stroke Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An artery disease that is characterized by dysfunction of the blood vessels supplying the brain. (Human Disease Ontology, DOID_6713)
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Genes

340 genes associated with the disease stroke in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9
ABLIM1 actin binding LIM protein 1
ACAN aggrecan
ACAT1 acetyl-CoA acetyltransferase 1
ACE angiotensin I converting enzyme
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional)
ADCY2 adenylate cyclase 2 (brain)
ADD1 adducin 1 (alpha)
ADGRG3 adhesion G protein-coupled receptor G3
ADGRL3 adhesion G protein-coupled receptor L3
ADSS adenylosuccinate synthase
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AIM1 absent in melanoma 1
AK5 adenylate kinase 5
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPT2 angiopoietin 2
ANKRD6 ankyrin repeat domain 6
ANO10 anoctamin 10
ANXA13 annexin A13
APC adenomatous polyposis coli
APCDD1 adenomatosis polyposis coli down-regulated 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLNR apelin receptor
APOA1 apolipoprotein A-I
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
ARSJ arylsulfatase family, member J
ASIC2 acid sensing (proton gated) ion channel 2
ASTN2 astrotactin 2
ATP10A ATPase, class V, type 10A
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
ATP8B4 ATPase, class I, type 8B, member 4
ATXN1 ataxin 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAG3 BCL2-associated athanogene 3
BAIAP3 BAI1-associated protein 3
BCAN brevican
BCAS3 breast carcinoma amplified sequence 3
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BIVM basic, immunoglobulin-like variable motif containing
BLZF1 basic leucine zipper nuclear factor 1
BMP8A bone morphogenetic protein 8a
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C19ORF57 chromosome 19 open reading frame 57
C4ORF51 chromosome 4 open reading frame 51
CA10 carbonic anhydrase X
CABLES1 Cdk5 and Abl enzyme substrate 1
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CADPS2 Ca++-dependent secretion activator 2
CAMTA1 calmodulin binding transcription activator 1
CAPN3 calpain 3, (p94)
CASC4 cancer susceptibility candidate 4
CD14 CD14 molecule
CD44 CD44 molecule (Indian blood group)
CDAN1 codanin 1
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CENPF centromere protein F, 350/400kDa
CHN2 chimerin 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CMTM8 CKLF-like MARVEL transmembrane domain containing 8
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNTN5 contactin 5
CNTNAP2 contactin associated protein-like 2
CNTNAP5 contactin associated protein-like 5
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL1A2 collagen, type I, alpha 2
CPB2 carboxypeptidase B2 (plasma)
CRAMP1L Crm, cramped-like (Drosophila)
CREB3L2 cAMP responsive element binding protein 3-like 2
CRP C-reactive protein, pentraxin-related
CSMD1 CUB and Sushi multiple domains 1
CTTN cortactin
CUX1 cut-like homeobox 1
DAAM1 dishevelled associated activator of morphogenesis 1
DCDC2 doublecortin domain containing 2
DCLK1 doublecortin-like kinase 1
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DLG2 discs, large homolog 2 (Drosophila)
DNAH12 dynein, axonemal, heavy chain 12
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DOCK1 dedicator of cytokinesis 1
DOCK2 dedicator of cytokinesis 2
DPP10 dipeptidyl-peptidase 10 (non-functional)
DSCAML1 Down syndrome cell adhesion molecule like 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DTNBP1 dystrobrevin binding protein 1
EBF1 early B-cell factor 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EHF ets homologous factor
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELOVL7 ELOVL fatty acid elongase 7
ENG endoglin
EPHB1 EPH receptor B1
ERI3 ERI1 exoribonuclease family member 3
ERN1 endoplasmic reticulum to nucleus signaling 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EXOSC3 exosome component 3
F2 coagulation factor II (thrombin)
F5 coagulation factor V (proaccelerin, labile factor)
FABP2 fatty acid binding protein 2, intestinal
FAM155A family with sequence similarity 155, member A
FAM196B family with sequence similarity 196, member B
FAM63B family with sequence similarity 63, member B
FAM71F1 family with sequence similarity 71, member F1
FCRL4 Fc receptor-like 4
FGB fibrinogen beta chain
FGD4 FYVE, RhoGEF and PH domain containing 4
FHIT fragile histidine triad
FMN2 formin 2
FRMD4A FERM domain containing 4A
FRMPD1 FERM and PDZ domain containing 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATA2 GATA binding protein 2
GATA6 GATA binding protein 6
GCLC glutamate-cysteine ligase, catalytic subunit
GLRA1 glycine receptor, alpha 1
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPC5 glypican 5
GPR156 G protein-coupled receptor 156
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIK4 glutamate receptor, ionotropic, kainate 4
GRM5 glutamate receptor, metabotropic 5
GUCY2D guanylate cyclase 2D, membrane (retina-specific)
HDAC9 histone deacetylase 9
HDC histidine decarboxylase
HHLA2 HERV-H LTR-associating 2
HLF hepatic leukemia factor
HMCN1 hemicentin 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HPSE2 heparanase 2 (inactive)
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4
ICAM1 intercellular adhesion molecule 1
IGSF5 immunoglobulin superfamily, member 5
IL1A interleukin 1, alpha
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INTS7 integrator complex subunit 7
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA6 integrin, alpha 6
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB6 integrin, beta 6
JAG2 jagged 2
JAKMIP3 Janus kinase and microtubule interacting protein 3
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5
KCNIP4 Kv channel interacting protein 4
KCNK17 potassium channel, two pore domain subfamily K, member 17
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1
KIAA1549 KIAA1549
KIF26B kinesin family member 26B
KIRREL3 kin of IRRE like 3 (Drosophila)
KRT82 keratin 82, type II
KRT83 keratin 83, type II
KRT85 keratin 85, type II
L3MBTL4 l(3)mbt-like 4 (Drosophila)
LDB2 LIM domain binding 2
LHCGR luteinizing hormone/choriogonadotropin receptor
LHFPL3 lipoma HMGIC fusion partner-like 3
LOC285423 uncharacterized LOC285423
LPAL2 lipoprotein, Lp(a)-like 2, pseudogene
LPL lipoprotein lipase
LTBP1 latent transforming growth factor beta binding protein 1
LY6E lymphocyte antigen 6 complex, locus E
MBD5 methyl-CpG binding domain protein 5
METTL16 methyltransferase like 16
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MSH2 mutS homolog 2
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MYO16 myosin XVI
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NAV2 neuron navigator 2
NBEA neurobeachin
NCF1 neutrophil cytosolic factor 1
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
NFIB nuclear factor I/B
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ2 ninjurin 2
NKAIN2 Na+/K+ transporting ATPase interacting 2
NKAIN3 Na+/K+ transporting ATPase interacting 3
NLRP1 NLR family, pyrin domain containing 1
NME7 NME/NM23 family member 7
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOL4 nucleolar protein 4
NOM1 nucleolar protein with MIF4G domain 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH3 notch 3
NPPA natriuretic peptide A
NRG1 neuregulin 1
NRG2 neuregulin 2
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae)
NTM neurotrimin
NUDCD1 NudC domain containing 1
OR6X1 olfactory receptor, family 6, subfamily X, member 1
OTOG otogelin
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PALLD palladin, cytoskeletal associated protein
PAN3 PAN3 poly(A) specific ribonuclease subunit
PANK3 pantothenate kinase 3
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PCNXL2 pecanex-like 2 (Drosophila)
PCSK2 proprotein convertase subtilisin/kexin type 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDS5A PDS5 cohesin associated factor A
PDZRN4 PDZ domain containing ring finger 4
PEPD peptidase D
PHACTR2 phosphatase and actin regulator 2
PHF21A PHD finger protein 21A
PID1 phosphotyrosine interaction domain containing 1
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCE1 phospholipase C, epsilon 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PON1 paraoxonase 1
PRKCH protein kinase C, eta
PRKG1 protein kinase, cGMP-dependent, type I
PROX1 prospero homeobox 1
PSD3 pleckstrin and Sec7 domain containing 3
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTH2R parathyroid hormone 2 receptor
PTPRD protein tyrosine phosphatase, receptor type, D
RALYL RALY RNA binding protein-like
RAP1GAP2 RAP1 GTPase activating protein 2
RBBP5 retinoblastoma binding protein 5
RBMS3 RNA binding motif, single stranded interacting protein 3
REEP5 receptor accessory protein 5
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RIN2 Ras and Rab interactor 2
RNASE4 ribonuclease, RNase A family, 4
RNF144A ring finger protein 144A
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPA1 replication protein A1, 70kDa
RUNX1 runt-related transcription factor 1
RYR3 ryanodine receptor 3
SAMD12 sterile alpha motif domain containing 12
SCG2 secretogranin II
SDC2 syndecan 2
SEC24A SEC24 family member A
SELE selectin E
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SHB Src homology 2 domain containing adaptor protein B
SHF Src homology 2 domain containing F
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
SLIT2 slit homolog 2 (Drosophila)
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SNRPN small nuclear ribonucleoprotein polypeptide N
SNX10 sorting nexin 10
SNX29 sorting nexin 29
SOBP sine oculis binding protein homolog (Drosophila)
SP4 Sp4 transcription factor
SPAG16 sperm associated antigen 16
SPATA13 spermatogenesis associated 13
SPHKAP SPHK1 interactor, AKAP domain containing
SPTB spectrin, beta, erythrocytic
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SRP19 signal recognition particle 19kDa
SSBP3 single stranded DNA binding protein 3
STAB2 stabilin 2
STARD9 StAR-related lipid transfer (START) domain containing 9
STON1-GTF2A1L STON1-GTF2A1L readthrough
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D16 TBC1 domain family, member 16
TBC1D20 TBC1 domain family, member 20
TBXAS1 thromboxane A synthase 1 (platelet)
TEAD3 TEA domain family member 3
TEK TEK tyrosine kinase, endothelial
TENM4 teneurin transmembrane protein 4
TESPA1 thymocyte expressed, positive selection associated 1
TEX101 testis expressed 101
TGM6 transglutaminase 6
THSD7B thrombospondin, type I, domain containing 7B
TMEM105 transmembrane protein 105
TMEM241 transmembrane protein 241
TMEM245 transmembrane protein 245
TMEM87A transmembrane protein 87A
TNF tumor necrosis factor
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNMD tenomodulin
TRABD2A TraB domain containing 2A
TRIM8 tripartite motif containing 8
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TTC23 tetratricopeptide repeat domain 23
TTLL8 tubulin tyrosine ligase-like family member 8
TYW1B tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)
UBASH3B ubiquitin associated and SH3 domain containing B
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative)
USP49 ubiquitin specific peptidase 49
VAMP3 vesicle-associated membrane protein 3
VAT1L vesicle amine transport 1-like
VCAM1 vascular cell adhesion molecule 1
VIT vitrin
VKORC1 vitamin K epoxide reductase complex, subunit 1
VWF von Willebrand factor
WDR72 WD repeat domain 72
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZC2HC1B zinc finger, C2HC-type containing 1B
ZDHHC13 zinc finger, DHHC-type containing 13
ZNF23 zinc finger protein 23
ZNF555 zinc finger protein 555
ZNF804B zinc finger protein 804B
ZNF831 zinc finger protein 831