C, epsilon 1 1.09906
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 1.07729
LOC650157 1.07729
PARP4 poly (ADP-ribose) polymerase family, member 4 1.0674
COL24A1 collagen, type XXIV, alpha 1 1.06478
CPNE5 copine V 1.05066
SNX29 sorting nexin 29 1.04365
ERBB4 erb-b2 receptor tyrosine kinase 4 1.04365
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 1.04365
CISD2 CDGSH iron sulfur domain 2 1.04365
PEBP4 phosphatidylethanolamine-binding protein 4 1.04365
HAVCR2 hepatitis A virus cellular receptor 2 1.04239
TMEM135 transmembrane protein 135 1.03592
PADI3 peptidyl arginine deiminase, type III 1.03536
SPEF2 sperm flagellar 2 1.01883
SLC35F1 solute carrier family 35, member F1 1.01692
ACTN4 actinin, alpha 4 1.00059
CLSTN2 calsyntenin 2 1.00059
CDH4 cadherin 4, type 1, R-cadherin (retinal) 1.00059
RNF103-CHMP3 RNF103-CHMP3 readthrough 1.00059
SUSD1 sushi domain containing 1 0.989326
SLC10A7 solute carrier family 10, member 7 0.9776
CNTN5 contactin 5 0.971092
SYCP2L synaptonemal complex protein 2-like 0.969142
RAP1GAP2 RAP1 GTPase activating protein 2 0.969142
ARHGAP25 Rho GTPase activating protein 25 0.969142
ZCCHC24 zinc finger, CCHC domain containing 24 0.969142
ADAM17 ADAM metallopeptidase domain 17 0.969142
SIN3A SIN3 transcription regulator family member A 0.969142
GIGYF1 GRB10 interacting GYF protein 1 0.96305
OFCC1 orofacial cleft 1 candidate 1 0.953971
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.947793
KIAA1715 KIAA1715 0.945838
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.942765
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 0.942765
CLCNKA chloride channel, voltage-sensitive Ka 0.931762
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.927635
THSD4 thrombospondin, type I, domain containing 4 0.919744
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.919744
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.919744
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.899912
CHL1 cell adhesion molecule L1-like 0.899912
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.899912
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.899912
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.899912
RAI14 retinoic acid induced 14 0.885423
OSBP2 oxysterol binding protein 2 0.884439
DCP1A decapping mRNA 1A 0.882984
ZNF536 zinc finger protein 536 0.882984
GPC6 glypican 6 0.882984
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 0.882984
LRP1B low density lipoprotein receptor-related protein 1B 0.882984
TMEM26 transmembrane protein 26 0.882984
MCOLN2 mucolipin 2 0.880765
SMAD3 SMAD family member 3 0.870439
CDH13 cadherin 13 0.868241
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.868241
PYGB phosphorylase, glycogen; brain 0.868241
IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) 0.862428
DAB2IP DAB2 interacting protein 0.855449
TMEM132D transmembrane protein 132D 0.855449
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.850902
FABP7 fatty acid binding protein 7, brain 0.850223
CA10 carbonic anhydrase X 0.843198
EFNA5 ephrin-A5 0.841148
PTPRT protein tyrosine phosphatase, receptor type, T 0.840142
ARRB1 arrestin, beta 1 0.838165
PRKCA protein kinase C, alpha 0.832497
PRKG1 protein kinase, cGMP-dependent, type I 0.82634
MAPK1 mitogen-activated protein kinase 1 0.823837
ZNF385D zinc finger protein 385D 0.816759
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.816759
DOCK4 dedicator of cytokinesis 4 0.808534
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.804323
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.798387
NGEF neuronal guanine nucleotide exchange factor 0.792855
CHD6 chromodomain helicase DNA binding protein 6 0.787244
CMYA5 cardiomyopathy associated 5 0.785384
KIAA1549L KIAA1549-like 0.784773
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.782964
ARID5B AT rich interactive domain 5B (MRF1-like) 0.777754
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.777754
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.774448
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.771787
ELAVL2 ELAV like neuron-specific RNA binding protein 2 0.77023
TP73 tumor protein p73 0.767696
RSAD2 radical S-adenosyl methionine domain containing 2 0.767198
WDR86 WD repeat domain 86 0.767198
LGALS4 lectin, galactoside-binding, soluble, 4 0.766212
CNPY3 canopy FGF signaling regulator 3 0.765174
ASS1 argininosuccinate synthase 1 0.764625
C5ORF56 chromosome 5 open reading frame 56 0.764079
EPT1 ethanolaminephosphotransferase 1 0.758788
LDAH lipid droplet associated hydrolase 0.758275
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.755257
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.754273
LPAR6 lysophosphatidic acid receptor 6 0.747666
NCEH1 neutral cholesterol ester hydrolase 1 0.744097
TK1 thymidine kinase 1, soluble 0.740245
PTK2 protein tyrosine kinase 2 0.739411
MYH11 myosin, heavy chain 11, smooth muscle 0.734094
MAP2 microtubule-associated protein 2 0.734094
ANKRD33B ankyrin repeat domain 33B 0.730636
MBD5 methyl-CpG binding domain protein 5 0.728954
PLSCR4 phospholipid scramblase 4 0.727711
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.724872
ZFPM2 zinc finger protein, FOG family member 2 0.721344
CADPS Ca++-dependent secretion activator 0.717203
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.712186
PARP12 poly (ADP-ribose) polymerase family, member 12 0.710458
PART1 prostate androgen-regulated transcript 1 (non-protein coding) 0.710116
C1S complement component 1, s subcomponent 0.702831
CDHR3 cadherin-related family member 3 0.696681
VWA3B von Willebrand factor A domain containing 3B 0.692786
WBSCR17 Williams-Beuren syndrome chromosome region 17 0.689964
EBF1 early B-cell factor 1 0.689042
SLC38A8 solute carrier family 38, member 8 0.687825
CSMD1 CUB and Sushi multiple domains 1 0.686922
RALYL RALY RNA binding protein-like 0.686028
NFIB nuclear factor I/B 0.685142
TENM4 teneurin transmembrane protein 4 0.685142
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.679359
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.679359
MCPH1 microcephalin 1 0.677522
LAMA1 laminin, alpha 1 0.676316
KLHL21 kelch-like family member 21 0.674532
MTPN myotrophin 0.673945
KCNIP4 Kv channel interacting protein 4 0.67307
FAM155A family with sequence similarity 155, member A 0.67249
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 0.670205
USP6NL USP6 N-terminal like 0.669362
CPQ carboxypeptidase Q 0.667971
SEC31B SEC31 homolog B (S. cerevisiae) 0.667695
KLHL1 kelch-like family member 1 0.665514
ALK anaplastic lymphoma receptor tyrosine kinase 0.664442
TCF21 transcription factor 21 0.664442
TGFB2 transforming growth factor, beta 2 0.662854
TMEM87B transmembrane protein 87B 0.652159
LINGO2 leucine rich repeat and Ig domain containing 2 0.652159
ITGA1 integrin, alpha 1 0.646866
NCOA1 nuclear receptor coactivator 1 0.644641
ORC4 origin recognition complex, subunit 4 0.640797
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.640327
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.638927
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.635958
ITGA9 integrin, alpha 9 0.635733
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.635061
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.634838
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.63329
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.631765
RAB40C RAB40C, member RAS oncogene family 0.631549
EML6 echinoderm microtubule associated protein like 6 0.630262
ACTA2 actin, alpha 2, smooth muscle, aorta 0.627944
SGCZ sarcoglycan, zeta 0.62629
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.62426
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 0.621289
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.619932
FSTL1 follistatin-like 1 0.619547
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 0.6144
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.612523
SSUH2 ssu-2 homolog (C. elegans) 0.611229
LAMB1 laminin, beta 1 0.60762
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.607443
PTPRM protein tyrosine phosphatase, receptor type, M 0.606212
TASP1 taspase, threonine aspartase, 1 0.605341
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 0.602774
FAS Fas cell surface death receptor 0.602605
COL13A1 collagen, type XIII, alpha 1 0.600931
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.600931
UBE3C ubiquitin protein ligase E3C 0.598473
ZBTB16 zinc finger and BTB domain containing 16 0.598311
BLOC1S5-TXNDC5 BLOC1S5-TXNDC5 readthrough (NMD candidate) 0.596707
TMEM232 transmembrane protein 232 0.595915
RNLS renalase, FAD-dependent amine oxidase 0.594349
ANTXR1 anthrax toxin receptor 1 0.592807
KRT13 keratin 13, type I 0.591893
ZNF516 zinc finger protein 516 0.590688
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.588613
CLMN calmin (calponin-like, transmembrane) 0.587592
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.587592
NCALD neurocalcin delta 0.587014
TRIM67 tripartite motif containing 67 0.586295
SEPT9 septin 9 0.586295
OPCML opioid binding protein/cell adhesion molecule-like 0.583787
DLG2 discs, large homolog 2 (Drosophila) 0.583301
GRM5 glutamate receptor, metabotropic 5 0.58318
VAV3 vav 3 guanine nucleotide exchange factor 0.582338
CD48 CD48 molecule 0.580327
TRPM5 transient receptor potential cation channel, subfamily M, member 5 0.578819
FAXC failed axon connections homolog (Drosophila) 0.57836
HEG1 heart development protein with EGF-like domains 1 0.578132
TMC3 transmembrane channel-like 3 0.578018
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.577337
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 0.577224
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.577111
SORBS1 sorbin and SH3 domain containing 1 0.572823
LOC285768 uncharacterized LOC285768 0.571756
ROR2 receptor tyrosine kinase-like orphan receptor 2 0.558007
RBM20 RNA binding motif protein 20 0.55667
IDE insulin-degrading enzyme 0.556012
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.556012
NLRP11 NLR family, pyrin domain containing 11 0.547426
MYO16 myosin XVI 0.547426
NRG3 neuregulin 3 0.542984
ZEB2 zinc finger E-box binding homeobox 2 0.541565
PCNXL2 pecanex-like 2 (Drosophila) 0.540725
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.539897
PCSK5 proprotein convertase subtilisin/kexin type 5 0.53868
OCA2 oculocutaneous albinism II 0.537489
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 0.537098
SPEG SPEG complex locus 0.535942
SPHKAP SPHK1 interactor, AKAP domain containing 0.534439
ADORA3 adenosine A3 receptor 0.53407
LOC100131691 0.529832
HTRA1 HtrA serine peptidase 1 0.528824
LOC441035 uncharacterized LOC441035 0.528162
LOC283177 uncharacterized LOC283177 0.527841
TET3 tet methylcytosine dioxygenase 3 0.526276
LYAR Ly1 antibody reactive 0.52446
NAV2 neuron navigator 2 0.520461
FLJ37453 uncharacterized LOC729614 0.520461
CRYAB crystallin, alpha B 0.519375
SOAT1 sterol O-acyltransferase 1 0.515252
CENPO centromere protein O 0.514509
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 0.512008
SCN10A sodium channel, voltage gated, type X alpha subunit 0.510092
POU6F2 POU class 6 homeobox 2 0.509391
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 0.508244
FAM47E family with sequence similarity 47, member E 0.508017
LAPTM4B lysosomal protein transmembrane 4 beta 0.506901
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 0.506461
NACA nascent polypeptide-associated complex alpha subunit 0.502259
PRPF3 pre-mRNA processing factor 3 0.501459
NCKIPSD NCK interacting protein with SH3 domain 0.499816
FXN frataxin 0.499404
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 0.497787
OR2L13 olfactory receptor, family 2, subfamily L, member 13 0.49545
WT1 Wilms tumor 1 0.49526
WNK2 WNK lysine deficient protein kinase 2 0.492128
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.491241
FSTL5 follistatin-like 5 0.489341
SNTG1 syntrophin, gamma 1 0.48718
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 0.486163
EPHB1 EPH receptor B1 0.485119
OR1I1 olfactory receptor, family 1, subfamily I, member 1 0.484604
TLK1 tousled-like kinase 1 0.484434
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.482591
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.482262
CDH8 cadherin 8, type 2 0.481772
PRDM16 PR domain containing 16 0.480966
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.480806
IGFBP7 insulin-like growth factor binding protein 7 0.478768
DARS aspartyl-tRNA synthetase 0.478614
C8ORF34 chromosome 8 open reading frame 34 0.478308
ABAT 4-aminobutyrate aminotransferase 0.476951
IRS1 insulin receptor substrate 1 0.476654
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.476506
SPTA1 spectrin, alpha, erythrocytic 1 0.476064
IP6K2 inositol hexakisphosphate kinase 2 0.475481
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 0.473207
HGD homogentisate 1,2-dioxygenase 0.472929
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.472241
CHRM3 cholinergic receptor, muscarinic 3 0.471968
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 0.471411
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 0.466578
MSI1 musashi RNA-binding protein 1 0.457258
PPP4C protein phosphatase 4, catalytic subunit 0.445034
NAE1 NEDD8 activating enzyme E1 subunit 1 0.437175
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.432689