substance abuse Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning. (Human Disease Ontology, DOID_302)
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Genes

510 genes co-occuring with the disease substance abuse in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TF transferrin 2.11145
GGT1 gamma-glutamyltransferase 1 2.10138
DRD2 dopamine receptor D2 1.8409
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.60636
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.59966
DRD4 dopamine receptor D4 1.53568
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 1.5348
GGT2 gamma-glutamyltransferase 2 1.5282
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 1.51896
CNR1 cannabinoid receptor 1 (brain) 1.51281
OPRM1 opioid receptor, mu 1 1.49701
CLMP CXADR-like membrane protein 1.48779
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.44518
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.42498
CD4 CD4 molecule 1.3664
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 1.33021
DRD3 dopamine receptor D3 1.32498
CRH corticotropin releasing hormone 1.25863
POMC proopiomelanocortin 1.103
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 1.07992
MOBP myelin-associated oligodendrocyte basic protein 1.05429
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.01047
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.995283
PDYN prodynorphin 0.994017
BDNF brain-derived neurotrophic factor 0.991065
IQUB IQ motif and ubiquitin domain containing 0.979268
PLSCR5 phospholipid scramblase family, member 5 0.979268
INTS8 integrator complex subunit 8 0.960797
COMT catechol-O-methyltransferase 0.958287
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 0.941611
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.941196
PNOC prepronociceptin 0.934556
ALB albumin 0.906909
DRD1 dopamine receptor D1 0.904442
CCK cholecystokinin 0.900335
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.89582
UROD uroporphyrinogen decarboxylase 0.892538
MAOA monoamine oxidase A 0.876966
CORT cortistatin 0.869596
AFP alpha-fetoprotein 0.866321
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.863865
BCHE butyrylcholinesterase 0.855268
C19ORF26 chromosome 19 open reading frame 26 0.849126
CAT catalase 0.848716
ANKK1 ankyrin repeat and kinase domain containing 1 0.84544
INS insulin 0.832738
MAOB monoamine oxidase B 0.829049
CARTPT CART prepropeptide 0.801974
ALPPL2 alkaline phosphatase, placental-like 2 0.788442
ALPP alkaline phosphatase, placental 0.788033
ALPL alkaline phosphatase, liver/bone/kidney 0.787213
DRD5 dopamine receptor D5 0.783116
TNF tumor necrosis factor 0.778613
CREB1 cAMP responsive element binding protein 1 0.770027
OTP orthopedia homeobox 0.767576
HCRT hypocretin (orexin) neuropeptide precursor 0.76431
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.754934
NPS neuropeptide S 0.753713
NPY neuropeptide Y 0.749644
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.74761
BPI bactericidal/permeability-increasing protein 0.747204
FOS FBJ murine osteosarcoma viral oncogene homolog 0.741923
OPRL1 opiate receptor-like 1 0.741517
TLR4 toll-like receptor 4 0.739082
TPH2 tryptophan hydroxylase 2 0.733811
F2 coagulation factor II (thrombin) 0.731786
CGA glycoprotein hormones, alpha polypeptide 0.730976
GRM5 glutamate receptor, metabotropic 5 0.722886
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 0.721673
UBL3 ubiquitin-like 3 0.720058
FTL ferritin, light polypeptide 0.716828
FTH1 ferritin, heavy polypeptide 1 0.716828
STARD3NL STARD3 N-terminal like 0.715215
HOMER2 homer scaffolding protein 2 0.706754
CTRC chymotrypsin C (caldecrin) 0.689893
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 0.683493
CRHR1 corticotropin releasing hormone receptor 1 0.680297
ACE angiotensin I converting enzyme 0.678302
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.675112
COCH cochlin 0.663975
NCALD neurocalcin delta 0.6608
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 0.659611
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.658026
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 0.647348
PRSS30P protease, serine, 30, pseudogene 0.642221
PRSS1 protease, serine, 1 (trypsin 1) 0.640645
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 0.639463
GLUD2 glutamate dehydrogenase 2 0.637102
PTH parathyroid hormone 0.633956
PRL prolactin 0.631598
SOD2 superoxide dismutase 2, mitochondrial 0.631205
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.629242
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.62728
GPX5 glutathione peroxidase 5 0.622967
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.620226
GPX4 glutathione peroxidase 4 0.619834
UCN3 urocortin 3 0.609276
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 0.608885
NRCAM neuronal cell adhesion molecule 0.608494
CCKBR cholecystokinin B receptor 0.607714
GPX1 glutathione peroxidase 1 0.603811
PENK proenkephalin 0.595233
ASTN1 astrotactin 1 0.594843
CCKAR cholecystokinin A receptor 0.593674
GRM2 glutamate receptor, metabotropic 2 0.588612
CTSB cathepsin B 0.586276
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.585108
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.582384
NPFF neuropeptide FF-amide peptide precursor 0.581606
CD79A CD79a molecule, immunoglobulin-associated alpha 0.576161
ARHGAP42 Rho GTPase activating protein 42 0.575772
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 0.573828
NPY5R neuropeptide Y receptor Y5 0.571884
ARHGAP10 Rho GTPase activating protein 10 0.571107
HFE hemochromatosis 0.569163
ERAS ES cell expressed Ras 0.569163
GALR3 galanin receptor 3 0.566054
FAAH fatty acid amide hydrolase 0.565277
BSN bassoon presynaptic cytomatrix protein 0.5645
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 0.562169
GCC1 GRIP and coiled-coil domain containing 1 0.561392
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.561004
FGD1 FYVE, RhoGEF and PH domain containing 1 0.558285
EED embryonic ectoderm development 0.557897
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 0.554015
SPINK1 serine peptidase inhibitor, Kazal type 1 0.552851
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator 0.549359
IGF1 insulin-like growth factor 1 (somatomedin C) 0.546644
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 0.546256
GRIK1 glutamate receptor, ionotropic, kainate 1 0.540442
GOLGB1 golgin B1 0.532701
MAN1A1 mannosidase, alpha, class 1A, member 1 0.531541
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 0.524202
SCAP SREBF chaperone 0.521117
TKT transketolase 0.518805
GAL galanin/GMAP prepropeptide 0.511112
SPX spexin hormone 0.508424
MEGF6 multiple EGF-like-domains 6 0.505739
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.503058
BGLAP bone gamma-carboxyglutamate (gla) protein 0.489311
GPSM1 G-protein signaling modulator 1 0.487407
DMAP1 DNA methyltransferase 1 associated protein 1 0.486646
CNOT2 CCR4-NOT transcription complex, subunit 2 0.484744
GRIK5 glutamate receptor, ionotropic, kainate 5 0.482084
SOX3 SRY (sex determining region Y)-box 3 0.481705
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.479047
PVALB parvalbumin 0.479047
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 0.478289
UCN urocortin 0.475634
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 0.472982
CAGE1 cancer antigen 1 0.469954
PRRC2A proline-rich coiled-coil 2A 0.467684
MEMO1 mediator of cell motility 1 0.46655
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.466172
PER1 period circadian clock 1 0.462394
HESX1 HESX homeobox 1 0.457864
SNX5 sorting nexin 5 0.457109
BAIAP3 BAI1-associated protein 3 0.455601
GRM7 glutamate receptor, metabotropic 7 0.452962
CRIP2 cysteine-rich protein 2 0.452585
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.449947
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.449947
LEP leptin 0.444676
APLF aprataxin and PNKP like factor 0.44129
FAM120B family with sequence similarity 120B 0.440162
IL6 interleukin 6 0.437906
ARRB1 arrestin, beta 1 0.431144
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.425514
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 0.424014
SMTNL1 smoothelin-like 1 0.42364
ADCY2 adenylate cyclase 2 (brain) 0.418768
FBXO3 F-box protein 3 0.418019
TH tyrosine hydroxylase 0.41727
KMT2A lysine (K)-specific methyltransferase 2A 0.416521
ANKRD23 ankyrin repeat domain 23 0.41465
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.413527
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 0.412405
ADRA2C adrenoceptor alpha 2C 0.407545
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 0.407172
NTSR2 neurotensin receptor 2 0.406051
MICA MHC class I polypeptide-related sequence A 0.405678
TFCP2 transcription factor CP2 0.403811
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.403064
MB myoglobin 0.400826
TBK1 TANK-binding kinase 1 0.397843
JMJD1C jumonji domain containing 1C 0.397471
MYDGF myeloid-derived growth factor 0.394118
GSTM2 glutathione S-transferase mu 2 (muscle) 0.390025
TRDMT1 tRNA aspartic acid methyltransferase 1 0.389281
MMP8 matrix metallopeptidase 8 0.385193
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 0.382223
CAPS2 calcyphosine 2 0.37555
TRH thyrotropin-releasing hormone 0.374068
ANKRD54 ankyrin repeat domain 54 0.373698
FBXO32 F-box protein 32 0.373698
TGFB1 transforming growth factor, beta 1 0.370368
HES2 hes family bHLH transcription factor 2 0.369997
SHBG sex hormone-binding globulin 0.369258
TAAR1 trace amine associated receptor 1 0.367779
ALAD aminolevulinate dehydratase 0.367779
CHAT choline O-acetyltransferase 0.366671
APOB apolipoprotein B 0.365932
TAC1 tachykinin, precursor 1 0.365193
GSTA3 glutathione S-transferase alpha 3 0.36187
GSTA2 glutathione S-transferase alpha 2 0.360764
GSTA4 glutathione S-transferase alpha 4 0.359657
PDCD6IP programmed cell death 6 interacting protein 0.35892
DISC1 disrupted in schizophrenia 1 0.35892
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.358183
GSTA1 glutathione S-transferase alpha 1 0.353763
IFNL3 interferon, lambda 3 0.349349
CRP C-reactive protein, pentraxin-related 0.345675
NRG1 neuregulin 1 0.345675
RORB RAR-related orphan receptor B 0.345308
IGSF6 immunoglobulin superfamily, member 6 0.341639
SIX1 SIX homeobox 1 0.339806
GRM3 glutamate receptor, metabotropic 3 0.338707
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.337242
IFNA1 interferon, alpha 1 0.33651
HEXB hexosaminidase B (beta polypeptide) 0.335778
TLN2 talin 2 0.334315
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.331391
APOL2 apolipoprotein L, 2 0.33066
PTK2 protein tyrosine kinase 2 0.330295
MESDC2 mesoderm development candidate 2 0.329565
TXN2 thioredoxin 2 0.326281
WASF3 WAS protein family, member 3 0.322273
IL1B interleukin 1, beta 0.322273
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.321545
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.321181
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 0.320817
HINT1 histidine triad nucleotide binding protein 1 0.319363
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.316456
MASTL microtubule associated serine/threonine kinase-like 0.309928
GRIK3 glutamate receptor, ionotropic, kainate 3 0.30848
HBA2 hemoglobin, alpha 2 0.307757
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.306672
TP53 tumor protein p53 0.306672
CRY2 cryptochrome circadian clock 2 0.305587
MGP matrix Gla protein 0.304142
MC3R melanocortin 3 receptor 0.30342
NGF nerve growth factor (beta polypeptide) 0.30342
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.298371
STXBP5 syntaxin binding protein 5 (tomosyn) 0.297291
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.294053
ADRBK2 adrenergic, beta, receptor kinase 2 0.289744
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.289027
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 0.287952
PNPLA3 patatin-like phospholipase domain containing 3 0.28616
IPO8 importin 8 0.28294
AOX1 aldehyde oxidase 1 0.279367
CSN1S1 casein alpha s1 0.277584
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 0.276158
PARP9 poly (ADP-ribose) polymerase family, member 9 0.275089
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.274732
SH3RF1 SH3 domain containing ring finger 1 0.274021
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.271174
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.269398
TRAPPC10 trafficking protein particle complex 10 0.269043
LPL lipoprotein lipase 0.267622
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.266558
RNMT RNA (guanine-7-) methyltransferase 0.26514
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) 0.26514
CCL2 chemokine (C-C motif) ligand 2 0.264785
NPSR1 neuropeptide S receptor 1 0.263368
SGCE sarcoglycan, epsilon 0.263014
SIX2 SIX homeobox 2 0.261952
FGGY FGGY carbohydrate kinase domain containing 0.261245
GLRX2 glutaredoxin 2 0.260538
EGOT eosinophil granule ontogeny transcript (non-protein coding) 0.260538
RGS7 regulator of G-protein signaling 7 0.259124
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 0.258064
GLDN gliomedin 0.257005
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 0.255241
OCLN occludin 0.254536
NRD1 nardilysin (N-arginine dibasic convertase) 0.253479
REG1A regenerating islet-derived 1 alpha 0.252774
CRY1 cryptochrome circadian clock 1 0.252422
TKFC triokinase/FMN cyclase 0.251718
FRS2 fibroblast growth factor receptor substrate 2 0.251015
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2 0.248554
LMO3 LIM domain only 3 (rhombotin-like 2) 0.247852
AVEN apoptosis, caspase activation inhibitor 0.247852
CSH2 chorionic somatomammotropin hormone 2 0.247501
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.246799
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.245396
MAP9 microtubule-associated protein 9 0.245046
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 0.243645
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.242945
ACPT acid phosphatase, testicular 0.242595
CHURC1 churchill domain containing 1 0.242595
TDO2 tryptophan 2,3-dioxygenase 0.241895
VRK2 vaccinia related kinase 2 0.241895
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.241546
ADAR adenosine deaminase, RNA-specific 0.240847
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 0.238403
LIPE lipase, hormone-sensitive 0.234225
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 0.22937
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 0.22937
DPYSL2 dihydropyrimidinase-like 2 0.228333
GSR glutathione reductase 0.227642
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 0.226607
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.224196
LAX1 lymphocyte transmembrane adaptor 1 0.223509
UNC13B unc-13 homolog B (C. elegans) 0.222822
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.222136
UGT8 UDP glycosyltransferase 8 0.220424
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 0.220081
ARPP21 cAMP-regulated phosphoprotein, 21kDa 0.215314
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.215314
APOA2 apolipoprotein A-II 0.214636
HOXA1 homeobox A1 0.213959
RGS4 regulator of G-protein signaling 4 0.212945
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.212945
CHRM2 cholinergic receptor, muscarinic 2 0.211261
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.210925
PRTN3 proteinase 3 0.210253
ADH6 alcohol dehydrogenase 6 (class V) 0.209583
C6ORF25 chromosome 6 open reading frame 25 0.209583
LAMB1 laminin, beta 1 0.208914
GPANK1 G patch domain and ankyrin repeats 1 0.207578
CCDC130 coiled-coil domain containing 130 0.206248
PLP1 proteolipid protein 1 0.205254
ATM ATM serine/threonine kinase 0.205254
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.204593
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.204263
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 0.204263
NOX3 NADPH oxidase 3 0.203275
KIN Kin17 DNA and RNA binding protein 0.202618
PMM2 phosphomannomutase 2 0.200656
MMP2 matrix metallopeptidase 2 0.198064
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 0.19742
ACOT7 acyl-CoA thioesterase 7 0.197099
MRPL49 mitochondrial ribosomal protein L49 0.197099
HTN3 histatin 3 0.197099
MME membrane metallo-endopeptidase 0.196139
TOX thymocyte selection-associated high mobility group box 0.194865
CCL4L2 chemokine (C-C motif) ligand 4-like 2 0.193915
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.192031
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 0.190786
CEL carboxyl ester lipase 0.190476
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 0.189859
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.189551
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 0.188938
CCL4L1 chemokine (C-C motif) ligand 4-like 1 0.188022
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.187113
AVP arginine vasopressin 0.186811
UNC13A unc-13 homolog A (C. elegans) 0.18621
MID2 midline 2 0.18591
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.183835
ALLC allantoicase 0.183541
WWC1 WW and C2 domain containing 1 0.183541
AASS aminoadipate-semialdehyde synthase 0.182086
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.181798
STX10 syntaxin 10 0.178682
DNAH8 dynein, axonemal, heavy chain 8 0.178403
PER2 period circadian clock 2 0.178403
PPARA peroxisome proliferator-activated receptor alpha 0.178126
APOE apolipoprotein E 0.173832
FBL fibrillarin 0.173314
PDLIM5 PDZ and LIM domain 5 0.172544
OTX2 orthodenticle homeobox 2 0.172291
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.172038
IL10 interleukin 10 0.171785
GRIP1 glutamate receptor interacting protein 1 0.171785
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.171785
DEFB1 defensin, beta 1 0.170299
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.170054
SRR serine racemase 0.170054
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.169091
FLNA filamin A, alpha 0.166995
FADD Fas (TNFRSF6)-associated via death domain 0.166544
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.166544
NR1I3 nuclear receptor subfamily 1, group I, member 3 0.165655
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.165217
PTPRB protein tyrosine phosphatase, receptor type, B 0.164359
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 0.163523
IRS4 insulin receptor substrate 4 0.162505
FOXJ2 forkhead box J2 0.161912
AKTIP AKT interacting protein 0.161716
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.161716
SOX2 SRY (sex determining region Y)-box 2 0.161716
TPH1 tryptophan hydroxylase 1 0.161523
TJP1 tight junction protein 1 0.159658
MTUS1 microtubule associated tumor suppressor 1 0.159124
HOMER1 homer scaffolding protein 1 0.158951
MAP6 microtubule-associated protein 6 0.158605
KLHL21 kelch-like family member 21 0.157929
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.14315
MAPK14 mitogen-activated protein kinase 14 0.142341
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.142198
NTS neurotensin 0.141872
IVD isovaleryl-CoA dehydrogenase 0.13954
SCP2 sterol carrier protein 2 0.139222
PSENEN presenilin enhancer gamma secretase subunit 0.13892
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.137322
ADCY5 adenylate cyclase 5 0.137145
NKX2-2 NK2 homeobox 2 0.13568
PRDM16 PR domain containing 16 0.13526
OPRK1 opioid receptor, kappa 1 0.135193
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.134738
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.134711
SYNE1 spectrin repeat containing, nuclear envelope 1 0.134647
PRDX2 peroxiredoxin 2 0.134446
BTC betacellulin 0.134361
NME1-NME2 NME1-NME2 readthrough 0.134343
TPT1 tumor protein, translationally-controlled 1 0.134324
CCR3 chemokine (C-C motif) receptor 3 0.134277
SCARB1 scavenger receptor class B, member 1 0.134037
PDCL phosducin-like 0.133939
PC pyruvate carboxylase 0.133475
SLC4A11 solute carrier family 4, sodium borate transporter, member 11 0.133298
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 0.13271
EGR2 early growth response 2 0.132574
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.13254
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.132344
THRSP thyroid hormone responsive 0.132072
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.13157
KLHL17 kelch-like family member 17 0.130908
PCDH8 protocadherin 8 0.130541
IRF7 interferon regulatory factor 7 0.129856
OXT oxytocin/neurophysin I prepropeptide 0.128488
HDAC2 histone deacetylase 2 0.128405
ITGB6 integrin, beta 6 0.127983
ETFA electron-transfer-flavoprotein, alpha polypeptide 0.127914
GRAP2 GRB2-related adaptor protein 2 0.127723
ATF3 activating transcription factor 3 0.127004
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.126967
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.126593
DCXR dicarbonyl/L-xylulose reductase 0.12609
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 0.126051
NRGN neurogranin (protein kinase C substrate, RC3) 0.124925
CREM cAMP responsive element modulator 0.124819
VKORC1 vitamin K epoxide reductase complex, subunit 1 0.124776
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.124537
MAGEC1 melanoma antigen family C1 0.124428
PITX3 paired-like homeodomain 3 0.124319
CLDN11 claudin 11 0.12387
RECK reversion-inducing-cysteine-rich protein with kazal motifs 0.122889
ALCAM activated leukocyte cell adhesion molecule 0.122672
TACR1 tachykinin receptor 1 0.122648
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.122452
SOCS3 suppressor of cytokine signaling 3 0.121466
SNCB synuclein, beta 0.121284
IGFBP1 insulin-like growth factor binding protein 1 0.120123
EPHB4 EPH receptor B4 0.119502
CCL4 chemokine (C-C motif) ligand 4 0.119389
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.118266
SARS seryl-tRNA synthetase 0.117841
EMP1 epithelial membrane protein 1 0.117435
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.116768
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.116671
CXCR2 chemokine (C-X-C motif) receptor 2 0.116016
MBP myelin basic protein 0.113843
FBXO17 F-box protein 17 0.113807
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.113369
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.111564
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.110861
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.110782
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 0.110582
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.110502
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.110383
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.110263
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 0.110104
HBA1 hemoglobin, alpha 1 0.110064
KLF11 Kruppel-like factor 11 0.109776
STX1B syntaxin 1B 0.109735
PRAC1 prostate cancer susceptibility candidate 1 0.109653
BHLHE22 basic helix-loop-helix family, member e22 0.109571
TLR3 toll-like receptor 3 0.109325
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.10891
MEF2C myocyte enhancer factor 2C 0.108783
TCF21 transcription factor 21 0.108699
GRM1 glutamate receptor, metabotropic 1 0.108488
MECP2 methyl CpG binding protein 2 0.107936
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.107893
AUTS2 autism susceptibility candidate 2 0.107763
FH fumarate hydratase 0.107763
C3 complement component 3 0.107589
CCL5 chemokine (C-C motif) ligand 5 0.107546
SAA4 serum amyloid A4, constitutive 0.107286
FOXH1 forkhead box H1 0.107199
MLXIPL MLX interacting protein-like 0.107112
LPA lipoprotein, Lp(a) 0.107112
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.106848
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.10667
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 0.106091
PLIN3 perilipin 3 0.106091
TTK TTK protein kinase 0.105868
ACHE acetylcholinesterase (Yt blood group) 0.105868
PAM peptidylglycine alpha-amidating monooxygenase 0.105822
UGP2 UDP-glucose pyrophosphorylase 2 0.105319
SOX10 SRY (sex determining region Y)-box 10 0.105091
DGAT2 diacylglycerol O-acyltransferase 2 0.104999
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.10477
RPLP0 ribosomal protein, large, P0 0.104254
GRB2 growth factor receptor-bound protein 2 0.10416
HRAS Harvey rat sarcoma viral oncogene homolog 0.104114
PPT1 palmitoyl-protein thioesterase 1 0.103973
RNPEP arginyl aminopeptidase (aminopeptidase B) 0.103549
TARBP2 TAR (HIV-1) RNA binding protein 2 0.103356
BIN2 bridging integrator 2 0.10326
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.102972
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.102732
HAMP hepcidin antimicrobial peptide 0.102684
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.102492
HP haptoglobin 0.102443
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.102295
CPB1 carboxypeptidase B1 (tissue) 0.102147
TET1 tet methylcytosine dioxygenase 1 0.101802