specific learning disability Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Impairment of certain skills such as reading or writing, coordination, self-control, or attention that interfere with the ability to learn. The impairment is not related to a global deficiency of intelligence. (Human Phenotype Ontology, HP_0001328)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0001328
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Genes

112 genes associated with the specific learning disability phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
MYO18B myosin XVIIIB 1.36327
PCSK6 proprotein convertase subtilisin/kexin type 6 1.25251
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 1.09488
COL4A2 collagen, type IV, alpha 2 1.06219
DAZAP1 DAZ associated protein 1 1.04365
ZFYVE28 zinc finger, FYVE domain containing 28 1.00386
SLC9C2 solute carrier family 9, member C2 (putative) 0.994551
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.994551
GPC3 glypican 3 0.991884
CDK1 cyclin-dependent kinase 1 0.969142
PRKCH protein kinase C, eta 0.969142
FBXL18 F-box and leucine-rich repeat protein 18 0.942765
MNS1 meiosis-specific nuclear structural 1 0.942765
CIDEC cell death-inducing DFFA-like effector c 0.930595
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.919744
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 0.884276
FAM155A family with sequence similarity 155, member A 0.882984
NLRP3 NLR family, pyrin domain containing 3 0.868241
PAMR1 peptidase domain containing associated with muscle regeneration 1 0.855449
VGLL4 vestigial-like family member 4 0.855449
ATXN10 ataxin 10 0.85193
TEX9 testis expressed 9 0.849998
OBP2A odorant binding protein 2A 0.82634
STAP1 signal transducing adaptor family member 1 0.825497
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.824663
ADAMTSL1 ADAMTS-like 1 0.823019
CERK ceramide kinase 0.820614
KIAA0196 KIAA0196 0.81601
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.815267
OXR1 oxidation resistance 1 0.813733
CCDC102B coiled-coil domain containing 102B 0.81297
ELP4 elongator acetyltransferase complex subunit 4 0.809986
FAM126A family with sequence similarity 126, member A 0.807817
RCAN3 RCAN family member 3 0.802966
GABPB1 GA binding protein transcription factor, beta subunit 1 0.801631
PIAS4 protein inhibitor of activated STAT, 4 0.800972
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.786
PTPRM protein tyrosine phosphatase, receptor type, M 0.784165
TKT transketolase 0.783563
CRBN cereblon 0.781779
PREP prolyl endopeptidase 0.781192
HNF1A HNF1 homeobox A 0.771787
SPATA13 spermatogenesis associated 13 0.770746
COX7B2 cytochrome c oxidase subunit VIIb2 0.766703
HHLA2 HERV-H LTR-associating 2 0.766212
NUAK1 NUAK family, SNF1-like kinase, 1 0.764625
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.764079
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.759822
ZNF385B zinc finger protein 385B 0.753784
CLSTN2 calsyntenin 2 0.74676
ZNF385D zinc finger protein 385D 0.746311
DPYSL3 dihydropyrimidinase-like 3 0.744976
FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 0.74366
TP63 tumor protein p63 0.731918
GRK5 G protein-coupled receptor kinase 5 0.726891
KCNT2 potassium channel, sodium activated subfamily T, member 2 0.720196
FAM49B family with sequence similarity 49, member B 0.716105
E2F8 E2F transcription factor 8 0.711145
TACR1 tachykinin receptor 1 0.70005
ZNF512 zinc finger protein 512 0.697013
MEGF6 multiple EGF-like-domains 6 0.686623
FHOD3 formin homology 2 domain containing 3 0.682247
RAB11FIP4 RAB11 family interacting protein 4 (class II) 0.681679
SGCZ sarcoglycan, zeta 0.67722
CNTNAP2 contactin associated protein-like 2 0.672202
THSD4 thrombospondin, type I, domain containing 4 0.669642
RPA1 replication protein A1, 70kDa 0.666327
ADGB androglobin 0.648376
TMEM87B transmembrane protein 87B 0.642222
FOXP1 forkhead box P1 0.638004
GRID2 glutamate receptor, ionotropic, delta 2 0.635733
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.629202
PRKCB protein kinase C, beta 0.623061
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.611966
CCDC82 coiled-coil domain containing 82 0.611413
CNTN5 contactin 5 0.603452
SHISA9 shisa family member 9 0.600931
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 0.593884
FILIP1 filamin A interacting protein 1 0.583544
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.582698
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 0.582219
CENPC centromere protein C 0.581386
LILRP2 leukocyte immunoglobulin-like receptor pseudogene 2 0.57986
GJA1 gap junction protein, alpha 1, 43kDa 0.576326
GTPBP10 GTP-binding protein 10 (putative) 0.576214
LTBP1 latent transforming growth factor beta binding protein 1 0.576102
HCRTR1 hypocretin (orexin) receptor 1 0.574995
MMP7 matrix metallopeptidase 7 0.572823
CERS6 ceramide synthase 6 0.568635
SAMD3 sterile alpha motif domain containing 3 0.562717
WWOX WW domain containing oxidoreductase 0.533704
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.522995
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.511765
DCDC2 doublecortin domain containing 2 0.505377
CHN2 chimerin 2 0.491241
MGMT O-6-methylguanine-DNA methyltransferase 0.490542
EFCAB2 EF-hand calcium binding domain 2 0.486163
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.47419
RYR3 ryanodine receptor 3 0.472653
GRIK1 glutamate receptor, ionotropic, kainate 1 0.469373
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.466578
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.461356
ANXA10 annexin A10 0.458671
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.457258
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.456449
ZFP28 ZFP28 zinc finger protein 0.455075
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.452261
DPYD dihydropyrimidine dehydrogenase 0.450636
RNF182 ring finger protein 182 0.447514
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.436883
DNAH5 dynein, axonemal, heavy chain 5 0.435659
DGKH diacylglycerol kinase, eta 0.429318