substance abuse Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning. (Human Disease Ontology, DOID_302)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:302
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Genes

250 genes associated with the disease substance abuse in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 2.60803
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.59303
CCDC63 coiled-coil domain containing 63 2.27756
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 1.88089
GGT1 gamma-glutamyltransferase 1 1.74205
TF transferrin 1.61187
BRAP BRCA1 associated protein 1.43445
HFE hemochromatosis 1.41668
HNF1A HNF1 homeobox A 1.34584
SRPRB signal recognition particle receptor, B subunit 1.32134
MYL2 myosin, light chain 2, regulatory, cardiac, slow 1.14874
RAB6B RAB6B, member RAS oncogene family 0.962837
MYLK myosin light chain kinase 0.770495
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.684927
CUX2 cut-like homeobox 2 0.625607
ZNF827 zinc finger protein 827 0.582555
C12ORF43 chromosome 12 open reading frame 43 0.549703
EXOC3L4 exocyst complex component 3-like 4 0.506539
UST uronyl-2-sulfotransferase 0.501547
FLT1 fms-related tyrosine kinase 1 0.496808
CDH13 cadherin 13 0.494812
OASL 2'-5'-oligoadenylate synthetase-like 0.491754
ADD1 adducin 1 (alpha) 0.488167
CCDC14 coiled-coil domain containing 14 0.485732
JPH1 junctophilin 1 0.484809
AUTS2 autism susceptibility candidate 2 0.479788
LPP LIM domain containing preferred translocation partner in lipoma 0.479546
PARP2 poly (ADP-ribose) polymerase 2 0.479192
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.478944
CCDC91 coiled-coil domain containing 91 0.465226
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.463727
FHIT fragile histidine triad 0.462841
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.461231
KANK1 KN motif and ankyrin repeat domains 1 0.453549
PGM1 phosphoglucomutase 1 0.451372
TOPBP1 topoisomerase (DNA) II binding protein 1 0.437635
PTPRK protein tyrosine phosphatase, receptor type, K 0.43359
MCC mutated in colorectal cancers 0.432867
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.432325
RORA RAR-related orphan receptor A 0.432325
WDFY4 WDFY family member 4 0.410854
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.409525
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 0.407124
AGBL1 ATP/GTP binding protein-like 1 0.403224
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 0.400649
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 0.398556
LMO1 LIM domain only 1 (rhombotin 1) 0.396759
KLHL1 kelch-like family member 1 0.394976
FBXL17 F-box and leucine-rich repeat protein 17 0.392011
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.390751
IYD iodotyrosine deiodinase 0.388154
RGL1 ral guanine nucleotide dissociation stimulator-like 1 0.386417
HNF4A hepatocyte nuclear factor 4, alpha 0.385833
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.382897
COL6A4P2 collagen, type VI, alpha 4 pseudogene 2 0.382752
TRPM8 transient receptor potential cation channel, subfamily M, member 8 0.382752
DMD dystrophin 0.382752
CUX1 cut-like homeobox 1 0.382752
PAX7 paired box 7 0.382752
LOC283299 uncharacterized LOC283299 0.380864
BPIFB6 BPI fold containing family B, member 6 0.380739
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.378231
CORO2A coronin, actin binding protein, 2A 0.37742
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.376937
CCSER1 coiled-coil serine-rich protein 1 0.376937
ZDHHC14 zinc finger, DHHC-type containing 14 0.376937
IL11 interleukin 11 0.376937
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 0.376937
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.373884
RPH3A rabphilin 3A 0.373216
LINC00578 long intergenic non-protein coding RNA 578 0.372858
SGCZ sarcoglycan, zeta 0.372858
PLCL1 phospholipase C-like 1 0.372858
CA8 carbonic anhydrase VIII 0.372858
TLR1 toll-like receptor 1 0.372545
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.372373
TRPM1 transient receptor potential cation channel, subfamily M, member 1 0.3712
LOC100505718 0.370568
SGMS1 sphingomyelin synthase 1 0.369654
MFSD9 major facilitator superfamily domain containing 9 0.369654
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 0.369654
CNTNAP4 contactin associated protein-like 4 0.369654
CDH8 cadherin 8, type 2 0.367725
CNTLN centlein, centrosomal protein 0.366972
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.366972
SCN1A sodium channel, voltage gated, type I alpha subunit 0.366972
ANKRD31 ankyrin repeat domain 31 0.366972
THADA thyroid adenoma associated 0.366972
ESRRG estrogen-related receptor gamma 0.364717
TMEM106B transmembrane protein 106B 0.364717
PLBD1 phospholipase B domain containing 1 0.364717
ADRA1A adrenoceptor alpha 1A 0.364717
TRAPPC9 trafficking protein particle complex 9 0.364717
PTPRE protein tyrosine phosphatase, receptor type, E 0.364717
NXPH1 neurexophilin 1 0.363908
BDKRB2 bradykinin receptor B2 0.363888
WWOX WW domain containing oxidoreductase 0.362938
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.362774
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.362774
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.362738
CSMD2 CUB and Sushi multiple domains 2 0.36272
ABHD17C abhydrolase domain containing 17C 0.361725
NELL1 NEL-like 1 (chicken) 0.361067
KCTD8 potassium channel tetramerization domain containing 8 0.361067
IGSF11 immunoglobulin superfamily, member 11 0.361067
SLC26A4 solute carrier family 26 (anion exchanger), member 4 0.361067
EXOC5 exocyst complex component 5 0.361067
DOCK2 dedicator of cytokinesis 2 0.360749
ASTN2 astrotactin 2 0.35969
CLUAP1 clusterin associated protein 1 0.359545
UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein (yeast) 0.357915
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.357411
SYCE1 synaptonemal complex central element protein 1 0.356893
RYR2 ryanodine receptor 2 (cardiac) 0.356893
GPR12 G protein-coupled receptor 12 0.356629
ZNF503-AS1 ZNF503 antisense RNA 1 0.356498
SH3GL3 SH3-domain GRB2-like 3 0.353655
C14ORF132 chromosome 14 open reading frame 132 0.353548
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 0.353334
MYO16 myosin XVI 0.353124
PHACTR3 phosphatase and actin regulator 3 0.35251
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.352113
MIR100HG mir-100-let-7a-2 cluster host gene 0.351258
NPAS3 neuronal PAS domain protein 3 0.349595
MOB3B MOB kinase activator 3B 0.349267
PLXNA4 plexin A4 0.34871
TSHB thyroid stimulating hormone, beta 0.348097
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.347293
RPAP2 RNA polymerase II associated protein 2 0.345867
TMEM156 transmembrane protein 156 0.345867
VAT1 vesicle amine transport 1 0.34561
GLMN glomulin, FKBP associated protein 0.345047
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 0.344986
CNTN4 contactin 4 0.344446
OSBPL6 oxysterol binding protein-like 6 0.343811
ZNF224 zinc finger protein 224 0.343811
TSHZ2 teashirt zinc finger homeobox 2 0.343698
LARGE like-glycosyltransferase 0.343531
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.343148
HOMER1 homer scaffolding protein 1 0.342986
SNX16 sorting nexin 16 0.342461
C1ORF146 chromosome 1 open reading frame 146 0.342409
EVI5 ecotropic viral integration site 5 0.342307
ZNF623 zinc finger protein 623 0.340978
ZC3H7A zinc finger CCCH-type containing 7A 0.340646
ANO3 anoctamin 3 0.340591
DLG2 discs, large homolog 2 (Drosophila) 0.340213
FASTKD1 FAST kinase domains 1 0.340001
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.339948
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 0.339687
DTX1 deltex 1, E3 ubiquitin ligase 0.339687
GTF2IRD1 GTF2I repeat domain containing 1 0.339126
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.337091
RIMBP2 RIMS binding protein 2 0.337046
CEMIP cell migration inducing protein, hyaluronan binding 0.33652
PEX5L peroxisomal biogenesis factor 5-like 0.334991
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 0.334755
LOC100422737 uncharacterized LOC100422737 0.333992
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.332908
PARD3B par-3 family cell polarity regulator beta 0.332803
CSMD1 CUB and Sushi multiple domains 1 0.332699
GRB10 growth factor receptor-bound protein 10 0.331855
GDA guanine deaminase 0.33124
LHFP lipoma HMGIC fusion partner 0.33124
MGAM maltase-glucoamylase 0.331082
TNIP1 TNFAIP3 interacting protein 1 0.330925
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.330863
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.330832
MTMR6 myotubularin related protein 6 0.330312
CARD8 caspase recruitment domain family, member 8 0.329866
KIAA0040 KIAA0040 0.32972
SCLY selenocysteine lyase 0.329576
UBE2F-SCLY UBE2F-SCLY readthrough (NMD candidate) 0.329576
CACHD1 cache domain containing 1 0.328787
ZNF284 zinc finger protein 284 0.328677
ZNF225 zinc finger protein 225 0.328299
FAM69A family with sequence similarity 69, member A 0.327643
COX7B2 cytochrome c oxidase subunit VIIb2 0.327643
TSPAN2 tetraspanin 2 0.327566
SIK3 SIK family kinase 3 0.327413
IGF1 insulin-like growth factor 1 (somatomedin C) 0.327286
OXR1 oxidation resistance 1 0.327211
SMAD7 SMAD family member 7 0.327186
RPL5 ribosomal protein L5 0.326331
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.325155
MASTL microtubule associated serine/threonine kinase-like 0.324667
ZNF609 zinc finger protein 609 0.324191
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.324043
LOC100379224 uncharacterized LOC100379224 0.323131
CDHR3 cadherin-related family member 3 0.322921
SYK spleen tyrosine kinase 0.322621
SYCP1 synaptonemal complex protein 1 0.322214
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.320667
ESPNL espin-like 0.320339
TRRAP transformation/transcription domain-associated protein 0.320318
NFIB nuclear factor I/B 0.320318
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.319917
SCAMP1 secretory carrier membrane protein 1 0.318388
EPHX2 epoxide hydrolase 2, cytoplasmic 0.316634
DOCK6 dedicator of cytokinesis 6 0.315813
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 0.315026
UBE2F ubiquitin-conjugating enzyme E2F (putative) 0.314569
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.311902
RAP1B RAP1B, member of RAS oncogene family 0.307483
PHACTR2 phosphatase and actin regulator 2 0.306871
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.306473
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.306473
FAM155A family with sequence similarity 155, member A 0.306473
LHFPL2 lipoma HMGIC fusion partner-like 2 0.306473
EMC2 ER membrane protein complex subunit 2 0.306473
OSBPL3 oxysterol binding protein-like 3 0.306473
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 0.306473
VAT1L vesicle amine transport 1-like 0.306375
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 0.305338
PLA2G4D phospholipase A2, group IVD (cytosolic) 0.304444
ATXN2 ataxin 2 0.304225
ADAMTSL1 ADAMTS-like 1 0.304225
A2ML1 alpha-2-macroglobulin-like 1 0.303164
MYO1H myosin IH 0.301181
COL22A1 collagen, type XXII, alpha 1 0.2985
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.297673
ZNF221 zinc finger protein 221 0.296876
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.296876
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.293269
CGNL1 cingulin-like 1 0.292613
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.290169
ZDHHC6 zinc finger, DHHC-type containing 6 0.290169
DPEP1 dipeptidase 1 (renal) 0.290169
ANXA2 annexin A2 0.290169
LAMA3 laminin, alpha 3 0.290169
FAM107B family with sequence similarity 107, member B 0.290169
LHX6 LIM homeobox 6 0.285037
MLXIPL MLX interacting protein-like 0.285037
MSH6 mutS homolog 6 0.285037
MED15 mediator complex subunit 15 0.285037
HNF1B HNF1 homeobox B 0.285037
ZNF214 zinc finger protein 214 0.280135
LINC00189 long intergenic non-protein coding RNA 189 0.279089
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1 0.275863
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 0.275863
TRAF4 TNF receptor-associated factor 4 0.275863
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.275863
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.27289
SEPT9 septin 9 0.27289
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 0.272197
ZHX2 zinc fingers and homeoboxes 2 0.270543
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.268989
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.268989
NOD2 nucleotide-binding oligomerization domain containing 2 0.268989
FCHO1 FCH domain only 1 0.268989