stroke Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A sudden, nonconvulsive loss of neurologic function due to an ischemic or hemorrhagic intracranial vascular event. In general, cerebrovascular accidents are classified by anatomic location in the brain, vascular distribution, etiology, age of the affected individual, and hemorrhagic vs. nonhemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)|A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)|A sudden, nonconvulsive loss of neurologic function due to an ischemic or hemorrhagic intracranial vascular event. In general, cerebrovascular accidents are classified by anatomic location in the brain, vascular distribution, etiology, age of the affected individual, and hemorrhagic vs. nonhemorrhagic nature (MeSH).|A sudden loss of neurological function secondary to hemorrhage or ischemia in the brain parenchyma due to a vascular event.|Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis. (Experimental Factor Ontology, EFO_0000712)
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Genes

428 genes co-occuring with the biological term stroke in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACAT1 acetyl-CoA acetyltransferase 1
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ADA adenosine deaminase
ADAM17 ADAM metallopeptidase domain 17
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADD1 adducin 1 (alpha)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRBK1 adrenergic, beta, receptor kinase 1
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHSG alpha-2-HS-glycoprotein
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX15 arachidonate 15-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANXA5 annexin A5
AOC3 amine oxidase, copper containing 3
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOA1 apolipoprotein A-I
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
APOM apolipoprotein M
APP amyloid beta (A4) precursor protein
AQP4 aquaporin 4
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ASIC1 acid sensing (proton gated) ion channel 1
ATP13A2 ATPase type 13A2
AVP arginine vasopressin
BDNF brain-derived neurotrophic factor
BRAP BRCA1 associated protein
C3 complement component 3
C4B complement component 4B (Chido blood group)
C5 complement component 5
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CALCA calcitonin-related polypeptide alpha
CARD8 caspase recruitment domain family, member 8
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle)
CAT catalase
CBS cystathionine-beta-synthase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCR2 chemokine (C-C motif) receptor 2
CD14 CD14 molecule
CD28 CD28 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD47 CD47 molecule
CD86 CD86 molecule
CDC42 cell division cycle 42
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2B-AS1 CDKN2B antisense RNA 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CECR1 cat eye syndrome chromosome region, candidate 1
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CETP cholesteryl ester transfer protein, plasma
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKM creatine kinase, muscle
CLEC16A C-type lectin domain family 16, member A
CNR1 cannabinoid receptor 1 (brain)
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COMT catechol-O-methyltransferase
CP ceruloplasmin (ferroxidase)
CPB2 carboxypeptidase B2 (plasma)
CRP C-reactive protein, pentraxin-related
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CST3 cystatin C
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DCN decorin
DDAH1 dimethylarginine dimethylaminohydrolase 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFB1 defensin, beta 1
DEFB4A defensin, beta 4A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
ECE1 endothelin converting enzyme 1
EDN1 endothelin 1
EDNRB endothelin receptor type B
ENG endoglin
ENO2 enolase 2 (gamma, neuronal)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHX2 epoxide hydrolase 2, cytoplasmic
EPO erythropoietin
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F10 coagulation factor X
F11 coagulation factor XI
F12 coagulation factor XII (Hageman factor)
F13A1 coagulation factor XIII, A1 polypeptide
F13B coagulation factor XIII, B polypeptide
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F2RL2 coagulation factor II (thrombin) receptor-like 2
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
FABP3 fatty acid binding protein 3, muscle and heart
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGF2 fibroblast growth factor 2 (basic)
FGF23 fibroblast growth factor 23
FGFR4 fibroblast growth factor receptor 4
FGG fibrinogen gamma chain
FMO3 flavin containing monooxygenase 3
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
G6PC glucose-6-phosphatase, catalytic subunit
G6PD glucose-6-phosphate dehydrogenase
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GAS6 growth arrest-specific 6
GCH1 GTP cyclohydrolase 1
GCKR glucokinase (hexokinase 4) regulator
GDF15 growth differentiation factor 15
GFAP glial fibrillary acidic protein
GGCX gamma-glutamyl carboxylase
GGT1 gamma-glutamyltransferase 1
GH1 growth hormone 1
GHR growth hormone receptor
GHRL ghrelin/obestatin prepropeptide
GJA4 gap junction protein, alpha 4, 37kDa
GLA galactosidase, alpha
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GOLGB1 golgin B1
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GP6 glycoprotein VI (platelet)
GP9 glycoprotein IX (platelet)
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GSTA4 glutathione S-transferase alpha 4
GSTM1 glutathione S-transferase mu 1
GSTO1 glutathione S-transferase omega 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HABP2 hyaluronan binding protein 2
HAVCR2 hepatitis A virus cellular receptor 2
HBA1 hemoglobin, alpha 1
HDAC9 histone deacetylase 9
HFE hemochromatosis
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HP haptoglobin
HSPA1A heat shock 70kDa protein 1A
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HVCN1 hydrogen voltage gated channel 1
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL10RB interleukin 10 receptor, beta
IL16 interleukin 16
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL20 interleukin 20
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
INS insulin
IRX4 iroquois homeobox 4
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
JAK2 Janus kinase 2
KALRN kalirin, RhoGEF kinase
KCNK17 potassium channel, two pore domain subfamily K, member 17
KDR kinase insert domain receptor
KIF5B kinesin family member 5B
KITLG KIT ligand
KL klotho
KLF2 Kruppel-like factor 2
KLK1 kallikrein 1
KLKB1 kallikrein B, plasma (Fletcher factor) 1
LDLR low density lipoprotein receptor
LEP leptin
LEPQTL1 Leptin, serum levels of
LIF leukemia inhibitory factor
LOX lysyl oxidase
LPA lipoprotein, Lp(a)
LPL lipoprotein lipase
LTA lymphotoxin alpha
LTA4H leukotriene A4 hydrolase
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
LTC4S leukotriene C4 synthase
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MAT1A methionine adenosyltransferase I, alpha
MBL2 mannose-binding lectin (protein C) 2, soluble
MEPE matrix extracellular phosphoglycoprotein
MFN2 mitofusin 2
MGP matrix Gla protein
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR124-1 microRNA 124-1
MIR124-2 microRNA 124-2
MIR124-3 microRNA 124-3
MIR126 microRNA 126
MIR145 microRNA 145
MIR146A microRNA 146a
MIR149 microRNA 149
MIR16-1 microRNA 16-1
MIR196A2 microRNA 196a-2
MIR21 microRNA 21
MIR211 microRNA 211
MIR221 microRNA 221
MIR223 microRNA 223
MIR30A microRNA 30a
MIR499A microRNA 499a
MIRLET7B microRNA let-7b
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MSTN myostatin
MTAP methylthioadenosine phosphorylase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYBPC3 myosin binding protein C, cardiac
NAMPT nicotinamide phosphoribosyltransferase
NDRG2 NDRG family member 2
NEFH neurofilament, heavy polypeptide
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NGB neuroglobin
NINJ2 ninjurin 2
NKX2-5 NK2 homeobox 5
NLGN1 neuroligin 1
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NOD1 nucleotide-binding oligomerization domain containing 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NOTCH3 notch 3
NOX4 NADPH oxidase 4
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NPR3 natriuretic peptide receptor 3
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NR3C2 nuclear receptor subfamily 3, group C, member 2
NTNG1 netrin G1
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PCSK9 proprotein convertase subtilisin/kexin type 9
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFD platelet derived growth factor D
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PHACTR1 phosphatase and actin regulator 1
PITX2 paired-like homeodomain 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLIN1 perilipin 1
PON1 paraoxonase 1
PON2 paraoxonase 2
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PRDX5 peroxiredoxin 5
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCH protein kinase C, eta
PRL prolactin
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PROCR protein C receptor, endothelial
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REN renin
RETN resistin
RNLS renalase, FAD-dependent amine oxidase
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROPN1 rhophilin associated tail protein 1
S100A9 S100 calcium binding protein A9
S100B S100 calcium binding protein B
SAA1 serum amyloid A1
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINA9 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
SPTBN5 spectrin, beta, non-erythrocytic 5
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SRSF3 serine/arginine-rich splicing factor 3
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TAC1 tachykinin, precursor 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCN2 transcobalamin II
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
THPO thrombopoietin
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNNI1 troponin I type 1 (skeletal, slow)
TNNI3 troponin I type 3 (cardiac)
TNNT2 troponin T type 2 (cardiac)
TP53 tumor protein p53
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TSPO translocator protein (18kDa)
TTC7B tetratricopeptide repeat domain 7B
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
USF1 upstream transcription factor 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VIMP VCP-interacting membrane selenoprotein
VKORC1 vitamin K epoxide reductase complex, subunit 1
VWF von Willebrand factor
XBP1 X-box binding protein 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZC3H12A zinc finger CCCH-type containing 12A
ZFHX3 zinc finger homeobox 3