substance dependence Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A substance-related disorder that involves the continued use of alcohol or other drugs despite despite problems related to use of the substance. (Human Disease Ontology, DOID_9973)
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Genes

594 genes co-occuring with the disease substance dependence in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 2.56721
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 2.46686
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 2.3422
DRD2 dopamine receptor D2 2.30396
OPRM1 opioid receptor, mu 1 2.23779
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.23459
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 2.23033
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 2.15768
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.13015
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.09806
ANKK1 ankyrin repeat and kinase domain containing 1 2.09618
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.08313
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2.00424
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 1.88528
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.83319
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 1.8169
DRD4 dopamine receptor D4 1.78849
FGD1 FYVE, RhoGEF and PH domain containing 1 1.74233
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 1.70679
GGT1 gamma-glutamyltransferase 1 1.68498
CNR1 cannabinoid receptor 1 (brain) 1.64397
DRD3 dopamine receptor D3 1.59742
OPRD1 opioid receptor, delta 1 1.59608
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.57735
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 1.53833
CRH corticotropin releasing hormone 1.53745
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 1.52776
PDYN prodynorphin 1.52556
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 1.52468
OPRK1 opioid receptor, kappa 1 1.49833
CHRM2 cholinergic receptor, muscarinic 2 1.49438
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 1.48911
ADH6 alcohol dehydrogenase 6 (class V) 1.47462
DRD1 dopamine receptor D1 1.47374
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 1.46627
COMT catechol-O-methyltransferase 1.45529
MAOA monoamine oxidase A 1.44738
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.42323
TAS2R16 taste receptor, type 2, member 16 1.41271
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 1.37469
BDNF brain-derived neurotrophic factor 1.35333
CRHR1 corticotropin releasing hormone receptor 1 1.35115
TTC12 tetratricopeptide repeat domain 12 1.30532
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 1.29571
NKAIN1 Na+/K+ transporting ATPase interacting 1 1.2861
POMC proopiomelanocortin 1.28435
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 1.26516
PKNOX2 PBX/knotted 1 homeobox 2 1.2582
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 1.23777
NPY neuropeptide Y 1.22822
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 1.22302
FOS FBJ murine osteosarcoma viral oncogene homolog 1.21955
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 1.21175
TPH1 tryptophan hydroxylase 1 1.19704
TF transferrin 1.19704
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.18539
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 1.18238
ADCY2 adenylate cyclase 2 (brain) 1.17636
MAOB monoamine oxidase B 1.17292
DSTN destrin (actin depolymerizing factor) 1.17078
GGT2 gamma-glutamyltransferase 2 1.16949
PENK proenkephalin 1.16307
CREB1 cAMP responsive element binding protein 1 1.15368
PHF3 PHD finger protein 3 1.14857
GRIK3 glutamate receptor, ionotropic, kainate 3 1.13416
TPH2 tryptophan hydroxylase 2 1.10973
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1.10636
NPFF neuropeptide FF-amide peptide precursor 1.10468
DRD5 dopamine receptor D5 1.10258
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.09671
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 1.0837
SERINC2 serine incorporator 2 1.08244
NRXN1 neurexin 1 1.07572
PCNX pecanex homolog (Drosophila) 1.04083
FAAH fatty acid amide hydrolase 1.03746
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 1.0362
GRM2 glutamate receptor, metabotropic 2 1.03114
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.02819
ANKRD7 ankyrin repeat domain 7 1.01849
OR51L1 olfactory receptor, family 51, subfamily L, member 1 1.01849
FSIP2 fibrous sheath interacting protein 2 1.01849
TESK2 testis-specific kinase 2 1.01849
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.01723
TH tyrosine hydroxylase 1.01723
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.00879
UNC79 unc-79 homolog (C. elegans) 1.0033
PNOC prepronociceptin 0.999924
GHRL ghrelin/obestatin prepropeptide 0.998236
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.988957
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.986007
FYB FYN binding protein 0.978006
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.97002
FRMD4A FERM domain containing 4A 0.95996
TAS2R38 taste receptor, type 2, member 38 0.958705
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.954525
HYKK hydroxylysine kinase 0.952438
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.945354
CCKBR cholecystokinin B receptor 0.937459
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.928759
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.922561
MTIF2 mitochondrial translational initiation factor 2 0.909787
C1QTNF7 C1q and tumor necrosis factor related protein 7 0.909787
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 0.909376
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.902799
NRXN3 neurexin 3 0.894179
AUTS2 autism susceptibility candidate 2 0.892948
GRM3 glutamate receptor, metabotropic 3 0.892129
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.878195
GRM7 glutamate receptor, metabotropic 7 0.878195
OPN3 opsin 3 0.877376
NRD1 nardilysin (N-arginine dibasic convertase) 0.875738
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.875329
OPRL1 opiate receptor-like 1 0.872872
IPO11 importin 11 0.867549
GAL galanin/GMAP prepropeptide 0.857724
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.855677
CASC4 cancer susceptibility candidate 4 0.848307
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.844211
HCRTR2 hypocretin (orexin) receptor 2 0.843392
MANEA mannosidase, endo-alpha 0.842573
CCK cholecystokinin 0.837656
ATP9A ATPase, class II, type 9A 0.830689
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.821257
GALR1 galanin receptor 1 0.820026
CCDC63 coiled-coil domain containing 63 0.817976
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.811411
NISCH nischarin 0.799513
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 0.782707
C15ORF53 chromosome 15 open reading frame 53 0.780251
DCXR dicarbonyl/L-xylulose reductase 0.776159
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 0.77575
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.760231
FAM53B family with sequence similarity 53, member B 0.757786
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.756564
HOMER2 homer scaffolding protein 2 0.74436
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 0.74436
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.741923
SRRD SRR1 domain containing 0.738271
GRM5 glutamate receptor, metabotropic 5 0.736243
HCRTR1 hypocretin (orexin) receptor 1 0.736243
ARID5A AT rich interactive domain 5A (MRF1-like) 0.735027
CLEC19A C-type lectin domain family 19, member A 0.735027
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.732191
GRIK1 glutamate receptor, ionotropic, kainate 1 0.730571
TMEM108 transmembrane protein 108 0.726524
DTWD2 DTW domain containing 2 0.726524
HINT1 histidine triad nucleotide binding protein 1 0.722077
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0.718443
THSD7B thrombospondin, type I, domain containing 7B 0.714408
CAMK4 calcium/calmodulin-dependent protein kinase IV 0.701526
C15ORF32 chromosome 15 open reading frame 32 0.699517
OSBPL5 oxysterol binding protein-like 5 0.697109
ADCY7 adenylate cyclase 7 0.695504
CRHBP corticotropin releasing hormone binding protein 0.692697
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.691495
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.690694
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.690694
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.689492
HCRT hypocretin (orexin) neuropeptide precursor 0.689092
ARRB2 arrestin, beta 2 0.680697
ADCY8 adenylate cyclase 8 (brain) 0.677903
CCKAR cholecystokinin A receptor 0.677504
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.676308
RGS17 regulator of G-protein signaling 17 0.673917
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.672722
CHRND cholinergic receptor, nicotinic, delta (muscle) 0.671527
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.663578
UBAP2 ubiquitin associated protein 2 0.659215
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 0.644981
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) 0.643797
ADRA2A adrenoceptor alpha 2A 0.641827
TAGLN3 transgelin 3 0.637495
NPS neuropeptide S 0.636708
NPY2R neuropeptide Y receptor Y2 0.633956
ASTN1 astrotactin 1 0.631205
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 0.624143
CSNK1E casein kinase 1, epsilon 0.623751
ACBD5 acyl-CoA binding domain containing 5 0.621792
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator 0.620617
ZCCHC14 zinc finger, CCHC domain containing 14 0.617486
PRL prolactin 0.614356
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.606543
FKBP5 FK506 binding protein 5 0.60303
CRHR2 corticotropin releasing hormone receptor 2 0.59991
STON2 stonin 2 0.595623
AGPS alkylglycerone phosphate synthase 0.594454
WASF3 WAS protein family, member 3 0.591727
IGBP1 immunoglobulin (CD79A) binding protein 1 0.591727
DSCAML1 Down syndrome cell adhesion molecule like 1 0.591337
HOMER1 homer scaffolding protein 1 0.587054
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 0.585108
GALR3 galanin receptor 3 0.584719
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 0.581217
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.579661
DAD1 defender against cell death 1 0.572662
GHSR growth hormone secretagogue receptor 0.570718
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 0.569163
TACR1 tachykinin receptor 1 0.559062
PECR peroxisomal trans-2-enoyl-CoA reductase 0.556344
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.554791
ARC activity-regulated cytoskeleton-associated protein 0.544318
RGS20 regulator of G-protein signaling 20 0.540829
ABLIM1 actin binding LIM protein 1 0.540055
LEP leptin 0.540055
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B 0.534248
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.533088
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.532701
KLF11 Kruppel-like factor 11 0.528449
GLRA3 glycine receptor, alpha 3 0.527676
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.526518
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.526518
ADORA1 adenosine A1 receptor 0.524974
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 0.523816
INTS8 integrator complex subunit 8 0.52343
MARK1 MAP/microtubule affinity-regulating kinase 1 0.514956
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.513417
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.512648
GRM8 glutamate receptor, metabotropic 8 0.506123
MEA1 male-enhanced antigen 1 0.505356
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.501144
THEMIS thymocyte selection associated 0.501144
FTO fat mass and obesity associated 0.499614
CPLX4 complexin 4 0.49274
GRM1 glutamate receptor, metabotropic 1 0.491597
ARRB1 arrestin, beta 1 0.491597
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.491215
GPR55 G protein-coupled receptor 55 0.491215
CREB3 cAMP responsive element binding protein 3 0.483604
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 0.483224
TDO2 tryptophan 2,3-dioxygenase 0.476014
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.474498
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 0.470711
EYS eyes shut homolog (Drosophila) 0.470332
SEC24D SEC24 family member D 0.469954
TAC1 tachykinin, precursor 1 0.46655
ARL15 ADP-ribosylation factor-like 15 0.466172
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.463905
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.462016
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.460129
NPY1R neuropeptide Y receptor Y1 0.457864
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.457864
CPLX3 complexin 3 0.456732
NRG3 neuregulin 3 0.455978
CSMD2 CUB and Sushi multiple domains 2 0.455224
RFX4 regulatory factor X, 4 (influences HLA class II expression) 0.455224
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.45447
MREG melanoregulin 0.453339
CLOCK clock circadian regulator 0.450324
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.4443
CDH13 cadherin 13 0.443171
MIB2 mindbomb E3 ubiquitin protein ligase 2 0.442418
EPHB1 EPH receptor B1 0.442042
UBE3C ubiquitin protein ligase E3C 0.441666
GRID1 glutamate receptor, ionotropic, delta 1 0.439034
C6ORF25 chromosome 6 open reading frame 25 0.43753
ANAPC1 anaphase promoting complex subunit 1 0.434524
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 0.431144
CHRM1 cholinergic receptor, muscarinic 1 0.428891
CSMD1 CUB and Sushi multiple domains 1 0.427765
NAP1L4 nucleosome assembly protein 1-like 4 0.42739
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.425139
LVRN laeverin 0.424014
TRH thyrotropin-releasing hormone 0.42364
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.419892
ADCY1 adenylate cyclase 1 (brain) 0.416147
ADCY3 adenylate cyclase 3 0.414276
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.409787
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 0.408292
TNN tenascin N 0.406425
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.404184
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.402692
ZNF699 zinc finger protein 699 0.398962
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.395235
NGF nerve growth factor (beta polypeptide) 0.394118
CHRM5 cholinergic receptor, muscarinic 5 0.393746
PDE10A phosphodiesterase 10A 0.388909
MOGS mannosyl-oligosaccharide glucosidase 0.387051
CALY calcyon neuron-specific vesicular protein 0.384451
BICD1 bicaudal D homolog 1 (Drosophila) 0.381481
NTS neurotensin 0.381481
DNASE2B deoxyribonuclease II beta 0.380368
COL25A1 collagen, type XXV, alpha 1 0.380368
DNM1 dynamin 1 0.378143
PLCL1 phospholipase C-like 1 0.377031
INSC inscuteable homolog (Drosophila) 0.372217
MGLL monoglyceride lipase 0.371107
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.369258
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.368888
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.367779
NCK2 NCK adaptor protein 2 0.36704
CINP cyclin-dependent kinase 2 interacting protein 0.364824
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.360764
ADCY5 adenylate cyclase 5 0.356341
SNPH syntaphilin 0.353395
RGMB repulsive guidance molecule family member b 0.349717
PRKG2 protein kinase, cGMP-dependent, type II 0.347511
NALCN sodium leak channel, non selective 0.345308
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.342006
DUSP8 dual specificity phosphatase 8 0.341272
KCNT1 potassium channel, sodium activated subfamily T, member 1 0.340906
GATA4 GATA binding protein 4 0.337608
CD4 CD4 molecule 0.333218
CHAT choline O-acetyltransferase 0.333218
NTSR1 neurotensin receptor 1 (high affinity) 0.332121
PER2 period circadian clock 2 0.3292
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.325552
HRH3 histamine receptor H3 0.321545
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.32009
HES2 hes family bHLH transcription factor 2 0.31464
SGCE sarcoglycan, epsilon 0.312464
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.311014
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 0.309566
RGS19 regulator of G-protein signaling 19 0.309204
LARS leucyl-tRNA synthetase 0.307033
GPD1L glycerol-3-phosphate dehydrogenase 1-like 0.303059
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 0.302337
C19ORF26 chromosome 19 open reading frame 26 0.296571
GDNF glial cell derived neurotrophic factor 0.295851
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.295851
GLUD2 glutamate dehydrogenase 2 0.292975
GAGE12F G antigen 12F 0.291539
ADRBK2 adrenergic, beta, receptor kinase 2 0.29118
MYOZ2 myozenin 2 0.28831
KDM4C lysine (K)-specific demethylase 4C 0.285444
FGD4 FYVE, RhoGEF and PH domain containing 4 0.285444
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 0.285444
NEUROD2 neuronal differentiation 2 0.284728
CORT cortistatin 0.284013
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.281153
AIM2 absent in melanoma 2 0.280082
TCTA T-cell leukemia translocation altered 0.27687
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.276514
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.275801
RBPMS RNA binding protein with multiple splicing 0.275801
ACPT acid phosphatase, testicular 0.275445
PDE4A phosphodiesterase 4A, cAMP-specific 0.274732
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.274376
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.27153
ARF4 ADP-ribosylation factor 4 0.271174
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.269753
PRDM16 PR domain containing 16 0.265494
MEGF6 multiple EGF-like-domains 6 0.264431
SYT2 synaptotagmin II 0.26266
NCAM1 neural cell adhesion molecule 1 0.261952
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 0.261952
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.261599
BPI bactericidal/permeability-increasing protein 0.261599
CDNF cerebral dopamine neurotrophic factor 0.261245
NRCAM neuronal cell adhesion molecule 0.259124
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.257005
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.255946
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.255594
HYLS1 hydrolethalus syndrome 1 0.250311
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.250311
ANK1 ankyrin 1, erythrocytic 0.250311
NPY5R neuropeptide Y receptor Y5 0.24996
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 0.249608
INADL InaD-like (Drosophila) 0.249257
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 0.246098
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.245747
AKAP5 A kinase (PRKA) anchor protein 5 0.243995
EFNA5 ephrin-A5 0.242245
SYNE1 spectrin repeat containing, nuclear envelope 1 0.240847
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.240497
XYLT2 xylosyltransferase II 0.240148
KANK1 KN motif and ankyrin repeat domains 1 0.238403
TAT tyrosine aminotransferase 0.238403
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.237706
CCDC88A coiled-coil domain containing 88A 0.236312
CPLX1 complexin 1 0.235268
LY96 lymphocyte antigen 96 0.233183
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.232142
SALL2 spalt-like transcription factor 2 0.231102
FAM13A family with sequence similarity 13, member A 0.22937
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 0.229024
GRK5 G protein-coupled receptor kinase 5 0.229024
MGP matrix Gla protein 0.227988
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.226952
TFIP11 tuftelin interacting protein 11 0.226952
UCN3 urocortin 3 0.226607
AVP arginine vasopressin 0.22145
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.221108
CREB3L4 cAMP responsive element binding protein 3-like 4 0.219057
DLL1 delta-like 1 (Drosophila) 0.219057
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 0.217693
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.217352
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 0.214636
BCHE butyrylcholinesterase 0.213959
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.213959
DSC3 desmocollin 3 0.212608
DTNBP1 dystrobrevin binding protein 1 0.211261
GLS2 glutaminase 2 (liver, mitochondrial) 0.203275
MC5R melanocortin 5 receptor 0.202618
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.201635
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 0.200331
PDLIM5 PDZ and LIM domain 5 0.200006
TECR trans-2,3-enoyl-CoA reductase 0.198386
CPLX2 complexin 2 0.192657
NLGN4X neuroligin 4, X-linked 0.190786
DACT3 dishevelled-binding antagonist of beta-catenin 3 0.190168
IFI44L interferon-induced protein 44-like 0.189859
EPHB2 EPH receptor B2 0.185016
CHM choroideremia (Rab escort protein 1) 0.184128
AKAP9 A kinase (PRKA) anchor protein 9 0.182086
POLI polymerase (DNA directed) iota 0.180367
AKR1C3 aldo-keto reductase family 1, member C3 0.179802
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.179239
RXRB retinoid X receptor, beta 0.17896
NLE1 notchless homolog 1 (Drosophila) 0.178403
VIPR2 vasoactive intestinal peptide receptor 2 0.177576
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.177301
ITGAD integrin, alpha D 0.176757
RNF19B ring finger protein 19B 0.176485
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.176215
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.176215
ACSL4 acyl-CoA synthetase long-chain family member 4 0.175947
NPPA natriuretic peptide A 0.175947
CNOT2 CCR4-NOT transcription complex, subunit 2 0.175947
CIRBP cold inducible RNA binding protein 0.175947
CRLF1 cytokine receptor-like factor 1 0.174881
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.174881
SOD2 superoxide dismutase 2, mitochondrial 0.171036
ACTG1 actin gamma 1 0.170789
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.169571
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.169571
SYN1 synapsin I 0.168381
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.167915
CNTN4 contactin 4 0.167915
SEPT6 septin 6 0.165655
SPATA21 spermatogenesis associated 21 0.162908
CNTN6 contactin 6 0.162109
ACTN1 actinin, alpha 1 0.161912
NRG1 neuregulin 1 0.161716
PLCG1 phospholipase C, gamma 1 0.161523
MGAM maltase-glucoamylase 0.160761
HSPH1 heat shock 105kDa/110kDa protein 1 0.160021
MAP6 microtubule-associated protein 6 0.159302
FBXO2 F-box protein 2 0.159302
TOR1A torsin family 1, member A (torsin A) 0.158951
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.158778
GPX5 glutathione peroxidase 5 0.158097
ADGRL4 adhesion G protein-coupled receptor L4 0.144661
PATE1 prostate and testis expressed 1 0.143928
NOS1 nitric oxide synthase 1 (neuronal) 0.143168
CNTN3 contactin 3 (plasmacytoma associated) 0.14237
NOTO notochord homeobox 0.141982
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.141905
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.141687
ADORA2A adenosine A2a receptor 0.141485
MAPK7 mitogen-activated protein kinase 7 0.141182
TAC3 tachykinin 3 0.140383
NPSR1 neuropeptide S receptor 1 0.139797
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.139419
APEH acylaminoacyl-peptide hydrolase 0.138941
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 0.138879
TACR3 tachykinin receptor 3 0.138827
CXADR coxsackie virus and adenovirus receptor 0.138414
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.138124
NCOR2 nuclear receptor corepressor 2 0.137386
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.136923
EFNB1 ephrin-B1 0.136621
ACTB actin, beta 0.136044
ADCY4 adenylate cyclase 4 0.135148
STXBP1 syntaxin binding protein 1 0.134808
SYT1 synaptotagmin I 0.134438
RAB3A RAB3A, member RAS oncogene family 0.134343
ADRA1A adrenoceptor alpha 1A 0.134131
STX8 syntaxin 8 0.133358
SIX4 SIX homeobox 4 0.132608
COCH cochlin 0.132014
ADCY10 adenylate cyclase 10 (soluble) 0.131836
ADCY9 adenylate cyclase 9 0.130899
NOVA2 neuro-oncological ventral antigen 2 0.130839
NR1I3 nuclear receptor subfamily 1, group I, member 3 0.130804
ADCY6 adenylate cyclase 6 0.13042
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.12914
NTF3 neurotrophin 3 0.12909
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.12897
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.128232
NRL neural retina leucine zipper 0.128104
NSF N-ethylmaleimide-sensitive factor 0.127952
ABAT 4-aminobutyrate aminotransferase 0.127786
NPR1 natriuretic peptide receptor 1 0.127698
GUCY2C guanylate cyclase 2C 0.127643
ASPN asporin 0.127632
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 0.126631
FHL1 four and a half LIM domains 1 0.126052
RGS4 regulator of G-protein signaling 4 0.12549
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 0.12536
NOS2 nitric oxide synthase 2, inducible 0.124493
HSPB1 heat shock 27kDa protein 1 0.123579
PEBP1 phosphatidylethanolamine binding protein 1 0.123357
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.122552
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.120021
GYPA glycophorin A (MNS blood group) 0.119018
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.119018
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.115916
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.107853
LRRC38 leucine rich repeat containing 38 0.107853
PAM peptidylglycine alpha-amidating monooxygenase 0.107826
NLGN1 neuroligin 1 0.107771
CNTN1 contactin 1 0.107412
NR2C2 nuclear receptor subfamily 2, group C, member 2 0.107026
FTCD formimidoyltransferase cyclodeaminase 0.105194
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 0.10431
PIR pirin (iron-binding nuclear protein) 0.10419
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.104011
PER3 period circadian clock 3 0.103256
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.102797
TOX3 TOX high mobility group box family member 3 0.102304
GDF5 growth differentiation factor 5 0.102272
NDEL1 nudE neurodevelopment protein 1-like 1 0.101614
HAS1 hyaluronan synthase 1 0.101301
UST uronyl-2-sulfotransferase 0.100436
MARS methionyl-tRNA synthetase 0.099756
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.099002
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.097933
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.097699
CLPTM1L CLPTM1-like 0.097498
EGLN2 egl-9 family hypoxia-inducible factor 2 0.097463
CGA glycoprotein hormones, alpha polypeptide 0.097223
ADRA1D adrenoceptor alpha 1D 0.096984
GGN gametogenetin 0.09671
HHIP hedgehog interacting protein 0.09671
ZDHHC23 zinc finger, DHHC-type containing 23 0.095917
CTSA cathepsin A 0.093658
NFYA nuclear transcription factor Y, alpha 0.093443
MFRP membrane frizzled-related protein 0.093407
BEST1 bestrophin 1 0.093189
CYTL1 cytokine-like 1 0.093189
PDE4B phosphodiesterase 4B, cAMP-specific 0.092789
GABARAP GABA(A) receptor-associated protein 0.092644
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.092499
CNR2 cannabinoid receptor 2 (macrophage) 0.092354
SKI SKI proto-oncogene 0.092318
FOXD3 forkhead box D3 0.092281
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.092245
PSENEN presenilin enhancer gamma secretase subunit 0.092063
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.092063
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.091952
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.091619
IL1RL1 interleukin 1 receptor-like 1 0.091582
NEUROD1 neuronal differentiation 1 0.091434
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 0.091361
PNPLA3 patatin-like phospholipase domain containing 3 0.091324
EXT1 exostosin glycosyltransferase 1 0.091213
F2R coagulation factor II (thrombin) receptor 0.090733
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 0.090696
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.089343
FLNB filamin B, beta 0.089039
STX1A syntaxin 1A (brain) 0.088772
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 0.088314
LTBP1 latent transforming growth factor beta binding protein 1 0.088199
ALLC allantoicase 0.088008
PCSK7 proprotein convertase subtilisin/kexin type 7 0.087547
GALR2 galanin receptor 2 0.087197
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.086616
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.086616
ERAS ES cell expressed Ras 0.086228
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.086149
THAP1 THAP domain containing, apoptosis associated protein 1 0.086149
B3GAT2 beta-1,3-glucuronyltransferase 2 0.085991
ERBB4 erb-b2 receptor tyrosine kinase 4 0.085834
LATS1 large tumor suppressor kinase 1 0.085559
LMO1 LIM domain only 1 (rhombotin 1) 0.085441
GRIK4 glutamate receptor, ionotropic, kainate 4 0.085126
HSPA4 heat shock 70kDa protein 4 0.085087
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.085008
HSPA8 heat shock 70kDa protein 8 0.08493
ALYREF Aly/REF export factor 0.084891
GAGE12I G antigen 12I 0.084891
SKP1 S-phase kinase-associated protein 1 0.084653
ENO2 enolase 2 (gamma, neuronal) 0.084533
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 0.084294
JUN jun proto-oncogene 0.084015
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.083816
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.083736
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 0.083736
CNTF ciliary neurotrophic factor 0.083736
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.083338
CRYGD crystallin, gamma D 0.082733
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.082652
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 0.082451
CKMT1B creatine kinase, mitochondrial 1B 0.082209
C1QBP complement component 1, q subcomponent binding protein 0.082088
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.081846
SOS1 son of sevenless homolog 1 (Drosophila) 0.081725
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.081725
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.081562
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.08148
HIP1 huntingtin interacting protein 1 0.081235
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.081112
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.081031
VCP valosin containing protein 0.08099