spontaneous chromosome breakage Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description chromosome breakage due to inherent instability of chromosomes (Mammalian Phenotype Ontology, MP_0004029)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004029
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Genes

22 gene mutations causing the spontaneous chromosome breakage phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
COPS5 COP9 signalosome subunit 5
FANCA Fanconi anemia, complementation group A
FANCC Fanconi anemia, complementation group C
FANCG Fanconi anemia, complementation group G
LIG4 ligase IV, DNA, ATP-dependent
MCM4 minichromosome maintenance complex component 4
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MDC1 mediator of DNA-damage checkpoint 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NHEJ1 nonhomologous end-joining factor 1
RAG1 recombination activating gene 1
RECQL RecQ helicase-like
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
SIRT6 sirtuin 6
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4